听力与言语-语言病理学

行为科学

医学伦理学

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  • Erratum: Twist promotes tumor metastasis in basal-like breast cancer by transcriptionally upregulating ROR1: Erratum.

    abstract::[This corrects the article DOI: 10.7150/thno.21477.]. ...

    journal_title:Theranostics

    pub_type: 已发布勘误

    doi:10.7150/thno.56462

    authors: Cao J,Wang X,Dai T,Wu Y,Zhang M,Cao R,Zhang R,Wang G,Jiang R,Zhou BP,Shi J,Kang T

    更新日期:2021-01-01 00:00:00

  • m6A regulator-based methylation modification patterns characterized by distinct tumor microenvironment immune profiles in colon cancer.

    abstract::Recent studies have highlighted the biological significance of RNA N6-methyladenosine (m6A) modification in tumorigenicity and progression. However, it remains unclear whether m6A modifications also have potential roles in immune regulation and tumor microenvironment (TME) formation. Methods: In this study, we curated...

    journal_title:Theranostics

    pub_type: 杂志文章

    doi:10.7150/thno.52717

    authors: Chong W,Shang L,Liu J,Fang Z,Du F,Wu H,Liu Y,Wang Z,Chen Y,Jia S,Chen L,Li L,Chen H

    更新日期:2021-01-01 00:00:00

  • Endocytic pathway inhibition attenuates extracellular vesicle-induced reduction of chemosensitivity to bortezomib in multiple myeloma cells.

    abstract::Extracellular vesicles (EVs), including exosomes and microvesicles, derived from bone marrow stromal cells (BMSCs) have been demonstrated as key factors in the progression and drug resistance of multiple myeloma (MM). EV uptake involves a variety of mechanisms which largely depend on the vesicle origin and recipient c...

    journal_title:Theranostics

    pub_type: 杂志文章

    doi:10.7150/thno.47996

    authors: Tu C,Du Z,Zhang H,Feng Y,Qi Y,Zheng Y,Liu J,Wang J

    更新日期:2021-01-01 00:00:00

  • A skeleton muscle model using GelMA-based cell-aligned bioink processed with an electric-field assisted 3D/4D bioprinting.

    abstract::The most important requirements of biomedical substitutes used in muscle tissue regeneration are appropriate topographical cues and bioactive components for the induction of myogenic differentiation/maturation. Here, we developed an electric field-assisted 3D cell-printing process to fabricate cell-laden fibers with a...

    journal_title:Theranostics

    pub_type: 杂志文章

    doi:10.7150/thno.50794

    authors: Yang GH,Kim W,Kim J,Kim G

    更新日期:2021-01-01 00:00:00

  • Intravital molecular imaging reveals the restrained capacity of CTLs in the killing of tumor cells in the liver.

    abstract::Cytotoxic T lymphocytes (CTLs) and their gene-engineered cells display great application prospects in tumor immunotherapy. The timing of CTL-induced molecular events in tumor cells is unclear, and we also unknow whether the killing efficiency of CTLs is restrained in the liver, an immunotolerant organ with a high tumo...

    journal_title:Theranostics

    pub_type: 杂志文章

    doi:10.7150/thno.44979

    authors: Liu L,Dai B,Li R,Liu Z,Zhang Z

    更新日期:2021-01-01 00:00:00

  • Histone H3K27 methyltransferase EZH2 and demethylase JMJD3 regulate hepatic stellate cells activation and liver fibrosis.

    abstract::Rationale: As the central hallmark of liver fibrosis, transdifferentiation of hepatic stellate cells (HSCs), the predominant contributor to fibrogenic hepatic myofibroblast responsible for extracellular matrix (ECM) deposition, is characterized with transcriptional and epigenetic remodeling. We aimed to characterize t...

    journal_title:Theranostics

    pub_type: 杂志文章

    doi:10.7150/thno.46360

    authors: Jiang Y,Xiang C,Zhong F,Zhang Y,Wang L,Zhao Y,Wang J,Ding C,Jin L,He F,Wang H

    更新日期:2021-01-01 00:00:00

  • Melanocortin 1 receptor attenuates early brain injury following subarachnoid hemorrhage by controlling mitochondrial metabolism via AMPK/SIRT1/PGC-1α pathway in rats.

