abstract：BACKGROUND:As vaccines for the coronavirus become available, it will be important to know the rate of COVID-19 vaccine acceptability in adults with multiple sclerosis (MS), given that vaccination will be a key strategy for preventing SARS-CoV-2 infections. Using a national sample of adults with MS in the United States ...

journal_title：Multiple sclerosis and related disorders

authors： Ehde DM,Roberts MK,Herring TE,Alschuler KN

更新日期：2021-01-22 00:00:00

abstract：BACKGROUND:Cognitive deficits, especially in attention, are common in persons with MS (PwMS) and are associated with clinically meaningful outcomes, such as work disability and lower quality of life (QOL). In this study, we aimed to determine whether Cogmed Working Memory Training (CWMT) improves attention/working memo...

journal_title：Multiple sclerosis and related disorders

authors： Blair M,Goveas D,Safi A,Marshall C,Rosehart H,Orenczuk S,Morrow SA

更新日期：2021-01-17 00:00:00

abstract：OBJECTIVE:To estimate pooled prevalence of cognitive impairment in neuromyelitis opticaspectrum disorders (NMOSD) cases. METHODS:We searched PubMed, Scopus, EMBASE, Web of Science, and google scholar. We also searched the gray literature including references of the included studies, and conference abstracts which were...

journal_title：Multiple sclerosis and related disorders

authors： Moghadasi AN,Mirmosayyeb O,Mohammadi A,Sahraian MA,Ghajarzadeh M

更新日期：2021-01-15 00:00:00

abstract：BACKGROUND:Multiple Sclerosis (MS) patients find it difficult to understand the complex risk-benefit profiles of disease-modifying drugs. An evidence-based protocol was designed to improve patient's understanding of treatment information: Benefit and Risk Information for Medication in Multiple Sclerosis (BRIMMS). OBJE...

journal_title：Multiple sclerosis and related disorders

authors： Reen GK,Silber E,Langdon DW

更新日期：2021-01-12 00:00:00

abstract：:Falls in people with Multiple Sclerosis (PwMS) is a serious issue. It can lead to a lot of problems including sustaining injuries, losing consciousness and hospitalization. Having a model that can predict the probability of these falls and the factors correlated with them and can help caregivers and family members to ...

journal_title：Multiple sclerosis and related disorders

authors： Piryonesi SM,Rostampour S,Piryonesi SA

更新日期：2021-01-07 00:00:00

abstract：:A 31-year-old pregnant woman presented with headache, fever and left-sided focal motor seizures, which progressed to bilateral tonic-clonic seizures. Her medical history included Crohn's disease treated with azathioprine and adalimumab, which were discontinued when she became pregnant. Her cerebro-spinal fluid was ent...

journal_title：Multiple sclerosis and related disorders

authors： Stamenova S,Redha I,Schmierer K,Garcia ME

更新日期：2020-12-31 00:00:00

abstract：BACKGROUND:There are limited data on the impact of coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on people with multiple sclerosis (MS). OBJECTIVE:To better understand SARS-CoV-2 infection in ocrelizumab-treated people with MS. METHODS:Internal Roche/Ge...

journal_title：Multiple sclerosis and related disorders

authors： Hughes R,Whitley L,Fitovski K,Schneble HM,Muros E,Sauter A,Craveiro L,Dillon P,Bonati U,Jessop N,Pedotti R,Koendgen H

更新日期：2020-12-30 00:00:00

abstract：BACKGROUND:Alemtuzumab significantly improved clinical and MRI outcomes vs. subcutaneous interferon beta-1a (SC IFNB-1a) in the CARE-MS trials (NCT00530348, NCT00548405), with sustained efficacy in 2 consecutive extensions (NCT00930553, NCT02255656 [TOPAZ]). METHODS:Post hoc analysis of 8-year alemtuzumab efficacy and...

journal_title：Multiple sclerosis and related disorders

authors： Bass AD,Arroyo R,Boster AL,Boyko AN,Eichau S,Ionete C,Limmroth V,Navas C,Pelletier D,Pozzilli C,Ravenscroft J,Sousa L,Tintoré M,Uitdehaag BMJ,Baker DP,Daizadeh N,Choudhry Z,Rog D,CARE-MS I, CARE-MS II, CAMMS03409, and

