听力与言语-语言病理学

行为科学

医学伦理学

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  • Deciphering the multifaceted roles of TET proteins in T-cell lineage specification and malignant transformation.

    abstract::TET proteins are DNA demethylases that can oxidize 5-methylcytosine (5mC) to generate 5-hydroxymethylcytosine (5hmC) and other oxidized mC bases (oxi-mCs). Importantly, TET proteins govern cell fate decisions during development of various cell types by activating a cell-specific gene expression program. In this review...

    journal_title:Immunological reviews

    pub_type: 杂志文章,评审

    doi:10.1111/imr.12940

    authors: Tsagaratou A

    更新日期:2021-01-07 00:00:00

  • Established and emergent roles for Ikaros transcription factors in lymphoid cell development and function.

    abstract::Ikaros zinc finger transcription factors are important regulators of the gene programs underlying the development of hematopoietic cell lineages. The family consists of five members: Ikaros, Helios, Aiolos, Eos, and Pegasus, which engage in both homo- and heterotypic intrafamilial interactions to exert diverse functio...

    journal_title:Immunological reviews

    pub_type: 杂志文章,评审

    doi:10.1111/imr.12936

    authors: Read KA,Jones DM,Freud AG,Oestreich KJ

    更新日期:2020-12-17 00:00:00

  • Deciphering human γδ T cell response in cancer: Lessons from tumor-infiltrating γδ T cells.

    abstract::The finding that γδ T cells are present among tumor-infiltrating lymphocytes in humans suggests they participate in tumor immune surveillance, but their relevance is unclear because the relative abundance of tumor-infiltrating γδ T cells correlates with positive or negative, or even do not correlate with prognosis. Th...

    journal_title:Immunological reviews

    pub_type: 杂志文章,评审

    doi:10.1111/imr.12904

    authors: Lo Presti E,Dieli F,Fourniè JJ,Meraviglia S

    更新日期:2020-11-01 00:00:00

  • Fast-acting γδ T-cell subpopulation and protective immunity against infections.

    abstract::Unique Vγ2Vδ2 (Vγ9Vδ2) T cells existing only in human and non-human primates, account for the majority of circulating γδ T cells in human adults. Vγ2Vδ2 T cells are the sole γδ T-cell subpopulation capable of recognizing the microbial (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate (HMBPP) produced by selected pathoge...

    journal_title:Immunological reviews

    pub_type: 杂志文章,评审

    doi:10.1111/imr.12927

    authors: Shen L,Huang D,Qaqish A,Frencher J,Yang R,Shen H,Chen ZW

    更新日期:2020-11-01 00:00:00

  • The role of innate immunity in Alzheimer's disease.

    abstract::The amyloid hypothesis has dominated Alzheimer's disease (AD) research for almost 30 years. This hypothesis hinges on the predominant clinical role of the amyloid beta (Aβ) peptide in propagating neurofibrillary tangles (NFTs) and eventual cognitive impairment in AD. Recent research in the AD field has identified the ...

    journal_title:Immunological reviews

    pub_type: 杂志文章,评审

    doi:10.1111/imr.12896

    authors: Ennerfelt HE,Lukens JR

    更新日期:2020-09-01 00:00:00

  • Primary immunodeficiencies in cytosolic pattern-recognition receptor pathways: Toward host-directed treatment strategies.

    abstract::In the last decade, the paradigm of primary immunodeficiencies (PIDs) as rare recessive familial diseases that lead to broad, severe, and early-onset immunological defects has shifted toward collectively more common, but sporadic autosomal dominantly inherited isolated defects in the immune response. Patients with PID...

    journal_title:Immunological reviews

    pub_type: 杂志文章,评审

    doi:10.1111/imr.12898

    authors: van der Made CI,Hoischen A,Netea MG,van de Veerdonk FL

    更新日期:2020-09-01 00:00:00

  • The microbiome and cytosolic innate immune receptors.

