听力与言语-语言病理学

行为科学

医学伦理学

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  • ADAM15 Participates in Tick-Borne Encephalitis Virus Replication.

    abstract::Tick-borne encephalitis virus (TBEV), a major tick-borne viral pathogen of humans, is known to cause neurological diseases such as meningitis, encephalitis, and meningoencephalitis. However, the life cycle and pathogenesis of TBEV are not well understood. Here, we show that the knockdown or knockout of ADAM15 (a disin...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.01926-20

    authors: Yang Q,Pei R,Wang Y,Zhou Y,Yang M,Chen X,Chen J

    更新日期:2021-01-28 00:00:00

  • Loss of the vaccinia virus 35-amino acid hydrophobic O3 protein is partially compensated by mutations in the transmembrane domains of other entry proteins.

    abstract::Eleven highly conserved proteins comprise the poxvirus entry-fusion complex (EFC). We focused on vaccinia virus (VACV) O3, a 35-amino acid, largely hydrophobic component of unknown specific function. Experimental evolution was carried out by blindly passaging a virus that was severely impaired in entry due to deletion...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.02228-20

    authors: Tak AI,Americo JL,Diesterbeck US,Moss B

    更新日期:2021-01-27 00:00:00

  • Reovirus RNA recombination is sequence directed and generates internally deleted defective genome segments during passage.

    abstract::For viruses with segmented genomes, genetic diversity is generated by genetic drift, reassortment, and recombination. Recombination produces RNA populations distinct from full-length gene segments and can influence viral population dynamics, persistence, and host immune responses. Viruses in the Reoviridae family, inc...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.02181-20

    authors: Smith SC,Gribble J,Diller JR,Wiebe MA,Thoner TW Jr,Denison MR,Ogden KM

    更新日期:2021-01-20 00:00:00

  • Influenza Virus Neuraminidase Engages CD83 and Promotes Pulmonary Injury.

    abstract::Influenza A viruses cause severe respiratory illnesses in humans and animals. Overreaction of the innate immune response to influenza virus infection results in hypercytokinemia, which is responsible for mortality and morbidity. However, the mechanism by which influenza induces hypercytokinemia is not fully understood...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.01753-20

    authors: Ma N,Li X,Jiang H,Dai Y,Xu G,Zhang Z

    更新日期:2021-01-13 00:00:00

  • Human Noroviruses Attach to Intestinal Tissues of a Broad Range of Animal Species.

    abstract::Human noroviruses are the most common nonbacterial cause of gastroenteritis outbreaks, with new variants and genotypes frequently emerging. The origin of these new viruses is unknown; however, animals have been proposed as a potential source, as human noroviruses have been detected in animal species. Here, we investig...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.01492-20

    authors: Villabruna N,Schapendonk CME,Aron GI,Koopmans MPG,de Graaf M

    更新日期:2021-01-13 00:00:00

  • Effective Inhibition of SARS-CoV-2 Entry by Heparin and Enoxaparin Derivatives.

    abstract::Severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) has caused a pandemic of historic proportions and continues to spread globally, with enormous consequences to human health. Currently there is no vaccine, effective therapeutic, or prophylactic. As with other betacoronaviruses, attachment and entry o...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.01987-20

    authors: Tandon R,Sharp JS,Zhang F,Pomin VH,Ashpole NM,Mitra D,McCandless MG,Jin W,Liu H,Sharma P,Linhardt RJ

    更新日期:2021-01-13 00:00:00

  • Possible Action of Transition Divalent Metal Ions at the Inter-Pentameric Interface of Inactivated Foot-and-Mouth Disease Virus Provide A Simple but Effective Approach to Enhance Stability.

    abstract::The structural instability of inactivated foot-and-mouth disease virus (FMDV) hinders the development of vaccine industry. Here we found that some transition metal ions like Cu2+ and Ni2+ could specifically bind to FMDV capsids at capacities about 7089 and 3448 metal ions per capsid, respectively. These values are abo...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.02431-20

    authors: Lin X,Yang Y,Song Y,Li S,Zhang X,Su Z,Zhang S

    更新日期:2021-01-13 00:00:00

  • Insight into vaccine development for Alpha-coronaviruses based on structural and immunological analyses of spike proteins.

