解剖学和形态学

男科学

听力与言语-语言病理学

行为科学

细胞和组织工程学

牙科,口腔外科和医学

皮肤病学

肠胃学和肝脏学

医学伦理学

医学实验室技术

医学,法律

神经影像学

护理

产科医学和妇科医学

周围血管疾病

基本医疗保健

放射学,核医学和医学成像

康复学

兽医学

伦理学

老年医学

心理学,精神分析

你正在浏览RESPIRATORY RESEARCH期刊下所有文献
  • Idiopathic pulmonary fibrosis patients with severe physiologic impairment: characteristics and outcomes.

    abstract:RESEARCH QUESTION:There is no widely accepted grading system for IPF disease severity, although physiologic impairment based on pulmonary function testing is frequently employed. We sought to describe clinical and functional characteristics as well as outcomes of patients with severe physiologic impairment. PATIENTS A...

    journal_title:Respiratory research

    pub_type: 杂志文章

    doi:10.1186/s12931-020-01600-z

    authors: Pastre J,Barnett S,Ksovreli I,Taylor J,Brown AW,Shlobin OA,Ahmad K,Khangoora V,Aryal S,King CS,Nathan SD

    更新日期:2021-01-06 00:00:00

  • Airway regulatory T cells are decreased in COPD with a rapid decline in lung function.

    abstract:BACKGROUND:Differences in the expression of regulatory T cells (Tregs) have been suggested to explain why some smokers develop COPD and some do not. Upregulation of Tregs in response to smoking would restrain airway inflammation and thus the development of COPD; while the absense of such upregulation would over time le...

    journal_title:Respiratory research

    pub_type: 杂志文章

    doi:10.1186/s12931-020-01593-9

    authors: Eriksson Ström J,Pourazar J,Linder R,Blomberg A,Lindberg A,Bucht A,Behndig AF

    更新日期:2020-12-14 00:00:00

  • Five novel clinical phenotypes for critically ill patients with mechanical ventilation in intensive care units: a retrospective and multi database study.

    abstract:BACKGROUND:Although protective mechanical ventilation (MV) has been used in a variety of applications, lung injury may occur in both patients with and without acute respiratory distress syndrome (ARDS). The purpose of this study is to use machine learning to identify clinical phenotypes for critically ill patients with...

    journal_title:Respiratory research

    pub_type: 杂志文章

    doi:10.1186/s12931-020-01588-6

    authors: Su L,Zhang Z,Zheng F,Pan P,Hong N,Liu C,He J,Zhu W,Long Y,Liu D

    更新日期:2020-12-10 00:00:00

  • Serum surfactant protein D as a predictive biomarker for the efficacy of pirfenidone in patients with idiopathic pulmonary fibrosis: a post-hoc analysis of the phase 3 trial in Japan.

    abstract:BACKGROUND:Idiopathic pulmonary fibrosis (IPF) is a progressive, fatal disorder with a variable disease course. The recent advancement of antifibrotic therapy has increased the need for reliable and specific biomarkers. This study aimed to assess alveolar epithelial biomarkers as predictors for the efficacy of the anti...

    journal_title:Respiratory research

    pub_type: 杂志文章

    doi:10.1186/s12931-020-01582-y

    authors: Ikeda K,Chiba H,Nishikiori H,Azuma A,Kondoh Y,Ogura T,Taguchi Y,Ebina M,Sakaguchi H,Miyazawa S,Suga M,Sugiyama Y,Nukiwa T,Kudoh S,Takahashi H,Pirfenidone Clinical Study Group in Japan.

    更新日期:2020-11-30 00:00:00

  • Analysis of body mass index, weight loss and progression of idiopathic pulmonary fibrosis.

    abstract:BACKGROUND:Nintedanib is an approved therapy for idiopathic pulmonary fibrosis (IPF). Some patients treated with nintedanib experience weight loss. Exploratory data suggest that low body mass index or weight loss are associated with worse outcomes in patients with IPF. We investigated whether BMI at baseline or weight ...

    journal_title:Respiratory research

    pub_type: 杂志文章

    doi:10.1186/s12931-020-01528-4

    authors: Jouneau S,Crestani B,Thibault R,Lederlin M,Vernhet L,Valenzuela C,Wijsenbeek M,Kreuter M,Stansen W,Quaresma M,Cottin V

    更新日期:2020-11-25 00:00:00

  • The efficacy of mesenchymal stromal cell-derived therapies for acute respiratory distress syndrome-a meta-analysis of preclinical trials.

