解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Although microvascular dysfunction (MVD) has been well characterized in individual organs as different disease entities, clinical evidence is mounting in support of an underlying systemic process. To address this hypothesis, we systematically searched PubMed and Medline for studies in adults published between 2014 and...
journal_title:Microvascular research
pub_type: 杂志文章,评审
doi:10.1016/j.mvr.2020.104123
更新日期:2021-03-01 00:00:00
abstract::Diabetic retinopathy (DR) is a disease that causes blindness due to vascular leakage or abnormal angiogenesis. Hepatocyte growth factor (HGF) is increased in the serum or vitreous fluid in proliferative diabetic retinopathy (PDR) patients, although the effect of HGF on the blood vessels remains unclear. This study foc...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2020.104103
更新日期:2021-01-01 00:00:00
abstract:PURPOSE:To investigate conjunctival microvascular responses in patients with mild diabetic retinopathy (MDR) and methylenetetrahydrofolate reductase (MTHFR) polymorphisms (D + PM) after administration of Ocufolin™, a medical food containing 900 μg l-methylfolate (levomefolate calcium or [6S]-5-methyltetrahydrofolic aci...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2020.104066
更新日期:2020-11-01 00:00:00
abstract:PURPOSE:Subcutaneous tissue is a promising site for cell transplantation; advantages include minimally invasive procedures and easy post-transplant monitoring. However, limited vascularity is the major known challenge. To address this challenge, a prevascularized graft bed is prepared in recipients. We aimed to establi...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2020.104070
更新日期:2020-11-01 00:00:00
abstract::Cardiovascular diseases, among all diseases, are taking the most victims worldwide. Coronary artery occlusion, takes responsibility of about 30% of the yearly global deaths in the world (Heart Disease and Stroke Statistics 2017 At-a-Glance, 2017), raising the need for viable substitutes for cardiovascular tissues. Dep...
journal_title:Microvascular research
pub_type: 杂志文章,评审
doi:10.1016/j.mvr.2020.104027
更新日期:2020-09-01 00:00:00
abstract:OBJECTIVE:This study aims to investigate the correlation between the expression of miR-210 in peripheral blood and the number of peripheral endothelial progenitor cells (EPCs) in patients with type 2 diabetes mellitus (T2DM). We also determined the effect of miR-210 on EPC proliferation, adhesion, migration, tube forma...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2020.104032
更新日期:2020-09-01 00:00:00
abstract:AIMS:The purpose of the present study was to investigate the possible role of TIPE2 on acute lung injury (ALI) induced by myocardial ischemia/reperfusion (MIR) in diabetic rats. METHODS:Sprague-Dawley (SD) rats were randomly separated into four groups: control+sham (C + sham); control+MIR (C + MIR); diabetes+sham (D +...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2020.104009
更新日期:2020-07-01 00:00:00
abstract:OBJECTIVE:The relationship between NF-κB Interacting lncRNA (NKILA) and angiogenesis in breast cancer has never been studied. Our study aimed to investigate effect of NKILA on proliferation, migration, apoptosis, as well as angiogenesis in breast cancer. METHODS:NKILA was over-expressed in MDA-MB-231 cells by transfec...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2019.103968
更新日期:2020-05-01 00:00:00
abstract::Alzheimer's disease (AD) is a chronic neuro-degenerative disease that adversely affect many people on a global scale. Despite different diagnostic and therapeutic treatment, there is no cure for AD. The brain is one of the most complex organ and researchers are still trying to understand so as to find a cure. OBJECTI...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2019.103928
更新日期:2020-03-01 00:00:00
abstract:OBJECTIVE:In the present study, we used a two-kidney-two-clip (2k2c) stroke-prone renovascular hypertension rat model (RHRSP) to investigate the protective effects of ligustrazine (TMP) on cerebral arteries and to examine PI3K/Akt pathway behavior under this protection. METHODS:The cerebral artery remodeling was induc...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2019.103938
更新日期:2020-03-01 00:00:00
abstract:PURPOSE:The conjunctival microcirculation is a readily-accessible vascular bed for quantitative haemodynamic assessment and has been studied previously using a digital charge-coupled device (CCD). Smartphone video imaging of the conjunctiva, and haemodynamic parameter quantification, represents a novel approach. We rep...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2019.103907
更新日期:2019-11-01 00:00:00
abstract:BACKGROUND:Impairments at the microvascular level might lead to more overt cardiovascular complications, therefore, being able to early detect microvascular dysfunction would be beneficial. Thus, the present study investigated whether near-infrared spectroscopy (NIRS) assessment of microvascular responsiveness (reoxyge...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2019.04.009
更新日期:2019-09-01 00:00:00
abstract:OBJECTIVE:High aerobic fitness may prevent age-related decrements in cutaneous vasodilation while type 2 diabetes may exacerbate this decline. The mechanisms underlying these responses remain unclear, but may be due to an excess of reactive oxygen species. We hypothesized that superoxide scavenging or NADPH oxidase inh...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2019.103886
更新日期:2019-09-01 00:00:00
abstract:BACKGROUND:The burden of type 1 diabetes (T1D) is growing worldwide, stressing the requirement to limit the threat of its long-term complications. In this regard, the development of methods for the early diagnosis and non-invasive monitoring of vascular abnormalities is widely recognized as one of the greatest prioriti...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2019.04.002
更新日期:2019-07-01 00:00:00
abstract::Venous thromboembolism (VTE), encompassing deep venous thrombosis (DVT) and pulmonary embolism (PE), is the third most common cardiovascular disease. miR-150 is one of important microRNAs which play critical role in various cellular function such as endothelial progenitor cells (EPCs). In this study, we investigate th...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2018.10.003
更新日期:2019-05-01 00:00:00
abstract::Oxidative stress, which is defined as an imbalance between proxidant and antioxidant systems, is the essential mechanism involving in the ischemic process. During the early stage of brain ischemia, reactive oxygen species (ROS) are increased. Increased ROS are thought of a consequence of brain ischemia and exacerbatin...