    abstract::Coronaviruses that infect humans belong to the Alpha-coronavirus (including HCoV-229E) and Beta-coronavirus (including SARS-CoV and SARS-CoV-2) genera. In particular, SARS-CoV-2 is currently a major threat to public health worldwide. The spike (S) homotrimers bind to their receptors via the receptor-binding domain (RB...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.02284-20

    authors: Shi Y,Shi J,Sun L,Tan Y,Wang G,Guo F,Hu G,Fu Y,Fu ZF,Xiao S,Peng G

    更新日期:2021-01-07 00:00:00

  • Tetramerization of Phosphoprotein is Essential for Respiratory Syncytial Virus Budding while its N Terminal Region Mediates Direct Interactions with the Matrix Protein.

    abstract::It was shown previously that the Matrix (M), Phosphoprotein (P), and the Fusion (F) proteins of Respiratory syncytial virus (RSV) are sufficient to produce virus-like particles (VLPs) that resemble the RSV infection-induced virions. However, the exact mechanism and interactions among the three proteins are not known. ...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.02217-20

    authors: Bajorek M,Galloux M,Richard CA,Szekely O,Rosenzweig R,Sizun C,Eleouet JF

    更新日期:2021-01-06 00:00:00

  • Roles of Cholesterol in Early and Late Steps of the Nipah Virus Membrane Fusion Cascade.

    abstract::Cholesterol has been implicated in various viral life cycle steps for different enveloped viruses, including viral entry into host cells, cell-cell fusion, and viral budding from infected cells. Enveloped viruses acquire their membranes from their host cells. Though cholesterol has been associated with binding and ent...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.02323-20

    authors: Contreras EM,Johnston GP,Buchholz DW,Ortega V,Monreal IA,Zamora JLR,Cheung T,Aguilar HC

    更新日期:2021-01-06 00:00:00

  • Foot-and-Mouth Disease Virus Structural Protein VP1 Destroys the Stability of TPL2 Trimer by Degradation TPL2 to Evade Host Antiviral Immunity.

    abstract::Tumor progression locus 2 (TPL2) is a serine/threonine kinase that belongs to the mitogen-activated protein 3 kinase (MAP3K) family, and it plays an important role in pathogen infection. The trimer complex of TPL2, p105, and ABIN2 is essential for maintenance of TPL2 steady-state levels and host cell response to patho...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.02149-20

    authors: Zhang K,Yan M,Hao J,Shen C,Zhu Z,Zhang D,Hou J,Xu G,Li D,Zheng H,Liu X

    更新日期:2020-12-23 00:00:00

  • Fowl Adenovirus Serotype 4 Induces Hepatic Steatosis via Activation of Liver X Receptor-α.

    abstract::Fowl adenovirus serotype 4 (FAdV-4) is a hepatotropic virus that causes severe hepatic damage characterized by basophilic intranuclear inclusion bodies, vacuolar degeneration, and multifocal necrosis in hepatocytes. Many aspects of FAdV-4 infection and pathogenesis, however, remain unknown. Here, we found that FAdV-4-...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.01938-20

    authors: Yuan F,Hou L,Wei L,Quan R,Wang J,Liu H,Liu J

    更新日期:2020-12-23 00:00:00

  • Replication of Small Ruminant Lentiviruses in Aluminum Hydroxide-Induced Granulomas in Sheep: a Potential New Factor for Viral Dissemination.

    abstract::Aluminum (Al)-based salts are widely used adjuvants in ruminants and other species to strengthen the immune response elicited against vaccine antigen(s). However, they can lead to the formation of long-lasting granulomas composed of abundant activated macrophages. Small ruminant lentiviruses (SRLV) are widely distribu...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.01859-20

    authors: Echeverría I,de Miguel R,Asín J,Rodríguez-Largo A,Fernández A,Pérez M,de Andrés D,Luján L,Reina R

    更新日期:2020-12-22 00:00:00

  • Inter-domain Flexibility of Chikungunya Virus nsP2 Helicase-Protease Differentially Influences Viral RNA Replication and Infectivity.

    abstract::Chikungunya virus (CHIKV) is a mosquito-borne alphavirus responsible for chikungunya fever. Nonstructural protein 2 (nsP2), a multifunctional protein essential for viral replication, has an N-terminal helicase region (nsP2h), which as both nucleotide triphosphatase and RNA triphosphatase activities, as well as a C-ter...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.01470-20

    authors: Law YS,Wang S,Tan YB,Shih O,Utt A,Goh WY,Lian BJ,Chen MW,Jeng US,Merits A,Luo D

