听力与言语-语言病理学

行为科学

医学伦理学

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  • Atrial Fibrillation and the Prognostic Performance of Biomarkers in Heart Failure.

    abstract:BACKGROUND:Consideration of circulating biomarkers for risk stratification in heart failure (HF) is recommended, but the influence of atrial fibrillation (AF) on prognostic performance of many markers is unclear. We investigated the influence of AF on the prognostic performance of circulating biomarkers in HF. METHODS...

    journal_title:Clinical chemistry

    pub_type: 杂志文章

    doi:10.1093/clinchem/hvaa287

    authors: Tan ESJ,Chan SP,Liew OW,Chong JPC,Leong GKT,Yeo DPS,Ong HY,Jaufeerally F,Yap J,Sim D,Ng TP,Ling LH,Lam CSP,Richards AM

    更新日期:2021-01-08 00:00:00

  • Limitations of Accelerated Stability Model Based on the Arrhenius Equation for Shelf Life Estimation of In Vitro Diagnostic Products.

    abstract:BACKGROUND:An accelerated stability model based on the Arrhenius Equation can be used to estimate stability of diagnostic reagents. Here we review 3 examples in which the model does not accurately predict the stability of diagnostic reagents. METHODS:We prepared several pilot lots of quality controls materials contain...

    journal_title:Clinical chemistry

    pub_type: 杂志文章

    doi:10.1093/clinchem/hvaa282

    authors: Ebrahim A,DeVore K,Fischer T

    更新日期:2020-12-04 00:00:00

  • SARS-CoV-2 Whole Genome Amplification and Sequencing for Effective Population-Based Surveillance and Control of Viral Transmission.

    abstract:BACKGROUND:With the gradual reopening of economies and resumption of social life, robust surveillance mechanisms should be implemented to control the ongoing COVID-19 pandemic. Unlike RT-qPCR, SARS-CoV-2 whole genome sequencing (cWGS) has the added advantage of identifying cryptic origins of the virus, and the extent o...

    journal_title:Clinical chemistry

    pub_type: 杂志文章

    doi:10.1093/clinchem/hvaa187

    authors: Harilal D,Ramaswamy S,Loney T,Suwaidi HA,Khansaheb H,Alkhaja A,Varghese R,Deesi Z,Nowotny N,Alsheikh-Ali A,Abou Tayoun A

    更新日期:2020-11-01 00:00:00

  • Distinguishing Non-Small Cell Lung Cancer Subtypes in Fine Needle Aspiration Biopsies by Desorption Electrospray Ionization Mass Spectrometry Imaging.

    abstract:BACKGROUND:Distinguishing adenocarcinoma and squamous cell carcinoma subtypes of non-small cell lung cancers is critical to patient care. Preoperative minimally-invasive biopsy techniques, such as fine needle aspiration (FNA), are increasingly used for lung cancer diagnosis and subtyping. Yet, histologic distinction of...

    journal_title:Clinical chemistry

    pub_type: 杂志文章

    doi:10.1093/clinchem/hvaa207

    authors: Bensussan AV,Lin J,Guo C,Katz R,Krishnamurthy S,Cressman E,Eberlin LS

    更新日期:2020-11-01 00:00:00

  • Association between SARS-CoV-2 neutralizing antibodies and commercial serological assays.

    abstract:INTRODUCTION:Commercially available SARS-CoV-2 serological assays based on different viral antigens have been approved for the qualitative determination of anti-SARS-CoV-2 antibodies. However, there are limited published data associating the results from commercial assays with neutralizing antibodies. METHODS:67 speci...

    journal_title:Clinical chemistry

    pub_type: 杂志文章

    doi:10.1093/clinchem/hvaa211

    authors: Tang MS,Case JB,Franks CE,Chen RE,Anderson NW,Henderson JP,Diamond MS,Gronowski AM,Farnsworth CW

    更新日期:2020-09-07 00:00:00

  • Ultrasensitive DNA Immune Repertoire Sequencing Using Unique Molecular Identifiers.

    abstract:BACKGROUND:Immune repertoire sequencing of the T-cell receptor can identify clonotypes that have expanded as a result of antigen recognition or hematological malignancies. However, current sequencing protocols display limitations with nonuniform amplification and polymerase-induced errors during sequencing. Here, we de...

