abstract：BACKGROUND:Remission is the primary objective of treating juvenile idiopathic arthritis (JIA). It is still debatable whether early intensive treatment is superior in terms of earlier achievement of remission. The aim of this study was to evaluate the effectiveness of early etanercept+methotrexate (ETA+MTX) combination ...

journal_title：Pediatric rheumatology online journal

authors： Alexeeva E,Horneff G,Dvoryakovskaya T,Denisova R,Nikishina I,Zholobova E,Malievskiy V,Santalova G,Stadler E,Balykova L,Spivakovskiy Y,Kriulin I,Alshevskaya A,Moskalev A

更新日期：2021-01-06 00:00:00

abstract：BACKGROUND:To characterize suicidality among youth with juvenile fibromyalgia syndrome (JFMS) receiving treatment from pediatric rheumatologists at a tertiary care center in order to determine the prevalence of suicidality in JFMS and to explore risk factors for persistent suicidal ideation. METHODS:We performed a cro...

journal_title：Pediatric rheumatology online journal

authors： Gmuca S,Sonagra M,Xiao R,Miller KS,Thomas NH,Young JF,Weiss PF,Sherry DD,Gerber JS

更新日期：2021-01-06 00:00:00

abstract：BACKGROUND:Kawasaki disease (KD) is the most common pediatric systemic vasculitides of unknown etiology. Recent clinical studies led to reappraisal of the usefulness of initial combination therapy of intravenous immunoglobulin (IVIG) plus a corticosteroid for patients with severe KD. However, the molecular mechanisms u...

journal_title：Pediatric rheumatology online journal

authors： Inoue T,Murakami S,Matsumoto K,Matsuda A

更新日期：2020-10-06 00:00:00

abstract：BACKGROUND:Intraarticular corticosteroids (IACs) have been used to treat temporomandibular joint (TMJ) arthritis. However, prospective clinical studies with magnetic resonance imaging (MRI) scoring are lacking. The aim of this study was to examine efficacy and safety of a single IAC in the TMJ in adolescents with juven...

journal_title：Pediatric rheumatology online journal

authors： Frid P,Augdal TA,Larheim TA,Halbig J,Rypdal V,Songstad NT,Rosén A,Tylleskär KB,Berstad JR,Flatø B,Stoustrup P,Rosendahl K,Kirkhus E,Nordal E

更新日期：2020-10-01 00:00:00

abstract：BACKGROUND:Acquired complement deficiency can occur in the setting of autoimmune syndromes, such as systemic lupus erythematosus (SLE), with very low or, occasionally, undetectable C3 levels. Based on inherited complement defects, patients with transiently low complement may be at similar risk for serious bacterial inf...

journal_title：Pediatric rheumatology online journal

authors： Al-Shaikhly T,Hayward K,Basiaga ML,Allenspach EJ

更新日期：2020-09-24 00:00:00

abstract：BACKGROUND:Temporomandibular joint (TMJ) arthritis and involvement is commonly seen in Juvenile Idiopathic Arthritis (JIA). Therapy includes conservative measures, but also includes intraarticular corticosteroid injections (IASI) and systemic immunosuppressive therapy. Despite aggressive medical therapy, some patients ...

journal_title：Pediatric rheumatology online journal

authors： Lypka M,Shah K,Jones J

更新日期：2020-09-04 00:00:00

abstract：:On March 11th, 2020 the World Health Organization declared COVID-19 a global pandemic. The infection, transmitted by 2019 novel coronavirus (2019-nCov), was first discovered in December 2019, in Wuhan, Hubei Province, and then rapidly spread worldwide. Italy was early and severely involved, with a critical spread of t...

journal_title：Pediatric rheumatology online journal

authors： Licciardi F,Giani T,Baldini L,Favalli EG,Caporali R,Cimaz R

更新日期：2020-04-22 00:00:00

abstract：:In 2018, an international Task Force formulated recommendations for treating Juvenile Idiopathic Arthritis (JIA) to target. The Task Force has not yet resolved three issues. The first issue is the lack of a single "best" target. The Task Force decided not to recommend the use of a specific instrument to assess inactiv...

journal_title：Pediatric rheumatology online journal

authors： Schoemaker CG,Swart JF,Wulffraat NM

更新日期：2020-04-16 00:00:00

abstract：BACKGROUND:Familial chilblain lupus (FCL) is a rare, chronic form of cutaneous lupus erythematosus, which is characterized by painful bluish-red inflammatory cutaneous lesions in acral locations. Mutations in TREX1, SAMHD1 and STING have been described in FCL patients. Less than 10 TREX1 mutation positive FCL families ...

