听力与言语-语言病理学

行为科学

医学伦理学

你正在浏览TRENDS IN CELL BIOLOGY期刊下所有文献
  • CDK1, the Other 'Master Regulator' of Autophagy.

    abstract::Autophagy and cap-dependent mRNA translation are tightly regulated by the mechanistic target of rapamycin complex 1 (mTORC1) signalling complex in response to nutrient availability. However, the regulation of these processes, and mTORC1 itself, is different during mitosis, and this has remained an area of significant ...

    journal_title:Trends in cell biology

    pub_type: 杂志文章,评审

    doi:10.1016/j.tcb.2020.11.001

    authors: Odle RI,Florey O,Ktistakis NT,Cook SJ

    更新日期:2021-02-01 00:00:00

  • A New Paradigm in Catalase Research.

    abstract::Recent findings provide evidence for dynamic and highly regulated dual subcellular localization of catalase, a hydrogen peroxide (H2O2)-metabolizing enzyme, in peroxisomes and the cytosol. These data suggest a number of important implications for the field of oxidative stress biology. ...

    journal_title:Trends in cell biology

    pub_type: 杂志文章

    doi:10.1016/j.tcb.2020.12.006

    authors: Fujiki Y,Bassik MC

    更新日期:2021-01-06 00:00:00

  • Protein Sorting within Chloroplasts.

    abstract::Chloroplasts have multiple suborganellar membranes. Correct and efficient translocation of chloroplast proteins from their site of synthesis into or across membranes to their functional compartments are fundamental processes. In recent years, several new components and regulatory mechanisms involved in chloroplast pro...

    journal_title:Trends in cell biology

    pub_type: 杂志文章,评审

    doi:10.1016/j.tcb.2020.09.011

    authors: Xu X,Ouyang M,Lu D,Zheng C,Zhang L

    更新日期:2021-01-01 00:00:00

  • Turning up the Green Light.

    abstract::Fluorescent proteins (FPs) have become indispensable tools in biological research for labeling cells and proteins and sensing their biochemical activity. By introducing 'folding mutations', Campbell et al. engineered a new GFP variant with dramatically enhanced cellular brightness and stability, facilitating advanced ...

    journal_title:Trends in cell biology

    pub_type: 杂志文章

    doi:10.1016/j.tcb.2020.12.007

    authors: Cassereau J,Courdavault V,Nägerl UV

    更新日期:2020-12-29 00:00:00

  • Actin on and around the Nucleus.

    abstract::Actin plays roles in many important cellular processes, including cell motility, organelle movement, and cell signaling. The discovery of transmembrane actin-binding proteins at the outer nuclear membrane (ONM) raises the exciting possibility that actin can play a role in direct force transmission to the nucleus and t...

    journal_title:Trends in cell biology

    pub_type: 杂志文章,评审

    doi:10.1016/j.tcb.2020.11.009

    authors: Davidson PM,Cadot B

    更新日期:2020-12-26 00:00:00

  • Lipid Metabolism in Regulation of Macrophage Functions.

    abstract::Macrophages are cells of the innate immune system that regulate the maintenance of tissue homeostasis, host defense during pathogen infection, and tissue repair in response to tissue injury. Recent studies indicate that macrophage functions are influenced by cellular metabolism, including lipid metabolism. Here, we re...

    journal_title:Trends in cell biology

    pub_type: 杂志文章,评审

    doi:10.1016/j.tcb.2020.09.006

    authors: Yan J,Horng T

    更新日期:2020-12-01 00:00:00

  • Cristae Membrane Dynamics - A Paradigm Change.

    abstract::Mitochondria are dynamic organelles that have essential metabolic and regulatory functions. Earlier studies using electron microscopy (EM) revealed an immense diversity in the architecture of cristae - infoldings of the mitochondrial inner membrane (IM) - in different cells, tissues, bioenergetic and metabolic conditi...

