解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract:BACKGROUND:IL4Rα and IL13Rα1 are constituents of the type II IL4 receptor. Recently, IL4Rα and IL13Rα1 were reported to have roles in cancer progression and suggested as potential prognostic markers. However, studies on IL4Rα and IL13Rα1 in soft-tissue sarcomas have been limited. METHODS:This study investigated the im...
journal_title:Diagnostic pathology
pub_type: 杂志文章
doi:10.1186/s13000-020-01066-z
更新日期:2021-01-09 00:00:00
abstract:BACKGROUND:High grade basal-like breast carcinomas are triple negative, express basal cytokeratins, and are known for the overall poor prognosis and aggressive behavior. HPV related multiphenotypic sino-nasal carcinoma has overlapping histology with basal-like breast carcinomas, but carry the defining feature of associ...
journal_title:Diagnostic pathology
pub_type: 杂志文章
doi:10.1186/s13000-020-01050-7
更新日期:2020-11-20 00:00:00
abstract:BACKGROUND:Esophageal squamous cell carcinoma (ESCC) still remains intractable disease with few therapeutic options. Programmed death-ligand 1 (PD-L1), which is essential for immune evasion, is involved in the pathogenesis of ESCC and thus is a potential therapeutic target. PIK3CA, KRAS, and BRAF mutations, microsatell...
journal_title:Diagnostic pathology
pub_type: 杂志文章
doi:10.1186/s13000-020-01045-4
更新日期:2020-10-14 00:00:00
abstract:BACKGROUND:The tumor transformation mechanism of a plasmacytoid urothelial carcinoma remains unexplained. We describe the case of a plasmacytoid urothelial carcinoma of the renal pelvis in which the expression of zinc finger E-box-binding homeobox 1 (ZEB1), a key nuclear transcription factor in an epithelial-mesenchyma...
journal_title:Diagnostic pathology
pub_type: 杂志文章
doi:10.1186/s13000-020-01043-6
更新日期:2020-10-08 00:00:00
abstract:BACKGROUND:The presence of histologically different neoplasms in the same organ is rare in pathologic practice. We report the first case of synchronous clear cell renal cell carcinoma (clear cell RCC) and papillary renal neoplasm with reverse polarity (PRNRP) with comprehensive immunohistochemical and molecular charact...
journal_title:Diagnostic pathology
pub_type: 杂志文章
doi:10.1186/s13000-020-01042-7
更新日期:2020-10-06 00:00:00
abstract:BACKGROUND:Several studies reported the dysregulation of miR-541 in the progression of some human malignancies. Osteosarcoma (OS) is one of the most common primary malignant bone tumors. This study aimed to assess the expression and clinical significance of miR-541 in OS patients and explore the biological function of ...
journal_title:Diagnostic pathology
pub_type: 杂志文章
doi:10.1186/s13000-020-01008-9
更新日期:2020-07-24 00:00:00
abstract:BACKGROUND:Mesonephric-like adenocarcinoma (M-LAC) is a rare, recently described tumor occurring in the uterine corpus and ovary, which shares the same morphological and immunohistochemical features with the more common mesonephric adenocarcinoma (MAC), which mostly arises the uterine cervix. Despite the similarities b...
journal_title:Diagnostic pathology
pub_type: 杂志文章
doi:10.1186/s13000-020-01012-z
更新日期:2020-07-21 00:00:00
abstract:BACKGROUND:Primary intestinal follicular lymphoma (PI-FL) is a rare and indolent lymphoma and is challenging for diagnosis with endoscopic biopsy specimens. Whole slide imaging (WSI) has been increasingly used for assisting pathologic diagnosis, but not for lymphoma yet, probably because there are usually too many immu...
journal_title:Diagnostic pathology
pub_type: 杂志文章
doi:10.1186/s13000-020-00991-3
更新日期:2020-07-07 00:00:00
abstract:BACKGROUND:The outbreak of a novel coronavirus since December 2019, became an emergency of major international concern. As of June 21, 2020, the SARS-CoV-2 pandemic has caused 8,769,844 confirmed infections with 463,745 fatal cases worldwide. The SARS-CoV-2 outbreak is a major challenge for clinicians. In our clinic, w...
journal_title:Diagnostic pathology
pub_type: 杂志文章
doi:10.1186/s13000-020-00994-0
更新日期:2020-06-29 00:00:00
abstract:BACKGROUND:We examined the vascularity of mammary Paget disease histologically to confirm the increased blood flow observed previously by clinical imaging. The relationships among blood vessel density (BVD), histopathological parameters of blood flow in the nipple, and the expression of angiogenic factors such as basic...