    abstract::Mitochondria-mediated oxidative stress and apoptosis contribute greatly to early brain injury (EBI) following subarachnoid hemorrhage (SAH). This study hypothesized that activation of melanocortin 1 receptor (MC1R), using BMS-470539, attenuates EBI by controlling mitochondrial metabolism after SAH. Methods: We utilize...

    journal_title:Theranostics

    pub_type: 杂志文章

    doi:10.7150/thno.49426

    authors: Xu W,Yan J,Ocak U,Lenahan C,Shao A,Tang J,Zhang J,Zhang JH

    更新日期:2021-01-01 00:00:00

  • PLAGL2 promotes the proliferation and migration of gastric cancer cells via USP37-mediated deubiquitination of Snail1.

    abstract::Rationale: PLAGL2 (pleomorphic adenoma gene like-2), a zinc finger PLAG transcription factor, is aberrantly expressed in several malignant tumors. However, the biological roles of PLAGL2 and its underlying mechanism in gastric cancer (GC) remain unclear. Methods: A series of experiments in vitro and in vivo were condu...

    journal_title:Theranostics

    pub_type: 杂志文章

    doi:10.7150/thno.47800

    authors: Wu L,Zhao N,Zhou Z,Chen J,Han S,Zhang X,Bao H,Yuan W,Shu X

    更新日期:2021-01-01 00:00:00

  • Discovery of extracellular vesicles derived miR-181a-5p in patient's serum as an indicator for bone-metastatic prostate cancer.

    abstract::Purpose: To identify extracellular vesicle (EV)-delivered microRNAs in the patient's serum as indicators for bone-metastatic prostate cancer. Methods: First, the profiling change of serum EV-delivered miRNAs in patients with either benign prostatic hyperplasia (BPH), non-bone metastatic prostate cancer or bone-metasta...

    journal_title:Theranostics

    pub_type: 杂志文章

    doi:10.7150/thno.49186

    authors: Wang Y,Fang YX,Dong B,Du X,Wang J,Wang X,Gao WQ,Xue W

    更新日期:2021-01-01 00:00:00

  • The pivotal roles of exosomes derived from endogenous immune cells and exogenous stem cells in myocardial repair after acute myocardial infarction.

    abstract::Acute myocardial infarction (AMI) is one of the leading causes of mortality around the world, and the inflammatory response plays a pivotal role in the progress of myocardial necrosis and ventricular remodeling, dysfunction and heart failure after AMI. Therapies aimed at modulating immune response after AMI on a molec...

    journal_title:Theranostics

    pub_type: 杂志文章,评审

    doi:10.7150/thno.53326

    authors: Xiong YY,Gong ZT,Tang RJ,Yang YJ

    更新日期:2021-01-01 00:00:00

  • Suppressing Sart1 to modulate macrophage polarization by siRNA-loaded liposomes: a promising therapeutic strategy for pulmonary fibrosis.

    abstract::Idiopathic pulmonary fibrosis (IPF) is a chronic and diffuse form of interstitial lung disease of unknown etiology with a fatal outcome. Although various strategies for IPF have been developed over the last few decades, no significant positive impact on the prognosis of IPF has been observed. According to the current ...

    journal_title:Theranostics

    pub_type: 杂志文章

    doi:10.7150/thno.48152

    authors: Pan T,Zhou Q,Miao K,Zhang L,Wu G,Yu J,Xu Y,Xiong W,Li Y,Wang Y

    更新日期:2021-01-01 00:00:00

  • Phosphoproteomics identify arachidonic-acid-regulated signal transduction pathways modulating macrophage functions with implications for ovarian cancer.

    abstract::Arachidonic acid (AA) is a polyunsaturated fatty acid present at high concentrations in the ovarian cancer (OC) microenvironment and associated with a poor clinical outcome. In the present study, we have unraveled a potential link between AA and macrophage functions. Methods: AA-triggered signal transduction was studi...

    journal_title:Theranostics

    pub_type: 杂志文章

    doi:10.7150/thno.52442

    authors: Dietze R,Hammoud MK,Gómez-Serrano M,Unger A,Bieringer T,Finkernagel F,Sokol AM,Nist A,Stiewe T,Reinartz S,Ponath V,Preußer C,von Strandmann EP,Müller-Brüsselbach S,Graumann J,Müller R

