abstract：:The increasingly older population in most developed countries will likely experience aging-related chronic diseases such as diabetes, metabolic syndrome, heart and lung diseases, osteoporosis, arthritis, dementia, and/or cancer. Genetic and environmental factors, but also lifestyle choices including physical activity ...

journal_title：GeroScience

authors： Brandhorst S

更新日期：2021-01-07 00:00:00

abstract：:Analysis of skeletal muscle mass and composition is essential for studying the biology of age-related sarcopenia, loss of muscle mass, and function. Muscle immunohistochemistry (IHC) allows for simultaneous visualization of morphological characteristics and determination of fiber type composition. The information glea...

journal_title：GeroScience

authors： Bonilla HJ,Messi ML,Sadieva KA,Hamilton CA,Buchman AS,Delbono O

更新日期：2020-12-01 00:00:00

abstract：:The COVID-19 pandemic is an extraordinary global emergency that has led to the implementation of unprecedented measures in order to stem the spread of the infection. Internationally, governments are enforcing measures such as travel bans, quarantine, isolation, and social distancing leading to an extended period of ti...

journal_title：GeroScience

authors： Kirwan R,McCullough D,Butler T,Perez de Heredia F,Davies IG,Stewart C

更新日期：2020-12-01 00:00:00

abstract：:Frailty is a geriatric syndrome defined as a status of extreme vulnerability to stressors, leading to a higher risk of negative health-related outcomes. "Inflammaging", an age-related state of low-grade chronic inflammation, is characterized by an increased concentration of pro-inflammatory cytokines and acute phase p...

journal_title：GeroScience

authors： Marcos-Pérez D,Sánchez-Flores M,Proietti S,Bonassi S,Costa S,Teixeira JP,Fernández-Tajes J,Pásaro E,Laffon B,Valdiglesias V

更新日期：2020-12-01 00:00:00

abstract：:To investigate whether blood-brain barrier (BBB) disruption is a potential mechanism of usual age-related cognitive decline, we conducted dynamic contrast-enhanced (DCE) MRI to measure BBB leakage in a healthy sample, and investigated the association with longitudinal cognitive decline. In a sample of neurologically a...

journal_title：GeroScience

authors： Verheggen ICM,de Jong JJA,van Boxtel MPJ,Postma AA,Jansen JFA,Verhey FRJ,Backes WH

更新日期：2020-12-01 00:00:00

abstract：:The distinction between severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-related and community-acquired pneumonias poses significant difficulties, as both frequently involve the elderly. This study aimed to predict the risk of SARS-CoV-2-related pneumonia based on clinical characteristics at hospital prese...

journal_title：GeroScience

authors： Horváth VJ,Hajdú N,Vági O,Schnábel K,Szelke E,Körei AE,Békeffy M,Svébis MM,Domján BA,Berényi T,Takács I,Ungvári Z,Kun A,Tabák ÁG

更新日期：2020-11-11 00:00:00

abstract：:Fibroblast Growth Factor 21 (FGF21), Growth Differentiation Factor 15 (GDF15), and Humanin (HN) are mitochondrial stress-related mitokines, whose role in health and disease is still debated. In this study, we confirmed that their plasma levels are positively correlated with age in healthy subjects. However, when looki...

journal_title：GeroScience

authors： Conte M,Sabbatinelli J,Chiariello A,Martucci M,Santoro A,Monti D,Arcaro M,Galimberti D,Scarpini E,Bonfigli AR,Giuliani A,Olivieri F,Franceschi C,Salvioli S

更新日期：2020-10-31 00:00:00

abstract：:Maintaining good cognitive function at older age is important, but our knowledge of patterns and predictors of cognitive aging is still limited. We used Bayesian model-based clustering to group 5064 participants of the Long Life Family Study (ages 49-110 years) into clusters characterized by distinct trajectories of c...

journal_title：GeroScience

authors： Sebastiani P,Andersen SL,Sweigart B,Du M,Cosentino S,Thyagarajan B,Christensen K,Schupf N,Perls TT