    abstract:BACKGROUND:The investigation of mesenchymal stromal cell (MSC)-conditioned medium or extracellular vesicles (exosomes or microvesicles) as a remedy for acute lung injury (ALI) or acute respiratory distress syndrome (ARDS) has become a fast-growing field in recent years. Our purpose was to conduct a meta-analysis to inv...

    journal_title:Respiratory research

    pub_type: 杂志文章

    doi:10.1186/s12931-020-01574-y

    authors: Wang F,Fang B,Qiang X,Shao J,Zhou L

    更新日期:2020-11-20 00:00:00

  • Auxiliary diagnostic value of tumor biomarkers in pleural fluid for lung cancer-associated malignant pleural effusion.

    abstract:BACKGROUND:Pleural effusion (PE) can be divided into benign pleural effusion (BPE) and malignant pleural effusion (MPE). There is no consensus on the identification of lung cancer-associated MPE using the optimal cut-off levels from five common tumor biomarkers (CEA, CYFRA 21-1, CA125, SCC-Ag, and NSE). Therefore, we a...

    journal_title:Respiratory research

    pub_type: 杂志文章

    doi:10.1186/s12931-020-01557-z

    authors: Zhang H,Li C,Hu F,Zhang X,Shen Y,Chen Y,Li F

    更新日期:2020-10-29 00:00:00

  • Chronic exposure to ambient particulate matter induces gut microbial dysbiosis in a rat COPD model.

    abstract:BACKGROUND:The role of the microbiota in the pathogenesis of chronic obstructive pulmonary disease (COPD) following exposure to ambient particulate matter (PM) is largely unknown. METHODS:Fifty-four male Sprague-Dawley rats were exposed to clean air, biomass fuel (BMF), or motor vehicle exhaust (MVE) for 4, 12, and 24...

    journal_title:Respiratory research

    pub_type: 杂志文章

    doi:10.1186/s12931-020-01529-3

    authors: Li N,Yang Z,Liao B,Pan T,Pu J,Hao B,Fu Z,Cao W,Zhou Y,He F,Li B,Ran P

    更新日期:2020-10-19 00:00:00

  • CASCADE: a phase 2, randomized, double-blind, placebo-controlled, parallel-group trial to evaluate the effect of tezepelumab on airway inflammation in patients with uncontrolled asthma.

    abstract:BACKGROUND:Patients with severe, uncontrolled asthma, particularly those with a non-eosinophilic phenotype, have a great unmet need for new treatments that act on a broad range of inflammatory pathways in the airway. Tezepelumab is a human monoclonal antibody that blocks the activity of thymic stromal lymphopoietin, an...

    journal_title:Respiratory research

    pub_type: 杂志文章

    doi:10.1186/s12931-020-01513-x

    authors: Emson C,Diver S,Chachi L,Megally A,Small C,Downie J,Parnes JR,Bowen K,Colice G,Brightling CE

    更新日期:2020-10-13 00:00:00

  • COVID-19 multidisciplinary high dependency unit: the Milan model.

    abstract::COVID-19 is a complex and heterogeneous disease. The pathogenesis and the complications of the disease are not fully elucidated, and increasing evidence shows that SARS-CoV-2 causes a systemic inflammatory disease rather than a pulmonary disease. The management of hospitalized patients in COVID-19 dedicated units is a...

    journal_title:Respiratory research

    pub_type: 杂志文章,评审

    doi:10.1186/s12931-020-01516-8

    authors: Aliberti S,Amati F,Pappalettera M,Di Pasquale M,D'Adda A,Mantero M,Gramegna A,Simonetta E,Oneta AM,Privitera E,Gori A,Bozzi G,Peyvandi F,Minoia F,Filocamo G,Abbruzzese C,Vicenzi M,Tagliabue P,Alongi S,Blasi F

    更新日期:2020-10-09 00:00:00

  • Artificial intelligence accuracy in detecting pathological breath sounds in children using digital stethoscopes.

    abstract:BACKGROUND:Manual auscultation to detect abnormal breath sounds has poor inter-observer reliability. Digital stethoscopes with artificial intelligence (AI) could improve reliable detection of these sounds. We aimed to independently test the abilities of AI developed for this purpose. METHODS:One hundred and ninety two...

    journal_title:Respiratory research

    pub_type: 杂志文章

    doi:10.1186/s12931-020-01523-9

    authors: Kevat A,Kalirajah A,Roseby R

    更新日期:2020-09-29 00:00:00

  • Regulation of ATP binding cassette transporter A1 (ABCA1) expression: cholesterol-dependent and - independent signaling pathways with relevance to inflammatory lung disease.