    更新日期:2020-12-16 00:00:00

  • High-Resolution Mapping of Human Norovirus Antigens via Genomic Phage Display Library Selections and Deep Sequencing.

    abstract::Norovirus (NoV) infections are a leading cause of gastroenteritis. The humoral immune response plays an important role in the control of NoV, and recent studies have identified neutralizing antibodies that bind the capsid protein VP1 to block viral infection. Here, we utilize a NoV GI.1 Jun-Fos-assisted phage display ...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.01495-20

    authors: Huang W,Soeung V,Boragine DM,Hu L,Prasad BVV,Estes MK,Atmar RL,Palzkill T

    更新日期:2020-12-09 00:00:00

  • Escape of HIV-1 envelope glycoprotein from the restriction of infection by IFITM3.

    abstract::Interferon-induced transmembrane protein 3 (IFITM3) is a cellular factor that reduces HIV-1 infectivity by an incompletely understood mechanism. We show here that viruses differing only in the envelope glycoprotein (Env) expressed on their surface have different sensitivities to IFITM3. Measurements of the sensitivity...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.01994-20

    authors: Drouin A,Migraine J,Durand MA,Moreau A,Burlaud-Gaillard J,Beretta M,Roingeard P,Bouvin-Pley M,Braibant M

    更新日期:2020-12-09 00:00:00

  • Zika Virus-Like Particles Bearing a Covalent Dimer of Envelope Protein Protect Mice from Lethal Challenge.

    abstract::Zika virus (ZIKV) envelope (E) protein is the major target of neutralizing antibodies in infected hosts and thus represents a candidate of interest for vaccine design. However, a major concern in the development of vaccines against ZIKV and the related dengue virus is the induction of cross-reactive poorly neutralizin...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.01415-20

    authors: De Lorenzo G,Tandavanitj R,Doig J,Setthapramote C,Poggianella M,Sanchez-Velazquez R,Scales HE,Edgar JM,Kohl A,Brewer J,Burrone OR,Patel AH

    更新日期:2020-12-09 00:00:00

  • Regulation of VP30-Dependent Transcription by RNA Sequence and Structure in the Genomic Ebola Virus Promoter.

    abstract::Viral transcription and replication of Ebola virus (EBOV) is balanced by transcription factor VP30, an RNA binding protein. An RNA hairpin at the transcription start site (TSS) of the first gene (NP hairpin) in the 3'-leader promoter is thought to mediate the VP30 dependency of transcription. Here, we investigated the...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.02215-20

    authors: Bach S,Demper JC,Grünweller A,Becker S,Biedenkopf N,Hartmann RK

    更新日期:2020-12-02 00:00:00

  • Interferon-Induced Transmembrane Protein 3 Is a Virus-Associated Protein Which Suppresses Porcine Reproductive and Respiratory Syndrome Virus Replication by Blocking Viral Membrane Fusion.

    abstract::Porcine reproductive and respiratory syndrome virus (PRRSV) infection eliminates production of type I interferons (IFNs) in host cells, which triggers an antiviral immune response through the induction of downstream IFN-stimulated genes (ISGs), thus escaping the fate of host-mediated clearance. The IFN-induced transme...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.01350-20

    authors: Zhang A,Duan H,Zhao H,Liao H,Du Y,Li L,Jiang D,Wan B,Wu Y,Ji P,Zhou EM,Zhang G

    更新日期:2020-11-23 00:00:00

  • Dengue Virus Targets Nrf2 for NS2B3-Mediated Degradation Leading to Enhanced Oxidative Stress and Viral Replication.

    abstract::Dengue virus (DENV) is a mosquito-borne virus that infects upward of 300 million people annually and has the potential to cause fatal hemorrhagic fever and shock. While the parameters contributing to dengue immunopathogenesis remain unclear, the collapse of redox homeostasis and the damage induced by oxidative stress ...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.01551-20

    authors: Ferrari M,Zevini A,Palermo E,Muscolini M,Alexandridi M,Etna MP,Coccia EM,Fernandez-Sesma A,Coyne C,Zhang DD,Marques ETA,Olagnier D,Hiscott J