    journal_title:Trends in cell biology

    pub_type: 杂志文章,评审

    doi:10.1016/j.tcb.2020.08.008

    authors: Kondadi AK,Anand R,Reichert AS

    更新日期:2020-12-01 00:00:00

  • Photoreceptor Discs: Built Like Ectosomes.

    abstract::The light-sensitive outer segment organelle of the vertebrate photoreceptor cell is a modified cilium filled with hundreds of flattened 'disc' membranes that provide vast light-absorbing surfaces. The outer segment is constantly renewed with new discs added at its base every day. This continuous process is essential f...

    journal_title:Trends in cell biology

    pub_type: 杂志文章,评审

    doi:10.1016/j.tcb.2020.08.005

    authors: Spencer WJ,Lewis TR,Pearring JN,Arshavsky VY

    更新日期:2020-11-01 00:00:00

  • Tight Junction Structure and Function Revisited.

    abstract::Tight junctions (TJs) are intercellular junctions critical for building the epithelial barrier and maintaining epithelial polarity. The claudin family of membrane proteins play central roles in TJ structure and function. However, recent findings have uncovered claudin-independent aspects of TJ structure and function, ...

    journal_title:Trends in cell biology

    pub_type: 杂志文章,评审

    doi:10.1016/j.tcb.2020.08.004

    authors: Otani T,Furuse M

    更新日期:2020-10-01 00:00:00

  • Hematopoietic Reprogramming Entangles with Hematopoiesis.

    abstract::Hematopoiesis generally refers to hematopoietic development in fetuses and adults, as well as to hematopoietic stem cell differentiation into progeny lineages. The multiple processes that generate diverse hematopoietic cells have been considered to be unidirectional. However, many reports have recently demonstrated th...

    journal_title:Trends in cell biology

    pub_type: 杂志文章,评审

    doi:10.1016/j.tcb.2020.07.006

    authors: Wei C,Yu P,Cheng L

    更新日期:2020-10-01 00:00:00

  • A Novel Paradigm for Expert Core Facility Staff Training.

    abstract::Scientific research relies on a range of technologies, many of which are developing at a fast pace. Technical experts able to advise researchers on experimental design and validate the performance1 of shared instruments are increasingly recognized as critical members of the research community. Here I describe a novel ...

    journal_title:Trends in cell biology

    pub_type: 杂志文章

    doi:10.1016/j.tcb.2020.06.001

    authors: Waters JC

    更新日期:2020-09-01 00:00:00

  • Heterogeneity in mRNA Translation.

    abstract::During mRNA translation, the genetic information stored in mRNA is translated into a protein sequence. It is imperative that the genetic information is translated with high precision. Surprisingly, however, recent experimental evidence has demonstrated that translation can be highly heterogeneous, even among different...

    journal_title:Trends in cell biology

    pub_type: 杂志文章,评审

    doi:10.1016/j.tcb.2020.04.008

    authors: Sonneveld S,Verhagen BMP,Tanenbaum ME

    更新日期:2020-08-01 00:00:00

  • Complex Cartography: Regulation of E2F Transcription Factors by Cyclin F and Ubiquitin.

    abstract::The E2F family of transcriptional regulators sits at the center of cell cycle gene expression and plays vital roles in normal and cancer cell cycles. Whereas control of E2Fs by the retinoblastoma family of proteins is well established, much less is known about their regulation by ubiquitin pathways. Recent studies pla...

    journal_title:Trends in cell biology

    pub_type: 杂志文章,评审

    doi:10.1016/j.tcb.2020.05.002

    authors: Emanuele MJ,Enrico TP,Mouery RD,Wasserman D,Nachum S,Tzur A

    更新日期:2020-08-01 00:00:00

  • Classical and Nonclassical Intercellular Communication in Senescence and Ageing.

    abstract::Intercellular communication refers to the different ways through which cells communicate with each other and transfer a variety of messages. These communication methods involve a number of different processes that occur individually or simultaneously, which change depending on the physiological or pathological context...

