abstract：INTRODUCTION:Hypophosphatasia (HPP) is caused by mutations in the ALPL that encodes the tissue-nonspecific isoenzyme of alkaline phosphatase (ALP). Clinical manifestations range from extreme life-threatening lethal forms to no signs or symptoms at all. MATERIALS AND METHODS:Consecutive 30,000 outpatients and inpatient...

journal_title：Journal of bone and mineral metabolism

authors： İnci A,Ergin FBC,Yüce BT,Çiftçi B,Demir E,Buyan N,Okur İ,Biberoğlu G,Öktem RM,Tümer L,Ezgü FS

更新日期：2021-01-06 00:00:00

abstract：INTRODUCTION:Etelcalcetide binds to the extracellular domain of the calcium-sensing receptor (CaSR), while cinacalcet binds to the 7-transmembrane domain of the CaSR; however, it is unknown, whether etelcalcetide has similar effects to cinacalcet on parathyroid hormone (PTH) secretion. MATERIALS AND METHODS:The PTH-ca...

journal_title：Journal of bone and mineral metabolism

authors： Hayashi N,Imanishi Y,Hirakawa T,Kobayashi I,Tateishi T,Miyaoka D,Nagata Y,Mori K,Morioka T,Inoue A,Harada K,Inaba M,Emoto M

更新日期：2020-11-16 00:00:00

abstract：INTRODUCTION:Very few studies have been performed to evaluate both the severity and site of aortic calcification (AC) in both end-stage kidney disease (ESKD) and diabetes mellitus (DM). The purpose of our study was to examine the utility of a newly developed three-dimensional (3D) visualization and quantification metho...

journal_title：Journal of bone and mineral metabolism

authors： Fujii H,Kono K,Watanabe K,Goto S,Nishii T,Kono A,Nishi S

更新日期：2020-11-03 00:00:00

abstract：:Accumulating evidence has shown that patients with lifestyle diseases such as type 2 diabetes mellitus, chronic kidney disease, and chronic obstructive pulmonary disease are at increased risk of osteoporotic fracture. Fractures deteriorate quality of life, activities of daily living, and mortality as well as a lifesty...

journal_title：Journal of bone and mineral metabolism

authors： Kanazawa I,Inaba M,Inoue D,Uenishi K,Saito M,Shiraki M,Suzuki A,Takeuchi Y,Hagino H,Fujiwara S,Sugimoto T,from the Japan Osteoporosis Society Lifestyle diseases-related Fracture Risk Investigation Committee.

更新日期：2020-11-01 00:00:00

abstract：INTRODUCTION:Surgical treatment in patients with medication-related osteonecrosis of the jaw (MRONJ) is superior to conservative treatment. However, treatment outcome in patients with periosteal reaction (PR) was significantly poorer than that of those without PR. The purpose of this retrospective study was to analyze ...

journal_title：Journal of bone and mineral metabolism

authors： Soutome S,Yanamoto S,Sumi M,Hayashida S,Kojima Y,Sawada S,Rokutanda S,Iwai H,Saito T,Umeda M

更新日期：2020-10-12 00:00:00

abstract：INTRODUCTION:The specific aims of the study were to compare possible differences in sclerostin and preadipocyte factor-1 (Pref-1) between rhythmic gymnasts (RG), swimmers (SW) and untrained controls (UC), and to investigate the relationships of sclerostin and Pref-1 with bone mineral characteristics in studied groups. ...

journal_title：Journal of bone and mineral metabolism

authors： Jürimäe J,Karvelyte V,Remmel L,Tamm AL,Purge P,Gruodyte-Raciene R,Kamandulis S,Maasalu K,Gracia-Marco L,Tillmann V

更新日期：2020-09-02 00:00:00

abstract：INTRODUCTION:Aromatase inhibitors are known to accelerate bone loss in patients with breast cancer. However, how much AIs affect the efficacy of antiresorptive agents has not been studied. The study aimed to compare the effect of alendronate on bone mineral density (BMD) between patients with and without AI treatment. ...

journal_title：Journal of bone and mineral metabolism

authors： Kong SH,Kim JH,Kim SW,Shin CS

更新日期：2020-09-01 00:00:00

abstract：INTRODUCTION:Data is currently lacking regarding association between the cholecystectomy/hepatectomy/pancreatectomy and the development of osteoporotic fracture. A retrospective cohort study was conducted to investigate the relationship between cholecystectomy/hepatectomy/pancreatectomy and the subsequent risk of devel...