journal_title:Diagnostic pathology
pub_type: 杂志文章
doi:10.1186/s13000-020-00988-y
更新日期:2020-06-11 00:00:00
abstract:BACKGROUND:Transbronchial needle aspiration (TBNA) is a minimally invasive procedure performed to diagnose lymph node (LN) adenopathy. TBNA with and without endobronchial ultrasound (EBUS) guidance has a high diagnostic yield for malignant LN enlargement, but the value for diagnosing benign LN enlargement has been less...
journal_title:Diagnostic pathology
pub_type: 杂志文章
doi:10.1186/s13000-020-00958-4
更新日期:2020-04-15 00:00:00
abstract:OBJECTIVES:Non-Hodgkin's lymphoma (NHL) primarily derived from the base of the tongue, is rare. Human papillomavirus (HPV) and Epstein-Barr virus (EBV) are important aetiological risk factors for tumours of the head and neck. This study describes the clinicopathological features of NHL in the tongue base and the status...
journal_title:Diagnostic pathology
pub_type: 杂志文章
doi:10.1186/s13000-020-00936-w
更新日期:2020-04-01 00:00:00
abstract:OBJECTIVE:FNA is a simple, safe, cost-effective and accurate diagnostic tool for the initial screening of patients with thyroid nodules. The aims of this study were to determine the diagnostic utility of FNAC performed in our institution, assess the cytomorphologic features that contribute to diagnostic errors and prop...
journal_title:Diagnostic pathology
pub_type: 杂志文章
doi:10.1186/s13000-019-0924-z
更新日期:2020-01-03 00:00:00
abstract:BACKGROUND:Ischemia/reperfusion (I/R) injury of heart is one of the major causes of acute cardiac injury, which may result in worsening or even loss of heart function. With novel microRNAs being evolutionarily discovered, numbers of them remained functionally unknown. We aimed to discover novel microRNAs with therapeut...
journal_title:Diagnostic pathology
pub_type: 杂志文章
doi:10.1186/s13000-019-0894-1
更新日期:2019-10-31 00:00:00
abstract:BACKGROUND:Gastrointestinal stromal tumors (GISTs), a type of mesenchymal tumor in the gastrointestinal tract, are believed to be closely associated with PDGFRA and C-KIT mutations. Schwannoma in the stomach, which is an unusual location, is a rare disorder. The simultaneous occurrence of the two diseases is rarer than...
journal_title:Diagnostic pathology
pub_type: 杂志文章
doi:10.1186/s13000-019-0898-x
更新日期:2019-10-23 00:00:00
abstract:BACKGROUND:Rapid ("warm") autopsies of patients with advanced metastatic cancer provide important insight into the natural history, pathobiology and histomorphology of disease in treatment-resistant tumors. Plasmacytoid urothelial carcinoma (PUC) is a rare variant of urothelial carcinoma characterized by neoplastic cel...
journal_title:Diagnostic pathology
pub_type: 杂志文章
doi:10.1186/s13000-019-0896-z
更新日期:2019-10-21 00:00:00
abstract:BACKGROUND:Recent studies have shown that T cell-mediated cellular immune mechanisms play important roles in the progression of hepatitis B to liver cirrhosis, but the underlying mechanisms remain unclear. This present study was aimed to determine the relationship between Treg/Th17 and hepatitis B-associated liver cirr...
journal_title:Diagnostic pathology
pub_type: 杂志文章
doi:10.1186/s13000-019-0891-4
更新日期:2019-10-21 00:00:00
abstract:BACKGROUND:To evaluate the clinical utility of LIM Domain Only 2 (LMO2) negative and CD38 positive in diagnosis of Burkitt lymphoma (BL). METHODS:LMO2 and CD38 expression determined by immunohistochemistry in 75 BL, 12 High-grade B-cell lymphoma, NOS (HGBL,NOS) and 3 Burkitt-like lymphomas with the 11q aberration. RE...
journal_title:Diagnostic pathology
pub_type: 杂志文章
doi:10.1186/s13000-019-0876-3
更新日期:2019-09-04 00:00:00
abstract:BACKGROUND:Esophageal cancer is one of the leading causes of cancer related deaths among the Iranians. There is still a high ratio of mortality and low 5 years survival which are related to the late onset and diagnosis. Majority of patients refer for the treatment in advanced stages of tumor progression. MAIN BODY:It ...
journal_title:Diagnostic pathology
pub_type: 杂志文章,评审
doi:10.1186/s13000-019-0875-4
更新日期:2019-08-31 00:00:00
abstract:BACKGROUND:Choriocarcinoma is a highly aggressive, malignant trophoblastic neoplasm that can be gestational or non-gestational in origin. Accurate discrimination between these two subtypes, the causative pregnancy type, and the pregnancy-to-treatment interval for gestational choriocarcinoma are vital for clinical manag...