journal_title:Microvascular research
pub_type: 杂志文章,评审
doi:10.1016/j.mvr.2018.12.005
更新日期:2019-05-01 00:00:00
abstract::Age-related macular degeneration (AMD) is a common cause of blindness worldwide. While recent studies have revealed that the loss of choroidal endothelial cells (ChECs) is critical to the disease pathogenesis of dry AMD, in vitro studies are needed to fully elucidate the disease mechanism. However, these studies remai...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2018.12.002
更新日期:2019-05-01 00:00:00
abstract::Tetrahydroxystilbene glucoside (TSG) is the main water-soluble component in Polygonum multiflorum Thunb, and it has many cardioprotective effects. Although TSG is able to relax blood vessels, its relaxation of rat superior mesenteric arteries and the underlying mechanism of this process are not clearly understood. The...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2018.10.007
更新日期:2019-05-01 00:00:00
abstract:BACKGROUND:Understanding the differences in skin blood flow (SBF) on the plantar and dorsal foot in people with diabetes mellitus (DM) may help to assess the influence of diabetes and neuropathy on microvascular dysfunction and risks of diabetic foot ulcers in this population. However, there is no study comparing SBF o...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2018.11.002
更新日期:2019-03-01 00:00:00
abstract::Fluid homeostasis is required for life. Processes involved in fluid balance are strongly related to exchanges at the microvascular level. Computational models have been presented in the literature to analyze the microvascular-interstitial interactions. As far as we know, none of those models consider a physiological d...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2018.11.003
更新日期:2019-03-01 00:00:00
abstract:PURPOSE:Diabetic retinopathy (DR) is characterized by pro-inflammatory, pro-angiogenic and pro-fibrotic environment during the various stages of the disease progression. Basement membrane changes in the retina and formation of fibrovascular membrane are characteristically seen in DR. In the present study the effect of ...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2018.09.001
更新日期:2019-01-01 00:00:00
abstract::Timely diagnostics of microcirculatory system abnormalities, which are the most severe diabetic complications, is one of the major problems facing modern health care. Functional abnormalities manifest themselves earlier than the structural ones, and therefore their assessment is the issue of primary importance. In thi...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2018.05.005
更新日期:2018-11-01 00:00:00
abstract::Circulation of blood depends, in part, on the ability of red blood cells (RBCs) to aggregate, disaggregate, and deform. The primary intrinsic disaggregating force of RBCs is derived from their electronegativity, which is largely determined by sialylated glycoproteins on the plasma membrane. Given supraphysiological sh...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2018.05.008
更新日期:2018-11-01 00:00:00
abstract::This article describes the interaction between solid particles and blood propagating through a capillary. A slip condition is considered on the walls of the capillary. The rheological features of the blood are discussed by considering as a two-phase Newtonian fluid model, i.e., the suspension of cells in plasma. A per...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2018.04.004
更新日期:2018-09-01 00:00:00
abstract::Homeostasis around vascular endothelium is a function of the equilibrium between the bioavailability of nitric oxide (NO) and oxidizing reactive oxygen species (ROS). Within the vascular endothelium, NO enhances vasodilatation, reduces platelet aggression and adhesion (anti-thrombotic), prevents smooth muscle prolifer...
journal_title:Microvascular research
pub_type: 杂志文章,评审
doi:10.1016/j.mvr.2018.03.012
更新日期:2018-09-01 00:00:00
abstract::Preeclampsia (PE), a dangerous hypertensive complication of pregnancy, is associated with widespread maternal vascular dysfunction. However, the effect of PE on the cerebral vasculature that can lead to stroke and cognitive decline is not well understood. We hypothesized that function of cortical parenchymal arteriole...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2018.04.007
更新日期:2018-09-01 00:00:00
abstract::Systemic sclerosis (SSc) is a connective tissue disease with high morbidity and mortality, characterized by autoimmunity, obliterative vasculopathy involving mainly the microvasculature, and fibrosis. SSc-specific nailfold capillaroscopic changes have been defined, and nailfold capillaroscopy (NFC) is now unequivocall...