journal_title：Pediatric rheumatology online journal

authors： Yi C,Li Q,Xiao J

更新日期：2020-04-15 00:00:00

abstract：BACKGROUND/PURPOSE:To assess EDI-OCT (enhanced depth imaging optical coherence tomography) of choroid for inflammatory signs in children with polyarteritis nodosa (PAN) and adenosine deaminase-2 deficiency (DADA-2). METHODS:In this cross-sectional study conducted between June 2017 and September 2018, we evaluated chil...

journal_title：Pediatric rheumatology online journal

authors： Baytaroğlu A,Kadayifçilar S,Ağin A,Deliktaş Ö,Demir S,Bilginer Y,Karakaya J,Özen S,Eldem B

更新日期：2020-04-03 00:00:00

abstract：BACKGROUND:Early diagnosis and treatment of Juvenile Idiopathic Arthritis (JIA) is essential to optimize outcomes. Wait times (WTs) to consultation with a pediatric rheumatologist consultation is a Canadian quality measure, with benchmarks set at 7 days for systemic JIA (sJIA) and 4 weeks for other JIA categories. In t...

journal_title：Pediatric rheumatology online journal

authors： Barber CEH,Barnabe C,Benseler S,Chin R,Johnson N,Luca N,Miettunen P,Twilt M,Veeramreddy D,Shiff NJ,Schmeling H

更新日期：2020-03-06 00:00:00

abstract：:Following publication of the original article [1], we have been notified that the colour representation of the graph is not correct in Figure 6 legend. ...

journal_title：Pediatric rheumatology online journal

authors： Lee WF,Wu CY,Yang HY,Lee WI,Chen LC,Ou LS,Huang JL

更新日期：2020-02-18 00:00:00

abstract：BACKGROUND:Fibrodysplasia ossificans progressiva (FOP) is the most catastrophic form of heterotopic ossification, due to ongoing intracellular signaling through the bone morphogenic protein pathway. The paroxysmal appearance of inflammatory lumps and elevated inflammatory markers during flares, suggest that FOP is an a...

journal_title：Pediatric rheumatology online journal

authors： Haviv R,Moshe V,De Benedetti F,Prencipe G,Rabinowicz N,Uziel Y

更新日期：2019-12-21 00:00:00

abstract：BACKGROUND:Juvenile Idiopathic Arthritis (JIA) may cause significant impairment in health-related quality of life (HrQoL), despite effective therapies. The aim of this study was to assess HrQoL during first-year treatment in patients with new-onset polyarticular JIA, and to compare treatment strategies. METHODS:In ACU...

journal_title：Pediatric rheumatology online journal

authors： Tarkiainen M,Tynjälä P,Vähäsalo P,Kröger L,Aalto K,Lahdenne P

更新日期：2019-12-16 00:00:00

abstract：BACKGROUND:JIA-associated uveitis (JIAU) is a serious, sight-threatening disease with significant long-term complications and risk of blindness, even with improved contemporary treatments. The MIWGUC was set up in order to propose specific JIAU activity and response items and to validate their applicability for clinica...

journal_title：Pediatric rheumatology online journal

authors： Foeldvari I,Klotsche J,Simonini G,Edelsten C,Angeles-Han ST,Bangsgaard R,de Boer J,Brumm G,Torrent RB,Constantin T,DeLibero C,Diaz J,Gerloni VM,Guedes M,Heiligenhaus A,Kotaniemi K,Leinonen S,Minden K,Miranda V,Miser

更新日期：2019-10-01 00:00:00

abstract：BACKGROUND:The prediction of resistance to intravenous immunoglobulins (IVIG) is currently still one of the main research areas in Kawasaki disease (KD). Several studies have reported on the use of N-terminal pro-brain natriuretic peptide (NT-ProBNP) to this end. However, considering the age-dependency of NT-ProBNP lev...

journal_title：Pediatric rheumatology online journal

authors： Shao S,Luo C,Zhou K,Hua Y,Wu M,Liu L,Liu X,Wang C

更新日期：2019-09-18 00:00:00

abstract：BACKGROUND:Deficiency of interleukin-36 receptor antagonist (DITRA) is a life threatening monogenic autoinflammatory disease caused by loss of function mutations in the IL36RN gene. Affected patients develop recurrent episodes of generalized pustular psoriasis (GPP) with systemic inflammation and fever. We here review ...

