abstract：:Immunotherapy with anti-programmed cell death-1 (PD-1) agents is an effective treatment for metastatic melanoma. Octogenarians and nonagenarians represent a significant cohort of melanoma patients. This multicenter retrospective analysis enrolled 499 patients treated with nivolumab or pembrolizumab. Seventy-three pati...

journal_title：Melanoma research

authors： Cybulska-Stopa B,Ziętek M,Kamińska-Winciorek G,Czarnecka AM,Piejko K,Galus Ł,Ziółkowska B,Kieszko S,Kempa-Kamińska N,Calik J,Zemełka T,Kubiatowski T,Suwiński R,Mackiewicz J,Rutkowski P

更新日期：2021-02-01 00:00:00

abstract：:Single-agent anti-PD1 antibodies are usually very well tolerated, but serious toxicity can still occur. Despite the PD-1 pathway seems to be relevant in the pathogenesis of immune-related myositis, anti-PD1-related myositis is generally a rare side effect of the treatment and usually not serious. However, its frequenc...

journal_title：Melanoma research

authors： Liu WK,Naban N,Kaul A,Patel N,Fusi A

更新日期：2021-02-01 00:00:00

abstract：:Immune-checkpoint inhibitors (ICIs) exposed the oncology community to novel immune-related adverse events (irAEs). Here, we report on a retrospective analysis of patients with melanoma who developed an ICI-related, unilateral, acute and peripheral facial nerve paralysis (Bell's palsy).We retrospectively reviewed all t...

journal_title：Melanoma research

authors： Beninato T,Fucà G,Di Guardo L,Vetrano I,Valeri B,Nesa F,Del Vecchio M,Cimminiello C

更新日期：2021-01-22 00:00:00

abstract：:The Eastern Cooperative Oncology Group consensus guidelines from 2016 recommend interruption of targeted therapy with BRAF- and MEK-inhibitors during radiotherapy with data being based mostly on BRAF monotherapy. The aim of this study is to provide data on the safety of concurrent radiotherapy and combination targeted...

journal_title：Melanoma research

authors： Ziegler JS,Kroeze S,Hilbers ML,Imhof L,Guckenberger M,Levesque MP,Dummer R,Cheng P,Mangana J

更新日期：2020-12-01 00:00:00

abstract：:Little is known on whether melanocortin 1 receptor (MC1R) associated cutaneous melanoma (CM) risk varies depending on histological subtype and body site, and whether tumour thickness at diagnosis (the most important prognostic factor for CM patients) differs between MC1R variant carriers and wild-type individuals. We ...

journal_title：Melanoma research

authors： Caini S,Gandini S,Botta F,Tagliabue E,Raimondi S,Nagore E,Zanna I,Maisonneuve P,Newton-Bishop J,Polsky D,Lazovich D,Kumar R,Kanetsky PA,Hoiom V,Ghiorzo P,Landi MT,Ribas G,Menin C,Stratigos AJ,Palmieri G,Guida G,

更新日期：2020-10-01 00:00:00

abstract：:The treatment of cancer during pregnancy presents a unique challenge. Optimal treatments are often altered or even delayed to protect fetal growth and organogenesis. The landscape of cancer treatment has shifted dramatically over the past several years and treatment with checkpoint inhibitors, including anti-PD1 and a...

journal_title：Melanoma research

authors： Bucheit AD,Hardy JT,Szender JB,Glitza Oliva IC

更新日期：2020-08-01 00:00:00

abstract：:Cellular senescence is a major barricade on the path of cancer development, yet proteins secreted from senescent cells exert complex and often discordant effects on subsequent cancer evolution. Somatic genome alternations driving the formation of nevi and melanoma are efficient inducers of cellular senescence. Melanoc...

journal_title：Melanoma research

authors： Chavanet A,Hill KR,Jiménez-Andrade Y,Choo MK,White K,Park JM

更新日期：2020-08-01 00:00:00

abstract：:The aim of this study was to evaluate metastatic latency and survival after the occurrence of metastases in patients with choroidal/ciliary body melanoma treated with proton therapy. This was a retrospective cohort study. All consecutive patients with choroidal/ciliary body melanoma treated with proton therapy between...