    更新日期:2020-11-23 00:00:00

  • Herpes Simplex Virus Entry by a Nonconventional Endocytic Pathway.

    abstract::Herpes simplex virus 1 (HSV-1) causes significant morbidity and mortality in humans worldwide. HSV-1 enters epithelial cells via an endocytosis mechanism that is low-pH dependent. However, the precise intracellular pathway has not been identified, including the compartment where fusion occurs. In this study, we utiliz...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.01910-20

    authors: Tebaldi G,Pritchard SM,Nicola AV

    更新日期:2020-11-23 00:00:00

  • Interferon Regulatory Factor 7 Attenuates Chronic Gammaherpesvirus Infection.

    abstract::Gammaherpesviruses are ubiquitous pathogens that establish lifelong infections and are associated with a variety of malignancies, including lymphomas. Interferon regulatory factor 7 (IRF-7) is an innate immune transcription factor that restricts acute replication of diverse viruses, including murine gammaherpesvirus 6...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.01554-20

    authors: Johnson KE,Aurubin CA,Jondle CN,Lange PT,Tarakanova VL

    更新日期:2020-11-23 00:00:00

  • Characterization of Novel Cross-Reactive Influenza B Virus Hemagglutinin Head Specific Antibodies That Lack Hemagglutination Inhibition Activity.

    abstract::Humoral immune responses to influenza virus vaccines in elderly individuals are poorly adapted toward new antigenically drifted influenza virus strains. Instead, older individuals respond in an original antigenic sin fashion and produce much more cross-reactive but less potent antibodies. Here, we investigated four in...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.01185-20

    authors: Kirkpatrick E,Henry C,McMahon M,Jiang K,Strohmeier S,van Bakel H,Wilson PC,Krammer F

    更新日期:2020-11-09 00:00:00

  • Characterization of the Herpes Simplex Virus (HSV) Tegument Proteins That Bind to gE/gI and US9, Which Promote Assembly of HSV and Transport into Neuronal Axons.

    abstract::The herpes simplex virus (HSV) heterodimer gE/gI and another membrane protein, US9, which has neuron-specific effects, promote the anterograde transport of virus particles in neuronal axons. Deletion of both HSV gE and US9 blocks the assembly of enveloped particles in the neuronal cytoplasm, which explains why HSV vir...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.01113-20

    authors: DuRaine G,Wisner TW,Johnson DC

    更新日期:2020-11-09 00:00:00

  • Development of Styrene Maleic Acid Lipid Particles as a Tool for Studies of Phage-Host Interactions.

    abstract::The infection of a bacterium by a phage starts with attachment to a receptor molecule on the host cell surface by the phage. Since receptor-phage interactions are crucial to successful infections, they are major determinants of phage host range and, by extension, of the broader effects that phages have on bacterial co...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.01559-20

    authors: de Jonge PA,Smit Sibinga DJC,Boright OA,Costa AR,Nobrega FL,Brouns SJJ,Dutilh BE

    更新日期:2020-11-09 00:00:00

  • The Dynamic Interface of Viruses with STATs.

    abstract::Viruses commonly antagonize the antiviral type I interferon response by targeting signal transducer and activator of transcription 1 (STAT1) and STAT2, key mediators of interferon signaling. Other STAT family members mediate signaling by diverse cytokines important to infection, but their relationship with viruses is ...

    journal_title:Journal of virology

    pub_type: 杂志文章,评审

    doi:10.1128/JVI.00856-20

    authors: Harrison AR,Moseley GW

    更新日期:2020-10-27 00:00:00

  • Mechanistic Target of Rapamycin Signaling Activation Antagonizes Autophagy To Facilitate Zika Virus Replication.

    abstract::Zika virus (ZIKV), a mosquito-transmitted flavivirus, is linked to microcephaly and other neurological defects in neonates and Guillain-Barré syndrome in adults. The molecular mechanisms regulating ZIKV infection and pathogenic outcomes are incompletely understood. Signaling by the mechanistic (mammalian) target of ra...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.01575-20

    authors: Sahoo BR,Pattnaik A,Annamalai AS,Franco R,Pattnaik AK

    更新日期:2020-10-27 00:00:00

  • Severe Human Lassa Fever Is Characterized by Nonspecific T-Cell Activation and Lymphocyte Homing to Inflamed Tissues.