journal_title：Pediatric rheumatology online journal

authors： Hospach T,Glowatzki F,Blankenburg F,Conzelmann D,Stirnkorb C,Müllerschön CS,von den Driesch P,Köhler LM,Rohlfs M,Klein C,Hauck F

更新日期：2019-07-08 00:00:00

abstract：BACKGROUND:Juvenile Dermatomyositis is a rare, potentially life-threatening condition with no known cure. There is no published literature capturing how children and young people feel about their condition, from their perspective. This study was therefore unique in that it asked children and young people what is it lik...

journal_title：Pediatric rheumatology online journal

authors： Livermore P,Gray S,Mulligan K,Stinson JN,Wedderburn LR,Gibson F

更新日期：2019-06-18 00:00:00

abstract：BACKGROUND:Relapsing periodic arthritis is a general term used for a group of diseases with recurring and periodic nature, in which the joints are intermittently involved. The aim of this study is to evaluation of the possible relationship between MEFV gene mutations in intermittent arthritis of children which has recu...

journal_title：Pediatric rheumatology online journal

authors： Salehzadeh F,Barak M,Nematdoust Haghi R

更新日期：2019-06-06 00:00:00

abstract：:Familial Mediterranean fever (FMF) is the most common monogenic autoinflammatory disease in Canada and is characterized by a clinical syndrome of episodic inflammatory symptoms. Traditionally, the disease is defined by autosomal recessive inheritance of MEFV gene variants, yet FMF also not uncommonly manifests in indi...

journal_title：Pediatric rheumatology online journal

authors： Westwell-Roper C,Niemietz I,Tucker LB,Brown KL

更新日期：2019-05-14 00:00:00

abstract：BACKGROUND:CANDLE syndrome (an acronym for Chronic Atypical Neutrophilic Dermatosis with Lipodystrophy and Elevated Temperature) is a recently described rare autosomal recessive disorder charaterized by systemic autoinflammation. Clinical manifestations include presentation in the first year of life, episodes of fever ...

journal_title：Pediatric rheumatology online journal

authors： Boyadzhiev M,Marinov L,Boyadzhiev V,Iotova V,Aksentijevich I,Hambleton S

更新日期：2019-05-02 00:00:00

abstract：BACKGROUND:To develop and test the feasibility and initial effectiveness of the Treatment and Education Approach for Childhood-onset Lupus (TEACH) protocol, a 6-session cognitive behavioral therapy (CBT) intervention for adolescents and young adults (AYA) with childhood-onset systemic lupus erythematosus (cSLE). METHO...

journal_title：Pediatric rheumatology online journal

authors： Cunningham NR,Fussner LM,Moorman E,Avar Aydin PO,Brunner HI,Kashikar-Zuck S

更新日期：2019-02-18 00:00:00

abstract：BACKGROUND:Hemophagocytic lymphohistiocytosis (HLH) and macrophage activation syndrome (MAS) were historically thought to be distinct entities, often managed in isolation. In fact, these conditions are closely related. A collaborative approach, which incorporates expertise from subspecialties that previously treated HL...

journal_title：Pediatric rheumatology online journal

authors： Halyabar O,Chang MH,Schoettler ML,Schwartz MA,Baris EH,Benson LA,Biggs CM,Gorman M,Lehmann L,Lo MS,Nigrovic PA,Platt CD,Priebe GP,Rowe J,Sundel RP,Surana NK,Weinacht KG,Mann A,Yuen JC,Meleedy-Rey P,Starmer A,Ban

更新日期：2019-02-14 00:00:00

abstract：BACKGROUND:Of 37 pediatric rheumatology fellowship training programs in the United States, many have three or fewer fellows at a given time, making large-scale assessment of fellow performance difficult. An objective structured clinical examination (OSCE) is a scenario-based simulation method that assesses individual p...

journal_title：Pediatric rheumatology online journal

authors： Curran ML,Martin EE,Thomas EC,Singh R,Armana S,Kauser A,Zaheer EA,Sherry DD

更新日期：2019-02-08 00:00:00

abstract：BACKGROUND:Patient recruitment can be very challenging in paediatric studies, especially in relatively uncommon conditions, such as juvenile idiopathic arthritis (JIA). However, involving children and young people (CYP) in the design of such trials could promise a more rapid trajectory towards making evidence-based tre...