journal_title：Melanoma research

authors： Bellocq D,Roy P,Kodjikian L,Mathis T,Nguyen AM,Herault J,Rivoire M,Négrier S,Thariat J,Grange JD

更新日期：2020-06-01 00:00:00

abstract：:Prognostic groups defined by lactate dehydrogenase concentration and number of organ sites containing metastases have been reported for patients treated with dabrafenib and trametinib for advanced melanoma. We aimed to validate these prognostic groups for patients treated with vemurafenib and cobimetinib in the coBRIM...

journal_title：Melanoma research

authors： Sorich MJ,Rowland A,Hopkins AM

更新日期：2020-06-01 00:00:00

abstract：:Checkpoint inhibitor immunotherapy is a transformative treatment for advanced malignancies, but can be associated with numerous immune-related adverse events (irAEs). The majority of irAEs include those that closely resemble known cutaneous and neurocutaneous autoimmune or autoinflammatory diseases, such as scleroderm...

journal_title：Melanoma research

authors： Kosche C,Stout M,Sosman J,Lukas RV,Choi JN

更新日期：2020-06-01 00:00:00

abstract：:In patients with metastatic cancer, gut microbiome composition differs between responder and non-responders to immune checkpoint inhibitors. However, there is little consensus on the microbiome taxa associated with response or lack of response. Additionally, recognized confounders of gut microbiome composition have ge...

journal_title：Melanoma research

authors： Wind TT,Gacesa R,Vich Vila A,de Haan JJ,Jalving M,Weersma RK,Hospers GAP

更新日期：2020-06-01 00:00:00

abstract：:A large body of evidence in the scientific literature suggests that the numbers of common and atypical nevi are strong, independent risk factors for the occurrence of cutaneous malignant melanoma. Furthermore, some studies recently found an association between high nevus counts and an improved melanoma prognosis. The ...

journal_title：Melanoma research

authors： De Giorgi V,Scarfì F,Gori A,Maida P,Trane L,Silvestri F,Portelli F,Massi D,Covarelli P,Gandini S

更新日期：2020-04-01 00:00:00

abstract：:Therapeutic failures in cancer therapy are often associated with metabolic plasticity. The use of metabolic modulators as anti-cancer agents has been effective in correcting metabolic alterations; however, molecular events behind metabolic switch are still largely unexplored. Herein, we characterize the molecular and ...

journal_title：Melanoma research

authors： Pistoni M,Tondelli G,Gallo C,Torricelli F,Maresca A,Carelli V,Ciarrocchi A,Dallaglio K

更新日期：2020-02-01 00:00:00

abstract：:This study examines whether 6-thioguanine resistant T cells (mutant) from metastatic melanoma patients are enriched for melanoma-associated T cells compared to T cells obtained analogously without thioguanine selection (wild-type). Melanoma-associated antigen pentamer staining was performed on 5 tumour and 9 periphera...

journal_title：Melanoma research

authors： Zuleger CL,Newton MA,Ma X,Ong IM,Pei Q,Albertini MR

更新日期：2020-02-01 00:00:00

abstract：:Ipilimumab is approved for adjuvant melanoma treatment at a dose of 10 mg/kg, but its use is limited owing to high toxicity and treatment-associated costs. We retrospectively analyzed 29 patients who underwent complete resection of stage IIC-III melanoma and were treated with ipilimumab 3 mg/kg in an adjuvant setting....

journal_title：Melanoma research

authors： Mangana J,Dimitriou F,Braun R,Ludwig S,Dummer R,Barysch MJ

更新日期：2019-12-01 00:00:00

abstract：:A proportion of patients diagnosed with melanoma has a positive family history. Despite increasing knowledge on the genes responsible for familial clustering, the genetic basis in the majority of the families with an inherited predisposition to melanoma remains to be clarified. To identify novel melanoma-susceptibilit...

journal_title：Melanoma research

authors： Salgado C,Kwesi-Maliepaard EM,Jochemsen AG,Visser M,Harland M,van Leeuwen F,van Doorn R,Gruis N