    更新日期:2021-01-01 00:00:00

  • Endothelial Klf2-Foxp1-TGFβ signal mediates the inhibitory effects of simvastatin on maladaptive cardiac remodeling.

    abstract::Aims: Pathological cardiac fibrosis and hypertrophy are common features of left ventricular remodeling that often progress to heart failure (HF). Endothelial cells (ECs) are the most abundant non-myocyte cells in adult mouse heart. Simvastatin, a strong inducer of Krüppel-like Factor 2 (Klf2) in ECs, ameliorates press...

    journal_title:Theranostics

    pub_type: 杂志文章

    doi:10.7150/thno.48153

    authors: Li H,Wang Y,Liu J,Chen X,Duan Y,Wang X,Shen Y,Kuang Y,Zhuang T,Tomlinson B,Chan P,Yu Z,Cheng Y,Zhang L,Liu Z,Zhang Y,Zhao Z,Zhang Q,Liu J

    更新日期:2021-01-01 00:00:00

  • Extracellular vesicles derived from hypoxic glioma stem-like cells confer temozolomide resistance on glioblastoma by delivering miR-30b-3p.

    abstract::Rationale: Glioma stem-like cells (GSCs) contribute to temozolomide (TMZ) resistance in gliomas, although the mechanisms have not been delineated. Methods:In vitro functional experiments (colony formation assay, flow cytometric analysis, TUNEL assay) were used to assess the ability of extracellular vesicles (EVs) from...

    journal_title:Theranostics

    pub_type: 杂志文章

    doi:10.7150/thno.47057

    authors: Yin J,Ge X,Shi Z,Yu C,Lu C,Wei Y,Zeng A,Wang X,Yan W,Zhang J,You Y

    更新日期:2021-01-01 00:00:00

  • Manganese porphyrin-based metal-organic framework for synergistic sonodynamic therapy and ferroptosis in hypoxic tumors.

    abstract::Development of efficient therapeutic strategy to incorporate ultrasound (US)-triggered sonodynamic therapy (SDT) and ferroptosis is highly promising in cancer therapy. However, the SDT efficacy is severely limited by the hypoxia and high glutathione (GSH) in the tumor microenvironment, and ferroptosis is highly associ...

    journal_title:Theranostics

    pub_type: 杂志文章

    doi:10.7150/thno.45511

    authors: Xu Q,Zhan G,Zhang Z,Yong T,Yang X,Gan L

    更新日期:2021-01-01 00:00:00

  • IL20RA signaling enhances stemness and promotes the formation of an immunosuppressive microenvironment in breast cancer.

    abstract::Rationale: Tumor microenvironment interacts with tumor cells to regulate their stemness properties through various cytokines and cytokine receptors. Previous studies revealed the possible role of interleukin 20 receptor subunit alpha (IL20RA) signaling in the progression of several types of tumors. However, its regula...

    journal_title:Theranostics

    pub_type: 杂志文章

    doi:10.7150/thno.45280

    authors: Gao W,Wen H,Liang L,Dong X,Du R,Zhou W,Zhang X,Zhang C,Xiang R,Li N

    更新日期:2021-01-01 00:00:00

  • Activation of EP4 receptor limits transition of acute to chronic heart failure in lipoxygenase deficient mice.

    abstract::Aim: Immune responsive 12/15 lipoxygenase (12/15LOX)-orchestrate biosynthesis of essential inflammation-resolution mediators during acute inflammatory response in post-myocardial infarction (MI). Lack of 12/15LOX dampens proinflammatory mediator 12-(S)-hydroxyeicosatetraenoic acid (12-(S)-HETE), improves post-MI survi...

    journal_title:Theranostics

    pub_type: 杂志文章

    doi:10.7150/thno.51183

    authors: Kain V,Ingle KA,Rajasekaran NS,Halade GV

    更新日期:2021-01-01 00:00:00

  • Nanofibrous nerve guidance conduits decorated with decellularized matrix hydrogel facilitate peripheral nerve injury repair.