journal_title：Pediatric rheumatology online journal

authors： Sherratt FC,Roper L,Stones SR,McErlane F,Peak M,Beresford MW,Foster H,Ramanan AV,Rooney M,Baildam E,Young B

更新日期：2018-12-04 00:00:00

abstract：OBJECTIVE:To follow up the refractory juvenile dermatomyositis (JDM) with autologous hematopoietic stem cell transplantation (AHSCT) in a long time and to investigate whether AHSCT is effective and safe to treat refractory JDM. METHODS:We collected the AHSCT and follow-up data of three patients with refractory JDM who...

journal_title：Pediatric rheumatology online journal

authors： Zhu J,Su G,Lai J,Dong B,Kang M,Li S,Zhou Z,Wu F

更新日期：2018-11-20 00:00:00

abstract：BACKGROUND:Diagnosis of Periodic Fever, Aphthous stomatitis, Pharyngitis and Cervical Adenitis (PFAPA) syndrome is currently based on the modified Marshall's criteria, but no validated evidence based classification criteria for PFAPA has been established so far. METHODS:A multistep process, based on the Delphi and Nom...

journal_title：Pediatric rheumatology online journal

authors： Vanoni F,Caorsi R,Aeby S,Cochard M,Antón J,Berg S,Brik R,Dolezalova P,Koné-Paut I,Neven B,Ozen S,Pillet P,Stojanov S,Wouters C,Gattorno M,Hofer M

更新日期：2018-09-21 00:00:00

abstract：BACKGROUND:Henoch-Schonlein Purpura (HSP) is one of the most common vasculitides of childhood, with 10-20 cases per 100,000 children. It frequently occurs following an infectious trigger and involves IgA and C3 deposition in small vessel walls. HSP is characterized by palpable purpura plus IgA deposition on biopsy, art...

journal_title：Pediatric rheumatology online journal

authors： Bloom JL,Darst JR,Prok L,Soep JB

更新日期：2018-09-04 00:00:00

abstract：BACKGROUND:Kawasaki disease (KD) is an acute febrile systemic vasculitis that affects small and medium blood vessels. Intensified treatments for the most severely affected patients have been proposed recently, and the early identification of KD patients at high risk for coronary artery aneurysms (CAA) is crucial. Howev...

journal_title：Pediatric rheumatology online journal

authors： Chbeir D,Gaschignard J,Bonnefoy R,Beyler C,Melki I,Faye A,Meinzer U

更新日期：2018-07-18 00:00:00

abstract：BACKGROUND:Kawasaki Disease (KD), the leading cause of acquired heart disease in children in the developed world, is extremely rare in neonates. We present a case of incomplete KD in a neonate and a review of the literature on neonatal KD. CASE PRESENTATION:A previously healthy full term 15 day old Caucasian male with...

journal_title：Pediatric rheumatology online journal

authors： Altammar F,Lang B

更新日期：2018-07-03 00:00:00

abstract：BACKGROUND:Juvenile dermatomyositis (JDM) is the most common inflammatory myopathy in childhood and a major cause of morbidity among children with pediatric rheumatic diseases. The management of JDM is very heterogeneous. The JDM working group of the Society for Pediatric Rheumatology (GKJR) aims to define consensus- a...

journal_title：Pediatric rheumatology online journal

authors： Hinze CH,Oommen PT,Dressler F,Urban A,Weller-Heinemann F,Speth F,Lainka E,Brunner J,Fesq H,Foell D,Müller-Felber W,Neudorf U,Rietschel C,Schwarz T,Schara U,Haas JP

更新日期：2018-06-25 00:00:00

abstract：BACKGROUND:Bisphosphonates are recommended for use as first-line therapy for the prevention and treatment of glucocorticoid-induced osteoporosis in adults. However, the appropriate usage of bisphosphonates for the prevention or treatment of glucocorticoid-induced osteoporosis in children remains unclear. METHODS:We pe...

journal_title：Pediatric rheumatology online journal

authors： Inoue Y,Mitsunaga K,Yamamoto T,Chiba K,Yamaide F,Nakano T,Morita Y,Yamaide A,Suzuki S,Arima T,Yamaguchi KI,Tomiita M,Shimojo N,Kohno Y

更新日期：2018-06-18 00:00:00

abstract：BACKGROUND:Recently preliminary ultrasonography (US) definitions, in B mode, for normal components of pediatric joints have been developed by the OMERACT US group. The aim of the current study was to include Doppler findings in the evaluation and definition of normal joint features that can be visualized in healthy chi...

journal_title：Pediatric rheumatology online journal

authors： Collado P,Windschall D,Vojinovic J,Magni-Manzoni S,Balint P,Bruyn GAW,Hernandez-Diaz C,Nieto JC,Ravagnani V,Tzaribachev N,Iagnocco A,D'Agostino MA,Naredo E,OMERACT ultrasound subtask force on pediatric.