    journal_title:Trends in cell biology

    pub_type: 杂志文章,评审

    doi:10.1016/j.tcb.2020.05.003

    authors: Fafián-Labora JA,O'Loghlen A

    更新日期:2020-08-01 00:00:00

  • Membrane Architecture in the Spotlight of Correlative Microscopy.

    abstract::Cellular membranes differ in their molecular organisation, shape, and dynamics. Knowing how these properties of membrane architecture relate to the presence and function of specific membrane components is fundamental for understanding membrane-associated cellular processes. Correlative light and electron microscopy (C...

    journal_title:Trends in cell biology

    pub_type: 杂志文章,评审

    doi:10.1016/j.tcb.2020.04.003

    authors: Ganeva I,Kukulski W

    更新日期:2020-07-01 00:00:00

  • ER-Phagy: Quality Control and Turnover of Endoplasmic Reticulum.

    abstract::The endoplasmic reticulum (ER) is the largest organelle in cells and has fundamental functions, such as folding, processing, and trafficking of proteins, cellular metabolism, and ion storage. To maintain its function, it is turned over constitutively, and even more actively under certain stress conditions. Quality con...

    journal_title:Trends in cell biology

    pub_type: 杂志文章,评审

    doi:10.1016/j.tcb.2020.02.001

    authors: Chino H,Mizushima N

    更新日期:2020-05-01 00:00:00

  • Subcellular Chemical Imaging: New Avenues in Cell Biology.

    abstract::To better understand the physiology and acclimation capability of the cell, one of the great challenges of the future is to access the interior of a cell and unveil its chemical landscape (composition and distribution of elements and molecules). Chemical imaging has greatly improved in sensitivity and spatial resoluti...

    journal_title:Trends in cell biology

    pub_type: 杂志文章,评审

    doi:10.1016/j.tcb.2019.12.007

    authors: Decelle J,Veronesi G,Gallet B,Stryhanyuk H,Benettoni P,Schmidt M,Tucoulou R,Passarelli M,Bohic S,Clode P,Musat N

    更新日期:2020-03-01 00:00:00

  • Squeezing in a Meal: Myosin Functions in Phagocytosis.

    abstract::Phagocytosis is a receptor-mediated, actin-dependent process of internalization of large extracellular particles, such as pathogens or apoptotic cells. Engulfment of phagocytic targets requires the activity of myosins, actin-dependent molecular motors, which perform a variety of functions at distinct steps during phag...

    journal_title:Trends in cell biology

    pub_type: 杂志文章,评审

    doi:10.1016/j.tcb.2019.11.002

    authors: Barger SR,Gauthier NC,Krendel M

    更新日期:2020-02-01 00:00:00

  • Protecting the Aging Genome.

    abstract::Mounting evidence suggests that DNA damage plays a central role in aging. Multiple tiers of defense have evolved to reduce the accumulation of DNA damage, including reducing damaging molecules, repairing DNA damage, and inducing senescence or apoptosis in response to persistent DNA damage. Mutations in or failure of t...

    journal_title:Trends in cell biology

    pub_type: 杂志文章,评审

    doi:10.1016/j.tcb.2019.12.001

    authors: Petr MA,Tulika T,Carmona-Marin LM,Scheibye-Knudsen M

    更新日期:2020-02-01 00:00:00

  • Coupling DNA Damage and Repair: an Essential Safeguard during Programmed DNA Double-Strand Breaks?

    abstract::DNA double-strand breaks (DSBs) are the most toxic DNA lesions given their oncogenic potential. Nevertheless, programmed DSBs (prDSBs) contribute to several biological processes. Formation of prDSBs is the 'price to pay' to achieve these essential biological functions. Generated by domesticated PiggyBac transposases, ...

    journal_title:Trends in cell biology

    pub_type: 杂志文章,评审

    doi:10.1016/j.tcb.2019.11.005

    authors: Bétermier M,Borde V,de Villartay JP

    更新日期:2020-02-01 00:00:00

  • Endogenous Fluorescence Tagging by CRISPR.