    abstract::Rationale: Peripheral nerve injury (PNI) is a great challenge for regenerative medicine. Nerve autograft is the gold standard for clinical PNI repair. Due to its significant drawbacks, artificial nerve guidance conduits (NGCs) have drawn much attention as replacement therapies. We developed a combinatorial NGC consist...

    journal_title:Theranostics

    pub_type: 杂志文章

    doi:10.7150/thno.50825

    authors: Zheng C,Yang Z,Chen S,Zhang F,Rao Z,Zhao C,Quan D,Bai Y,Shen J

    更新日期:2021-01-01 00:00:00

  • Phototherapy-based combination strategies for bacterial infection treatment.

    abstract::The development of nanomedicine is expected to provide an innovative direction for addressing challenges associated with multidrug-resistant (MDR) bacteria. In the past decades, although nanotechnology-based phototherapy has been developed for antimicrobial treatment since it rarely causes bacterial resistance, the cl...

    journal_title:Theranostics

    pub_type: 杂志文章,评审

    doi:10.7150/thno.52729

    authors: Wei G,Yang G,Wang Y,Jiang H,Fu Y,Yue G,Ju R

    更新日期:2020-10-30 00:00:00

  • YTHDF1-enhanced iron metabolism depends on TFRC m6A methylation.

    abstract::Background: Among head and neck squamous cell carcinomas (HNSCCs), hypopharyngeal squamous cell carcinoma (HPSCC) has the worst prognosis. Iron metabolism, which plays a crucial role in tumor progression, is mainly regulated by alterations to genes and post-transcriptional processes. The recent discovery of the N6-met...

    journal_title:Theranostics

    pub_type: 杂志文章

    doi:10.7150/thno.51231

    authors: Ye J,Wang Z,Chen X,Jiang X,Dong Z,Hu S,Li W,Liu Y,Liao B,Han W,Shen J,Xiao M

    更新日期:2020-10-26 00:00:00

  • Targeting Epstein-Barr virus oncoprotein LMP1-mediated high oxidative stress suppresses EBV lytic reactivation and sensitizes tumors to radiation therapy.

    abstract::Generating oxidative stress is a critical mechanism by which host cells defend against infection by pathogenic microorganisms. Radiation resistance is a critical problem in radiotherapy against cancer. Epstein-Barr virus (EBV) is a cancer-causing virus and its reactivation plays an important role in the development of...

    journal_title:Theranostics

    pub_type: 杂志文章

    doi:10.7150/thno.46006

    authors: Hu J,Li Y,Li H,Shi F,Xie L,Zhao L,Tang M,Luo X,Jia W,Fan J,Zhou J,Gao Q,Qiu S,Wu W,Zhang X,Liao W,Bode AM,Cao Y

    更新日期:2020-10-25 00:00:00

  • Retraction of "Novel Bioluminescent Activatable Reporter for Src Tyrosine Kinase Activity in Living Mice".

    abstract::[This retracts the article DOI: 10.7150/thno.14306.]. ...

    journal_title:Theranostics

    pub_type: 撤回出版物

    doi:10.7150/thno.52610

    authors: Leng W,Li D,Chen L,Xia H,Tang Q,Chen B,Gong Q,Gao F,Bi F

    更新日期:2020-09-30 00:00:00

  • Nanoscale microenvironment engineering based on layer-by-layer self-assembly to regulate hair follicle stem cell fate for regenerative medicine.

    abstract::Hair regenerative medicine, a promising strategy for the treatment of hair loss, will likely involve the transplantation of autologous hair follicular stem cells (HFSCs) and dermal papilla cells (DPCs) into regions of hair loss. Cyclic hair regeneration results from the periodic partial activation of HFSCs. However, p...

    journal_title:Theranostics

    pub_type: 杂志文章

    doi:10.7150/thno.48723

    authors: Chen P,Miao Y,Zhang F,Huang J,Chen Y,Fan Z,Yang L,Wang J,Hu Z

    更新日期:2020-09-22 00:00:00

  • Inactivation of tumor suppressor gene Clusterin leads to hyperactivation of TAK1-NF-κB signaling axis in lung cancer cells and denotes a therapeutic opportunity.

    abstract::Purpose: Clinical success of precision medicine is severely limited by de novo or acquired drug resistance. It remains a clinically unmet need to treat these patients. Tumor suppressor genes (TSGs) play a critical role in tumorigenesis and impact the therapeutic effect of various treatments. Experimental Design: Using...

