听力与言语-语言病理学

行为科学

医学伦理学

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  • Exploring ubiquinone biosynthesis inhibition as a strategy for improving atovaquone efficacy in malaria.

    abstract::Atovaquone (AV) acts on the malaria parasite by competing with ubiquinol (UQH2) for its union to the mitochondrial bc1 complex, preventing the ubiquinone-8,9 (UQ) redox recycling, which is a necessary step in pyrimidine biosynthesis. This study focused on UQ biosynthesis in Plasmodium falciparum and adopted proof-of-c...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章

    doi:10.1128/AAC.01516-20

    authors: Verdaguer IB,Crispim M,Zafra CA,Sussmann RAC,Buriticá NL,Melo HR,Azevedo MF,Almeida FG,Kimura EA,Katzin AM

    更新日期:2021-01-25 00:00:00

  • Novel transferable resistance-nodulation-division pump gene cluster tmexCD2-toprJ2 that confers tigecycline resistance in Raoultella ornithinolytica.

    abstract::We recently identified a novel plasmid-mediated RND-type efflux pump gene cluster, tmexCD1-toprJ1 in Klebsiella pneumoniae, that conferred resistance to multiple antimicrobials, including tigecycline. While homologs of tmexCD1-toprJ1 were found encoded in many other bacterial species in GenBank, their function and tra...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章

    doi:10.1128/AAC.02229-20

    authors: Wang CZ,Gao X,Yang QW,Lv LC,Wan M,Yang J,Cai ZP,Liu JH

    更新日期:2021-01-25 00:00:00

  • Efg1 and Cas5 Orchestrate Cell Wall Damage Response to Caspofungin in Candida albicans.

    abstract::Echinocandins are recommended as the first-line drugs for the treatment of systemic candidiasis. Cas5 is a key transcription factor involved in the response to cell wall damage induced by echinocandins. In this study, through a genetic screen, we identified a second transcription factor, Efg1, that is also crucial for...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章

    doi:10.1128/AAC.01584-20

    authors: Xiong K,Su C,Sun Q,Lu Y

    更新日期:2021-01-20 00:00:00

  • Characterization of a Plasmid-Encoded Resistance-Nodulation-Division Efflux Pump in Klebsiella pneumoniae and Klebsiella quasipneumoniae from Patients in China.

    abstract::Two multidrug-resistant (MDR) mcr-1-harboring Klebsiella pneumoniae isolates from patients with urinary tract infections and one MDR Klebsiella quasipneumoniae isolate from a patient with bloodstream infection were identified to carry tmexCD1-toprJ1 The addition of the efflux pump inhibitor reduced the tigecycline MIC...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章

    doi:10.1128/AAC.02075-20

    authors: He R,Yang Y,Wu Y,Zhong LL,Yang Y,Chen G,Qin M,Liang X,Ahmed MAEE,Lin M,Yan B,Xia Y,Dai M,Chen H,Tian GB

    更新日期:2021-01-20 00:00:00

  • Variability of Hydroxy-Itraconazole in Relation to Itraconazole Bloodstream Concentrations.

    abstract::We analyzed the relationship between itraconazole (ITZ) and hydroxy-itraconazole (OH-ITZ) levels in 1223 human samples. Overall, there was a statistically significant correlation between ITZ and OH-ITZ levels (correlation coefficient 0.7838), and OH-ITZ levels were generally higher than that of ITZ (median OH-ITZ:ITZ ...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章

    doi:10.1128/AAC.02353-20

    authors: Wiederhold NP,Schwartz IS,Patterson TF,Thompson GR 3rd

    更新日期:2021-01-19 00:00:00

  • Boromycin has potent anti-Toxoplasma and anti-Cryptosporidium activity.

    abstract::Toxoplasma gondii and Cryptosporidium parvum, members of the phylum Apicomplexa, are significant pathogens of both humans and animals worldwide for which new and effective therapeutics are needed. Here we describe the activity of the antibiotic boromycin against Toxoplasma and Cryptosporidium Boromycin potently inhibi...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章

    doi:10.1128/AAC.01278-20

    authors: Abenoja J,Cotto-Rosario A,O'Connor R

    更新日期:2021-01-19 00:00:00

  • Development and Characterization of Monoolein-Based Liposomes of Carvacrol, Cinnamaldehyde, Citral or Thymol with anti-Candida Activities.