更新日期：2020-10-01 00:00:00

abstract：:As mitigation of brain aging continues to be a key public health priority, a wholistic and comprehensive consideration of the aging body has identified immunosenescence as a potential contributor to age-related brain injury and disease. Importantly, the nervous and immune systems engage in bidirectional communication ...

journal_title：GeroScience

authors： Engler-Chiurazzi EB,Monaghan KL,Wan ECK,Ren X

更新日期：2020-10-01 00:00:00

abstract：:Cardiac diastolic dysfunction in aging arises from increased ventricular stiffness caused by inflammation and interstitial fibrosis. The diastolic dysfunction contributes to heart failure with preserved ejection fraction (HFpEF), which in the aging population is more common in women. This report examines its progressi...

journal_title：GeroScience

authors： Trial J,Diaz Lankenau R,Angelini A,Tovar Perez JE,Taffet GE,Entman ML,Cieslik KA

更新日期：2020-08-26 00:00:00

abstract：:Evolving debate suggests that handgrip strength, a measure of muscular strength, might be associated with the risk of fractures; however, the evidence is conflicting. We aimed to assess the association of handgrip strength with the risk of fracture in the general population. Handgrip strength, measured using a dynamom...

journal_title：GeroScience

authors： Kunutsor SK,Seidu S,Voutilainen A,Blom AW,Laukkanen JA

更新日期：2020-08-19 00:00:00

abstract：:Loss of protein homeostasis is a hallmark of the aging process. We and others have previously shown that maintenance of proteostasis is a shared characteristic of slowed-aging models. Rapamycin (Rap) exerts sex-specific effects on murine lifespan, but the combination of Rap with the anti-hyperglycemic drug metformin (...

journal_title：GeroScience

authors： Wolff CA,Lawrence MM,Porter H,Zhang Q,Reid JJ,Laurin JL,Musci RV,Linden MA,Peelor FF 3rd,Wren JD,Creery JS,Cutler KJ,Carson RH,Price JC,Hamilton KL,Miller BF

更新日期：2020-08-05 00:00:00

abstract：:The understanding of how aging contributes to dementia remains obscure. To address this problem, a chemical biology approach was used employing CAD031, an Alzheimer's disease (AD) drug candidate identified using a discovery platform based upon phenotypic screens that mimic toxicities associated with the aging brain. S...

journal_title：GeroScience

authors： Currais A,Huang L,Petrascheck M,Maher P,Schubert D

更新日期：2020-07-23 00:00:00

abstract：:An increase in the burden of senescent cells in tissues with age contributes to driving aging and the onset of age-related diseases. Genetic and pharmacologic elimination of senescent cells extends both health span and life span in mouse models. Heterochronic parabiosis in mice has been used to identify bloodborne, ci...

journal_title：GeroScience

authors： Yousefzadeh MJ,Wilkinson JE,Hughes B,Gadela N,Ladiges WC,Vo N,Niedernhofer LJ,Huffman DM,Robbins PD

更新日期：2020-06-01 00:00:00

abstract：:Damage to DNA is especially important for aging. High DNA repair could contribute, in principle, to lower such damage in long-lived species. However, previous studies showed that repair of endogenous damage to nuclear DNA (base excision repair, BER) is negatively or not correlated with mammalian longevity. However, we...

journal_title：GeroScience

authors： Gredilla R,Sánchez-Román I,Gómez A,López-Torres M,Barja G

更新日期：2020-04-01 00:00:00

abstract：:Age-related muscle weakness and loss of muscle mass (sarcopenia) is a universal problem in the elderly. Our previous studies indicate that alpha motor neurons (α-MNs) play a critical role in this process. The goal of the current study is to uncover changes in the aging spinal cord that contribute to loss of innervatio...

journal_title：GeroScience

authors： Piekarz KM,Bhaskaran S,Sataranatarajan K,Street K,Premkumar P,Saunders D,Zalles M,Gulej R,Khademi S,Laurin J,Peelor R,Miller BF,Towner R,Van Remmen H

更新日期：2020-04-01 00:00:00

abstract：:Cytomegalovirus (CMV) is one of the largest and most ubiquitous latent persistent viruses. Most humans are infected with CMV early in life, and all immunocompetent humans spend several decades living with CMV. In the vast majority of the hosts, CMV does not cause manifest disease, and CMV therefore can be considered p...