    journal_title:Clinical chemistry

    pub_type: 杂志文章

    doi:10.1093/clinchem/hvaa159

    authors: Johansson G,Kaltak M,Rîmniceanu C,Singh AK,Lycke J,Malmeström C,Hühn M,Vaarala O,Cardell S,Ståhlberg A

    更新日期:2020-09-01 00:00:00

  • A Machine Learning Approach for the Automated Interpretation of Plasma Amino Acid Profiles.

    abstract:BACKGROUND:Plasma amino acid (PAA) profiles are used in routine clinical practice for the diagnosis and monitoring of inherited disorders of amino acid metabolism, organic acidemias, and urea cycle defects. Interpretation of PAA profiles is complex and requires substantial training and expertise to perform. Given previ...

    journal_title:Clinical chemistry

    pub_type: 杂志文章

    doi:10.1093/clinchem/hvaa134

    authors: Wilkes EH,Emmett E,Beltran L,Woodward GM,Carling RS

    更新日期:2020-09-01 00:00:00

  • 99th Percentile Upper-Reference Limit of Cardiac Troponin and the Diagnosis of Acute Myocardial Infarction.

    abstract:BACKGROUND:Concerns exist regarding how the 99th percentile upper reference limit (URL) of cardiac troponin (cTn) is determined and whether it should be derived from normal healthy individuals. CONTENT:The 99th percentile URL of cTn is an important criterion to standardize the diagnosis of myocardial infarction (MI) f...

    journal_title:Clinical chemistry

    pub_type: 杂志文章

    doi:10.1093/clinchem/hvaa158

    authors: Sandoval Y,Apple FS,Saenger AK,Collinson PO,Wu AHB,Jaffe AS

    更新日期:2020-09-01 00:00:00

  • Clinical Correlations of Programmed Cell Death Ligand 1 Status in Liquid and Standard Biopsies in Breast Cancer.

    abstract:BACKGROUND:Data regarding the prognostic value of programmed cell death ligand 1 (PD-L1) expression on circulating tumor cells (CTCs) are lacking. However, CTCs could represent an alternative approach to serial biopsies, allowing real-time monitoring of cancer phenotype. METHODS:We evaluated, in a dedicated prospectiv...

    journal_title:Clinical chemistry

    pub_type: 杂志文章

    doi:10.1093/clinchem/hvaa121

    authors: Jacot W,Mazel M,Mollevi C,Pouderoux S,D'Hondt V,Cayrefourcq L,Bourgier C,Boissiere-Michot F,Berrabah F,Lopez-Crapez E,Bidard FC,Viala M,Maudelonde T,Guiu S,Alix-Panabières C

    更新日期:2020-08-01 00:00:00

  • 25-Hydroxyvitamin D and Risk of Osteoporotic Fractures: Mendelian Randomization Analysis in 2 Large Population-Based Cohorts.

    abstract:BACKGROUND:Whether low plasma 25-hydroxyvitamin D concentrations cause osteoporotic fractures is unclear. We tested the hypothesis that low plasma 25-hydroxyvitamin D concentrations are associated with increased risk of osteoporotic fractures using a Mendelian randomization analysis. METHODS:We genotyped 116 335 rando...

    journal_title:Clinical chemistry

    pub_type: 杂志文章

    doi:10.1093/clinchem/hvaa049

    authors: Çolak Y,Afzal S,Nordestgaard BG

    更新日期:2020-05-01 00:00:00

  • ISSAID/EMQN Best Practice Guidelines for the Genetic Diagnosis of Monogenic Autoinflammatory Diseases in the Next-Generation Sequencing Era.

    abstract:BACKGROUND:Monogenic autoinflammatory diseases are caused by pathogenic variants in genes that regulate innate immune responses, and are characterized by sterile systemic inflammatory episodes. Since symptoms can overlap within this rapidly expanding disease category, accurate genetic diagnosis is of the utmost importa...

    journal_title:Clinical chemistry

    pub_type: 杂志文章

    doi:10.1093/clinchem/hvaa024

    authors: Shinar Y,Ceccherini I,Rowczenio D,Aksentijevich I,Arostegui J,Ben-Chétrit E,Boursier G,Gattorno M,Hayrapetyan H,Ida H,Kanazawa N,Lachmann HJ,Mensa-Vilaro A,Nishikomori R,Oberkanins C,Obici L,Ohara O,Ozen S,Sarkisian T

    更新日期:2020-04-01 00:00:00

  • Urothelial Carcinoma Detection Based on Copy Number Profiles of Urinary Cell-Free DNA by Shallow Whole-Genome Sequencing.