    abstract::Fluorescent proteins have revolutionized biomedical research as they are easy to use for protein tagging, cope without fixation or permeabilization, and thus, enable live cell imaging in various models. Current methods allow easy and quick integration of fluorescent markers to endogenous genes of interest. In this rev...

    journal_title:Trends in cell biology

    pub_type: 杂志文章,评审

    doi:10.1016/j.tcb.2019.08.004

    authors: Bukhari H,Müller T

    更新日期:2019-11-01 00:00:00

  • Information Theory: New Look at Oncogenic Signaling Pathways.

    abstract::Sustained pro-proliferative signaling is one of the hallmarks of cancer. Although it is generally understood that the oncogenic signaling pathways are overactivated, or at least abnormally activated, in cancer cells, important mechanistic details of such abnormal activation remain unresolved. Among these details are s...

    journal_title:Trends in cell biology

    pub_type: 杂志文章,评审

    doi:10.1016/j.tcb.2019.08.005

    authors: Zielińska KA,Katanaev VL

    更新日期:2019-11-01 00:00:00

  • Tug of War in the Xenophagy World.

    abstract::Xenophagy, the process of eliminating intracellular pathogens through the autophagy machinery, is an important defense mechanism against infectious disease, yet the underlying molecular mechanisms remain incompletely understood. Recent work (Xu et al., Cell, 2019) used the discovery of an inhibitor of xenophagy, SopF,...

    journal_title:Trends in cell biology

    pub_type: 杂志文章,评审

    doi:10.1016/j.tcb.2019.08.001

    authors: Pao KC,Rape M

    更新日期:2019-10-01 00:00:00

  • Acetate Metabolism in Physiology, Cancer, and Beyond.

    abstract::Acetate and the related metabolism of acetyl-coenzyme A (acetyl-CoA) confer numerous metabolic functions, including energy production, lipid synthesis, and protein acetylation. Despite its importance as a nutrient for cellular metabolism, its source has been unclear. Recent studies have provided evidence to support th...

    journal_title:Trends in cell biology

    pub_type: 杂志文章,评审

    doi:10.1016/j.tcb.2019.05.005

    authors: Bose S,Ramesh V,Locasale JW

    更新日期:2019-09-01 00:00:00

  • Defining and Modulating 'BRCAness'.

    abstract::The concept of 'BRCAness' defines the pathogenesis and vulnerability of multiple cancers. The canonical definition of BRCAness is a defect in homologous recombination repair, mimicking BRCA1 or BRCA2 loss. In turn, BRCA-deficient cells utilize error-prone DNA-repair pathways, causing increased genomic instability, whi...

    journal_title:Trends in cell biology

    pub_type: 杂志文章,评审

    doi:10.1016/j.tcb.2019.06.005

    authors: Byrum AK,Vindigni A,Mosammaparast N

    更新日期:2019-09-01 00:00:00

  • Lysosome Fission: Planning for an Exit.

    abstract::Lysosomes are acidic and degradative organelles that receive and digest a plethora of molecular and particulate cargo delivered by endocytosis, autophagy, and phagocytosis. The mechanisms responsible for sorting, transporting, and ultimately delivering membranes and cargo to lysosomes through fusion have been intensel...

    journal_title:Trends in cell biology

    pub_type: 杂志文章,评审

    doi:10.1016/j.tcb.2019.05.003

    authors: Saffi GT,Botelho RJ

    更新日期:2019-08-01 00:00:00

  • APC/C Ubiquitin Ligase: Coupling Cellular Differentiation to G1/G0 Phase in Multicellular Systems.

    abstract::The anaphase-promoting complex/cyclosome (APC/C) is an evolutionarily conserved ubiquitin ligase that controls cell cycle progression through spatiotemporally regulated proteolysis. Although recent studies revealed its postmitotic function, our knowledge of the role of APC/C beyond cell cycle regulation in the biology...