更新日期：2019-12-01 00:00:00

abstract：:Desmoplastic melanoma (DM) due to its rare and locally aggressive nature, can be difficult to study and to treat effectively. Whether the optimal treatment approach for these tumors should include adjuvant radiation has been unclear in the literature. In this retrospective study of the National Cancer Database, 2390 p...

journal_title：Melanoma research

authors： Abbott JL,Qureshi MM,Truong MT,Sahni D

更新日期：2019-08-01 00:00:00

abstract：:A vaccine that could expand melanoma-specific T cells might reduce the risk of recurrence of resected melanoma and could provide an alternative or adjunct to standard immunotherapy options. We tested the safety and immunogenicity of a vaccine coupling a melanoma-associated peptide with a xenogenic peptide (to promote ...

journal_title：Melanoma research

authors： Block MS,Nevala WK,Pang YP,Allred JB,Strand C,Markovic SN

更新日期：2019-08-01 00:00:00

abstract：:Selective inhibition of the mutant BRAF protein is a highly promising therapeutic approach for melanoma patients carrying the BRAF mutation. Despite the remarkable clinical response, most patients develop resistance and experience tumour regrowth. To clarify the molecular background of BRAF inhibitor resistance, we ge...

journal_title：Melanoma research

authors： Szász I,Koroknai V,Kiss T,Vízkeleti L,Ádány R,Balázs M

更新日期：2019-08-01 00:00:00

abstract：:Uveal melanoma is a rare form of melanoma and the most frequent primary eye malignancy in adults. The major molecular alterations underlying uveal melanoma pathogenesis affect mainly the GNAQ, GNA11, SF3B1, and BAP1 genes. In this study, we somatically genotyped 31 Brazilian uveal melanomas for BRAF, GNA11, GNAQ, SF3B...

journal_title：Melanoma research

authors： Sarubi HC,Pereira NB,Gomes CC,Gomez RS,Carmo ACM,Melo FM,Bastos-Rodrigues L,Pedrosa MS,Friedman E,De Marco L

更新日期：2019-06-01 00:00:00

abstract：:Inositol hexaphosphate (IP6) also called phytic acid is a polyphosphorylated carbohydrate naturally found in cereals, nuts, grains, and high-fiber-containing foods. It has been shown to inhibit the growth of many different tumor cell lines both in vitro and in vivo like colon, pancreas, liver, prostate, and even melan...

journal_title：Melanoma research

authors： Khurana S,Baldeo C,Joseph RW

更新日期：2019-06-01 00:00:00

abstract：:There is a scarcity of available data on unmet information needs (UINs) of melanoma patients (MPs) from Germany and of MPs with clinical stage IV. In a multicenter cross-sectional survey, we explored the UINs of 529 MPs by applying a standardized questionnaire. Subgroup differences in scope and contents of UINs were d...

journal_title：Melanoma research

authors： Brütting J,Bergmann M,Garzarolli M,Rauschenberg R,Weber C,Berking C,Tilgen W,Schadendorf D,Meier F,NVKH supporting group.

更新日期：2019-04-01 00:00:00

abstract：:In several solid tumors, an increased stathmin expression is associated with both poor prognosis and resistance to certain chemotherapy types. However, the data regarding melanocytic lesions are very limited. The goals of our study are as follows: the assessment of stathmin expression in benign and malignant melanocyt...

journal_title：Melanoma research

authors： Dundr P,Simon K,Němejcová K,Bártů M,Tichá I,Michálková R,Jakša R,Věcková Z,Kodet O

更新日期：2019-04-01 00:00:00

abstract：:Significant advances have been made in the treatment of melanoma by targeting key cellular pathways, but additional targets are needed as many patients do not respond or relapse with resistant disease. MicroRNA-155 (MiR-155) has previously been shown to regulate melanoma cell growth and acts as a tumor suppressor. We ...

journal_title：Melanoma research

authors： DiSano JA,Huffnagle I,Gowda R,Spiegelman VS,Robertson GP,Pameijer CR

更新日期：2019-04-01 00:00:00

abstract：:The aim was to evaluate toxicity and oncological outcome of combined stereotactic radiosurgery (SRS) and immunotherapy or targeted therapy in patients with multiple brain metastases originating from malignant melanoma. Despite the fact that both SRS and kinase inhibitors or immune checkpoint inhibitors are considered ...