    abstract::The role of the ATP binding cassette transporter A1 (ABCA1) in maintaining cellular lipid homeostasis in cardiovascular disease is well established. More recently, the important beneficial role played by ABCA1 in modulating pathogenic disease mechanisms, such as inflammation, in a broad range of chronic conditions has...

    journal_title:Respiratory research

    pub_type: 杂志文章,评审

    doi:10.1186/s12931-020-01515-9

    authors: He P,Gelissen IC,Ammit AJ

    更新日期:2020-09-25 00:00:00

  • Pentraxin 3 promotes airway inflammation in experimental asthma.

    abstract:BACKGROUND:Pentraxin 3 (PTX3) regulates multiple aspects of innate immunity and tissue inflammation. Recently, it has been reported that PTX3 deficiency enhances interleukin (IL)-17A-dominant pulmonary inflammation in an ovalbumin (OVA)-induced mouse asthma model. However, whether PTX3 treatment would provide protectio...

    journal_title:Respiratory research

    pub_type: 杂志文章

    doi:10.1186/s12931-020-01499-6

    authors: Gao P,Tang K,Lu Y,Huang Z,Wang S,Wang M,Wang J,Zhao J,Xie J

    更新日期:2020-09-16 00:00:00

  • Oxidative stress mediates the apoptosis and epigenetic modification of the Bcl-2 promoter via DNMT1 in a cigarette smoke-induced emphysema model.

    abstract:BACKGROUND:Emphysema is a crucial pathological characteristic of chronic obstructive pulmonary disease (COPD). Oxidative stress, apoptosis and epigenetic mechanisms contribute to the pathogenesis of emphysema. However, an attempt to accurately identify whether these mechanisms interact with each other and how they are ...

    journal_title:Respiratory research

    pub_type: 杂志文章

    doi:10.1186/s12931-020-01495-w

    authors: Zeng H,Li T,He X,Cai S,Luo H,Chen P,Chen Y

    更新日期:2020-09-03 00:00:00

  • Outcome measures for airway clearance techniques in children with chronic obstructive lung diseases: a systematic review.

    abstract:BACKGROUND:Airway clearance techniques (ACTs) are an important aspect of the treatment of children with chronic obstructive lung diseases. Unfortunately, a sound evidence base is lacking and airway clearance strategies are largely based on clinical expertise. One of the reasons for the limited evidence is the lack of a...

    journal_title:Respiratory research

    pub_type: 杂志文章,评审

    doi:10.1186/s12931-020-01484-z

    authors: Lauwers E,Ides K,Van Hoorenbeeck K,Verhulst S

    更新日期:2020-08-17 00:00:00

  • A comparison of four different models of acute respiratory distress syndrome in sheep.

    abstract:BACKGROUND:Acute respiratory distress syndrome (ARDS) can have various causes. The study objective was to investigate whether different pathophysiologic models of ARDS would show different respiratory, cardiovascular and inflammatory outcomes. METHODS:We performed a prospective, randomized study in 27 ventilated ewes ...

    journal_title:Respiratory research

    pub_type: 杂志文章

    doi:10.1186/s12931-020-01475-0

    authors: Engel M,Nowacki RME,Jonker EM,Ophelders D,Nikiforou M,Kloosterboer N,Zimmermann LJI,van Waardenburg DA,Kramer BW

    更新日期:2020-08-08 00:00:00

  • Impact of gastroesophageal reflux on longitudinal lung function and quantitative computed tomography in the COPDGene cohort.

    abstract:RATIONALE:Gastroesophageal reflux disease (GERD) is a common comorbidity in chronic obstructive pulmonary disease (COPD) and has been associated with increased risk of acute exacerbations, hospitalization, emergency room visits, costs, and quality-of-life impairment. However, it remains unclear whether GERD contributes...

    journal_title:Respiratory research

    pub_type: 杂志文章

    doi:10.1186/s12931-020-01469-y

    authors: Baldomero AK,Wendt CH,Petersen A,Gaeckle NT,Han MK,Kunisaki KM,COPDGene Investigators.