    journal_title:Theranostics

    pub_type: 杂志文章

    doi:10.7150/thno.44829

    authors: Chen Z,Fan Z,Dou X,Zhou Q,Zeng G,Liu L,Chen W,Lan R,Liu W,Ru G,Yu L,He QY,Chen L

    更新日期:2020-09-16 00:00:00

  • Alpha radioimmunotherapy using 225Ac-proteus-DOTA for solid tumors - safety at curative doses.

    abstract::This is the initial report of an α-based pre-targeted radioimmunotherapy (PRIT) using 225Ac and its theranostic pair, 111In. We call our novel tumor-targeting DOTA-hapten PRIT system "proteus-DOTA" or "Pr." Herein we report the first results of radiochemistry development, radiopharmacology, and stoichiometry of tumor ...

    journal_title:Theranostics

    pub_type: 杂志文章

    doi:10.7150/thno.48810

    authors: Cheal SM,McDevitt MR,Santich BH,Patel M,Yang G,Fung EK,Veach DR,Bell M,Ahad A,Vargas DB,Punzalan B,Pillarsetty NVK,Xu H,Guo HF,Monette S,Michel AO,Piersigilli A,Scheinberg DA,Ouerfelli O,Cheung NV,Larson SM

    更新日期:2020-09-14 00:00:00

  • Noninvasive quantification of target availability during therapy using paired-agent fluorescence tomography.

    abstract::Immuno-oncological treatment strategies that target abnormal receptor profiles of tumors are an increasingly important feature of cancer therapy. Yet, assessing receptor availability (RA) and drug-target engagement, important determinants of therapeutic efficacy, is challenging with current imaging strategies, largely...

    journal_title:Theranostics

    pub_type: 杂志文章

    doi:10.7150/thno.45273

    authors: Meng B,Folaron MR,Strawbridge RR,Sadeghipour N,Samkoe KS,Tichauer K,Davis SC

    更新日期:2020-09-14 00:00:00

  • CSRP2 suppresses colorectal cancer progression via p130Cas/Rac1 axis-meditated ERK, PAK, and HIPPO signaling pathways.

    abstract::Metastasis is a major cause of death in patients with colorectal cancer (CRC). Cysteine-rich protein 2 (CSRP2) has been recently implicated in the progression and metastasis of a variety of cancers. However, the biological functions and underlying mechanisms of CSRP2 in the regulation of CRC progression are largely un...

    journal_title:Theranostics

    pub_type: 杂志文章

    doi:10.7150/thno.45674

    authors: Chen L,Long X,Duan S,Liu X,Chen J,Lan J,Liu X,Huang W,Geng J,Zhou J

    更新日期:2020-09-02 00:00:00

  • circPTCH1 promotes invasion and metastasis in renal cell carcinoma via regulating miR-485-5p/MMP14 axis.

    abstract::Background: Circular RNAs (circRNAs) are a new class of non-coding RNAs (ncRNAs) that are derived from exons or introns by special selective shearing. circRNAs have been shown to play critical roles in various human cancers. However, their roles in renal cell carcinoma (RCC) and the underlying mechanisms remain largel...

    journal_title:Theranostics

    pub_type: 杂志文章

    doi:10.7150/thno.47239

    authors: Liu H,Hu G,Wang Z,Liu Q,Zhang J,Chen Y,Huang Y,Xue W,Xu Y,Zhai W

    更新日期:2020-08-29 00:00:00

  • LPA3-mediated lysophosphatidic acid signaling promotes postnatal heart regeneration in mice.

    abstract::Background: Lysophosphatidic acid (LPA) is a small glycerophospholipid that acts as a potent extracellular signal in various biological processes and diseases. Our previous work demonstrated that the expression of the LPA receptors LPA1 and LPA3 is elevated in the early postnatal heart. However, the role of this stage...

    journal_title:Theranostics

    pub_type: 杂志文章

    doi:10.7150/thno.47913

    authors: Wang F,Liu S,Pei J,Cai L,Liu N,Liang T,Dong X,Cong X,Chun J,Chen J,Hu S,Chen X