    abstract:BACKGROUND:Current noninvasive assays for urothelial carcinoma (UC) lack clinical sensitivity and specificity. Given the utility of plasma cell-free DNA (cfDNA) biomarkers, the development of urinary cfDNA biomarkers may improve the diagnostic sensitivity. METHODS:We assessed copy number alterations (CNAs) by shallow ...

    journal_title:Clinical chemistry

    pub_type: 杂志文章

    doi:10.1373/clinchem.2019.309633

    authors: Ge G,Peng D,Guan B,Zhou Y,Gong Y,Shi Y,Hao X,Xu Z,Qi J,Lu H,Zhang X,Zhan Y,Li Y,Wu Y,Ding G,Shen Q,He Q,Li X,Zhou L,Ci W

    更新日期:2020-01-01 00:00:00

  • Diagnostic Evaluation of a High-Sensitivity Troponin I Point-of-Care Assay.

    abstract:BACKGROUND:Increasing numbers of patients are presenting worldwide to emergency departments with suspected myocardial infarction. The use of point-of-care troponin assays might enable faster decision-making in this high-risk population and reduce the burden on emergency facilities. Here, we evaluate the diagnostic perf...

    journal_title:Clinical chemistry

    pub_type: 杂志文章

    doi:10.1373/clinchem.2019.307405

    authors: Sörensen NA,Neumann JT,Ojeda F,Giannitsis E,Spanuth E,Blankenberg S,Westermann D,Zeller T

    更新日期:2019-12-01 00:00:00

  • Comparative Analysis of Biochemical Biases by Ligation- and Template-Switch-Based Small RNA Library Preparation Protocols.

    abstract:BACKGROUND:Small RNAs are key players in the regulation of gene expression and differentiation. However, many different classes of small RNAs (sRNAs) have been described with distinct biogenesis pathways and, as a result, with different biochemical properties. To analyze sRNAs by deep sequencing, complementary DNA synt...

    journal_title:Clinical chemistry

    pub_type: 杂志文章

    doi:10.1373/clinchem.2019.305045

    authors: Meistertzheim M,Fehlmann T,Drews F,Pirritano M,Gasparoni G,Keller A,Simon M

    更新日期:2019-12-01 00:00:00

  • Temporal Changes in Cardiac Troponin I Are Associated with Risk of Cardiovascular Events in the General Population: The Nord-Trøndelag Health Study.

    abstract:BACKGROUND:Cardiac troponins are associated with cardiovascular risk in the general population, but whether temporal changes in cardiac troponin I provide independent prognostic information remains uncertain. Using a large community-based cohort with follow-up close to the present day, we aimed to investigate the assoc...

    journal_title:Clinical chemistry

    pub_type: 杂志文章

    doi:10.1373/clinchem.2018.301069

    authors: Lyngbakken MN,Røsjø H,Holmen OL,Dalen H,Hveem K,Omland T

    更新日期:2019-07-01 00:00:00

  • Detection of Colorectal Cancer in Circulating Cell-Free DNA by Methylated CpG Tandem Amplification and Sequencing.

    abstract:BACKGROUND:Aberrant DNA hypermethylation of CpG islands occurs frequently throughout the genome in human colorectal cancer (CRC). A genome-wide DNA hypermethylation analysis technique using circulating cell-free DNA (cfDNA) is attractive for the noninvasive early detection of CRC and discrimination between CRC and othe...

    journal_title:Clinical chemistry

    pub_type: 杂志文章

    doi:10.1373/clinchem.2019.301804

    authors: Li J,Zhou X,Liu X,Ren J,Wang J,Wang W,Zheng Y,Shi X,Sun T,Li Z,Kang A,Tang F,Wen L,Fu W

    更新日期:2019-07-01 00:00:00

  • Noninvasive Detection of Bladder Cancer by Shallow-Depth Genome-Wide Bisulfite Sequencing of Urinary Cell-Free DNA for Methylation and Copy Number Profiling.

    abstract:BACKGROUND:The current diagnosis and monitoring of bladder cancer are heavily reliant on cystoscopy, an invasive and costly procedure. Previous efforts in urine-based detection of bladder cancer focused on targeted approaches that are predicated on the tumor expressing specific aberrations. We aimed to noninvasively de...