    journal_title:Trends in cell biology

    pub_type: 杂志文章,评审

    doi:10.1016/j.tcb.2019.03.001

    authors: Kimata Y

    更新日期:2019-07-01 00:00:00

  • Metastasis Stemming from Circulating Tumor Cell Clusters.

    abstract::Circulating tumor cell (CTC) clusters have an enhanced capacity to initiate metastases, compared with single cells, but it is unclear how they gain such advantage. A recent study by Gkountela etal. (Cell 2019;176:98-112) links the physical state of clusters with increased accessibility of stem cell-related transcripti...

    journal_title:Trends in cell biology

    pub_type: 杂志文章,评审

    doi:10.1016/j.tcb.2019.02.001

    authors: Yu M

    更新日期:2019-04-01 00:00:00

  • Functions of Microtubule Disassembly during Neurite Pruning.

    abstract::Large-scale neurite pruning, the developmentally regulated degeneration of axons or dendrites, is an important specificity mechanism during neuronal circuit formation. Pruning is usually restricted to single neurite branches and can occur by local degeneration or retraction. How this spatial regulation is achieved, an...

    journal_title:Trends in cell biology

    pub_type: 杂志文章,评审

    doi:10.1016/j.tcb.2019.01.002

    authors: Rumpf S,Wolterhoff N,Herzmann S

    更新日期:2019-04-01 00:00:00

  • Tales of Detailed Poly(A) Tails.

    abstract::Poly(A) tails are non-templated additions of adenosines at the 3' ends of most eukaryotic mRNAs. In the nucleus, these RNAs are co-transcriptionally cleaved at a poly(A) site and then polyadenylated before being exported to the cytoplasm. In the cytoplasm, poly(A) tails play pivotal roles in the translation and stabil...

    journal_title:Trends in cell biology

    pub_type: 杂志文章,评审

    doi:10.1016/j.tcb.2018.11.002

    authors: Nicholson AL,Pasquinelli AE

    更新日期:2019-03-01 00:00:00

  • Principles of Actomyosin Regulation In Vivo.

    abstract::The actomyosin cytoskeleton is responsible for most force-driven processes in cells and tissues. How it assembles into the necessary structures at the right time and place is an important question. Here, we focus on molecular mechanisms of actomyosin regulation recently elucidated in animal models, and highlight sever...

    journal_title:Trends in cell biology

    pub_type: 杂志文章,评审

    doi:10.1016/j.tcb.2018.09.006

    authors: Agarwal P,Zaidel-Bar R

    更新日期:2019-02-01 00:00:00

  • WNT Signaling in Cancer Immunosurveillance.

    abstract::Deregulated WNT signaling has been shown to favor malignant transformation, tumor progression, and resistance to conventional cancer therapy in a variety of preclinical and clinical settings. Accumulating evidence suggests that aberrant WNT signaling may also subvert cancer immunosurveillance, hence promoting immunoev...

    journal_title:Trends in cell biology

    pub_type: 杂志文章,评审

    doi:10.1016/j.tcb.2018.08.005

    authors: Galluzzi L,Spranger S,Fuchs E,López-Soto A

    更新日期:2019-01-01 00:00:00

  • The Different Routes to Metastasis via Hypoxia-Regulated Programs.

    abstract::Hypoxia is linked to metastasis; however, how it affects metastatic progression is not clear due to limited consensus in the literature. We posit that this lack of consensus is due to hypoxia being studied using different approaches, such as in vitro, primary tumor, or metastasis assays in an isolated manner. Here, we...

    journal_title:Trends in cell biology

    pub_type: 杂志文章,评审

    doi:10.1016/j.tcb.2018.06.008

    authors: Nobre AR,Entenberg D,Wang Y,Condeelis J,Aguirre-Ghiso JA

    更新日期:2018-11-01 00:00:00

  • Lysosomes nor Mice Move Forward without Borcs7.