    abstract::There is an increasing need for novel drugs and new strategies for the therapy of invasive candidiasis. This study aimed to develop and characterize liposome-based nanoparticles of carvacrol, cinnamaldehyde, citral or thymol with anti-Candida activities. Dioctadecyldimethylammonium bromide- and monoolein-based liposom...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章

    doi:10.1128/AAC.01628-20

    authors: Miranda-Cadena K,Dias M,Costa-Barbosa A,Collins T,Marcos-Arias C,Eraso E,Pais C,Quindós G,Sampaio P

    更新日期:2021-01-19 00:00:00

  • An Integrated HOCl-Producing E-Scaffold Is Active Against Monomicrobial and Polymicrobial Biofilms.

    abstract::Oxidizing agents like hypochlorous acid (HOCl) have antimicrobial activity. We developed an integrated electrochemical scaffold or 'e-scaffold' that delivers a continuous low dose of HOCl aimed at targeting microbial biofilms without exceeding concentrations toxic to humans, as a prototype of a device being developed ...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章

    doi:10.1128/AAC.02007-20

    authors: Flurin L,Raval YS,Mohamed A,Greenwood-Quaintance KE,Cano EJ,Beyenal H,Patel R

    更新日期:2021-01-04 00:00:00

  • β-lactam combinations that exhibit synergy against Mycobacteroides abscessus clinical isolates.

    abstract::Mycobacteroides abscessus (Mab) is an opportunistic environmental pathogen that can cause chronic pulmonary disease in the setting of structural lung conditions such as bronchiectasis, COPD and cystic fibrosis. These infections are often incurable and associated with rapid lung function decline. Mab is naturally resis...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章

    doi:10.1128/AAC.02545-20

    authors: Story-Roller E,Galanis C,Lamichhane G

    更新日期:2020-12-23 00:00:00

  • A Tetrahydrophthalazinone Inhibitor of Phosphodiesterase with In Vitro Activity Against Intracellular Trypanosomatids.

    abstract::The phosphodiesterase inhibitor tetrahydrophthalazinone NPD-008 was explored by phenotypic in vitro screening, target validation and ultrastructural approaches against Trypanosoma cruzi NPD-008 displayed activity against different forms and strains of T. cruzi (EC50 = 6.6 - 39.5 μM), increased cAMP levels of T. cruzi ...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章

    doi:10.1128/AAC.00960-20

    authors: de Araújo JS,Peres RB,Bernardino da Silva P,Batista MM,Sterk GJ,Maes L,Caljon G,Leurs R,de Koning HP,Kalejaiye TD,Soeiro MNC

    更新日期:2020-12-23 00:00:00

  • BENZNIDAZOLE IN CEREBROSPINAL FLUID. A CASE SERIES OF CHAGAS DISEASE MENINGOENCEPHALITIS IN HIV POSITIVE PATIENTS.

    abstract::BackgroundChagas disease reactivation in HIV positive people is an opportunistic infection with 79-100% mortality. It commonly involves the central nervous system (CNS). Early treatment with trypanocidal drugs such as benznidazole (BNZ) is crucial for this severe manifestation of Trypanosoma cruzi infection. However, ...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章

    doi:10.1128/AAC.01922-20

    authors: Fernández ML,Marson ME,Mastrantonio GE,Corti MA,Fleitas U,Lloveras SC,Lista N,Priarone MM,Domínguez C,Garcia-Bournissen F

    更新日期:2020-12-23 00:00:00

  • Olorofim Susceptibility Testing of 1,423 Danish Mold Isolates Obtained in 2018-2019 Confirms Uniform and Broad-Spectrum Activity.