    journal_title:Clinical chemistry

    pub_type: 杂志文章

    doi:10.1373/clinchem.2018.301341

    authors: Cheng THT,Jiang P,Teoh JYC,Heung MMS,Tam JCW,Sun X,Lee WS,Ni M,Chan RCK,Ng CF,Chan KCA,Chiu RWK,Lo YMD

    更新日期:2019-07-01 00:00:00

  • The National Glycohemoglobin Standardization Program: Over 20 Years of Improving Hemoglobin A1c Measurement.

    abstract:BACKGROUND:Measurement of hemoglobin A1c (HbA1c) in the blood is integral to and essential for the treatment of patients with diabetes mellitus. HbA1c reflects the mean blood glucose concentration over the preceding 8 to 12 weeks. Although the clinical value of HbA1c was initially limited by large differences in result...

    journal_title:Clinical chemistry

    pub_type: 杂志文章,评审

    doi:10.1373/clinchem.2018.296962

    authors: Little RR,Rohlfing C,Sacks DB

    更新日期:2019-07-01 00:00:00

  • Commutability of a Whole-Blood External Quality Assessment Material for Point-of-Care C-Reactive Protein, Glucose, and Hemoglobin Testing.

    abstract:BACKGROUND:The optimal situation in external quality assessment (EQA) is to use commutable materials. No previous study has examined the commutability of a whole-blood material for point-of-care (POC) testing. The aim of this study was to determine the commutability of the Norwegian Quality Improvement of Laboratory Ex...

    journal_title:Clinical chemistry

    pub_type: 杂志文章

    doi:10.1373/clinchem.2018.300202

    authors: Bukve T,Sandberg S,Vie WS,Sølvik U,Christensen NG,Stavelin A

    更新日期:2019-06-01 00:00:00

  • Dairy Intake and Body Composition and Cardiometabolic Traits among Adults: Mendelian Randomization Analysis of 182041 Individuals from 18 Studies.

    abstract:BACKGROUND:Associations between dairy intake and body composition and cardiometabolic traits have been inconsistently observed in epidemiological studies, and the causal relationship remains ill-defined. METHODS:We performed Mendelian randomization analysis using an established genetic variant located upstream of the ...

    journal_title:Clinical chemistry

    pub_type: 杂志文章

    doi:10.1373/clinchem.2018.300335

    authors: Mendelian Randomization of Dairy Consumption Working Group.,CHARGE consortium.

    更新日期:2019-06-01 00:00:00

  • Extracellular Vesicles Long RNA Sequencing Reveals Abundant mRNA, circRNA, and lncRNA in Human Blood as Potential Biomarkers for Cancer Diagnosis.

    abstract:BACKGROUND:Extracellular vesicles (EVs) contain a rich cargo of different RNA species with specialized functions and clinical applications. However, the landscape and characteristics of extracellular vesicle long RNA (exLR) in human blood remain largely unknown. METHODS:We presented an optimized strategy for exLR sequ...

    journal_title:Clinical chemistry

    pub_type: 杂志文章

    doi:10.1373/clinchem.2018.301291

    authors: Li Y,Zhao J,Yu S,Wang Z,He X,Su Y,Guo T,Sheng H,Chen J,Zheng Q,Li Y,Guo W,Cai X,Shi G,Wu J,Wang L,Wang P,He X,Huang S

    更新日期:2019-06-01 00:00:00

  • Low HDL Cholesterol and High Risk of Autoimmune Disease: Two Population-Based Cohort Studies Including 117341 Individuals.

    abstract:BACKGROUND:HDL is quantitatively the most important lipoprotein in most species and mechanistic evidence points toward a role for HDL in normal immune function. We tested the hypothesis that concentrations of HDL cholesterol are associated with risk of autoimmune disease. METHODS:From 2 studies of the general populati...

    journal_title:Clinical chemistry

    pub_type: 杂志文章

    doi:10.1373/clinchem.2018.299636

    authors: Madsen CM,Varbo A,Nordestgaard BG

    更新日期:2019-05-01 00:00:00

  • A Mendelian Randomization-Based Approach to Identify Early and Sensitive Diagnostic Biomarkers of Disease.

    abstract:BACKGROUND:Identifying markers of chronic kidney disease (CKD) that occur early in the disease process and are specific to loss of kidney function rather than other underlying causes of disease may allow earlier, more accurate identification of patients who will develop CKD. We therefore sought to identify diagnostic b...