journal_title:Microvascular research
pub_type: 杂志文章,评审
doi:10.1016/j.mvr.2018.03.004
更新日期:2018-07-01 00:00:00
abstract:BACKGROUND:Ischemia-reperfusion (IR) injury impairs microcirculatory function by reducing nitric oxide (NO) bioavailability and increasing sympathetic tone. This study non-invasively examined the effects of acute upper limb IR injury on local thermal hyperemia (LTH) in glabrous and non-glabrous finger skin. MATERIALS ...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2018.02.003
更新日期:2018-07-01 00:00:00
abstract::The aim of this study was to analyze the development of vascular architecture as well as vascular morphometry and morphology of anastomosed microvascular free flaps. Free pectoral skin flaps were raised in 25 rats and anastomosed to the femoral vessels in the groin region. CD31 immunohistology was performed after 3, 7...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2018.03.006
更新日期:2018-07-01 00:00:00
abstract::Local skin heating to 42°C causes rapid increases in cutaneous perfusion (initial peak), followed by a brief nadir and subsequent sustained elevation (plateau). Several studies have demonstrated that nitric oxide synthase (NOS) largely contributes to the plateau response during local heating. In this study, we tested ...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2017.12.001
更新日期:2018-05-01 00:00:00
abstract:BACKGROUND:Sedentary behaviour is linked to increased cardiovascular disease risk in Rheumatoid Arthritis (RA), but the biological processes underlying this relationship are not understood. OBJECTIVES:To investigate the cross-sectional associations of habitual sedentary behaviour, with endothelial function in RA. MET...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2018.01.005
更新日期:2018-05-01 00:00:00
abstract::The key points in the design of microfluidic Lab-On-a-Chips for blood tests are the simplicity of the microfluidic chip geometry, the portability of the monitoring system and the ease on-chip integration of the data analysis procedure. The majority of those, recently designed, have been used for blood separation, howe...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2017.09.003
更新日期:2018-03-01 00:00:00
abstract::Innate immunity is characterized by the coordinated activity of multiple leukocytes mobilizing at or near the site of tissue injury. Slow rolling and/or adherent leukocytes have been shown to hydrodynamically recruit free-stream leukocytes to a model of inflamed tissue. In this paper, we numerically investigate the hy...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2017.09.002
更新日期:2018-01-01 00:00:00
abstract::Fluorescence-mediated photoplethysmography (FM-PPG) was developed to facilitate determination of tissue microvascular (capillary) blood perfusion, requiring intra-venous injection of a small bolus (~0.33mL) of dye (25mg/mL ICG) and acquisition of high-speed angiogram images (>15images/s). The methodology is applicable...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2017.05.009
更新日期:2017-11-01 00:00:00
abstract:OBJECTIVE:Studies on the acute effects of coffee on the microcirculation have shown contradicting results. This study aimed to investigate if intake of caffeine-containing coffee changes blood flow and microvascular reactivity in the skin. METHODS:We measured acute changes in cutaneous vascular conductance (CVC) in th...
journal_title:Microvascular research
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.mvr.2017.06.006
更新日期:2017-11-01 00:00:00
abstract::We previously reported that the cutaneous vasodilator response to local warming in males required noradrenaline (NA) and neuropeptide-Y (NPY). Animal work has shown no role for NPY in female vascular control. We investigated the contribution of NA and NPY in human female cutaneous vascular control. Nine female and nin...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2017.04.003
更新日期:2017-09-01 00:00:00
abstract:OBJECTIVE:The present study was examined whether fluvastatin, 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, can increase the production of interstitial adenosine via activation of ecto-5'-nucleotidase in the ventricular myocardium, with use of microdialysis techniques in in situ rat hearts. METH...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2016.04.006
更新日期:2016-09-01 00:00:00
abstract::Sanguinate, a polyethylene glycol-conjugated carboxyhemoglobin, was investigated for cerebral vasoactivity in healthy male Sprague-Dawley rats (Study 1) and for its ability to increase brain tissue oxygen pressure (PbtO2) after controlled cortical impact (CCI) - traumatic brain injury (TBI) (Study 2). In both studies ...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2016.06.001
更新日期:2016-09-01 00:00:00
abstract:PURPOSE:To examine the possible role of Klotho (Kl) in human microvasculature. METHODS:The expression level of Kl in primary human dermal microvascular endothelial cells (HDMECs) and primary human dermal fibroblasts (HFb) was detected by real-time polymerase chain reaction amplification (qRT-PCR), Western blot analyse...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2016.05.005
更新日期:2016-09-01 00:00:00
abstract:UNLABELLED:Metabolic syndrome (MetS) increases the risk of the subsequent development of cardiovascular disease. This study aimed to determine if the harmonic indexes of finger photoplethysmography (PPG) waveforms can be used to discriminate different arterial pulse transmission conditions between MetS and healthy subj...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2016.04.001
更新日期:2016-07-01 00:00:00