    abstract::Olorofim is a novel antifungal drug in phase 2 trials. It has shown promising in vitro activity against various molds, except for Mucorales. Initially, we observed a broad range of EUCAST MICs for Aspergillus fumigatus Here, we explored the MIC variability in more detail and prospectively investigated the susceptibili...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章

    doi:10.1128/AAC.01527-20

    authors: Astvad KMT,Jørgensen KM,Hare RK,Datcu R,Arendrup MC

    更新日期:2020-12-16 00:00:00

  • Efficacy of Telavancin in Comparison to Linezolid in a Porcine Model of Severe Methicillin-Resistant Staphylococcus aureus Pneumonia.

    abstract::Current guidelines recommend vancomycin and linezolid as first-line agents against methicillin-resistant Staphylococcus aureus (MRSA) nosocomial pneumonia. Telavancin is a potential new therapeutic alternative, specifically in monomicrobial MRSA pneumonia. This study compared the efficacies of telavancin versus linezo...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章

    doi:10.1128/AAC.01009-20

    authors: Battaglini D,Motos A,Li Bassi G,Yang H,Pagliara F,Yang M,Aguilera Xiol E,Meli A,Bobi J,Frigola G,Senussi T,Idone F,Travierso C,Chiurazzi C,Fernandez-Barat L,Rigol M,Ramirez J,Pelosi P,Chiumello D,Antonelli M,Nicol

    更新日期:2020-12-16 00:00:00

  • Heterogeneity and Diversity of mcr-8 Genetic Context in Chicken-Associated Klebsiella pneumoniae.

    abstract::Increasing mobile colistin resistance, mediated by the mcr gene family, in Enterobacteriaceae has become a global concern. Among the 10 reported mcr genes, mcr-8 was first identified in Klebsiella pneumoniae, which could cause severe infections with high mortality. Information about the prevalence and genetic context ...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章

    doi:10.1128/AAC.01872-20

    authors: Wu B,Wang Y,Ling Z,Yu Z,Shen Z,Zhang S,Wang X

    更新日期:2020-12-16 00:00:00

  • Systematic Investigation of Resistance Evolution to Common Antibiotics Reveals Conserved Collateral Responses across Common Human Pathogens.

    abstract::As drug resistance continues to grow, treatment strategies that turn resistance into a disadvantage for the organism will be increasingly relied upon to treat infections and to lower the rate of multidrug resistance. The majority of work in this area has investigated how resistance evolution toward a single antibiotic...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章

    doi:10.1128/AAC.01273-20

    authors: Rodriguez de Evgrafov MC,Faza M,Asimakopoulos K,Sommer MOA

    更新日期:2020-12-16 00:00:00

  • New Perspectives on Antimicrobial Agents: Remdesivir Treatment for COVID-19.

    abstract::Remdesivir was recently approved by the Food and Drug Administration for the treatment of hospitalized patients with coronavirus disease 2019 (COVID-19). Remdesivir is the prodrug of an adenosine analogue that inhibits viral replication of several RNA virus families, including Coronaviridae Preclinical data in animal ...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章,评审

    doi:10.1128/AAC.01814-20

    authors: Aleissa MM,Silverman EA,Paredes Acosta LM,Nutt CT,Richterman A,Marty FM

    更新日期:2020-12-16 00:00:00

  • An Exposure-Response Perspective on the Clinical Dose of Pretomanid.

    abstract::Pretomanid was approved by the U.S. FDA, via the limited population pathway for antibacterial and antifungal drugs, as part of a three-drug regimen with bedaquiline and linezolid for the treatment of extensively drug-resistant and treatment-intolerant or nonresponsive multidrug-resistant tuberculosis. The recommended ...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章

    doi:10.1128/AAC.01121-20

    authors: Nedelman JR,Salinger DH,Subramoney V,Woolson R,Wade K,Li M,Everitt D,Mendel CM,Spigelman M

    更新日期:2020-12-16 00:00:00

  • BKC-2, a New BKC Variant Detected in MCR-9.1-producing Enterobacter hormaechei subsp. xiangfangensis.

