abstract：:Meta-analyses and several large cohort studies have demonstrated that antiseptic mouthwashes are associated with mortality in hospitalized patients. A clear pathogenic mechanism is lacking, leading to controversy and a reluctance to abandon or limit the use of antiseptic mouthwashes. Here, we generate the hypothesis t...

journal_title：Intensive care medicine

authors： Blot S

更新日期：2021-01-01 00:00:00

abstract：:Extracorporeal life support (ECLS) can support gas exchange in patients with the acute respiratory distress syndrome (ARDS). During ECLS, venous blood is drained from a central vein via a cannula, pumped through a semipermeable membrane that permits diffusion of oxygen and carbon dioxide, and returned via a cannula to...

journal_title：Intensive care medicine

authors： Combes A,Schmidt M,Hodgson CL,Fan E,Ferguson ND,Fraser JF,Jaber S,Pesenti A,Ranieri M,Rowan K,Shekar K,Slutsky AS,Brodie D

更新日期：2020-12-01 00:00:00

abstract：:Neuromuscular blocking agents (NMBAs) inhibit patient-initiated active breath and the risk of high tidal volumes and consequent high transpulmonary pressure swings, and minimize patient/ ventilator asynchrony in acute respiratory distress syndrome (ARDS). Minimization of volutrauma and ventilator-induced lung injury (...

journal_title：Intensive care medicine

authors： Hraiech S,Yoshida T,Annane D,Duggal A,Fanelli V,Gacouin A,Heunks L,Jaber S,Sottile PD,Papazian L

更新日期：2020-12-01 00:00:00

abstract：PURPOSE:Motivated by a new randomized trial (the PEPTIC trial) that raised the issue of an increase in mortality with proton pump inhibitors (PPIs) relative to histamine-2 receptor antagonists (H2RAs), we updated our prior systematic review and network meta-analysis (NMA) addressing the impact of pharmacological gastro...

journal_title：Intensive care medicine

authors： Wang Y,Ge L,Ye Z,Siemieniuk RA,Reintam Blaser A,Wang X,Perner A,Møller MH,Alhazzani W,Cook D,Guyatt GH

更新日期：2020-11-01 00:00:00

abstract：:The article "Accumulation of hydroxyethyl starch in human and animal tissues: a systematic review", written by Christian J. Wiedermann and Michael Joannidis, was originally published Online First without Open Access. ...

journal_title：Intensive care medicine

authors： Wiedermann CJ,Joannidis M

更新日期：2020-10-14 00:00:00

abstract：PURPOSE:To study the association between early initiation of intra-arrest therapeutic hypothermia and neurologic outcome in out-of-hospital cardiac arrest. METHODS:A prespecified sub-analysis of the PRINCESS trial (NCT01400373) that randomized 677 bystander-witnessed cardiac arrests to transnasal evaporative intra-arr...

journal_title：Intensive care medicine

authors： Awad A,Taccone FS,Jonsson M,Forsberg S,Hollenberg J,Truhlar A,Ringh M,Abella BS,Becker LB,Vincent JL,Svensson L,Nordberg P

更新日期：2020-07-01 00:00:00

abstract：PURPOSE:Little is known on the incidence of discomfort during the end-of-life of intensive care unit (ICU) patients and the impact of sedation on such discomfort. The aim of this study was to assess the incidence of discomfort events according to levels of sedation. METHODS:Post-hoc analysis of an observational prospe...

journal_title：Intensive care medicine

authors： Robert R,Le Gouge A,Kentish-Barnes N,Adda M,Audibert J,Barbier F,Bourcier S,Bourenne J,Boyer A,Devaquet J,Grillet G,Guisset O,Hyacinthe AC,Jourdain M,Lerolle N,Lesieur O,Mercier E,Messika J,Renault A,Vinatier I,Az

更新日期：2020-06-01 00:00:00

abstract：PURPOSE:Little evidence of increased thrombotic risk is available in COVID-19 patients. Our purpose was to assess thrombotic risk in severe forms of SARS-CoV-2 infection. METHODS:All patients referred to 4 intensive care units (ICUs) from two centers of a French tertiary hospital for acute respiratory distress syndrom...