    abstract::The discovery of innate immune sensors (pattern recognition receptors, PRRs) has profoundly transformed the notion of innate immunity, in providing a mechanistic basis for host immune interactions with a wealth of environmental signals, leading to a variety of immune-mediated outcomes including instruction and activat...

    journal_title:Immunological reviews

    pub_type: 杂志文章,评审

    doi:10.1111/imr.12901

    authors: Liwinski T,Zheng D,Elinav E

    更新日期:2020-09-01 00:00:00

  • The 3Ds in virus-like particle based-vaccines: "Design, Delivery and Dynamics".

    abstract::Vaccines need to be rationally designed in order be delivered to the immune system for maximizing induction of dynamic immune responses. Virus-like particles (VLPs) are ideal platforms for such 3D vaccines, as they allow the display of complex and native antigens in a highly repetitive form on their surface and can ea...

    journal_title:Immunological reviews

    pub_type: 杂志文章,评审

    doi:10.1111/imr.12863

    authors: Mohsen MO,Augusto G,Bachmann MF

    更新日期:2020-07-01 00:00:00

  • Obesity and CD8 T cell metabolism: Implications for anti-tumor immunity and cancer immunotherapy outcomes.

    abstract::Obesity is an established risk factor for many cancers and has recently been found to alter the efficacy of T cell-based immunotherapies. Currently, however, the effects of obesity on immunometabolism remain unclear. Understanding these associations is critical, given the fact that T cell metabolism is tightly linked ...

    journal_title:Immunological reviews

    pub_type: 杂志文章,评审

    doi:10.1111/imr.12849

    authors: Turbitt WJ,Buchta Rosean C,Weber KS,Norian LA

    更新日期:2020-05-01 00:00:00

  • Pathogenic Th1 responses in CHIKV-induced inflammation and their modulation upon Plasmodium parasites co-infection.

    abstract::The induction of polyarthritis and polyarthralgia is a hallmark of arthritogenic alphavirus infections, with an exceptionally higher morbidity observed with chikungunya virus (CHIKV). While the mechanisms underlying these incapacitating acute symptoms remain partially understood, the progression to chronic conditions ...

    journal_title:Immunological reviews

    pub_type: 杂志文章,评审

    doi:10.1111/imr.12825

    authors: Torres-Ruesta A,Teo TH,Chan YH,Rénia L,Ng LFP

    更新日期:2020-03-01 00:00:00

  • Impaired T cell receptor signaling and development of T cell-mediated autoimmune arthritis.

    abstract::Mutations of the genes encoding T-cell receptor (TCR)-proximal signaling molecules, such as ZAP-70, can be causative of immunological diseases ranging from T-cell immunodeficiency to T-cell-mediated autoimmune disease. For example, SKG mice, which carry a hypomorphic point mutation of the Zap-70 gene, spontaneously de...

    journal_title:Immunological reviews

    pub_type: 杂志文章,评审

    doi:10.1111/imr.12841

    authors: Takeuchi Y,Hirota K,Sakaguchi S

    更新日期:2020-03-01 00:00:00

  • Differentiation and adaptation of natural killer cells for anti-malarial immunity.

    abstract::Natural killer cells employ a diverse arsenal of effector mechanisms to target intracellular pathogens. Differentiation of natural killer (NK) cell activation pathways occurs along a continuum from reliance on innate pro-inflammatory cytokines and stress-induced host ligands through to interaction with signals derived...

    journal_title:Immunological reviews

    pub_type: 杂志文章,评审

    doi:10.1111/imr.12798

    authors: Goodier MR,Wolf AS,Riley EM

    更新日期:2020-01-01 00:00:00

  • Memory T-cell exhaustion and tolerance in transplantation.

    abstract::One of the biggest barriers to achieving allograft tolerance is the presence of immunological memory within the recipient, which confers a faster, more robust immune response that is in most cases more resistant to pharmacologic immunosuppression. This review will identify the mechanisms by which alloreactive T cells ...

    journal_title:Immunological reviews

    pub_type: 杂志文章,评审

    doi:10.1111/imr.12824

    authors: Hartigan CR,Sun H,Ford ML

    更新日期:2019-11-01 00:00:00

  • Cell circuits and niches controlling B cell development.