    abstract::We performed the characterization of a multidrug-resistant (MDR) Enterobacter spp. isolate highlighting the genetic aspects of the antimicrobial resistance genes. An Enterobacter spp. isolate (Ec61) was recovered in 2014 from a transtracheal aspirate sample from a patient admitted to a Brazilian tertiary hospital and ...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章

    doi:10.1128/AAC.01193-20

    authors: Martins WMBS,Martins ER,de Andrade LK,Farzana R,Walsh TR,Toleman MA,Nogueira MCL,Gales AC

    更新日期:2020-12-14 00:00:00

  • Susceptibility trends of zoliflodacin against multidrug-resistant Neisseria gonorrhoeae clinical isolates in Nanjing, China (2014-2018).

    abstract::Previously, we reported potent activity of a novel spiropyrimidinetrione, zoliflodacin, against N. gonorrhoeae isolates from symptomatic men in Nanjing, China, collected in 2013. Here, we investigated trends of susceptibilities of zoliflodacin in 986 isolates collected from men between 2014 and 2018. N. gonorrhoeae is...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章

    doi:10.1128/AAC.00863-20

    authors: Le W,Su X,Lou X,Li X,Gong X,Wang B,Genco CA,Mueller JP,Rice PA

    更新日期:2020-12-14 00:00:00

  • The polyaminoisoprenyl potentiator NV716 revives old disused antibiotics against intracellular forms of infection by Pseudomonas aeruginosa.

    abstract::Active efflux confers intrinsic resistance to multiple antibiotics in Pseudomonas aeruginosa, including old disused molecules. Beside resistance, intracellular survival is another reason for failure to eradicate bacteria with antibiotics. We evaluated the capacity of polyaminoisoprenyl potentiators (designed as efflux...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章

    doi:10.1128/AAC.02028-20

    authors: Wang GW,Brunel JM,Bolla JM,Van Bambeke F

    更新日期:2020-12-14 00:00:00

  • In Vitro Characterization of the Carbohydrate-Binding Agents HHA, GNA and UDA as Inhibitors of Influenza a and B Virus Replication.

    abstract::Here, we report on the anti-influenza virus activity of the mannose-binding agents, Hippeastrum hybrid agglutinin (HHA) and Galanthus nivalis agglutinin (GNA), and the (N-acetylglucosamine)n-specific Urtica dioica agglutinin (UDA). These carbohydrate-binding agents (CBA) strongly inhibited various influenza A(H1N1), A...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章

    doi:10.1128/AAC.01732-20

    authors: Vanderlinden E,Van Winkel N,Naesens L,Van Damme EJM,Persoons L,Schols D

    更新日期:2020-12-07 00:00:00

  • Most-probable number based minimum duration of killing assay for determining the spectrum of rifampicin susceptibility in clinical M. tuberculosis isolates.

    abstract::Accurate antibiotic susceptibility testing is essential for successful tuberculosis treatment. Recent studies have highlighted the limitations of minimum inhibitory concentrations (MIC) based phenotypic susceptibility methods in detecting other aspects of antibiotic susceptibilities in bacteria. Duration and peak of a...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章

    doi:10.1128/AAC.01439-20

    authors: Vijay S,Nhung HN,Bao NLH,Thu DDA,Trieu LPT,Phu NH,Thwaites GE,Javid B,Thuong NTT

    更新日期:2020-11-30 00:00:00

  • Developing New Drugs for Mycobacterium tuberculosis Therapy: What Information Do We Get from Preclinical Animal Models?

    abstract::Preclinical animal models of infection are employed to develop new agents but also to screen among molecules to rank them. There are often major differences between human pharmacokinetic (PK) profiles and those developed by animal models of infection, and these may lead to substantial differences in efficacy relative ...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章

    doi:10.1128/AAC.01376-20

    authors: Drusano GL,Duncanson B,Scanga CA,Kim S,Schmidt S,Neely MN,Yamada WM,Vicchiarelli M,Peloquin CA,Louie A

    更新日期:2020-11-17 00:00:00

  • A Choline-Recognizing Monomeric Lysin, ClyJ-3m, Shows Elevated Activity against Streptococcus pneumoniae.