    abstract::Lassa fever (LF) is a zoonotic viral hemorrhagic fever caused by Lassa virus (LASV), which is endemic to West African countries. Previous studies have suggested an important role for T-cell-mediated immunopathology in LF pathogenesis, but the mechanisms by which T cells influence disease severity and outcome are not w...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.01367-20

    authors: Port JR,Wozniak DM,Oestereich L,Pallasch E,Becker-Ziaja B,Müller J,Rottstegge M,Olal C,Gómez-Medina S,Oyakhliome J,Ighodalo Y,Omomoh E,Olokor T,Adomeh DI,Asogun D,Ogbani-Emovon E,Hartmann K,Krasemann S,Nelson EV,Esc

    更新日期:2020-10-14 00:00:00

  • Functional and Structural Insights into a Vif/PPP2R5 Complex Elucidated Using Patient HIV-1 Isolates and Computational Modeling.

    abstract::Human immunodeficiency virus type 1 (HIV-1) Vif recruits a cellular ubiquitin ligase complex to degrade antiviral APOBEC3 enzymes (APOBEC3C-H) and PP2A phosphatase regulators (PPP2R5A to PPP2R5E). While APOBEC3 antagonism is the canonical function of HIV-1 Vif, this viral accessory protein is also known to trigger G2/...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.00631-20

    authors: Salamango DJ,McCann JL,Demir Ö,Becker JT,Wang J,Lingappa JR,Temiz NA,Brown WL,Amaro RE,Harris RS

    更新日期:2020-10-14 00:00:00

  • SERINC5 Inhibits HIV-1 Infectivity by Altering the Conformation of gp120 on HIV-1 Particles.

    abstract::SERINC5 is a 10-transmembrane-domain cellular protein that is incorporated into budding HIV-1 particles and reduces HIV-1 infectivity by inhibiting virus-cell fusion. HIV-1 susceptibility to SERINC5 is determined by sequences in the viral Env glycoprotein gp120, and the antiviral effect of SERINC5 is counteracted by t...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.00594-20

    authors: Featherstone A,Aiken C

    更新日期:2020-09-29 00:00:00

  • Porcine Reproductive and Respiratory Syndrome Virus Structural Protein GP3 Regulates Claudin 4 To Facilitate the Early Stages of Infection.

    abstract::Claudins (CLDN) are a family of proteins that represent the most important components of tight junctions, where they establish the paracellular barrier that controls the flow of molecules in the intercellular space between epithelial cells. Several types of viruses make full use of CLDN to facilitate entry into cells....

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.00124-20

    authors: Ding G,Liu J,Shao Q,Wang B,Feng J,Li Y,Li L,Cao S,Cong F,Zhao Y,Liu S,Xiao Y

    更新日期:2020-09-29 00:00:00

  • Antiviral Properties of the LSD1 Inhibitor SP-2509.

    abstract::Lysine-specific demethylase 1 (LSD1) targets cellular proteins, including histone H3, p53, E2F, and Dnmt1, and is involved in the regulation of gene expression, DNA replication, the cell cycle, and the DNA damage response. LSD1 catalyzes demethylation of histone H3K9 associated with herpes simplex virus 1 (HSV-1) imme...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.00974-20

    authors: Harancher MR,Packard JE,Cowan SP,DeLuca NA,Dembowski JA

    更新日期:2020-09-15 00:00:00

  • Cortactin Interacts with Hepatitis C Virus Core and NS5A Proteins: Implications for Virion Assembly.

    abstract::Hepatitis C virus (HCV) exploits cellular proteins to facilitate viral propagation. To identify the cellular factors involved in the HCV life cycle, we previously performed protein microarray assays using either HCV nonstructural 5A (NS5A) protein or core protein as a probe. Interestingly, cellular cortactin strongly ...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.01306-20

    authors: Nguyen LP,Nguyen TTT,Nguyen HC,Pham HT,Han KM,Choi DH,Park EM,Kang SM,Tark D,Lim YS,Hwang SB

    更新日期:2020-09-15 00:00:00

  • Genetic Analyses of Contributions of Viral Interleukin-6 Interactions and Signaling to Human Herpesvirus 8 Productive Replication.