    abstract::Studies over the last decade uncovered overlapping niches for hematopoietic stem cells (HSCs), multipotent progenitor cells, common lymphoid progenitors, and early B cell progenitors. HSC and lymphoid niches are predominantly composed by mesenchymal progenitor cells (MPCs) and by a small subset of endothelial cells. N...

    journal_title:Immunological reviews

    pub_type: 杂志文章,评审

    doi:10.1111/imr.12749

    authors: Zehentmeier S,Pereira JP

    更新日期:2019-05-01 00:00:00

  • T cell and dendritic cell interactions in lymphoid organs: More than just being in the right place at the right time.

    abstract::The initiation of T lymphocyte responses within secondary lymphoid organs involves interactions with different subsets of dendritic cells (DCs). Recent studies have revealed the complexity of microanatomical organization within lymphoid organs. Exactly how T cells and DCs locate each other and the type of cellular int...

    journal_title:Immunological reviews

    pub_type: 杂志文章,评审

    doi:10.1111/imr.12753

    authors: Ugur M,Mueller SN

    更新日期:2019-05-01 00:00:00

  • T follicular helper cell heterogeneity: Time, space, and function.

    abstract::T follicular helper (Tfh) cells play a crucial role in orchestrating the humoral arm of adaptive immune responses. Mature Tfh cells localize to follicles in secondary lymphoid organs (SLOs) where they provide help to B cells in germinal centers (GCs) to facilitate immunoglobulin affinity maturation, class-switch recom...

    journal_title:Immunological reviews

    pub_type: 杂志文章,评审

    doi:10.1111/imr.12740

    authors: Song W,Craft J

    更新日期:2019-03-01 00:00:00

  • Lessons from primary immunodeficiencies: Autoimmune regulator and autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy.

    abstract::The discovery of the autoimmune regulator (AIRE) protein and the delineation of its critical contributions in the establishment of central immune tolerance has significantly expanded our understanding of the immunological mechanisms that protect from the development of autoimmune disease. The parallel identification a...

    journal_title:Immunological reviews

    pub_type: 杂志文章,评审

    doi:10.1111/imr.12714

    authors: Constantine GM,Lionakis MS

    更新日期:2019-01-01 00:00:00

  • Insights into immunity from clinical and basic science studies of DOCK8 immunodeficiency syndrome.

    abstract::DOCK8 immunodeficiency syndrome (DIDS) is a progressive combined immunodeficiency that can be distinguished from other combined immunodeficiencies or hyperimmunoglobulinemia E syndromes in featuring (a) profound susceptibility to virus infections of the skin, with associated skin cancers, and (b) severe food allergies...

    journal_title:Immunological reviews

    pub_type: 杂志文章,评审

    doi:10.1111/imr.12723

    authors: Su HC,Jing H,Angelus P,Freeman AF

    更新日期:2019-01-01 00:00:00

  • Neuroendocrine regulation of innate lymphoid cells.

    abstract::The activities of the immune system in repairing tissue injury and combating pathogens were long thought to be independent of the nervous system. However, a major regulatory role of immunomodulatory molecules released locally or systemically by the neuroendocrine system has recently emerged. A number of observations a...

    journal_title:Immunological reviews

    pub_type: 杂志文章,评审

    doi:10.1111/imr.12707

    authors: Quatrini L,Vivier E,Ugolini S

    更新日期:2018-11-01 00:00:00

  • Spatial and temporal coordination of antiviral responses by group 1 ILCs.

    abstract::Group 1 innate lymphocytes consist of a phenotypically, spatially, and functionally heterogeneous population of NK cells and ILC1s that are engaged during pathogen invasion. We are only beginning to understand the context-dependent roles that different subsets of group 1 innate lymphocytes play during homeostatic pert...