    abstract::Streptococcus pneumoniae is a leading pathogen for bacterial pneumonia, which can be treated with bacteriophage lysins harboring a conserved choline binding module (CBM). Such lysins regularly function as choline-recognizing dimers. Previously, we reported a pneumococcus-specific lysin ClyJ comprising the binding doma...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章

    doi:10.1128/AAC.00311-20

    authors: Luo D,Huang L,Gondil VS,Zhou W,Yang W,Jia M,Hu S,He J,Yang H,Wei H

    更新日期:2020-11-17 00:00:00

  • Structural Insights into Inhibition of the Acinetobacter-Derived Cephalosporinase ADC-7 by Ceftazidime and Its Boronic Acid Transition State Analog.

    abstract::Extended-spectrum class C β-lactamases have evolved to rapidly inactivate expanded-spectrum cephalosporins, a class of antibiotics designed to be resistant to hydrolysis by β-lactamase enzymes. To better understand the mechanism by which Acinetobacter-derived cephalosporinase-7 (ADC-7), a chromosomal AmpC enzyme, hydr...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章

    doi:10.1128/AAC.01183-20

    authors: Curtis BN,Smolen KA,Barlow SJ,Caselli E,Prati F,Taracila MA,Bonomo RA,Wallar BJ,Powers RA

    更新日期:2020-11-17 00:00:00

  • Sulfonated Nanomaterials with Broad-Spectrum Antiviral Activity Extending beyond Heparan Sulfate-Dependent Viruses.

    abstract::Viral infections are among the main causes of death worldwide, and we lack antivirals for the majority of viruses. Heparin-like sulfated or sulfonated compounds have been known for decades for their ability to prevent infection by heparan sulfate proteoglycan (HSPG)-dependent viruses but only in a reversible way. We h...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章

    doi:10.1128/AAC.02001-20

    authors: Cagno V,Gasbarri M,Medaglia C,Gomes D,Clement S,Stellacci F,Tapparel C

    更新日期:2020-11-17 00:00:00

  • Low Tenofovir Plasma Exposure in HIV Oral Pre-exposure Prophylaxis Recipients with Gastrointestinal Disorders.

    abstract::Four pre-exposure prophylaxis (PrEP) users with gastro-intestinal disorders (sleeve gastrectomy, terminal ileitis, celiac disease or chronic diarrhea) and receiving oral tenofovir disoproxil fumarate/emtricitabine (TDF/FTC) were included. Despite a self-reported high adherence, trough plasma tenofovir concentrations (...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章

    doi:10.1128/AAC.01902-20

    authors: Calcagno A,Dal Conte I,Cattaneo D,Testi R,Mistrangelo M,Gervasoni C,de Nicolò A,Bonora S,D'Avolio A,Di Perri G

    更新日期:2020-10-26 00:00:00

  • Rifabutin Is Bactericidal against Intracellular and Extracellular Forms of Mycobacterium abscessus.

    abstract::Mycobacterium abscessus is increasingly recognized as an emerging opportunistic pathogen causing severe lung diseases. As it is intrinsically resistant to most conventional antibiotics, there is an unmet medical need for effective treatments. Repurposing of clinically validated pharmaceuticals represents an attractive...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章

    doi:10.1128/AAC.00363-20

    authors: Johansen MD,Daher W,Roquet-Banères F,Raynaud C,Alcaraz M,Maurer FP,Kremer L

    更新日期:2020-10-20 00:00:00

  • Identification of a Novel Plasmid-Borne Gentamicin Resistance Gene in Nontyphoidal Salmonella Isolated from Retail Turkey.

    abstract::The spread of antibiotic-resistant bacteria presents a global health challenge. Efficient surveillance of bacteria harboring antibiotic resistance genes (ARGs) is a critical aspect to controlling the spread. Increased access to microbial genomic data from many diverse populations informs this surveillance but only whe...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章

    doi:10.1128/AAC.00867-20

    authors: Kim HL,Rodriguez RD,Morris SK,Zhao S,Donato JJ

    更新日期:2020-10-20 00:00:00

  • Weakest-Link Dynamics Predict Apparent Antibiotic Interactions in a Model Cross-Feeding Community.