journal_title:Diagnostic pathology
pub_type: 杂志文章
doi:10.1186/s13000-019-0866-5
更新日期:2019-08-17 00:00:00
abstract:BACKGROUND:Mesonephric adenocarcinoma (MNAC) is a rare tumor of the female genital tract, which originates from mesonephric duct remnants. Its diagnosis is pathologically challenging, because MNAC may exhibit a mixture of morphological patterns that complicates the differential diagnosis. CASE PRESENTATION:The patient...
journal_title:Diagnostic pathology
pub_type: 杂志文章
doi:10.1186/s13000-019-0847-8
更新日期:2019-07-03 00:00:00
abstract:BACKGROUND:Intestinal metaplasia (IM) of the gastric mucosa is classified as complete (Type I) and incomplete IM (Type II and III) subtypes, which showed significantly different risk for developing to gastric adenocarcinoma (GAC). GCRG213, a variant of L1-endonuclease (L1-EN), first identified in our lab, was upregulat...
journal_title:Diagnostic pathology
pub_type: 杂志文章
doi:10.1186/s13000-019-0838-9
更新日期:2019-06-21 00:00:00
abstract:BACKGROUND:Evaluation of core needle biopsies (CNB) is a standard procedure for the diagnosis of breast cancer. However, tissue processing and image preparation is a time- consuming procedure and instant on-site availability of high-quality images could substantially improve the efficacy of the diagnostic procedure. Co...
journal_title:Diagnostic pathology
pub_type: 杂志文章
doi:10.1186/s13000-019-0835-z
更新日期:2019-06-15 00:00:00
abstract:BACKGROUND:Primary central nervous system (CNS) diffuse large B-cell lymphoma (DLBCL) is a rare intracranial tumor, defined as DLBCL arising from the brain, spinal cord, leptomeninges and eye, with an overall annual incidence of 5 cases per million. The primary CNS anaplastic variant of DLBCL (A-DLBCL) is even less com...
journal_title:Diagnostic pathology
pub_type: 杂志文章
doi:10.1186/s13000-019-0826-0
更新日期:2019-05-20 00:00:00
abstract:BACKGROUND:Gastric mixed neuroendocrine-non-neuroendocrine neoplasms (MiNENs) are infrequently encountered in routine practice. Some gastric neuroendocrine carcinomas (NECs) have a variety of differentiation patterns; however, pancreatic acinar differentiation in gastric NECs is rare. The molecular abnormalities of NEC...
journal_title:Diagnostic pathology
pub_type: 杂志文章
doi:10.1186/s13000-019-0815-3
更新日期:2019-05-10 00:00:00
abstract::Insights into the molecular underpinnings of primary central nervous system tumors have radically changed the approach to tumor diagnosis and classification. Diagnostic emphasis has shifted from the morphology of a tumor under the microscope to an integrated approach based on morphologic and molecular features, includ...
journal_title:Diagnostic pathology
pub_type: 杂志文章,评审
doi:10.1186/s13000-019-0802-8
更新日期:2019-04-09 00:00:00
abstract:BACKGROUND:Automated image analysis enables quantitative measurement of steatosis in histological images. However, spatial heterogeneity of steatosis can make quantitative steatosis scores unreliable. To improve the reliability, we have developed novel scores that are "focused" on steatotic tissue areas. METHODS:Focus...
journal_title:Diagnostic pathology
pub_type: 杂志文章
doi:10.1186/s13000-018-0753-5
更新日期:2018-09-20 00:00:00
abstract:BACKGROUND:Lung adenocarcinoma with EGFR activating mutations will inevitably acquire resistance to first generation TKIs. Acquired EGFR T790M mutation causes about 50% of these resistance cases. Droplet digital PCR (ddPCR) and cobas enables quantification of T790M mutation. Whether these methods can predict clinical r...
journal_title:Diagnostic pathology
pub_type: 杂志文章
doi:10.1186/s13000-018-0728-6
更新日期:2018-08-13 00:00:00
abstract:BACKGROUND:The occurrence of malignant lymphoma after delivery is an extremely rare event. Although several cases of Hodgkin lymphoma and B cell lymphoma and a few cases of peripheral T cell lymphoma (PTCL) after delivery have been reported, there are no report of autopsy cases of PTCL in the puerperal period. CASE PR...
journal_title:Diagnostic pathology
pub_type: 杂志文章
doi:10.1186/s13000-018-0707-y
更新日期:2018-05-22 00:00:00
abstract:BACKGROUND:The programmed death receptor 1 (PD-1) protein is a cell-surface receptor on certain lymphocytes that, with its ligand programmed death ligand 1 (PD-L1), helps to down-regulate immune responses. Many cancer types express PD-L1 and evade immune recognition via the PD-1/PD-L1 interaction. Precision therapies t...