    journal_title:Immunological reviews

    pub_type: 杂志文章,评审

    doi:10.1111/imr.12710

    authors: Adams NM,Sun JC

    更新日期:2018-11-01 00:00:00

  • The dynamics of simian immunodeficiency virus after depletion of CD8+ cells.

    abstract::Human immunodeficiency virus infection is still one of the most important causes of morbidity and mortality in the world, with a disproportionate human and economic burden especially in poorer countries. Despite many years of intense research, an aspect that still is not well understood is what (immune) mechanisms con...

    journal_title:Immunological reviews

    pub_type: 杂志文章,评审

    doi:10.1111/imr.12691

    authors: Cardozo EF,Apetrei C,Pandrea I,Ribeiro RM

    更新日期:2018-09-01 00:00:00

  • The Bayesian optimist's guide to adaptive immune receptor repertoire analysis.

    abstract::Probabilistic modeling is fundamental to the statistical analysis of complex data. In addition to forming a coherent description of the data-generating process, probabilistic models enable parameter inference about given datasets. This procedure is well developed in the Bayesian perspective, in which one infers probab...

    journal_title:Immunological reviews

    pub_type: 杂志文章,评审

    doi:10.1111/imr.12664

    authors: Olson BJ,Matsen FA 4th

    更新日期:2018-07-01 00:00:00

  • What if protective immunity is antigen-driven and not due to so-called "memory" B and T cells?

    abstract::Vaccines or early childhood exposure to infection mediate immunity, that is, improved resistance against disease and death caused by a second infection with the same agent. This has been explained by and equaled to immunological memory, that is, an "altered immune system behavior" that is maintained in a presumably an...

    journal_title:Immunological reviews

    pub_type: 杂志文章,评审

    doi:10.1111/imr.12648

    authors: Zinkernagel RM

    更新日期:2018-05-01 00:00:00

  • The intra- and extracellular functions of ASC specks.

    abstract::Inflammasomes are the central signaling hubs of the inflammatory response. They process cytosolic evidence of infection, cell damage, or metabolic disturbances, and elicit a pro-inflammatory response mediated by members of the interleukin-1 family of cytokines and pyroptotoic cell death. On the molecular level, this i...

    journal_title:Immunological reviews

    pub_type: 杂志文章,评审

    doi:10.1111/imr.12611

    authors: Franklin BS,Latz E,Schmidt FI

    更新日期:2018-01-01 00:00:00

  • Autophagy limits activation of the inflammasomes.

    abstract::Inflammasomes are multiprotein complexes that control the maturation and production of interleukin-1 family members and play crucial roles in host defense against pathogens. However, dysregulated activation of inflammasomes is associated with intense inflammation, leading to the development of inflammatory diseases. T...

    journal_title:Immunological reviews

    pub_type: 杂志文章,评审

    doi:10.1111/imr.12613

    authors: Takahama M,Akira S,Saitoh T

    更新日期:2018-01-01 00:00:00

  • Metabolic regulation of macrophage phenotype and function.

    abstract::Studies in the last 20 years have given us a remarkable insight into the functional and phenotypic diversity of macrophages which reflects their integral role in host defence, homeostasis and pathogenesis. Mouse genetics, transcriptomic and epigenetic studies have provided an ontogenic and molecular perspective to the...

    journal_title:Immunological reviews

    pub_type: 杂志文章,评审

    doi:10.1111/imr.12603

    authors: Saha S,Shalova IN,Biswas SK

    更新日期:2017-11-01 00:00:00

  • Immunogenic stress and death of cancer cells: Contribution of antigenicity vs adjuvanticity to immunosurveillance.

    abstract::Cancer cells are subjected to constant selection by the immune system, meaning that tumors that become clinically manifest have managed to subvert or hide from immunosurveillance. Immune control can be facilitated by induction of autophagy, as well as by polyploidization of cancer cells. While autophagy causes the rel...

    journal_title:Immunological reviews

    pub_type: 杂志文章,评审

    doi:10.1111/imr.12582

    authors: Bloy N,Garcia P,Laumont CM,Pitt JM,Sistigu A,Stoll G,Yamazaki T,Bonneil E,Buqué A,Humeau J,Drijfhout JW,Meurice G,Walter S,Fritsche J,Weinschenk T,Rammensee HG,Melief C,Thibault P,Perreault C,Pol J,Zitvogel L,Se