journal_title：Journal of bone and mineral metabolism

authors： Cheng WZ,Lin YL,Su YC,Lin MC,Tseng CH,Lin RM,Huang ST

更新日期：2020-08-05 00:00:00

abstract：INTRODUCTION:Cold intolerance is defined as abnormal pain resulting from exposure to cold stimulation after trauma. However, the pathophysiology remains unclear. We recently demonstrated that regional osteoporotic changes accompanied by high bone turnover were involved in causing pain-like behaviors in the unloaded hin...

journal_title：Journal of bone and mineral metabolism

authors： Ibe K,Iba K,Hanaka M,Kiyomoto K,Hayakawa H,Teramoto A,Emori M,Yamashita T

更新日期：2020-07-01 00:00:00

abstract：INTRODUCTION:Previous studies have reported that the peak in lean body mass (LBM) precedes the peak in bone mineral content (BMC). However, it is unknown whether the trunk region growth is similar. MATERIALS AND METHODS:We investigated the difference between pubertal peak age in the increase of LBM in the trunk (trunk...

journal_title：Journal of bone and mineral metabolism

authors： Takei S,Taketomi S,Tanaka S,Torii S

更新日期：2020-05-01 00:00:00

abstract：INTRODUCTION:This study aimed to examine long-term persistence in new users of oral bisphosphonates in a population-wide cohort in Manitoba, Canada. MATERIALS AND METHODS:A longitudinal observational study was conducted using administrative health data characterizing long-term bisphosphonate persistence in those who s...

journal_title：Journal of bone and mineral metabolism

authors： Friesen KJ,Bugden S,Falk J

更新日期：2020-05-01 00:00:00

abstract：:Positive associations between vitamin D levels and hand grip strength have been reported worldwide, but the results are not consistent and few studies on East Asian populations have been published. The aim of this study was to determine whether such an association is present in a community-dwelling Japanese population...

journal_title：Journal of bone and mineral metabolism

authors： Kitsu T,Kabasawa K,Ito Y,Kitamura K,Watanabe Y,Tanaka J,Nakamura K,Narita I

更新日期：2020-03-01 00:00:00

abstract：:Sarcopenia is an age-related loss of skeletal muscle mass and strength. It has been widely recognized that low muscle mass was essential in the diagnosis of sarcopenia, whereas recent studies have emphasized the importance of muscle strength. In practice, muscle quality as well as muscle mass might determine the stren...

journal_title：Journal of bone and mineral metabolism

authors： Yakabe M,Hosoi T,Akishita M,Ogawa S

更新日期：2020-01-01 00:00:00

abstract：:Osteoporosis is the most common bone disease in humans. During bone remodeling, specialized blood vessels influenced by the endothelial cells (CD31hiEmcnhi, also called type H cells) are formatted to supply nutrients. Reductions in vascular supply are associated with bone loss resulting in osteoporosis. Therefore, the...

journal_title：Journal of bone and mineral metabolism

authors： Zhu Y,Ruan Z,Lin Z,Long H,Zhao R,Sun B,Cheng L,Tang L,Xia Z,Li C,Zhao S

更新日期：2019-11-01 00:00:00

abstract：:The MOVEMENT study was designed to assess the effectiveness of monthly intravenous ibandronate on bone mineral density (BMD) in daily clinical practice in Japanese patients with primary osteoporosis whose lumbar spine BMD did not increase despite oral bisphosphonate therapy. This study was a multicenter, prospective, ...

journal_title：Journal of bone and mineral metabolism

authors： Hagino H,Sakai A,Ikeda S,Imanishi Y,Tsurukami H,Nakajo S,Miyakoshi N

更新日期：2019-11-01 00:00:00

abstract：INTRODUCTION:Physical activity (PA) is a key factor of bone mass acquisition in peripubertal children. Sedentary behavior (SB) has been shown to influence bone outcomes. This study aimed to examine the association between objectively measured PA and SB and bone stiffness in Japanese children. MATERIALS AND METHODS:Par...

journal_title：Journal of bone and mineral metabolism

authors： Yamakita M,Ando D,Akiyama Y,Sato M,Suzuki K,Yamagata Z

更新日期：2019-11-01 00:00:00

abstract：:This study aimed to estimate the prevalence of locomotive syndrome, sarcopenia, and frailty and clarify their co-existence in a population-based cohort. The third survey of Research on Osteoarthritis/Osteoporosis Against Disability (ROAD) study was conducted between 2012 and 2013, examining 963 subjects (aged ≥ 60 yea...