journal_title：GeroScience

authors： Nikolich-Žugich J,Čicin-Šain L,Collins-McMillen D,Jackson S,Oxenius A,Sinclair J,Snyder C,Wills M,Lemmermann N

更新日期：2020-04-01 00:00:00

abstract：:The loss of vacuolar/lysosomal acidity is an early event during aging that has been linked to mitochondrial dysfunction. However, it is unclear how loss of vacuolar acidity results in age-related dysfunction. Through unbiased genetic screens, we determined that increased iron uptake can suppress the mitochondrial resp...

journal_title：GeroScience

authors： Chen KL,Ven TN,Crane MM,Brunner MLC,Pun AK,Helget KL,Brower K,Chen DE,Doan H,Dillard-Telm JD,Huynh E,Feng YC,Yan Z,Golubeva A,Hsu RA,Knight R,Levin J,Mobasher V,Muir M,Omokehinde V,Screws C,Tunali E,Tran RK,

更新日期：2020-04-01 00:00:00

abstract：:Beta-secretase (BACE1) is a key enzyme in the formation of amyloid-β; its activity/concentration is increased in brain and cerebrospinal fluid of patients with late-onset Alzheimer's disease (LOAD). Since BACE1 was found also in blood, we evaluated its potential as peripheral biomarker. To this aim, serum BACE1 activi...

journal_title：GeroScience

authors： Cervellati C,Trentini A,Rosta V,Passaro A,Bosi C,Sanz JM,Bonazzi S,Pacifico S,Seripa D,Valacchi G,Guerini R,Zuliani G

更新日期：2020-02-01 00:00:00

abstract：:Adjustment of cerebral blood flow (CBF) to the increased oxygen and nutrient demands of active brain regions via neurovascular coupling (NVC) has an essential role in maintenance of healthy cognitive function. In advanced age, cerebromicrovascular oxidative stress and endothelial dysfunction impair neurovascular coupl...

journal_title：GeroScience

authors： Wiedenhoeft T,Tarantini S,Nyúl-Tóth Á,Yabluchanskiy A,Csipo T,Balasubramanian P,Lipecz A,Kiss T,Csiszar A,Csiszar A,Ungvari Z

更新日期：2019-12-01 00:00:00

abstract：:In the last several years, numerous molecules derived from plants and vegetables have been tested for their antioxidant, anti-inflammatory, and anti-aging properties. One of them is sulforaphane (SFN), an isothiocyanate present in cruciferous vegetables. SFN activates the antioxidant and anti-inflammatory responses by...

journal_title：GeroScience

authors： Santín-Márquez R,Alarcón-Aguilar A,López-Diazguerrero NE,Chondrogianni N,Königsberg M

更新日期：2019-10-01 00:00:00

abstract：:Inhibition of mTOR signaling using rapamycin has been shown to increase lifespan and healthspan in multiple model organisms; however, the precise mechanisms for the beneficial effects of rapamycin remain uncertain. We have previously reported that rapamycin delays senescence in human cells and that enhanced mitochondr...

journal_title：GeroScience

authors： Nacarelli T,Azar A,Altinok O,Orynbayeva Z,Sell C

更新日期：2018-06-21 00:00:00

abstract：:The original version of this article unfortunately contained an error. ...

journal_title：GeroScience

authors： Lewis KN,Rubinstein ND,Buffenstein R

更新日期：2018-06-01 00:00:00

abstract：:Advances in breast cancer treatment have markedly increased survivorship over the past three decades, with over 3.1 million survivors expected to live into their 70s and 80s. Without symptom relief interventions, nearly 35% of these survivors will have life-altering and distressing cognitive symptoms. This pilot study...

journal_title：GeroScience

authors： Carlson BW,Craft MA,Carlson JR,Razaq W,Deardeuff KK,Benbrook DM

更新日期：2018-06-01 00:00:00

abstract：:The Geropathology Grading Platform (GGP) that is being developed by the Geropathology Research Network provides a grading system that allows investigators to assess biological aging in mice by measuring the pathological status of a wide range of tissues in a standardized scoring system. The GGP is a grading system tha...