更新日期：2020-12-24 00:00:00

abstract：BACKGROUND:The discovery of two immunoglobulin G (IgG) antibodies against aquaporin 4 (anti-AQP4) and myelin oligodendrocyte glycoprotein (anti-MOG) has led to the distinction of the disorders anti-AQP4 immunoglobulin G positive neuromyelitis spectrum disorder (AQP4-IgG+ NMOSD) and anti-MOG associated disorder (MOGAD)....

journal_title：Multiple sclerosis and related disorders

authors： Rempe T,Tarhan B,Rodriguez E,Viswanathan VT,Gyang TV,Carlson A,Tuna IS,Rees J

更新日期：2020-12-24 00:00:00

abstract：INTRODUCTION:Although multiple sclerosis (MS) is frequent in the northern hemisphere, there have not been recent epidemiological studies in the Scottish Highlands about MS. OBJECTIVES:To get updated data regarding MS prevalence, incidence and mortality in the Highlands. Time between symptom onset and MS diagnosis was ...

journal_title：Multiple sclerosis and related disorders

authors： Carod-Artal FJ

更新日期：2020-11-28 00:00:00

abstract：:Elsberg syndrome (ES) refers to the combination of myelitis and lumbosacral radiculitis associated with infection caused by the virus of the Herpesviridae family. We present a case of a 52-year-old man with a 9 months diagnosis of Crohn's disease, in use of infliximab with good disease control, complaining of 2 months...

journal_title：Multiple sclerosis and related disorders

authors： Santos DH,Carneiro de Oliveira RM,Junior WRF,Olivetti BC

更新日期：2020-11-25 00:00:00

abstract：BACKGROUND:Multiple sclerosis (MS) is the most common chronic inflammatory demyelinating disease of the central nervous system (CNS), and whether herpes simplex virus (HSV) infection is associated with the development of MS remains controversial. We aimed to investigate potential associations between MS or clinically i...

journal_title：Multiple sclerosis and related disorders

authors： Xu L,Zhang LJ,Yang L,Yang CS,Yi M,Zhang SN,Wang N,Huang CN,Liu MQ

更新日期：2020-11-19 00:00:00

abstract：BACKGROUND:Delayed multiple sclerosis (MS) diagnoses are not uncommon, an early diagnostic tool is urgently warranted. We aimed to develop an effective tool through electronic health records and machine learning techniques to early recognize MS patients from hospital visitors in China. METHODS:Two case sets were colle...

journal_title：Multiple sclerosis and related disorders

authors： Wang R,Luo W,Liu Z,Liu W,Liu C,Liu X,Zhu H,Li R,Song J,Hu X,Han S,Qiu W

更新日期：2020-11-18 00:00:00

abstract：:Multiple sclerosis (MS) is a complex chronic immune disease in the central nervous system, causing neurological disability among young and middle-aged adults. Impaired cognition is now emerging as a major clinical symptom being present in more than 50% of MS patients. Recent data support that neuroinflammation mediate...

journal_title：Multiple sclerosis and related disorders

authors： Barros C,Fernandes A

更新日期：2020-11-14 00:00:00

abstract：:Iatrogenic demyelination is a distinct clinical subtype of central nervous system inflammatory disorders. The Janus kinase inhibitor, tofacitinib, is an oral disease-modifying antirheumatic drug that has shown contradictory effects on multiple sclerosis in animal models. In this report, we describe a novel case of rev...

journal_title：Multiple sclerosis and related disorders

authors： Massoud F,Ismail II,Al-Hashel JY,Abboud H

更新日期：2020-11-01 00:00:00

abstract：BACKGROUND:A common and disruptive symptom of multiple sclerosis is difficulty in walking. Deficits in ankle proprioception and in plantarflexor muscle function may contribute to these mobility issues. In this study, ankle proprioceptive ability and plantarflexor performance of people with multiple sclerosis (PwMS) wer...