    abstract::Human herpesvirus 8 (HHV-8) viral interleukin-6 (vIL-6) is a cytokine that is poorly secreted and localized largely to the endoplasmic reticulum (ER). It has been implicated, along with other HHV-8 proinflammatory and/or angiogenic viral proteins, in HHV-8-associated Kaposi's sarcoma, primary effusion lymphoma (PEL), ...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.00909-20

    authors: Li Q,Xiang Q,Chen D,Nicholas J

    更新日期:2020-09-15 00:00:00

  • Reactivation of Epstein-Barr Virus by HIF-1α Requires p53.

    abstract::We previously reported that the cellular transcription factor hypoxia-inducible factor 1α (HIF-1α) binds a hypoxia response element (HRE) located within the promoter of Epstein-Barr virus's (EBV's) latent-lytic switch BZLF1 gene, Zp, inducing viral reactivation. In this study, EBV-infected cell lines derived from gast...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.00722-20

    authors: Kraus RJ,Cordes BA,Sathiamoorthi S,Patel P,Yuan X,Iempridee T,Yu X,Lee DL,Lambert PF,Mertz JE

    更新日期:2020-08-31 00:00:00

  • Inactivation of Genes by Frameshift Mutations Provides Rapid Adaptation of an Attenuated Vaccinia Virus.

    abstract::Unlike RNA viruses, most DNA viruses replicate their genomes with high-fidelity polymerases that rarely make base substitution errors. Nevertheless, experimental evolution studies have revealed rapid acquisition of adaptive mutations during serial passage of attenuated vaccinia virus (VACV). One way in which adaptatio...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.01053-20

    authors: Senkevich TG,Zhivkoplias EK,Weisberg AS,Moss B

    更新日期:2020-08-31 00:00:00

  • Limited Cross-Protection Provided by Prior Infection Contributes to High Prevalence of Influenza D Viruses in Cattle.

    abstract::Since its detection in swine, influenza D virus (IDV) has been shown to be present in multiple animal hosts, and bovines have been identified as its natural reservoir. However, it remains unclear how IDVs emerge, evolve, spread, and maintain in bovine populations. Through multiple years of virological and serological ...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.00240-20

    authors: Wan XF,Ferguson L,Oliva J,Rubrum A,Eckard L,Zhang X,Woolums AR,Lion A,Meyer G,Murakami S,Ma W,Horimoto T,Webby R,Ducatez MF,Epperson W

    更新日期:2020-08-31 00:00:00

  • A Novel Approach To Display Structural Proteins of Hepatitis C Virus Quasispecies in Patients Reveals a Key Role of E2 HVR1 in Viral Evolution.

    abstract::Hepatitis C virus (HCV) infection remains a major worldwide health problem despite development of highly effective direct-acting antivirals. HCV rapidly evolves upon acute infection and generates multiple viral variants (quasispecies), leading to immune evasion and persistent viral infection. Identification of epitope...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.00622-20

    authors: Tong Y,Li Q,Li R,Xu Y,Pan Y,Niu J,Zhong J

    更新日期:2020-08-17 00:00:00

  • P108 and T109 on E2 Glycoprotein Domain I Are Critical for the Adaptation of Classical Swine Fever Virus to Rabbits but Not for Virulence in Pigs.

    abstract::The classical swine fever virus (CSFV) live attenuated vaccine C-strain is adaptive to rabbits and attenuated in pigs, in contrast with the highly virulent CSFV Shimen strain. Previously, we demonstrated that P108 and T109 on the E2 glycoprotein (E2P108-T109) in domain I (E2DomainI) rather than R132, S133, and D191 in...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.01104-20

    authors: Xie L,Han Y,Ma Y,Yuan M,Li W,Li LF,Li M,Sun Y,Luo Y,Li S,Hu S,Li Y,Qiu HJ

    更新日期:2020-08-17 00:00:00

  • NF-κB-Interacting Long Noncoding RNA Regulates HIV-1 Replication and Latency by Repressing NF-κB Signaling.

    abstract::NF-κB-interacting long noncoding RNA (NKILA) was recently identified as a negative regulator of NF-κB signaling and plays an important role in the development of various cancers. It is well known that NF-κB-mediated activation of human immunodeficiency virus type 1 (HIV-1) long terminal repeat (LTR)-driven gene expres...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.01057-20

    authors: Wang H,Liu Y,Huan C,Yang J,Li Z,Zheng B,Wang Y,Zhang W

    更新日期:2020-08-17 00:00:00

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