journal_title：Intensive care medicine

authors： Helms J,Tacquard C,Severac F,Leonard-Lorant I,Ohana M,Delabranche X,Merdji H,Clere-Jehl R,Schenck M,Fagot Gandet F,Fafi-Kremer S,Castelain V,Schneider F,Grunebaum L,Anglés-Cano E,Sattler L,Mertes PM,Meziani F,CRICS TR

更新日期：2020-06-01 00:00:00

abstract：:The Editor-in-Chief has retracted this article [1] because a number of studies included in this review [2, 3, 4] (originally cited as references 98, 128, 129) have since been retracted. Consequently, this has rendered the content of the review unreliable. ...

journal_title：Intensive care medicine

authors： Editorial Office of Intensive Care Medicine.

更新日期：2020-06-01 00:00:00

abstract：PURPOSE:Indications and optimal timing for tracheostomy in traumatic brain-injured (TBI) patients are uncertain. This study aims to describe the patients' characteristics, timing, and factors related to the decision to perform a tracheostomy and differences in strategies among different countries and assess the effect ...

journal_title：Intensive care medicine

authors： Robba C,Galimberti S,Graziano F,Wiegers EJA,Lingsma HF,Iaquaniello C,Stocchetti N,Menon D,Citerio G,CENTER-TBI ICU Participants and Investigators.

更新日期：2020-05-01 00:00:00

abstract：:The original version of this article unfortunately contained a mistake. ...

journal_title：Intensive care medicine

authors： Arabi YM,Murthy S,Webb S

更新日期：2020-05-01 00:00:00

abstract：BACKGROUND:Vasopressors are administered to critically ill patients with vasodilatory shock not responsive to volume resuscitation, and less often in cardiogenic shock, and hypovolemic shock. OBJECTIVES:The objectives are to review safety and efficacy of vasopressors, pathophysiology, agents that decrease vasopressor ...

journal_title：Intensive care medicine

authors： Russell JA

更新日期：2019-11-01 00:00:00

abstract：:This narrative review focuses on thoracic ultrasonography (lung and pleural) with the aim of outlining its utility for the critical care clinician. The article summarizes the applications of thoracic ultrasonography for the evaluation and management of pneumothorax, pleural effusion, acute dyspnea, pulmonary edema, pu...

journal_title：Intensive care medicine

authors： Mayo PH,Copetti R,Feller-Kopman D,Mathis G,Maury E,Mongodi S,Mojoli F,Volpicelli G,Zanobetti M

更新日期：2019-09-01 00:00:00

abstract：PURPOSE:We examined whether influenza vaccination affects 1-year risk of myocardial infarction, stroke, heart failure, pneumonia, and death among intensive care unit (ICU) survivors aged ≥ 65 years. METHODS:Danish Intensive Care Database data on all elderly ( ≥ 65 years) patients hospitalized in Danish ICUs in the per...

journal_title：Intensive care medicine

authors： Christiansen CF,Thomsen RW,Schmidt M,Pedersen L,Sørensen HT

更新日期：2019-07-01 00:00:00

abstract：:The World Health Organization defines overweight and obesity as the condition where excess or abnormal fat accumulation increases risks to health. The prevalence of obesity is increasing worldwide and is around 20% in ICU patients. Adipose tissue is highly metabolically active, and especially visceral adipose tissue h...

journal_title：Intensive care medicine

authors： Schetz M,De Jong A,Deane AM,Druml W,Hemelaar P,Pelosi P,Pickkers P,Reintam-Blaser A,Roberts J,Sakr Y,Jaber S

更新日期：2019-06-01 00:00:00

abstract：PURPOSE:Protective mechanical ventilation based on multiple ventilator parameters such as tidal volume, plateau pressure, and driving pressure has been widely used in acute respiratory distress syndrome (ARDS). More recently, mechanical power (MP) was found to be associated with mortality. The study aimed to investigat...

journal_title：Intensive care medicine

authors： Zhang Z,Zheng B,Liu N,Ge H,Hong Y

更新日期：2019-06-01 00:00:00

abstract：PURPOSE:We assessed feasibility and safety of extracorporeal carbon dioxide removal (ECCO2R) to facilitate ultra-protective ventilation (VT 4 mL/kg and PPLAT ≤ 25 cmH2O) in patients with moderate acute respiratory distress syndrome (ARDS). METHODS:Prospective multicenter international phase 2 study. Primary endpoint w...