    更新日期:2020-08-29 00:00:00

  • CDK4/6 inhibition promotes immune infiltration in ovarian cancer and synergizes with PD-1 blockade in a B cell-dependent manner.

    abstract::Great progress has been made in the field of tumor immunotherapy in the past decade. However, the therapeutic effects of immune checkpoint blockade (ICB) against ovarian cancer are still limited. Recently, an inhibitor of cyclin-dependent kinases 4 and 6 (CDK4/6i) has been reported to enhance antitumor immunity in pre...

    journal_title:Theranostics

    pub_type: 杂志文章

    doi:10.7150/thno.44871

    authors: Zhang QF,Li J,Jiang K,Wang R,Ge JL,Yang H,Liu SJ,Jia LT,Wang L,Chen BL

    更新日期:2020-08-25 00:00:00

  • Dihydroartemisinin ameliorates psoriatic skin inflammation and its relapse by diminishing CD8+ T-cell memory in wild-type and humanized mice.

    abstract::Conventional immunosuppressants cause side effects and do not prevent the recurrence of autoimmune diseases. Moreover, they may not inhibit autoimmunity mediated by pathogenic memory T-cells. Dihydroartemisinin (DHA) has been shown to regulate autoimmunity. However, it remains unknown whether DHA impacts psoriasis and...

    journal_title:Theranostics

    pub_type: 杂志文章

    doi:10.7150/thno.45211

    authors: Chen Y,Yan Y,Liu H,Qiu F,Liang CL,Zhang Q,Huang RY,Han L,Lu C,Dai Z

    更新日期:2020-08-21 00:00:00

  • Multiplexed non-invasive tumor imaging of glucose metabolism and receptor-ligand engagement using dark quencher FRET acceptor.

    abstract::Rationale: Following an ever-increased focus on personalized medicine, there is a continuing need to develop preclinical molecular imaging modalities to guide the development and optimization of targeted therapies. Near-Infrared (NIR) Macroscopic Fluorescence Lifetime Förster Resonance Energy Transfer (MFLI-FRET) imag...

    journal_title:Theranostics

    pub_type: 杂志文章

    doi:10.7150/thno.45825

    authors: Rudkouskaya A,Sinsuebphon N,Ochoa M,Chen SJ,Mazurkiewicz JE,Intes X,Barroso M

    更新日期:2020-08-15 00:00:00

  • TRPM8-regulated calcium mobilization plays a critical role in synergistic chemosensitization of Borneol on Doxorubicin.

    abstract::Background: Lung cancer has a high mortality rate and is resistant to multiple chemotherapeutics. Natural Borneol (NB) is a monoterpenoid compound that facilitates the bioavailability of drugs. In this study, we investigated the effects of NB on chemosensitivity in the A549 human lung adenocarcinoma cell line and to e...

    journal_title:Theranostics

    pub_type: 杂志文章

    doi:10.7150/thno.45861

    authors: Lai H,Liu C,Hou L,Lin W,Chen T,Hong A

    更新日期:2020-08-13 00:00:00

  • Dysregulated Kras/YY1/ZNF322A/Shh transcriptional axis enhances neo-angiogenesis to promote lung cancer progression.

    abstract::Angiogenesis enhances cancer metastasis and progression, however, the roles of transcription regulation in angiogenesis are not fully defined. ZNF322A is an oncogenic zinc-finger transcription factor. Here, we demonstrate a new mechanism of Kras mutation-driven ZNF322A transcriptional activation and elucidate the inte...

    journal_title:Theranostics

    pub_type: 杂志文章

    doi:10.7150/thno.47491

    authors: Lin CC,Kuo IY,Wu LT,Kuan WH,Liao SY,Jen J,Yang YE,Tang CW,Chen YR,Wang YC

    更新日期:2020-08-08 00:00:00

  • Low-intensity Pulsed Ultrasound regulates alveolar bone homeostasis in experimental Periodontitis by diminishing Oxidative Stress.

    abstract::Periodontitis is a widespread oral disease that results in the loss of alveolar bone. Low-intensity pulsed ultrasound (LIPUS), which is a new therapeutic option, promotes alveolar bone regeneration in periodontal bone injury models. This study investigated the protective effect of LIPUS on oxidative stress in periodon...