    abstract::Lysosome function and position in the cytoplasm depends on the BORCS machinery, which tethers lysosomes to the kinesin microtubule motor. A recent paper of Snouwaert et al. in Cell Reports characterizes a mouse with a spontaneous mutation in the Borcs7 subunit, which causes axonal dystrophy and impaired motor function...

    journal_title:Trends in cell biology

    pub_type: 评论,杂志文章

    doi:10.1016/j.tcb.2018.08.002

    authors: Joshi U,Houwman JA,van der Sluijs P

    更新日期:2018-10-01 00:00:00

  • Synergistic Mechano-Chemical Sensing by Vascular Cilia.

    abstract::Endothelial cells can sense and respond to blood flow forces and signals, but the exact mechanisms employed remain poorly understood. A recent study describes how low-flow forces are sensed by primary cilia during development of the retinal vasculature, which sensitizes endothelial cells to BMP signaling. ...

    journal_title:Trends in cell biology

    pub_type: 评论,杂志文章

    doi:10.1016/j.tcb.2018.04.005

    authors: Follain G,Goetz JG

    更新日期:2018-07-01 00:00:00

  • Endoreplication: The Good, the Bad, and the Ugly.

    abstract::To battle adverse internal and external conditions and maintain homeostasis, diploid organisms employ various cellular processes, such as proliferation and apoptosis. In some tissues, an alternative mechanism, endoreplication, is employed toward similar goals. Endoreplication is an evolutionarily conserved cell cycle ...

    journal_title:Trends in cell biology

    pub_type: 杂志文章,评审

    doi:10.1016/j.tcb.2018.02.006

    authors: Shu Z,Row S,Deng WM

    更新日期:2018-06-01 00:00:00

  • Notching a New Pathway in Vascular Flow Sensing.

    abstract::Vascular barrier function is controlled at cell-cell junctions in response to blood flow, but how vascular endothelial cells sense and respond to flow remains to be understood. A recent study describes a flow-sensing pathway involving non-canonical Notch and cadherin signaling that sheds new light on mechanisms contro...

    journal_title:Trends in cell biology

    pub_type: 评论,杂志文章

    doi:10.1016/j.tcb.2017.12.003

    authors: Lagendijk AK,Yap AS,Hogan BM

    更新日期:2018-03-01 00:00:00

  • Zebrafish Infection: From Pathogenesis to Cell Biology.

    abstract::The study of host-pathogen interactions has illuminated fundamental research avenues in both infection and cell biology. Zebrafish (Danio rerio) larvae are genetically tractable, optically accessible, and present a fully functional innate immune system with macrophages and neutrophils that mimic their mammalian counte...

    journal_title:Trends in cell biology

    pub_type: 杂志文章,评审

    doi:10.1016/j.tcb.2017.10.002

    authors: Torraca V,Mostowy S

    更新日期:2018-02-01 00:00:00

  • 'Disc-o-Fever': Getting Down with Giardia's Groovy Microtubule Organelle.

    abstract::Protists have evolved a myriad of highly specialized cytoskeletal organelles that expand known functional capacities of microtubule (MT) polymers. One such innovation - the ventral disc - is a cup-shaped MT organelle that the parasite Giardia uses to attach to the small intestine of its host. The molecular mechanisms ...

    journal_title:Trends in cell biology

    pub_type: 杂志文章,评审

    doi:10.1016/j.tcb.2017.10.007

    authors: Nosala C,Hagen KD,Dawson SC

    更新日期:2018-02-01 00:00:00

  • Rebuilding Chromosomes After Catastrophe: Emerging Mechanisms of Chromothripsis.

    abstract::Cancer genome sequencing has identified chromothripsis, a complex class of structural genomic rearrangements involving the apparent shattering of an individual chromosome into tens to hundreds of fragments. An initial error during mitosis, producing either chromosome mis-segregation into a micronucleus or chromatin br...

    journal_title:Trends in cell biology

    pub_type: 杂志文章,评审

    doi:10.1016/j.tcb.2017.08.005

    authors: Ly P,Cleveland DW

    更新日期:2017-12-01 00:00:00

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