    journal_title:Clinical chemistry

    pub_type: 杂志文章

    doi:10.1373/clinchem.2018.291104

    authors: Mohammadi-Shemirani P,Sjaarda J,Gerstein HC,Treleaven DJ,Walsh M,Mann JF,McQueen MJ,Hess S,Paré G

    更新日期:2019-03-01 00:00:00

  • Advances in the Treatment of Hemophilia: Implications for Laboratory Testing.

    abstract:BACKGROUND:Until recently, clinical laboratories have monitored hemophilia treatment by measuring coagulation factors before/after infusion of human-derived or recombinant factors. Substantial changes are expected in the near future based on new therapeutic approaches that have been or are being developed. CONTENT:Hem...

    journal_title:Clinical chemistry

    pub_type: 杂志文章,评审

    doi:10.1373/clinchem.2017.284356

    authors: Tripodi A,Chantarangkul V,Novembrino C,Peyvandi F

    更新日期:2019-02-01 00:00:00

  • Completeness of Reporting of Systematic Reviews of Diagnostic Test Accuracy Based on the PRISMA-DTA Reporting Guideline.

    abstract:BACKGROUND:We evaluated the completeness of reporting of diagnostic test accuracy (DTA) systematic reviews using the recently developed Preferred Reporting Items for Systematic Reviews and MetaAnalyses (PRISMA)-DTA guidelines. METHODS:MEDLINE® was searched for DTA systematic reviews published October 2017 to January 2...

    journal_title:Clinical chemistry

    pub_type: 杂志文章,meta分析

    doi:10.1373/clinchem.2018.292987

    authors: Salameh JP,McInnes MDF,Moher D,Thombs BD,McGrath TA,Frank R,Dehmoobad Sharifabadi A,Kraaijpoel N,Levis B,Bossuyt PM

    更新日期:2019-02-01 00:00:00

  • Reduced Testicular Steroidogenesis and Increased Semen Oxidative Stress in Male Partners as Novel Markers of Recurrent Miscarriage.

    abstract:BACKGROUND:Recurrent pregnancy loss, (RPL) affecting 1%-2% of couples, is defined as ≥3 consecutive pregnancy losses before 20-week' gestation. Women with RPL are routinely screened for etiological factors, but routine screening of male partners is not currently recommended. Recently it has been suggested that sperm qu...

    journal_title:Clinical chemistry

    pub_type: 杂志文章

    doi:10.1373/clinchem.2018.289348

    authors: Jayasena CN,Radia UK,Figueiredo M,Revill LF,Dimakopoulou A,Osagie M,Vessey W,Regan L,Rai R,Dhillo WS

    更新日期:2019-01-01 00:00:00

  • Determinants of Vascular Age: An Epidemiological Perspective.

    abstract:BACKGROUND:Vascular age is an emerging health indicator and predictor of end-organ damage to the heart, brain, and kidney. Although there have been many review publications concerning risk factors for vascular aging, most include cross-sectional epidemiological studies, limiting inferences about temporality. There is a...

    journal_title:Clinical chemistry

    pub_type: 杂志文章,评审

    doi:10.1373/clinchem.2018.287623

    authors: Kucharska-Newton AM,Stoner L,Meyer ML

    更新日期:2019-01-01 00:00:00

  • Comparison between High-Sensitivity Cardiac Troponin T and Cardiac Troponin I in a Large General Population Cohort.

    abstract:BACKGROUND:Few data compare cardiac troponin T (cTnT) and cardiac troponin I (cTnI) in a general population. We sought to evaluate the distribution and association between cTnT, cTnI, and cardiovascular risk factors in a large general population cohort. METHODS:High-sensitivity cTnT and cTnI were measured in serum fro...

    journal_title:Clinical chemistry

    pub_type: 杂志文章

    doi:10.1373/clinchem.2018.292086

    authors: Welsh P,Preiss D,Shah ASV,McAllister D,Briggs A,Boachie C,McConnachie A,Hayward C,Padmanabhan S,Welsh C,Woodward M,Campbell A,Porteous D,Mills NL,Sattar N

    更新日期:2018-11-01 00:00:00

  • A "Culture" Shift: Broad Bacterial Detection, Identification, and Antimicrobial Susceptibility Testing Directly from Whole Blood.

    abstract:BACKGROUND:The time required for bloodstream pathogen detection, identification (ID), and antimicrobial susceptibility testing (AST) does not satisfy the acute needs of disease management. Conventional methods take up to 3 days for ID and AST. Molecular diagnostics have reduced times for ID, but their promise to suppla...