    abstract::With the growing global threat of antimicrobial resistance, novel strategies are required for combatting resistant pathogens. Combination therapy, in which multiple drugs are used to treat an infection, has proven highly successful in the treatment of cancer and HIV. However, this practice has proven challenging for t...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章

    doi:10.1128/AAC.00465-20

    authors: Adamowicz EM,Harcombe WR

    更新日期:2020-10-20 00:00:00

  • Cefiderocol Resistance in Acinetobacter baumannii: Roles of β-Lactamases, Siderophore Receptors, and Penicillin Binding Protein 3.

    abstract::Cefiderocol is a siderophore cephalosporin active against many multidrug-resistant (MDR) Gram-negative pathogens. We examined the resistance mechanisms in 12 Acinetobacter baumannii strains with cefiderocol MICs ranging from ≤0.03 to >32 μg/ml. Cefiderocol resistance could not be explained by β-lactamase activity. Cef...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章

    doi:10.1128/AAC.01221-20

    authors: Malik S,Kaminski M,Landman D,Quale J

    更新日期:2020-10-20 00:00:00

  • Novel Antibiotics May Be Noninferior but Are They Becoming Less Effective?: a Systematic Review.

    abstract::Novel antibiotics approved by noninferiority trials may become less effective over time in two scenarios: (i) the treatment effect in studies of novel antibiotics may be consistently worse than studies of older antibiotics; (ii) when a decreasingly effective control arm is used in a series of noninferiority trials. Ou...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章

    doi:10.1128/AAC.01597-20

    authors: Bai AD,Komorowski AS,Lo CKL,Tandon P,Li XX,Mokashi V,Cvetkovic A,Findlater A,Liang L,Loeb M,Mertz D

    更新日期:2020-10-20 00:00:00

  • Evaluation of the Combination of Azithromycin and Naphthoquine in Animal Malaria Models.

    abstract::Combination therapy using drugs with different mechanisms of action is the current state of the art in antimalarial treatment. However, except for artemisinin-based combination therapies, only a few other combinations are now available. Increasing concern regarding the emergence and spread of artemisinin resistance in...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章

    doi:10.1128/AAC.02307-19

    authors: Bei ZC,Li GF,Zhao JH,Zhang M,Ji XG,Wang JY

    更新日期:2020-10-20 00:00:00

  • Decreased Incidence of Methicillin-Resistant Staphylococcus aureus Bacteremia in Intensive Care Units: a 10-Year Clinical, Microbiological, and Genotypic Analysis in a Tertiary Hospital.

    abstract::There are limited long-term data on the trends in incidence and characteristics of methicillin-resistant Staphylococcus aureus (MRSA) bacteremia (MRSAB) in intensive care units (ICUs) in which infection control measures have been adopted. We evaluated the trend of incidence and changes in characteristics of MRSA bacte...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章

    doi:10.1128/AAC.01082-20

    authors: Kim H,Kim ES,Lee SC,Yang E,Kim HS,Sung H,Kim MN,Jung J,Kim MJ,Kim SH,Lee SO,Choi SH,Woo JH,Kim YS,Chong YP

    更新日期:2020-09-21 00:00:00

  • National Surveillance of Antimicrobial Susceptibility of Bacteremic Gram-Negative Bacteria with Emphasis on Community-Acquired Resistant Isolates: Report from the 2019 Surveillance of Multicenter Antimicrobial Resistance in Taiwan (SMART).

    abstract::A multicenter collection of bacteremic isolates of Escherichia coli (n = 423), Klebsiella pneumoniae (n = 372), Pseudomonas aeruginosa (n = 300), and Acinetobacter baumannii complex (n = 199) was analyzed for susceptibility. Xpert Carba-R assay and sequencing for mcr genes were performed for carbapenem- or colistin-re...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章

    doi:10.1128/AAC.01089-20

    authors: Liu PY,Lee YL,Lu MC,Shao PL,Lu PL,Chen YH,Cheng SH,Ko WC,Lin CY,Wu TS,Yen MY,Wang LS,Liu CP,Lee WS,Chen YS,Wang FD,Tseng SH,Lin CN,Tang HJ,Chen YH,Sheng WH,Lee CM,Liao MH,Hsueh PR