journal_title：Multiple sclerosis and related disorders

authors： Djajadikarta ZJ,Dongés SC,Brooks J,Kennedy DS,Gandevia SC,Taylor JL

更新日期：2020-11-01 00:00:00

abstract：BACKGROUND:Fatigue is a common impairment in a wide range of disorders. Numerous fatigue scales have been designed in an attempt to quantify this impairment without any clear distinction between them. The International Classification of Functioning, Disability and Health (ICF) is a useful tool for content comparison of...

journal_title：Multiple sclerosis and related disorders

authors： Alghwiri AA,Almhdawi KA,Marchetti G

更新日期：2020-11-01 00:00:00

abstract：INTRODUCTION:Italy has been the first European country severely affected by the COVID-19 pandemic. OBJECTIVE:To analyze the incidence of the clinical presentations suggestive for COVID-19 infection among patients with Multiple Sclerosis in the province of Lecco, in the North Italy, the closest province capital to Berg...

journal_title：Multiple sclerosis and related disorders

authors： Mantero V,Abate L,Balgera R,Basilico P,Salmaggi A,Cordano C

更新日期：2020-11-01 00:00:00

abstract：:Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system (CNS) commonly complicated by cognitive impairment. Unfortunately, no medical therapy has been proved to improve cognitive problems in these patients. This meta-analysis investigated the effectiveness of different categories...

journal_title：Multiple sclerosis and related disorders

authors： Motavalli A,Majdi A,Hosseini L,Talebi M,Mahmoudi J,Hosseini SH,Sadigh-Eteghad S

更新日期：2020-11-01 00:00:00

abstract：BACKGROUND:Olfactory dysfunction has been linked to clinical severity variables in multiple MS populations. Though, its prognostic value is still unknown. OBJECTIVE:The aim of this study was to explore the long-term outcome associated with Brief-Smell Identification Test (B-SIT) performance in a cohort of MS patients....

journal_title：Multiple sclerosis and related disorders

authors： da Silva AM,Torres C,Ferreira I,Moreira I,Samões R,Sousa AP,Santos E,Teixeira-Pinto A,Cavaco S

更新日期：2020-11-01 00:00:00

abstract：BACKGROUND:Multiple Sclerosis (MS) pathology is likely to disrupt central auditory pathways, thereby affecting an individual's ability to discriminate speech from noise. Despite the importance of speech discrimination in daily communication, it's characterization in the context of MS remains limited. This cross-section...

journal_title：Multiple sclerosis and related disorders

authors： Iva P,Fielding J,Clough M,White O,Noffs G,Godic B,Martin R,van der Walt A,Rajan R

更新日期：2020-11-01 00:00:00

abstract：:Myelin oligodendrocyte glycoprotein (MOG) antibody (MOG -Ab) positive cases can have a focal encephalitis like presentation. Many reports of anti N-methyl-D-aspartate receptor (NMDAR) encephalitis have documented simultaneous coexistence of MOG-Ab which is explained by the coexpression of NMDA receptors and MOG on oli...

journal_title：Multiple sclerosis and related disorders

authors： Cherian A,Divya KP,Shetty SC,Kannoth S,Thomas B

更新日期：2020-11-01 00:00:00

abstract：BACKGROUND:Cerebrospinal fluid (CSF) levels of neurofilament light (NFL), a biomarker of axonal damage, and CXCL13, a chemokine involved in B-cell regulation, are both associated with disease activity in multiple sclerosis (MS). OBJECTIVE:To explore the potential of NFL and CXCL13 to detect residual disease activity i...

journal_title：Multiple sclerosis and related disorders

authors： Novakova L,Axelsson M,Malmeström C,Zetterberg H,Blennow K,Svenningsson A,Lycke J

更新日期：2020-11-01 00:00:00

abstract：:A long-term neurologic sequela arising from COVID-19 infection in multiple sclerosis (MS) patients could be related both to the increase of cytokines and the activation of NLRP3 inflammasome by the Sars-CoV2. These two mechanisms may cause a worsening of MS several months after the resolution of the infection. ...