journal_title：GeroScience

authors： Snider TA,Richardson A,Stoner JA,Deepa SS

更新日期：2018-04-01 00:00:00

abstract：:Cognitive function declines substantially with age in both humans and animal models. In humans, this decline is associated with decreases in independence and quality of life. Although the methodology for analysis of cognitive function in human models is relatively well established, similar analyses in animal models ha...

journal_title：GeroScience

authors： Logan S,Owen D,Chen S,Chen WJ,Ungvari Z,Farley J,Csiszar A,Sharpe A,Loos M,Koopmans B,Richardson A,Sonntag WE

更新日期：2018-04-01 00:00:00

abstract：:The original version of this article unfortunately contained a mistake. ...

journal_title：GeroScience

authors： Shi J,Zhang B,Choi JY,Gao YT,Li H,Lu W,Long J,Kang D,Xiang YB,Wen W,Park SK,Ye X,Noh DY,Zheng Y,Wang Y,Chung S,Lin X,Cai Q,Shu XO

更新日期：2018-02-01 00:00:00

abstract：:Sepsis-associated encephalopathy (SAE) induces neuroinflammation, which is associated with cognitive impairment (CI). CI is also correlated with aging. We used contrast-enhanced magnetic resonance imaging (MRI), perfusion MRI, and MR spectroscopy to assess long-term alterations in BBB permeability, microvascularity, a...

journal_title：GeroScience

authors： Towner RA,Saunders D,Smith N,Towler W,Cruz M,Do S,Maher JE,Whitaker K,Lerner M,Morton KA

更新日期：2018-02-01 00:00:00

abstract：:Interventions that target biological mechanisms of aging have great potential to enhance quality of life by delaying morbidity and mortality. The FDA-approved drug rapamycin is a compelling candidate for such an intervention. In a previous study, it was reported that 3 months of rapamycin treatment is sufficient to in...

journal_title：GeroScience

authors： An JY,Quarles EK,Mekvanich S,Kang A,Liu A,Santos D,Miller RA,Rabinovitch PS,Cox TC,Kaeberlein M

更新日期：2017-08-01 00:00:00

abstract：:Hypertension in the elderly substantially increases both the risk of vascular cognitive impairment (VCI) and Alzheimer's disease (AD); however, the underlying mechanisms are not completely understood. This review discusses the effects of hypertension on structural and functional integrity of cerebral microcirculation,...

journal_title：GeroScience

authors： Csiszar A,Tarantini S,Fülöp GA,Kiss T,Valcarcel-Ares MN,Galvan V,Ungvari Z,Yabluchanskiy A

更新日期：2017-08-01 00:00:00

abstract：:Human cytomegalovirus (CMV) is one of the largest viruses known to cause human diseases. Chronic CMV infection, as defined by anti-CMV IgG serology, increases with age and is highly prevalent in older adults. It has complex biology with significant immunologic and health consequences. This article aims to summarize re...

journal_title：GeroScience

authors： Leng SX,Kamil J,Purdy JG,Lemmermann NA,Reddehase MJ,Goodrum FD

更新日期：2017-06-01 00:00:00

abstract：:Post-reproductive lifespan varies greatly among species; human post-reproductive lifespan comprises ~30-50% of their total longevity, while semelparous salmon and dasyurid marsupials post-reproductive lifespan comprises <4% of their total longevity. To examine if the magnitude of hypothalamic-pituitary-gonadal (HPG) a...

journal_title：GeroScience

authors： Atwood CS,Hayashi K,Meethal SV,Gonzales T,Bowen RL

更新日期：2017-02-01 00:00:00

abstract：:Growth hormone receptor knockout mice (GHRKO) are characterized by high insulin sensitivity and extended lifespan. Interestingly, the secretory activity of visceral fat in GHRKO mice is altered, stimulating whole body insulin sensitivity. In this study, we transplanted normal (N) mice with visceral fat pads from GHRKO...

journal_title：GeroScience

authors： Bennis MT,Schneider A,Victoria B,Do A,Wiesenborn DS,Spinel L,Gesing A,Kopchick JJ,Siddiqi SA,Masternak MM

更新日期：2017-02-01 00:00:00