更新日期：2018-04-10 00:00:00

abstract：BACKGROUND:Withholding live-attenuated vaccines in patients using interleukin (IL)-1 or IL-6 blocking agents is recommended by guidelines for both pediatric and adult rheumatic diseases, since there is a risk of infection in an immune suppressed host. However, this has never been studied. This retrospective, multicente...

journal_title：Pediatric rheumatology online journal

authors： Jeyaratnam J,Ter Haar NM,Lachmann HJ,Kasapcopur O,Ombrello AK,Rigante D,Dedeoglu F,Baris EH,Vastert SJ,Wulffraat NM,Frenkel J

更新日期：2018-03-21 00:00:00

abstract：BACKGROUND:Anti-TNF (Tumor necrosis factor) therapy is effective in treating pediatric patients with refractory rheumatic disease. There is however a concern that anti-TNF usage may increase the risk of malignancy. Reports on specific types of malignancy in this patient population have been emerging over the past decad...

journal_title：Pediatric rheumatology online journal

authors： Okihiro A,Hasija R,Fung L,Cameron B,Feldman BM,Laxer R,Schneider R,Silverman E,Spiegel L,Yeung RSM,Tse SML

更新日期：2018-03-14 00:00:00

abstract：BACKGROUND:Juvenile idiopathic arthritis (JIA) is the most common pediatric rheumatic disease and a leading cause of childhood disability. The objective of this study was to characterize the PK, safety, and taste acceptability of tofacitinib in patients with JIA. METHODS:This Phase 1, open-label, multiple-dose (twice ...

journal_title：Pediatric rheumatology online journal

authors： Ruperto N,Brunner HI,Zuber Z,Tzaribachev N,Kingsbury DJ,Foeldvari I,Horneff G,Smolewska E,Vehe RK,Hazra A,Wang R,Mebus CA,Alvey C,Lamba M,Krishnaswami S,Stock TC,Wang M,Suehiro R,Martini A,Lovell DJ,Pediatric Rheu

更新日期：2017-12-28 00:00:00

abstract：BACKGROUND:Because pediatric antineutrophil cytoplasmic antibody-associated vasculitis is rare, management generally relies on adult data. We assessed treatment practices, uptake of existing clinical assessment tools, and interest in pediatric treatment protocols among rheumatologists caring for children with granuloma...

journal_title：Pediatric rheumatology online journal

authors： Westwell-Roper C,Lubieniecka JM,Brown KL,Morishita KA,Mammen C,Wagner-Weiner L,Yen E,Li SC,O'Neil KM,Lapidus SK,Brogan P,Cimaz R,Cabral DA,for ARChiVe Investigators Network within the PedVas initiative.

更新日期：2017-08-07 00:00:00

abstract：BACKGROUND:The United States pediatric rheumatology workforce is committed to a mission of providing children access to pediatric rheumatology care. With a limited number and distribution of pediatric rheumatologists, telemedicine has been proposed as one way to meet this mission, yet the adoption of this modality has ...

journal_title：Pediatric rheumatology online journal

authors： Bullock DR,Vehe RK,Zhang L,Correll CK

更新日期：2017-07-11 00:00:00

abstract：BACKGROUND:Transition guidelines and recommendations for developing countries are limited and best transition practices in young patients with chronic medical conditions have been poorly examined. This study evaluates transition practices from pediatric to adult rheumatology care in Brazil. METHODS:Practicing pediatri...

journal_title：Pediatric rheumatology online journal

authors： Anelli CG,Amorim ALM,Osaku FM,Terreri MT,Len CA,Reiff A

更新日期：2017-05-30 00:00:00

abstract：BACKGROUND:There are few studies on radiographic outcome after long-term disease duration in juvenile idiopathic arthritis (JIA). We wanted to evaluate 29-year radiographic outcome in hands/wrists and predictors of damage in patients with long-term active JIA. METHODS:Patients diagnosed from 1980 to 1985, who had acti...

journal_title：Pediatric rheumatology online journal

authors： Selvaag AM,Kirkhus E,Törnqvist L,Lilleby V,Aulie HA,Flatø B

更新日期：2017-04-11 00:00:00