journal_title：Multiple sclerosis and related disorders

authors： Di Stadio A,Romani L,Bernitsas E

更新日期：2020-11-01 00:00:00

abstract：BACKGROUND:Daytime sleepiness is a common symptom of multiple sclerosis (MS) that may jeopardize safe driving. Our aim was to compare daytime sleepiness, recorded in real-time through eyelid tracking, in a simulated drive between individuals with MS (iwMS) and healthy controls. METHODS:Fifteen iwMS (age = median (Q1 -...

journal_title：Multiple sclerosis and related disorders

authors： Devos H,Alissa N,Lynch S,Sadeghi M,Akinwuntan AE,Siengsukon C

更新日期：2020-10-31 00:00:00

abstract：BACKGROUND:Research on Virtual Reality (VR) based motor rehabilitation for people with multiple sclerosis (MS) is rapidly growing in popularity, although few studies have focused on the upper limb (UL). The aims of this review were to investigate the effect of VR interventions on UL function in people with MS and deter...

journal_title：Multiple sclerosis and related disorders

authors： Webster A,Poyade M,Rooney S,Paul L

更新日期：2020-10-31 00:00:00

abstract：BACKGROUND:Dysphagia is a life-threating symptom in patients with multiple sclerosis (MS) because aspiration pneumonia develops as a consequence of swallowing disorders. Dysphagia can be detected by using patient-reported outcome measures in order to prevent complications. OBJECTIVE:To identify the dysphagia prevalenc...

journal_title：Multiple sclerosis and related disorders

authors： Tahir E,Kavaz E,Kemal Ö,Şen S,Terzi M

更新日期：2020-10-01 00:00:00

abstract：BACKGROUND:Gait performance often dictates an individual's ability to navigate the dynamic environments of everyday living. With each stride, the lower extremities move through phases of stance, swing, and double support. Coordinating these motions with high accuracy and consistency is imperative to constraining the ce...

journal_title：Multiple sclerosis and related disorders

authors： Richmond SB,Swanson CW,Peterson DS,Fling BW

更新日期：2020-10-01 00:00:00

abstract：BACKGROUND:Cognitive dysfunctions are very frequent in people living with multiple sclerosis (MS). Several studies have previously indicated grey matter (GM) atrophy as useful predictor of patients' cognitive impairment. However, considerable uncertainty exists about the possible impact of deep grey matter volumes on c...

journal_title：Multiple sclerosis and related disorders

authors： Lorefice L,Carta E,Frau J,Contu F,Casaglia E,Coghe G,Barracciu MA,Cocco E,Fenu G

更新日期：2020-10-01 00:00:00

abstract：BACKGROUND:The association between routine laboratory findings, including cerebrospinal fluid biomarkers, and neurological outcomes in patients with multiple sclerosis (MS) has not been fully elucidated. In this study, we evaluated blood and cerebrospinal fluid (CSF) analysis results at diagnosis and before treatment i...

journal_title：Multiple sclerosis and related disorders

authors： Akaishi T,Takahashi T,Fujihara K,Misu T,Nishiyama S,Takai Y,Fujimori J,Abe M,Ishii T,Aoki M,Nakashima I

更新日期：2020-10-01 00:00:00

abstract：BACKGROUND:Little is known about the factors associated with the selection of Disease Modifying Agents (DMA) for the management of Multiple Sclerosis (MS) since the introduction of oral DMAs in 2010. OBJECTIVES:To examine the factors associated with initiation of oral DMAs in patients with MS using data from electroni...

journal_title：Multiple sclerosis and related disorders

authors： Earla JR,Hutton GJ,Thornton JD,Aparasu RR

更新日期：2020-10-01 00:00:00

abstract：BACKGROUND:The epidemiology of multiple sclerosis (MS) and neuromyelitis optica (NMO) remains to be clarified or updated in many parts of Asia. This study aims to investigate the epidemiology and comorbidities of MS and NMO during 2001-2015 in Taiwan. METHODS:We conducted a retrospective nationwide population-based st...