journal_title：Melanoma research

authors： Stera S,Balermpas P,Blanck O,Wolff R,Wurster S,Baumann R,Szücs M,Loutfi-Krauss B,Wilhelm ML,Seifert V,Rades D,Rödel C,Dunst J,Hildebrandt G,Arnold A,Meissner M,Kähler KC

更新日期：2019-04-01 00:00:00

abstract：:Pelvic sentinel lymph nodes (SLNs) are commonly identified during inguinal SLN biopsy for melanoma, but retrieval is not uniform among surgeons/centers. Few studies have assessed rates of micrometastases in pelvic versus superficial inguinal SLNs. Previous studies suggested that presence of pelvic SLNs was predicted b...

journal_title：Melanoma research

authors： Swords DS,Andtbacka RHI,Bowles TL,Hyngstrom JR

更新日期：2019-02-01 00:00:00

abstract：:Genes in the S100 family are abnormally expressed in a variety of tumor cells and are associated with clinical pathology, but their prognostic value in melanoma patients has not yet been fully elucidated. In this study, we extracted and profiled S100 family mRNA expression data and corresponding clinical data from the...

journal_title：Melanoma research

authors： Xiong TF,Pan FQ,Li D

更新日期：2019-02-01 00:00:00

abstract：:The management of metastatic melanoma is a difficult matter. Nevertheless, the advent of target therapy has significantly improved patient outcome, provided that tumor molecular characteristics become available: the detection of drug-resistant clones can contribute to understanding the reasons for resistance onset, in...

journal_title：Melanoma research

authors： Scaini MC,Pigozzo J,Pizzi M,Manicone M,Chiarion-Sileni V,Zambenedetti P,Rugge M,Zanovello P,Rossi E,Zamarchi R,Facchinetti A

更新日期：2019-02-01 00:00:00

abstract：:Mucosal melanoma of the nasal cavity and paranasal sinus is always associated with poor prognosis, and 5-year overall survival does not exceed 40%. Our study aimed to compare the intraoperative conditions and prognosis of different surgical techniques to determine the optimum surgical approach for patients with mucosa...

journal_title：Melanoma research

authors： Yin G,Guo W,Chen X,Huang Z

更新日期：2019-02-01 00:00:00

abstract：:Conditional survival in patients with localized primary cutaneous malignant melanoma (CMM) is well described. However, conditional recurrence-free survival (RFS) has not been investigated before. The aim of this study was to determine conditional RFS and test for time dependency in prognostic factors in patients with ...

journal_title：Melanoma research

authors： Lyth J

更新日期：2018-12-01 00:00:00

abstract：:Sideritis leptoclada O. Schwarz et P.H. Davis extracts were evaluated for its singlet oxygen production capacity using spectrophotometric method. The extracts producing singlet oxygen were then evaluated for cytotoxicity against malignant melanoma cancer (HT-144) and fibroblast (3T3) cell lines using the 3-[4,5-dimeth...

journal_title：Melanoma research

authors： Aydoğmuş-Öztürk F,Günaydin K,Öztürk M,Jahan H,Duru ME,Choudhary MI

更新日期：2018-12-01 00:00:00

abstract：:Ophthalmological complications constitute a class effect of treatment with BRAF inhibitors. Encorafenib is a new BRAF inhibitor currently being tested in phase 3 clinical trials for advanced or metastatic melanoma as monotherapy or in combination with the MEK-inhibitor binimetinib. In this study, we present a case of ...

journal_title：Melanoma research

authors： Diamantopoulos PT,Stoungioti S,Anastasopoulou A,Papaxoinis G,Gogas H

更新日期：2018-12-01 00:00:00

abstract：:Immune checkpoint inhibitors targeting the programmed cell death (PD)-1 receptor have dramatically changed the landscape of metastatic melanoma treatment. Nevertheless, these immuno-modulatory agents have associated side effects, including dermatologic manifestations. To this end, we report a patient with metastatic m...