    更新日期:2020-09-21 00:00:00

  • Safety and Pharmacokinetics of Recombinant Human Plasma Gelsolin in Patients Hospitalized for Nonsevere Community-Acquired Pneumonia.

    abstract::There remains an unmet need to address the substantial morbidity and mortality associated with severe community-acquired pneumonia (sCAP). Recombinant human plasma gelsolin (rhu-pGSN) improves disease outcomes in diverse animal models of infectious and noninfectious inflammation. This blinded dose-escalation safety st...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章

    doi:10.1128/AAC.00579-20

    authors: Tannous A,Levinson SL,Bolognese J,Opal SM,DiNubile MJ

    更新日期:2020-09-21 00:00:00

  • Effect of Vancomycin-Associated Acute Kidney Injury on Incidence of 30-Day Readmissions among Hospitalized Veterans Affairs Patients with Skin and Skin Structure Infections.

    abstract::Among hospitalized adults who received vancomycin for their skin and skin structure infection (SSSI), patients who experienced acute kidney injury (AKI) had considerably higher 30-day readmission rates. Nearly half of the observed 30-day readmissions were due to non-SSSI-related reasons, which is consistent with the p...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章

    doi:10.1128/AAC.01268-20

    authors: Patel N,Stornelli N,Sangiovanni RJ,Huang DB,Lodise TP

    更新日期:2020-09-21 00:00:00

  • Five-Year Survey (2014 to 2018) of Azole Resistance in Environmental Aspergillus fumigatus Isolates from China.

    abstract::A total of 191 soil samples from Hangzhou, China, were submitted to detect non-wild-type (non-WT) Aspergillus fumigatus and its associated mechanisms. There were 2 (4.7%), 13 (12.4%), and 31 (23.1%) isolates identified as non-WT in 2014, 2016, and 2018, respectively. The resistant mutations of TR34/L98H, TR46/Y121F/T2...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章

    doi:10.1128/AAC.00904-20

    authors: Cao D,Wu R,Dong S,Wang F,Ju C,Yu S,Xu S,Fang H,Yu Y

    更新日期:2020-09-21 00:00:00

  • Pharmacokinetic-Pharmacodynamic Target Attainment Analyses To Support Dose Selection for ME1100, an Arbekacin Inhalation Solution.

    abstract::ME1100 (arbekacin inhalation solution) is an inhaled aminoglycoside that is being developed to treat patients with hospital-acquired and ventilator-associated bacterial pneumonia (HABP and VABP, respectively). Pharmacokinetic-pharmacodynamic (PK-PD) target attainment analyses were undertaken to evaluate ME1100 regimen...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章

    doi:10.1128/AAC.02367-19

    authors: Bhavnani SM,Hammel JP,Lakota EA,Safir MC,VanScoy BD,Nagira Y,Rubino CM,Sato N,Koresawa T,Kondo K,Ambrose PG

    更新日期:2020-09-21 00:00:00

  • Prolonged Exposure to β-Lactam Antibiotics Reestablishes Susceptibility of Daptomycin-Nonsusceptible Staphylococcus aureus to Daptomycin.

    abstract::Daptomycin-nonsusceptible (DAP-NS) Staphylococcus aureus often exhibits gain-in-function mutations in the mprF gene (involved in positive surface charge maintenance). Standard β-lactams, although relatively inactive against methicillin-resistant S. aureus (MRSA), may prevent the emergence of mprF mutations and DAP-NS....

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章

    doi:10.1128/AAC.00890-20

    authors: Jenson RE,Baines SL,Howden BP,Mishra NN,Farah S,Lew C,Berti AD,Shukla SK,Bayer AS,Rose WE

    更新日期:2020-08-20 00:00:00

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