    journal_title:Clinical chemistry

    pub_type: 杂志文章

    doi:10.1373/clinchem.2018.290189

    authors: Andini N,Hu A,Zhou L,Cogill S,Wang TH,Wittwer CT,Yang S

    更新日期:2018-10-01 00:00:00

  • Proteomic Discovery and Validation of the Confounding Effect of Heparin Administration on the Analysis of Candidate Cardiovascular Biomarkers.

    abstract:BACKGROUND:Several plasma proteins have been suggested as markers for a variety of cardiovascular conditions but fail to qualify in independent patient cohorts. This may relate to interference of medication on plasma protein concentrations. We used proteomics to identify plasma proteins that changed in concentration wi...

    journal_title:Clinical chemistry

    pub_type: 杂志文章

    doi:10.1373/clinchem.2017.282665

    authors: Beck HC,Jensen LO,Gils C,Ilondo AMM,Frydland M,Hassager C,Møller-Helgestad OK,Møller JE,Rasmussen LM

    更新日期:2018-10-01 00:00:00

  • Quantifying Atherogenic Lipoproteins: Current and Future Challenges in the Era of Personalized Medicine and Very Low Concentrations of LDL Cholesterol. A Consensus Statement from EAS and EFLM.

    abstract:BACKGROUND:The European Atherosclerosis Society-European Federation of Clinical Chemistry and Laboratory Medicine Consensus Panel aims to provide recommendations to optimize atherogenic lipoprotein quantification for cardiovascular risk management. CONTENT:We critically examined LDL cholesterol, non-HDL cholesterol, a...

    journal_title:Clinical chemistry

    pub_type: 杂志文章

    doi:10.1373/clinchem.2018.287037

    authors: Langlois MR,Chapman MJ,Cobbaert C,Mora S,Remaley AT,Ros E,Watts GF,Borén J,Baum H,Bruckert E,Catapano A,Descamps OS,von Eckardstein A,Kamstrup PR,Kolovou G,Kronenberg F,Langsted A,Pulkki K,Rifai N,Sypniewska G,Wik

    更新日期:2018-07-01 00:00:00

  • Noninvasive Detection of Cocaine and Heroin Use with Single Fingerprints: Determination of an Environmental Cutoff.

    abstract:BACKGROUND:Recent publications have explored the possibility of using fingerprints to confirm drug use, but none has yet dealt with environmental contamination from fingertips. Here we explored the possibility of establishing an environmental cutoff for drug testing from a single fingerprint. METHODS:Fingerprint sampl...

    journal_title:Clinical chemistry

    pub_type: 杂志文章

    doi:10.1373/clinchem.2017.281469

    authors: Ismail M,Stevenson D,Costa C,Webb R,de Puit M,Bailey M

    更新日期:2018-06-01 00:00:00

  • Evaluating Rapid Rule-out of Acute Myocardial Infarction Using a High-Sensitivity Cardiac Troponin I Assay at Presentation.

    abstract:BACKGROUND:Low concentrations of cardiac troponin (cTn) have been recommended for rapid rule-out of acute myocardial infarction (AMI). We examined the Beckman Coulter Access high-sensitivity cardiac troponin I (hs-cTnI) assay to identify a single test threshold that can safely rule out AMI. METHODS:This analysis used ...

    journal_title:Clinical chemistry

    pub_type: 杂志文章

    doi:10.1373/clinchem.2017.283887

    authors: Greenslade J,Cho E,Van Hise C,Hawkins T,Parsonage W,Ungerer J,Tate J,Pretorius C,Than M,Cullen L

    更新日期:2018-05-01 00:00:00

  • Systematic Review and Metaanalysis Comparing the Bias and Accuracy of the Modification of Diet in Renal Disease and Chronic Kidney Disease Epidemiology Collaboration Equations in Community-Based Populations.

    abstract:BACKGROUND:The majority of patients with chronic kidney disease are diagnosed and monitored in primary care. Glomerular filtration rate (GFR) is a key marker of renal function, but direct measurement is invasive; in routine practice, equations are used for estimated GFR (eGFR) from serum creatinine. We systematically a...

    journal_title:Clinical chemistry

    pub_type: 杂志文章,meta分析

    doi:10.1373/clinchem.2017.276683

    authors: McFadden EC,Hirst JA,Verbakel JY,McLellan JH,Hobbs FDR,Stevens RJ,O'Callaghan CA,Lasserson DS