    更新日期:2017-11-01 00:00:00

  • Interplay of innate lymphoid cells and the microbiota.

    abstract::Innate lymphoid cells (ILC) are a recently identified group of innate lymphocytes that are preferentially located at barrier surfaces. Barrier surfaces are in direct contact with complex microbial ecosystems, collectively referred to as the microbiota. It is now believed that the interplay of the microbiota with host ...

    journal_title:Immunological reviews

    pub_type: 杂志文章,评审

    doi:10.1111/imr.12580

    authors: Britanova L,Diefenbach A

    更新日期:2017-09-01 00:00:00

  • Crucial role for CD69 in allergic inflammatory responses: CD69-Myl9 system in the pathogenesis of airway inflammation.

    abstract::CD69 has been known as an early activation marker of lymphocytes; whereas, recent studies demonstrate that CD69 also has critical functions in immune responses. Early studies using human samples revealed the involvement of CD69 in various inflammatory diseases including asthma. Moreover, murine disease models using Cd...

    journal_title:Immunological reviews

    pub_type: 杂志文章,评审

    doi:10.1111/imr.12559

    authors: Kimura MY,Hayashizaki K,Tokoyoda K,Takamura S,Motohashi S,Nakayama T

    更新日期:2017-07-01 00:00:00

  • IL-33: biological properties, functions, and roles in airway disease.

    abstract::Interleukin (IL)-33 is a key cytokine involved in type 2 immunity and allergic airway diseases. Abundantly expressed in lung epithelial cells, IL-33 plays critical roles in both innate and adaptive immune responses in mucosal organs. In innate immunity, IL-33 and group 2 innate lymphoid cells (ILC2s) provide an essent...

    journal_title:Immunological reviews

    pub_type: 杂志文章,评审

    doi:10.1111/imr.12552

    authors: Drake LY,Kita H

    更新日期:2017-07-01 00:00:00

  • The many ways tissue phagocytes respond to dying cells.

    abstract::Apoptosis is an important component of normal tissue physiology, and the prompt removal of apoptotic cells is equally essential to avoid the undesirable consequences of their accumulation and disintegration. Professional phagocytes are highly specialized for engulfing apoptotic cells. The recent ability to track cells...

    journal_title:Immunological reviews

    pub_type: 杂志文章,评审

    doi:10.1111/imr.12537

    authors: Blander JM

    更新日期:2017-05-01 00:00:00

  • TAM receptor tyrosine kinases as emerging targets of innate immune checkpoint blockade for cancer therapy.

    abstract::Cancer immunotherapy utilizing T-cell checkpoint inhibitors has shown tremendous clinical success. Yet, this mode of treatment is effective in only a subset of patients. Unresponsive patients tend to have non-T-cell-inflamed tumors that lack markers associated with the activation of adaptive anti-tumor immune response...

    journal_title:Immunological reviews

    pub_type: 杂志文章,评审

    doi:10.1111/imr.12522

    authors: Akalu YT,Rothlin CV,Ghosh S

    更新日期:2017-03-01 00:00:00

  • The ectonucleotidases CD39 and CD73: Novel checkpoint inhibitor targets.

    abstract::Cancers are able to grow by subverting immune suppressive pathways, to prevent the malignant cells as being recognized as dangerous or foreign. This mechanism prevents the cancer from being eliminated by the immune system and allows disease to progress from a very early stage to a lethal state. Immunotherapies are new...

    journal_title:Immunological reviews

    pub_type: 杂志文章,评审

    doi:10.1111/imr.12528

    authors: Allard B,Longhi MS,Robson SC,Stagg J

    更新日期:2017-03-01 00:00:00

  • Polyvalent vaccine approaches to combat HIV-1 diversity.