journal_title：Journal of bone and mineral metabolism

authors： Yoshimura N,Muraki S,Iidaka T,Oka H,Horii C,Kawaguchi H,Akune T,Nakamura K,Tanaka S

更新日期：2019-11-01 00:00:00

abstract：:In end-stage osteoarthritis (OA) of the hip, the effect of bone metabolism with and without cartilage is unclear. In this study, we aimed to investigate histomorphology and microdamage in the subchondral bone of the femoral head in areas with and without articular cartilage in patients with end-stage OA. Nineteen femo...

journal_title：Journal of bone and mineral metabolism

authors： Shimamura M,Iwata K,Mashiba T,Miki T,Yamamoto T

更新日期：2019-09-01 00:00:00

abstract：:Osteonecrosis of the jaw (ONJ) associated with bisphosphonate therapy is a rare but severe side effect in osteoporosis patients. Recently, the number of osteoporosis patients with ONJ has dramatically increased in Japan. This has contributed to an increase in the number of patients avoiding extractions. However, there...

journal_title：Journal of bone and mineral metabolism

authors： Taguchi A,Uemura Y,Imai T,Tanaka S,Ohta H,Nakamura T,Orimo H,Sugimoto T,Soen S,Shiraki M,Adequate Treatment of Osteoporosis (A-TOP) research group.

更新日期：2019-09-01 00:00:00

abstract：:Aromatase inhibitors (AIs) are the gold standard therapy for breast cancer in postmenopausal women. AI suppresses the conversion of androgens to estrogens; however, this results in osteopenia, osteoporosis, and bone fracture, thus reducing the patient's quality of life. The use of adjuvant denosumab reduces the risk o...

journal_title：Journal of bone and mineral metabolism

authors： Nakatsukasa K,Koyama H,Ouchi Y,Sakaguchi K,Fujita Y,Matsuda T,Kato M,Konishi E,Taguchi T

更新日期：2019-09-01 00:00:00

abstract：:The effects of catecholamine excess due to pheochromocytoma on body composition, including skeletal muscle mass, are unknown. Here, we investigated the effects of catecholamine metabolites on body composition in subjects with pheochromocytoma. After body compositions using bioelectrical impedance analysis, urinary met...

journal_title：Journal of bone and mineral metabolism

authors： Lee SH,Kwak MK,Ahn SH,Kim H,Cho YY,Suh S,Song KH,Koh JM,Kim JH,Kim BJ

更新日期：2019-07-01 00:00:00

abstract：:In the course of complex regional pain syndrome (CRPS), local osteopenia in the subchondral/subcortical areas of the affected limb represents a central manifestation. Mechanistic aspects of CRPS-associated pathologies remain unclear, and knowledge about bone morphology in CRPS-affected areas is rare. The aim of this s...

journal_title：Journal of bone and mineral metabolism

authors： Oehler N,Rolvien T,Schmidt T,Butscheidt S,Oheim R,Barvencik F,Mussawy H

更新日期：2019-07-01 00:00:00

abstract：:The aim of this study was to survey the incidence of osteoporotic fragility fractures, which include vertebral, hip, distal radius, and proximal humerus fractures, in patients ≥ 50 years of age, from 2004 to 2015, in Sado City, Japan. We examined temporal changes in the incidence of these fractures from 2010 through 2...

journal_title：Journal of bone and mineral metabolism

authors： Imai N,Endo N,Shobugawa Y,Oinuma T,Takahashi Y,Suzuki K,Ishikawa Y,Makino T,Suzuki H,Miyasaka D,Sakuma M

更新日期：2019-05-01 00:00:00

abstract：:Metformin, an anti-hyperglycemic agent used for type 2 diabetes, has recently been found to have more effects apart from glucose regulation. We found that, in ultra-high-molecular-weight polyethylene particle-induced osteolysis mouse models, metformin had bone protect property and reduced the negative regulator of bon...