    更新日期:2018-03-01 00:00:00

  • Low- and High-renin Heart Failure Phenotypes with Clinical Implications.

    abstract:BACKGROUND:Blockade of the renin-angiotensin system (RAS) represents a main strategy in the therapy of heart failure with reduced ejection fraction (HFrEF), but the role of active renin concentration (ARC) for guiding therapy in the presence of an RAS blockade remains to be established. This study assessed angiotensin ...

    journal_title:Clinical chemistry

    pub_type: 杂志文章

    doi:10.1373/clinchem.2017.278705

    authors: Pavo N,Goliasch G,Wurm R,Novak J,Strunk G,Gyöngyösi M,Poglitsch M,Säemann MD,Hülsmann M

    更新日期:2018-03-01 00:00:00

  • Incidental Detection of Maternal Neoplasia in Noninvasive Prenatal Testing.

    abstract:BACKGROUND:Noninvasive prenatal testing (NIPT) uses cell-free DNA (cfDNA) as an analyte to detect copy-number alterations in the fetal genome. Because maternal and fetal cfDNA contributions are comingled, changes in the maternal genome can manifest as abnormal NIPT results. Circulating tumor DNA (ctDNA) present in case...

    journal_title:Clinical chemistry

    pub_type: 杂志文章

    doi:10.1373/clinchem.2017.277517

    authors: Dharajiya NG,Grosu DS,Farkas DH,McCullough RM,Almasri E,Sun Y,Kim SK,Jensen TJ,Saldivar JS,Topol EJ,van den Boom D,Ehrich M

    更新日期:2018-02-01 00:00:00

  • High-Speed Melting Analysis: The Effect of Melting Rate on Small Amplicon Microfluidic Genotyping.

    abstract:BACKGROUND:High-resolution DNA melting analysis of small amplicons is a simple and inexpensive technique for genotyping. Microfluidics allows precise and rapid control of temperature during melting. METHODS:Using a microfluidic platform for serial PCR and melting analysis, 4 targets containing single nucleotide varian...

    journal_title:Clinical chemistry

    pub_type: 杂志文章

    doi:10.1373/clinchem.2017.276147

    authors: Pryor RJ,Myrick JT,Palais RA,Sundberg SO,Paek JY,Wittwer CT,Knight IT

    更新日期:2017-10-01 00:00:00

  • Rapid RHD Zygosity Determination Using Digital PCR.

    abstract:BACKGROUND:Paternal zygosity testing is used for determining homo- or hemizygosity of RHD in pregnancies that are at a risk of hemolytic disease of the fetus and newborn. At present, this is achieved by using real-time PCR or the Rhesus box PCR, which can be difficult to interpret and unreliable, particularly for black...

    journal_title:Clinical chemistry

    pub_type: 杂志文章

    doi:10.1373/clinchem.2016.268698

    authors: Sillence KA,Halawani AJ,Tounsi WA,Clarke KA,Kiernan M,Madgett TE,Avent ND

    更新日期:2017-08-01 00:00:00

  • Detection of Chromosomal Translocation in Hematologic Malignancies by a Novel DNA-Based Looped Ligation Assay (LOLA).

    abstract:BACKGROUND:Disease-defining chromosomal translocations are seen in various neoplasms, especially in lymphomas and leukemias. Translocation detection at the DNA level is often complicated by chromosomal breakpoints that are distributed over very large regions. We have developed a ligation-based assay [the looped ligatio...

    journal_title:Clinical chemistry

    pub_type: 杂志文章

    doi:10.1373/clinchem.2016.270140

    authors: Harada S,Sizzle E,Lin MT,Gocke CD

    更新日期:2017-07-01 00:00:00

  • Analgesia and Opioids: A Pharmacogenetics Shortlist for Implementation in Clinical Practice.

    abstract:BACKGROUND:The use of opioids to alleviate pain is complicated by the risk of severe adverse events and the large variability in dose requirements. Pharmacogenetics (PGx) could possibly be used to tailor pain medication based on an individual's genetic background. Many potential genetic markers have been described, and...

    journal_title:Clinical chemistry

    pub_type: 杂志文章,评审

    doi:10.1373/clinchem.2016.264986

    authors: Matic M,de Wildt SN,Tibboel D,van Schaik RHN

    更新日期:2017-07-01 00:00:00

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