journal_title：Melanoma research

authors： Rambhia PH,Honda K,Arbesman J

更新日期：2018-10-01 00:00:00

abstract：:The correlation between ultraviolet radiation of the skin and melanoma incidence in humans is well established. Interestingly, epidemiologic data suggest also a correlation to an increased BMI pointing to metabolic trigger factors in melanoma pathogenesis. To substantiate this connection, we studied the expression of ...

journal_title：Melanoma research

authors： Kleemann J,Hrgovic I,Ter-Nedden J,Kleimann P,Steinhorst K,Härle K,Müller J,Kaufmann R,Meissner M,Kippenberger S

更新日期：2018-08-01 00:00:00

abstract：:Amelanotic melanomas (AMMs) account for a small proportion of all melanomas. They pose a risk of delayed diagnosis and, consequently, poor prognosis. AMMs may atypically present as a pyogenic granuloma-like lesion. This study sought to investigate the prevalence and clinical and histological features of AMM masqueradi...

journal_title：Melanoma research

authors： Moshe M,Levi A,Ad-El D,Ben-Amitai D,Mimouni D,Didkovsky E,Feinmesser M,Lapidoth M

更新日期：2018-08-01 00:00:00

abstract：:The aim of this study was to present the epidemiological, clinicopathological, and treatment characteristics of patients diagnosed and treated in a tertiary referral center and to analyze independent factors associated with these characteristics. In this cohort study, epidemiological, clinicopathological, and treatmen...

journal_title：Melanoma research

authors： Tsoutsos D,Papadopoulos S,Kehagias G,Mara A,Kyriopoulou E,Karonidis A,Spiliopoulos K,Mpalitsaris E,Karapiperis G,Panayotou P,Papaliodi E,Choreftaki T,Papaxoinis G,Benopoulou O,Ioannovich J,Gogas H

更新日期：2018-08-01 00:00:00

abstract：:Pregnancy-associated melanoma is defined as melanoma diagnosed during pregnancy or within 1 year of delivery. The association of pregnancy with melanoma is well known, but its underlying molecular mechanisms of association are poorly understood. The aim was to assess the expression of apoptosis-related genes in melano...

journal_title：Melanoma research

authors： Facina AS,Facina G,Guerreiro da Silva IDC,Corrêa SAA,Alexandre SM,Logullo ÂF,Hosomi JK,Nakamura MU

更新日期：2018-08-01 00:00:00

abstract：:Locally advanced cutaneous melanoma has marked quality-of-life implications; however, the patient experience of symptom management and subsequent impact on quality of life has not been well described. This study aims to address the impact on patients of advanced cutaneous melanoma through qualitative interviews. Adult...

journal_title：Melanoma research

authors： Weitman ES,Perez M,Thompson JF,Andtbacka RHI,Dalton J,Martin ML,Miller T,Gwaltney C,Sarson D,Wachter E,Zager JS

更新日期：2018-04-01 00:00:00

abstract：:Conjunctival melanoma is a rare disease, and little is known about its molecular background. Here, we present the case of a 48-year-old patient with conjunctival melanoma and metachronic lymph node and skin metastasis with KRAS p.K117Y mutation in exon 4 in all the lesions. The cancer genome interpreter predicted this...

journal_title：Melanoma research

authors： Del Carpio Huerta LP,Mas Castells M,Anguera Palacios G,Sullivan I,Gonzalez Vidal A,Majem Tarruella M

更新日期：2018-04-01 00:00:00

abstract：:For the treatment of choroidal melanoma, palladium-103 (Pd) and ruthenium-106 (Ru) plaque brachytherapy shows reduced toxicity compared with the historical standard iodine-125. No report has directly compared the clinical outcomes between Pd and Ru, and the reasons for the selection of one over the other remain purely...

journal_title：Melanoma research

authors： Danish H,Ferris MJ,Balagamwala E,Switchenko JM,Patel KR,Choudhary M,Craven C,Mendoza P,Suh J,Bergstrom C,Grossniklaus HE,M Aaberg T Sr,Singh A,Crocker IR,Khan MK

更新日期：2018-04-01 00:00:00