journal_title：Intensive care medicine

authors： Combes A,Fanelli V,Pham T,Ranieri VM,European Society of Intensive Care Medicine Trials Group and the “Strategy of Ultra-Protective lung ventilation with Extracorporeal CO2 Removal for New-Onset moderate to severe ARDS” (SUPERNOVA) investigators

更新日期：2019-05-01 00:00:00

abstract：PURPOSE:Clinical examination is often the first step to diagnose shock and estimate cardiac index. In the Simple Intensive Care Studies-I, we assessed the association and diagnostic performance of clinical signs for estimation of cardiac index in critically ill patients. METHODS:In this prospective, single-centre coho...

journal_title：Intensive care medicine

authors： Hiemstra B,Koster G,Wiersema R,Hummel YM,van der Harst P,Snieder H,Eck RJ,Kaufmann T,Scheeren TWL,Perner A,Wetterslev J,de Smet AMGA,Keus F,van der Horst ICC,SICS Study Group.

更新日期：2019-02-01 00:00:00

abstract：: ...

journal_title：Intensive care medicine

authors： Hernandez G,Bellomo R,Bakker J

更新日期：2019-01-01 00:00:00

abstract：PURPOSE:We set out to summarize the current challenges in academic conflict of interest. METHODS:This is a narrative review by a multidisciplinary, multinational panel of academic officers including deans of medical/pharmacy schools. RESULTS AND CONCLUSIONS:Disclosing conflict of interest has become the appropriate p...

journal_title：Intensive care medicine

authors： Annane D,Lerolle N,Meuris S,Sibilla J,Olsen KM

更新日期：2019-01-01 00:00:00

abstract：: ...

journal_title：Intensive care medicine

authors： Adler K,Schlieper D,Kindgen-Milles D,Meier S,Schallenburger M,Sellmann T,Schwager H,Schwartz J,Neukirchen M

更新日期：2019-01-01 00:00:00

abstract：: ...

journal_title：Intensive care medicine

authors： Varkila MRJ,Cremer OL

更新日期：2019-01-01 00:00:00

abstract：: ...

journal_title：Intensive care medicine

authors： Hawryluck L,Brindley PG

更新日期：2018-12-01 00:00:00

abstract：: ...

journal_title：Intensive care medicine

authors： De Cassai A,Dal Cin S,Bertini D

更新日期：2018-12-01 00:00:00

abstract：: ...

journal_title：Intensive care medicine

authors： Stefani A,Ruggiero C,Aramini B,Scamporlino A

更新日期：2018-12-01 00:00:00

abstract：: ...

journal_title：Intensive care medicine

authors： Vincent JL

更新日期：2018-12-01 00:00:00

abstract：: ...

journal_title：Intensive care medicine

authors： Baedorf Kassis E,Train S,MacNeil B,Loring SH,Talmor D

更新日期：2018-12-01 00:00:00

abstract：PURPOSE:Intensive care unit survivors suffer from prolonged impairment, reduced quality of life, and higher mortality rates after discharge compared to the general population. Socioeconomic status may play a partial but important role in mortality and recovery. Therefore, the detection of factors that are responsible f...

journal_title：Intensive care medicine

authors： Bastian K,Hollinger A,Mebazaa A,Azoulay E,Féliot E,Chevreul K,Fournier MC,Guidet B,Michel M,Montravers P,Pili-Floury S,Sonneville R,Siegemund M,Gayat E,FROG-ICU Study Investigators.

更新日期：2018-12-01 00:00:00

abstract：: ...

journal_title：Intensive care medicine

authors： Perner A,Hjortrup PB,Pettilä V

更新日期：2018-12-01 00:00:00

abstract：PURPOSE:To determine whether erythromycin is non-inferior to metoclopramide in facilitating post-pyloric placement of self-propelled spiral nasoenteric tubes (NETs) in critically ill patients. METHODS:A prospective, multicenter, open-label, parallel, and non-inferiority randomized controlled trial was conducted compar...

journal_title：Intensive care medicine

authors： Hu B,Ouyang X,Lei L,Sun C,Chi R,Guo J,Guo W,Zhang Y,Li Y,Huang D,Sun H,Nie Z,Yu J,Zhou Y,Wang H,Zhang J,Chen C