    更新日期:2020-08-03 00:00:00

  • Cell-specific expression of lung disease risk-related genes in the human small airway epithelium.

    abstract:BACKGROUND:The human small airway epithelium (SAE) plays a central role in the early events in the pathogenesis of most inherited and acquired lung disorders. Little is known about the molecular phenotypes of the specific cell populations comprising the SAE in humans, and the contribution of SAE specific cell populatio...

    journal_title:Respiratory research

    pub_type: 杂志文章

    doi:10.1186/s12931-020-01442-9

    authors: Zuo WL,Rostami MR,Shenoy SA,LeBlanc MG,Salit J,Strulovici-Barel Y,O'Beirne SL,Kaner RJ,Leopold PL,Mezey JG,Schymeinsky J,Quast K,Visvanathan S,Fine JS,Thomas MJ,Crystal RG

    更新日期:2020-07-29 00:00:00

  • ADAM15 expression is increased in lung CD8+ T cells, macrophages, and bronchial epithelial cells in patients with COPD and is inversely related to airflow obstruction.

    abstract:BACKGROUND:A disintegrin and metalloproteinase domain-15 (ADAM15) is expressed by activated leukocytes, and fibroblasts in vitro. Whether ADAM15 expression is increased in the lungs of COPD patients is not known. METHODS:ADAM15 gene expression and/or protein levels were measured in whole lung and bronchoalveolar lavag...

    journal_title:Respiratory research

    pub_type: 杂志文章

    doi:10.1186/s12931-020-01446-5

    authors: Wang X,Zhang D,Higham A,Wolosianka S,Gai X,Zhou L,Petersen H,Pinto-Plata V,Divo M,Silverman EK,Celli B,Singh D,Sun Y,Owen CA

    更新日期:2020-07-16 00:00:00

  • Relationship between age and bronchodilator response at diagnosis in adult-onset asthma.

    abstract:BACKGROUND:Possible variation in bronchodilator response (BDR) according to age at the diagnosis of adult-onset asthma is unknown. Our aim was to assess if BDR in FEV1 is related to age at diagnosis of adult-onset asthma and how many subjects fulfill the 400 mL criterion of BDR, the suggested cut-off for asthma-like re...

    journal_title:Respiratory research

    pub_type: 杂志文章

    doi:10.1186/s12931-020-01441-w

    authors: Tommola M,Won HK,Ilmarinen P,Jung H,Tuomisto LE,Lehtimäki L,Niemelä O,Kim TB,Kankaanranta H

    更新日期:2020-07-13 00:00:00

  • The need for fast-track, high-quality and low-cost studies about the role of the BCG vaccine in the fight against COVID-19.

    abstract::Bacillus Calmette-Guérin (BCG) vaccination is routine and near-universal in many low- and middle-income countries (LMIC). It has been suggested that BCG can have a protective effect on COVID-19 morbidity and mortality. This commentary discusses the limitations of the evidence around BCG and COVID-19. We argue that hig...

    journal_title:Respiratory research

    pub_type: 信件,评审

    doi:10.1186/s12931-020-01439-4

    authors: Pereira M,Paixão E,Trajman A,de Souza RA,da Natividade MS,Pescarini JM,Pereira SM,Barreto FR,Ximenes R,Dalcomo M,Ichihara MY,Nunes C,Barral-Netto M,Barreto ML

    更新日期:2020-07-11 00:00:00

  • Predictive factors of severe coronavirus disease 2019 in previously healthy young adults: a single-center, retrospective study.

    abstract:BACKGROUND:Several previously healthy young adults have developed Coronavirus Disease 2019 (COVID-19), and a few of them progressed to the severe stage. However, the factors are not yet determined. METHOD:We retrospectively analyzed 123 previously healthy young adults diagnosed with COVID-19 from January to March 2020...

    journal_title:Respiratory research

    pub_type: 杂志文章

    doi:10.1186/s12931-020-01412-1

    authors: Zhou C,Huang Z,Tan W,Li X,Yin W,Xiao Y,Tao Z,Geng S,Hu Y

    更新日期:2020-06-22 00:00:00

  • Weighted Epworth sleepiness scale predicted the apnea-hypopnea index better.

    abstract:BACKGROUND:The relationship between the Epworth sleepiness scale (ESS) and the apnea-hypopnea index (AHI) is uncertain and even poor. The major problem associated with the ESS might be a lack of consideration of weight in prediction in clinical practice. Would awarding different item-scores to the four scales of ESS it...

    journal_title:Respiratory research

    pub_type: 杂志文章

    doi:10.1186/s12931-020-01417-w

    authors: Guo Q,Song WD,Li W,Zeng C,Li YH,Mo JM,Lü ZD,Jiang M

    更新日期:2020-06-12 00:00:00

  • SN50 attenuates alveolar hypercoagulation and fibrinolysis inhibition in acute respiratory distress syndrome mice through inhibiting NF-κB p65 translocation.