    abstract::A key unresolved challenge for developing an effective HIV-1 vaccine is the discovery of strategies to elicit immune responses that are able to cross-protect against a significant fraction of the diverse viruses that are circulating worldwide. Here, we summarize some of the immunological implications of HIV-1 diversit...

    journal_title:Immunological reviews

    pub_type: 杂志文章,评审

    doi:10.1111/imr.12516

    authors: Korber B,Hraber P,Wagh K,Hahn BH

    更新日期:2017-01-01 00:00:00

  • Systems serology for evaluation of HIV vaccine trials.

    abstract::The scale and scope of the global epidemic, coupled to challenges with traditional vaccine development approaches, point toward a need for novel methodologies for HIV vaccine research. While the development of vaccines able to induce broadly neutralizing antibodies remains the ultimate goal, to date, vaccines continue...

    journal_title:Immunological reviews

    pub_type: 杂志文章,评审

    doi:10.1111/imr.12503

    authors: Ackerman ME,Barouch DH,Alter G

    更新日期:2017-01-01 00:00:00

  • Innate immune mediators in cancer: between defense and resistance.

    abstract::Chronic inflammation in the tumor microenvironment and evasion of the antitumor effector immune response are two of the emerging hallmarks required for oncogenesis and cancer progression. The innate immune system not only plays a critical role in perpetuating these tumor-promoting hallmarks but also in developing anti...

    journal_title:Immunological reviews

    pub_type: 杂志文章,评审

    doi:10.1111/imr.12464

    authors: Berraondo P,Minute L,Ajona D,Corrales L,Melero I,Pio R

    更新日期:2016-11-01 00:00:00

  • Old dogs-new tricks: immunoregulatory properties of C3 and C5 cleavage fragments.

    abstract::The activation of the complement system by canonical and non-canonical mechanisms results in the generation of multiple C3 and C5 cleavage fragments including anaphylatoxins C3a and C5a as well as opsonizing C3b/iC3b. It is now well appreciated that anaphylatoxins not only act as pro-inflammatory mediators but as immu...

    journal_title:Immunological reviews

    pub_type: 杂志文章,评审

    doi:10.1111/imr.12473

    authors: Verschoor A,Karsten CM,Broadley SP,Laumonnier Y,Köhl J

    更新日期:2016-11-01 00:00:00

  • Pathobiology of neutrophil-epithelial interactions.

    abstract::Polymorphonuclear neutrophils (PMNs) are innate immune system cells that play an essential role in eradicating invading pathogens. PMN migration to sites of infection/inflammation requires exiting the microcirculation and subsequent crossing of epithelial barriers in mucosa-lined organs such as the lungs and intestine...

    journal_title:Immunological reviews

    pub_type: 杂志文章,评审

    doi:10.1111/imr.12446

    authors: Brazil JC,Parkos CA

    更新日期:2016-09-01 00:00:00

  • Multifaceted effects of Francisella tularensis on human neutrophil function and lifespan.

    abstract::Francisella tularensis in an intracellular bacterial pathogen that causes a potentially lethal disease called tularemia. Studies performed nearly 100 years ago revealed that neutrophil accumulation in infected tissues correlates directly with the extent of necrotic damage during F. tularensis infection. However, the d...

    journal_title:Immunological reviews

    pub_type: 杂志文章,评审

    doi:10.1111/imr.12445

    authors: Kinkead LC,Allen LA

    更新日期:2016-09-01 00:00:00

  • Regulation of protein synthesis and autophagy in activated dendritic cells: implications for antigen processing and presentation.

    abstract::Antigenic peptides presented in the context of major histocompatibility complex (MHC) molecules originate from the degradation of both self and non-self proteins. T cells can therefore recognize at the surface of surveyed cells, the self-peptidome produced by the cell itself (mostly inducing tolerance) or immunogenic ...

    journal_title:Immunological reviews

    pub_type: 杂志文章,评审

    doi:10.1111/imr.12427

    authors: Argüello RJ,Reverendo M,Gatti E,Pierre P

    更新日期:2016-07-01 00:00:00

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