journal_title：Multiple sclerosis and related disorders

authors： Fang CW,Wang HP,Chen HM,Lin JW,Lin WS

更新日期：2020-10-01 00:00:00

abstract：BACKGROUND:Elevation of CXCL13, a key regulator of B-cell recruitment in cerebrospinal fluid (CSF) is implicated in multiple sclerosis (MS). OBJECTIVE:to evaluate if measurement of CXCL13 using a highly sensitive assay is of value in acute optic neuritis (ON) patients for the prediction of later MS. METHOD:CXCL13 was...

journal_title：Multiple sclerosis and related disorders

authors： Olesen MN,Nilsson AC,Pihl-Jensen G,Soelberg KK,Olsen DA,Brandslund I,Lillevang ST,Madsen JS,Frederiksen JL,Asgari N

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND:Multiple sclerosis (MS) is an inflammatory autoimmune neurologic disease that causes progressive destruction of myelin sheath and axons. Affecting more than 2 million people worldwide, MS may presents distinct clinical courses. However, information regarding key gene expression and genic pathways related to ...

journal_title：Multiple sclerosis and related disorders

authors： Nali LH,Olival GS,Sousa FTG,de Oliveira ACS,Montenegro H,da Silva IT,Dias-Neto E,Naya H,Spangenberg L,Penalva-de-Oliveira AC,Romano CM

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND:Neuromyelitis optica spectrum disorder (NMOSD) is a complex disease characterized by a severe inflammation of the central nervous system (CNS). This disease typically manifests with recurrent optic neuritis (ON) and acute transverse myelitis (ATM). The clinical and radiological spectrum of NMOSD is little kn...

journal_title：Multiple sclerosis and related disorders

authors： Edgar Patricio CD,Eleanor THG,Francisco José CZ,Gabriela ACM,Hyland AO,Fernando GL,María TA,Beatriz N,Marcos SD,Alfredo GPW

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND:Increasing evidence for contribution of hemostasis components in multiple sclerosis (MS) has been reported. Hemostasis protein inhibitors display key regulatory roles, extending to regulation of innate immune response and inflammation, and promotion of blood-brain barrier integrity. Whereas the effects on he...

journal_title：Multiple sclerosis and related disorders

authors： Ziliotto N,Lamberti N,Manfredini F,Straudi S,Baroni M,Tisato V,Carantoni M,Secchiero P,Basaglia N,Marchetti G,Bernardi F

更新日期：2020-09-01 00:00:00

abstract：:Multiple sclerosis is a chronic inflammatory and neurodegenerative disease of the central nervous system, and it is one of the most common neurological cause of disability in young adults. It is known that several factors contribute to increase the risk of development and pathogenesis of multiple sclerosis, nonetheles...

journal_title：Multiple sclerosis and related disorders

authors： Ferreira HB,Neves B,Guerra IM,Moreira A,Melo T,Paiva A,Domingues MR

更新日期：2020-09-01 00:00:00

abstract：OBJECTIVE:Ocrelizumab inhibits relapsing multiple sclerosis when administered every six months. Based on potential similar memory B cell depletion mechanisms with cladribine and alemtuzumab, we hypothesised that CD20-depletion of B cells by ocrelizumab may exhibit a duration of response exceeding the current licenced t...

journal_title：Multiple sclerosis and related disorders

authors： Baker D,Pryce G,James LK,Marta M,Schmierer K

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND/AIMS:Mesenchymal stem cells (MSCs) transplantation has been considered a possible therapeutic method for Multiple Sclerosis (MS). However, no quantitative data synthesis of MSCs therapy for MS exists. We conducted a systematic review and meta-analysis to evaluate the effects of MSCs in experimental autoimmun...

journal_title：Multiple sclerosis and related disorders

authors： Yanwu Y,Meiling G,Yunxia Z,Qiukui H,Birong D

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND:Optic neuropathies (ON) have several aetiologies and sometimes the diagnosis established ab initio is redefined after further investigations and/or new neurological events. We aim with this study to report clinical, paraclinical findings, treatment choices and disease course in patients admitted with a suspi...

journal_title：Multiple sclerosis and related disorders

authors： Alves JM,Seabra M,Braz L,Guimarães J

更新日期：2020-09-01 00:00:00