    journal_title:Theranostics

    pub_type: 杂志文章

    doi:10.7150/thno.42508

    authors: Ying S,Tan M,Feng G,Kuang Y,Chen D,Li J,Song J

    更新日期:2020-08-01 00:00:00

  • LncRNA-SLC16A1-AS1 induces metabolic reprogramming during Bladder Cancer progression as target and co-activator of E2F1.

    abstract::Long non-coding RNAs (lncRNAs) have emerged as integral components of E2F1-regulated gene regulatory networks (GRNs), but their implication in advanced or treatment-refractory malignancy is unknown. Methods: We combined high-throughput transcriptomic approaches with bioinformatics and structure modeling to search for ...

    journal_title:Theranostics

    pub_type: 杂志文章

    doi:10.7150/thno.44176

    authors: Logotheti S,Marquardt S,Gupta SK,Richter C,Edelhäuser BAH,Engelmann D,Brenmoehl J,Söhnchen C,Murr N,Alpers M,Singh KP,Wolkenhauer O,Heckl D,Spitschak A,Pützer BM

    更新日期:2020-07-29 00:00:00

  • Molecular signatures of BRCAness analysis identifies PARP inhibitor Niraparib as a novel targeted therapeutic strategy for soft tissue Sarcomas.

    abstract::Background: Patients with advanced soft tissue sarcomas (STS) have a dismal prognosis with few effective therapeutic options. A defect in the homologous recombination repair (HRR) pathway can accumulate DNA repair errors and gene mutations, which can lead to tumorigenesis. BRCAness describes tumors with an HRR deficie...

    journal_title:Theranostics

    pub_type: 杂志文章

    doi:10.7150/thno.45763

    authors: Li H,Tu J,Zhao Z,Chen L,Qu Y,Li H,Yao H,Wang X,Lee DF,Shen J,Wen L,Huang G,Xie X

    更新日期:2020-07-25 00:00:00

  • Chronic ethanol consumption and HBV induce abnormal lipid metabolism through HBx/SWELL1/arachidonic acid signaling and activate Tregs in HBV-Tg mice.

    abstract::Rationale: Chronic ethanol consumption as a public health problem worldwide boosts the development of chronic liver diseases in hepatitis B virus (HBV)-infected patients. Arachidonic acid metabolite prostaglandin E2 (PGE2) activates regulatory T cells (Tregs) function. Here, we aim to investigate the underlying mechan...

    journal_title:Theranostics

    pub_type: 杂志文章

    doi:10.7150/thno.46005

    authors: Liu Z,Wang J,Liu L,Yuan H,Bu Y,Feng J,Liu Y,Yang G,Zhao M,Yuan Y,Zhang H,Yun H,Zhang X

    更新日期:2020-07-23 00:00:00

  • Roles of long non-coding RNAs and emerging RNA-binding proteins in innate antiviral responses.

    abstract::The diseases caused by viruses posed a great challenge to human health, the development of which was driven by the imbalanced host immune response. Host innate immunity is an evolutionary old defense system that is critical for the elimination of the virus. The overactive innate immune response also leads to inflammat...

    journal_title:Theranostics

    pub_type: 杂志文章,评审

    doi:10.7150/thno.48520

    authors: Wang Y,Wang Y,Luo W,Song X,Huang L,Xiao J,Jin F,Ren Z,Wang Y

    更新日期:2020-07-23 00:00:00

  • Lentinan-functionalized Selenium Nanoparticles target Tumor Cell Mitochondria via TLR4/TRAF3/MFN1 pathway.

    abstract::Rationale: Malignant ascites caused by cancer cells results in poor prognosis and short average survival time. No effective treatment is currently available for malignant ascites. In this study, the effects of lentinan (LNT)-functionalized selenium nanoparticles (Selene) on malignant ascites were evaluated. Furthermor...

    journal_title:Theranostics

    pub_type: 杂志文章

    doi:10.7150/thno.46467

    authors: Liu HJ,Qin Y,Zhao ZH,Zhang Y,Yang JH,Zhai DH,Cui F,Luo C,Lu MX,Liu PP,Xu HW,Li K,Sun B,Chen S,Zhou HG,Yang C,Sun T

    更新日期:2020-07-11 00:00:00

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