journal_title：Journal of bone and mineral metabolism

authors： Yan Z,Zhu S,Tian X,Ye Z,Zhai D,Zhu Z,Wei D,Zhu Q,Lu Z,Cao X

更新日期：2019-05-01 00:00:00

abstract：:A link between vascular calcification and bone anomalies has been suggested in chronic kidney disease (CKD) patients with low bone turnover disease. We investigated the vascular expression of osteocyte markers in relation to bone microarchitecture and mineralization defects in a model of low bone turnover CKD rats wit...

journal_title：Journal of bone and mineral metabolism

authors： Bisson SK,Ung RV,Picard S,Valade D,Agharazii M,Larivière R,Mac-Way F

更新日期：2019-03-01 00:00:00

abstract：:Skull changes are poorly described in vitamin D insufficiency [serum 25-hydroxyvitamin D (s-25(OH)D) 25-50 nmol/L]. We aimed to investigate factors associated with cranial anthropometrics in infants, especially s-25(OH)D. In infants 2.5-6 months old from the Odense Child Cohort, associations between cord and pregnancy...

journal_title：Journal of bone and mineral metabolism

authors： Egge S,Christensen N,Lykkedegn S,Jensen TK,Christesen HT

更新日期：2018-11-01 00:00:00

abstract：:This study aimed to identify the osteogenesis effect of icariside II (ICSII) and icaritin (ICT) in vitro. Bone marrow mesenchymal stem cells (BMSCs) were treated with ICSII and ICT in order to detect the proliferation and differentiation of BMSCs, the expression of the osteogenesis-related proteins with or without ost...

journal_title：Journal of bone and mineral metabolism

authors： Luo G,Xu B,Wang W,Wu Y,Li M

更新日期：2018-11-01 00:00:00

abstract：:Osteocytes form a three-dimensional (3D) cellular network within the mineralized bone matrix. The cellular network has important roles in mechanosensation and mechanotransduction related to bone homeostasis. We visualized the embedded osteocyte network in chick calvariae and observed the flow-induced Ca2+ signaling in...

journal_title：Journal of bone and mineral metabolism

authors： Tanaka T,Hoshijima M,Sunaga J,Nishida T,Hashimoto M,Odagaki N,Osumi R,Aadachi T,Kamioka H

更新日期：2018-09-01 00:00:00

abstract：:The aim of this observational, non-randomized study was to clarify the unknown effects of switching oral bisphosphonates (BPs) to denosumab (DMAb) or daily teriparatide (TPTD) in patients with rheumatoid arthritis (RA). The characteristics of the 194 female patients included in the study were 183 postmenopausal, age 6...

journal_title：Journal of bone and mineral metabolism

authors： Ebina K,Hirao M,Hashimoto J,Hagihara K,Kashii M,Kitaguchi K,Matsuoka H,Iwahashi T,Chijimatsu R,Yoshikawa H

更新日期：2018-07-01 00:00:00

abstract：:Bone loss varies according to disease and age and these variations affect bone cells and extracellular matrix. Osteoporosis rat models are widely investigated to assess mechanical and structural properties of bone; however, bone matrix proteins and their discrepant regulation of diseased and aged bone are often overlo...

journal_title：Journal of bone and mineral metabolism

authors： Daghma DES,Malhan D,Simon P,Stötzel S,Kern S,Hassan F,Lips KS,Heiss C,El Khassawna T

更新日期：2018-05-01 00:00:00

abstract：:This study aimed to explore the effects of additional weight bearing in combination with low-magnitude high-frequency vibration (LMHFV; 45 Hz, 0.3 g) on bone quality. One hundred twenty rats were randomly divided into ten groups; namely, sedentary (SED), additional weight bearing in which the rat wears a backpack whos...

journal_title：Journal of bone and mineral metabolism

authors： Zhang T,Gao J,Fang J,Gong H

更新日期：2018-03-01 00:00:00

abstract：:Knowledge of the microenvironment of articular cartilage in health and disease is the key to accomplishing fundamental disease-modifying treatments for osteoarthritis. The proteins comprising the CCN Family are matricellular proteins with a remarkable relevance within the context of cartilage metabolism. CCN2 displays...

journal_title：Journal of bone and mineral metabolism

authors： Janune D,Abd El Kader T,Aoyama E,Nishida T,Tabata Y,Kubota S,Takigawa M

更新日期：2017-11-01 00:00:00

abstract：:In order to explore the effects of calcitonin gene-related peptide (CGRP) on bone mesenchymal stem cells (BMSCs) from ovariectomized (OVX) rats, an OVX rat model was used. An ELISA was performed to examine the changes in CGRP level in the plasma and skeleton. The BMSCs from the sham rats were designated group A. The B...