journal_title:Diagnostic pathology
pub_type: 杂志文章,评审
doi:10.1186/s13000-018-0689-9
更新日期:2018-02-09 00:00:00
abstract:BACKGROUND:Identification of predictive molecular alterations in lung adenocarcinoma is essential for accurate therapeutic decisions. Although several molecular approaches are available, a number of issues, including tumor heterogeneity, frequent material scarcity, and the large number of loci to be investigated, must ...
journal_title:Diagnostic pathology
pub_type: 杂志文章
doi:10.1186/s13000-017-0683-7
更新日期:2018-01-12 00:00:00
abstract:BACKGROUND:Sinonasal renal cell-like carcinoma (SRCLC) is an extremely rare low malignant tumor arising in the sinonasal tract, with histological mimicry of renal cell carcinoma. CASE PRESENTATION:We present a case of sinonasal renal cell-like carcinoma in a 63-year-old male patient. Computer tomography(CT) scanning r...
journal_title:Diagnostic pathology
pub_type: 杂志文章,评审
doi:10.1186/s13000-017-0660-1
更新日期:2017-10-17 00:00:00
abstract:BACKGROUND:Spontaneous isolated dissection of the superior mesenteric artery (SMA) can lead to bowel ischemia, aneurysm rupture, or even death. Studies have suggested that mechanical or hemodynamic stress on the vascular wall of the SMA may be a contributor, but its pathogenesis is unclear. CASE PRESENTATION:A 57-year...
journal_title:Diagnostic pathology
pub_type: 杂志文章
doi:10.1186/s13000-017-0664-x
更新日期:2017-10-16 00:00:00
abstract:BACKGROUND:Hyalinizing clear cell carcinoma (HCCC) is a rare low-grade tumour of salivary glands that was first described as a distinct entity in 1994 by Milchgrub et al. EWSR1-ATF1 fusion was found to be specific for this tumour. The majority of the reported cases of HCCC arise from minor salivary glands within the or...
journal_title:Diagnostic pathology
pub_type: 杂志文章
doi:10.1186/s13000-017-0659-7
更新日期:2017-09-25 00:00:00
abstract:BACKGROUND:Advancing knowledge in molecular pathogenesis of hepatocellular carcinoma (HCC) opens up new horizons in the diagnostic, prognostic and therapeutic perspectives. Assessing the expression of molecular targets prior to definitive treatment is gaining importance in clinical practice. In this study, we investiga...
journal_title:Diagnostic pathology
pub_type: 杂志文章
doi:10.1186/s13000-017-0649-9
更新日期:2017-08-01 00:00:00
abstract:BACKGROUND:Histologic grade is the most important predictor of the clinical outcome of non-muscle invasive (Ta, T1) papillary urothelial carcinoma (NMIPUCa), but its ambiguous criteria diminish its power to predict recurrence/progression for individual patients. We attempted to find an objective and reproducible histol...
journal_title:Diagnostic pathology
pub_type: 杂志文章,多中心研究
doi:10.1186/s13000-017-0639-y
更新日期:2017-07-24 00:00:00
abstract:BACKGROUND:GATA-binding protein 3 (GATA3) has been identified as a sensitive marker for breast carcinoma but its sensitivity in primary genital extramammary Paget diseases (EMPDs) has not been well studied. METHODS:Here we investigated immunohistochemical expression of GATA3 in 72 primary genital EMPDs (35 from female...
journal_title:Diagnostic pathology
pub_type: 杂志文章
doi:10.1186/s13000-017-0638-z
更新日期:2017-07-10 00:00:00
abstract:BACKGROUND:Malignant gastrointestinal neuroectodermal tumor (GNET) is an extremely rare entity that was first described by Zambrano et al. in 2003 as "Clear cell sarcoma-like tumor of the gastrointestinal tract". It shares some of the histological features of clear cell sarcoma (CCS) but lacks the immunohistochemical r...
journal_title:Diagnostic pathology
pub_type: 杂志文章,评审
doi:10.1186/s13000-017-0620-9
更新日期:2017-03-20 00:00:00
abstract:BACKGROUND:Microsatellite-unstable colorectal cancers (CRC) that are due to deficient DNA mismatch repair (dMMR) represent approximately 15% of all CRCs in the United States. These microsatellite-unstable CRCs represent a heterogenous group of diseases with distinct oncogenesis pathways. There are overlapping clinicopa...
journal_title:Diagnostic pathology
pub_type: 杂志文章,评审
doi:10.1186/s13000-017-0613-8
更新日期:2017-03-04 00:00:00
abstract:BACKGROUND:Epithelioid schwannoma as a rare variant poses a challenge to all pathologists, as this uncommon entity is extremely difficult to conclusively diagnose by morphological analyses on a resected sample alone owing to its unique histopathological features. However, few papers have described the detailed clinicop...
journal_title:Diagnostic pathology
pub_type: 杂志文章,评审
doi:10.1186/s13000-017-0604-9
更新日期:2017-01-19 00:00:00