更新日期：2018-12-01 00:00:00

abstract：PURPOSE:To assess the ability of quantitative pupillometry [using the Neurological Pupil index (NPi)] to predict an unfavorable neurological outcome after cardiac arrest (CA). METHODS:We performed a prospective international multicenter study (10 centers) in adult comatose CA patients. Quantitative NPi and standard ma...

journal_title：Intensive care medicine

authors： Oddo M,Sandroni C,Citerio G,Miroz JP,Horn J,Rundgren M,Cariou A,Payen JF,Storm C,Stammet P,Taccone FS

更新日期：2018-12-01 00:00:00

abstract：: ...

journal_title：Intensive care medicine

authors： Amrein K,Oudemans-van Straaten HM,Berger MM

更新日期：2018-11-01 00:00:00

abstract：: ...

journal_title：Intensive care medicine

authors： Perner A,Finfer S

更新日期：2018-11-01 00:00:00

abstract：: ...

journal_title：Intensive care medicine

authors： Darmon M,Kashani K,Schetz M

更新日期：2018-11-01 00:00:00

abstract：PURPOSE:Relatives of intensive care unit (ICU) patients suffer emotional distress that impairs their ability to acquire the information they need from the staff. We sought to evaluate whether providing relatives with a list of important questions was associated with better comprehension on day 5. METHODS:Randomized, p...

journal_title：Intensive care medicine

authors： Azoulay E,Forel JM,Vinatier I,Truillet R,Renault A,Valade S,Jaber S,Durand-Gasselin J,Schwebel C,Georges H,Merceron S,Cariou A,Moussa M,Hraiech S,Argaud L,Leone M,Curtis JR,Kentish-Barnes N,Jouve E,Papazian L

更新日期：2018-11-01 00:00:00

abstract：BACKGROUND:Trustworthy clinical practice guidelines (CPGs) require identification and careful management of conflicts of interest (COIs) among all participants in the guideline development. Furthermore, COIs are more common than anticipated. However, there are no universally accepted methods to identify and manage COIs...

journal_title：Intensive care medicine

authors： Alhazzani W,Lewis K,Jaeschke R,Rochwerg B,Møller MH,Evans L,Wilson KC,Patel S,Coopersmith CM,Cecconi M,Guyatt G,Akl EA

更新日期：2018-10-01 00:00:00

abstract：PURPOSE:Frail patients are known to experience poor outcomes. Nevertheless, we know less about how frailty manifests itself in patients' physiology during critical illness and how it affects resource use in intensive care units (ICU). We aimed to assess the association of frailty with short-term outcomes and organ supp...

journal_title：Intensive care medicine

authors： Zampieri FG,Iwashyna TJ,Viglianti EM,Taniguchi LU,Viana WN,Costa R,Corrêa TD,Moreira CEN,Maia MO,Moralez GM,Lisboa T,Ferez MA,Freitas CEF,de Carvalho CB,Mazza BF,Lima MFA,Ramos GV,Silva AR,Bozza FA,Salluh JIF,Soar

更新日期：2018-09-01 00:00:00

abstract：:In critically ill patients, it is frequently challenging to identify who will benefit from admission to the intensive care unit and life-sustaining interventions when the chances of a meaningful outcome are unclear. In addition, the acute illness not only affects the patients but also family members or surrogates who ...

journal_title：Intensive care medicine

authors： Vink EE,Azoulay E,Caplan A,Kompanje EJO,Bakker J

更新日期：2018-09-01 00:00:00

abstract：: ...

journal_title：Intensive care medicine

authors： Monnet X,Saugel B

更新日期：2018-06-01 00:00:00

abstract：PURPOSE:Acute kidney injury (AKI) frequently occurs after heart transplantation (HTx), but its relation to preoperative right heart hemodynamic (RHH) parameters remains unknown. Therefore, we aimed to determine their predictive properties for postoperative AKI severity within 30 days after HTx. METHODS:From 1984 to 20...

journal_title：Intensive care medicine

authors： Guven G,Brankovic M,Constantinescu AA,Brugts JJ,Hesselink DA,Akin S,Struijs A,Birim O,Ince C,Manintveld OC,Caliskan K

更新日期：2018-05-01 00:00:00