journal_title：Journal of bone and mineral metabolism

authors： Chen J,Ma G,Liu W,Liu Y,Ding Y

更新日期：2017-09-01 00:00:00

abstract：:Chronic kidney disease (CKD) mineral and bone disorders (CKD-MBD) may lead to low bone mineral density (BMD) and vascular calcification (VC), but links to the latter are unclear. Here we investigated associations between BMD, coronary artery calcium (CAC) scores, and histological signs of VC in end-stage renal disease...

journal_title：Journal of bone and mineral metabolism

authors： Chen Z,Sun J,Haarhaus M,Barany P,Wennberg L,Ripsweden J,Brismar TB,Lindholm B,Wernerson A,Söderberg M,Stenvinkel P,Qureshi AR

更新日期：2017-09-01 00:00:00

abstract：:Digital X-ray radiogrammetry (DXR) is a computer-assisted diagnosis technique for quantifying cortical hand bone mineral density (BMD) as well as the metacarpal index (MCI) in the metacarpal bones from radiographs. The objective was to compare DXR-BMD and DXR-MCI between healthy individuals and patients with rheumatoi...

journal_title：Journal of bone and mineral metabolism

authors： Pfeil A,Haugeberg G,Renz DM,Reinhardt L,Jung C,Franz M,Wolf G,Böttcher J

更新日期：2017-03-01 00:00:00

abstract：:Different model systems using osteoblastic cell lines have been developed to help understand the process of bone formation. Here, we report the establishment of two human osteoblastic cell lines obtained from primary cultures upon transduction of immortalizing genes. The resulting cell lines had no major differences t...

journal_title：Journal of bone and mineral metabolism

authors： Pérez-Campo FM,May T,Zauers J,Sañudo C,Delgado-Calle J,Arozamena J,Berciano MT,Lafarga M,Riancho JA

更新日期：2017-03-01 00:00:00

abstract：:Bone mass acquisition may be compromised in survivors of childhood acute lymphocytic leukemia due to various factors, including adiposity. Fat accumulation can affect bone through the direct effect of adipokines or indirectly through the state of chronic inflammation. The aim of this study was to evaluate the effect o...

journal_title：Journal of bone and mineral metabolism

authors： Siviero-Miachon AA,Spinola-Castro AM,de Martino Lee ML,Calixto AR,Geloneze B,Lazaretti-Castro M,Guerra-Junior G

更新日期：2017-01-01 00:00:00

abstract：:We investigated the combinatorial effects of whole-body vertical vibration (WBVV) with the primarily osteoanabolic parathyroid hormone (PTH) and the mainly antiresorptive strontium ranelate (SR) in a rat model of osteoporosis. Ovariectomies were performed on 76 three-month-old Sprague-Dawley rats (OVX, n = 76; NON-OVX...

journal_title：Journal of bone and mineral metabolism

authors： Hoffmann DB,Sehmisch S,Hofmann AM,Eimer C,Komrakova M,Saul D,Wassmann M,Stürmer KM,Tezval M

更新日期：2017-01-01 00:00:00

abstract：:Fracture healing is a complex biological process involving the proliferation of mesenchymal progenitor cells, and chondrogenic, osteogenic, and angiogenic differentiation. The mechanisms underlying the proliferation and differentiation of mesenchymal progenitor cells remain unclear. Here, we demonstrate Dickkopf-relat...

journal_title：Journal of bone and mineral metabolism

authors： Mori Y,Adams D,Hagiwara Y,Yoshida R,Kamimura M,Itoi E,Rowe DW

更新日期：2016-11-01 00:00:00

abstract：:Metabolic bone disease may appear as a complication of obesity surgery. Because an imbalance in the osteoprotegerin and receptor-activator of nuclear factor-κB ligand system may underlie osteoporosis, we aimed to study this system in humans in the metabolic bone disease occurring after obesity surgery. In this study w...

journal_title：Journal of bone and mineral metabolism

authors： Balsa JA,Lafuente C,Gómez-Martín JM,Galindo J,Peromingo R,García-Moreno F,Rodriguez-Velasco G,Martínez-Botas J,Gómez-Coronado D,Escobar-Morreale HF,Botella-Carretero JI

更新日期：2016-11-01 00:00:00