    abstract:BACKGROUND:It has been confirmed that NF-κB p65 signaling pathway is involved in the regulation of alveolar hypercoagulation and fibrinolysis inhibition in acute respiratory distress syndrome (ARDS). Whether SN50, a NF-κB cell permeable inhibitor, could attenuate alveolar hypercoagulation and fibrinolysis inhibition in...

    journal_title:Respiratory research

    pub_type: 杂志文章

    doi:10.1186/s12931-020-01372-6

    authors: Wu Y,Wang Y,Liu B,Cheng Y,Qian H,Yang H,Li X,Yang G,Zheng X,Shen F

    更新日期:2020-05-27 00:00:00

  • IL-33, diet-induced obesity, and pulmonary responses to ozone.

    abstract:BACKGROUND:Obesity augments pulmonary responses to ozone. We have reported that IL-33 contributes to these effects of obesity in db/db mice. The purpose of this study was to determine whether IL-33 also contributes to obesity-related changes in the response to ozone in mice with diet-induced obesity. METHODS:Male wild...

    journal_title:Respiratory research

    pub_type: 杂志文章

    doi:10.1186/s12931-020-01361-9

    authors: Kasahara DI,Shore SA

    更新日期:2020-04-23 00:00:00

  • The unsynchronized changes of CT image and nucleic acid detection in COVID-19: reports the two cases from Gansu, China.

    abstract::The novel coronavirus disease (COVID-19) outbreak started in December 2019 in Wuhan, China, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The CT image is used to assess the disease progress, whereas the continued two times of negative results from SARS-CoV-2 nucleic acid detection had been co...

    journal_title:Respiratory research

    pub_type: 信件

    doi:10.1186/s12931-020-01363-7

    authors: Gao J,Liu JQ,Wen HJ,Liu H,Hu WD,Han X,Li CX,Wang XJ

    更新日期:2020-04-22 00:00:00

  • The influence of chlorine in indoor swimming pools on the composition of breathing phase of professional swimmers.

    abstract:OBJECTIVES:Swimming is one of the most popular forms of physical activity. Pool water is cleaned with chlorine, which - in combination with compounds contained in water - could form chloramines and trichloromethane in the swimmer's lungs. The aim of the present study was to examine the effect of swimming training in an...

    journal_title:Respiratory research

    pub_type: 杂志文章

    doi:10.1186/s12931-020-01350-y

    authors: Swinarew AS,Stanula AJ,Gabor J,Raif P,Paluch J,Karpiński J,Kubik K,Okła H,Ostrowski A,Tkacz E,Skoczyński S,Waśkiewicz Z,Rosemann T,Nikolaidis PT,Knechtle B

    更新日期:2020-04-15 00:00:00

  • Sputum and blood transcriptomics characterisation of the inhaled PDE4 inhibitor CHF6001 on top of triple therapy in patients with chronic bronchitis.

    abstract:BACKGROUND:Although phosphodiesterase-4 (PDE4) inhibitors have been shown to reduce COPD exacerbation rate, their biological mechanism of action is not completely elucidated at the molecular level. We aimed to characterise the whole genome gene expression profile of the inhaled PDE4-inhibitor CHF6001 on top of triple t...

    journal_title:Respiratory research

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1186/s12931-020-1329-y

    authors: Govoni M,Bassi M,Vezzoli S,Lucci G,Emirova A,Nandeuil MA,Petruzzelli S,Jellema GL,Afolabi EK,Colgan B,Leaker B,Kornmann O,Beeh KM,Watz H,Singh D

    更新日期:2020-03-20 00:00:00

  • Prevalence and distribution patterns of allergens among children with asthma and asthma-like symptoms in Shanghai, China.

    abstract:OBJECTIVE:We aimed to identify the prevalence and distribution patterns of allergens among Chinese children with asthma/asthma-like symptoms (ALS). METHODS:A total of 3479 children with asthma/ALS were enrolled. Skin prick test (SPT) was used to test the allergen-specific IgE. We analysed allergens prevalence and dist...

    journal_title:Respiratory research

    pub_type: 杂志文章

    doi:10.1186/s12931-020-1318-1

    authors: Mao S,Wu L,Shi W

    更新日期:2020-02-18 00:00:00

  • Hospitalisation and mortality in patients with comorbid COPD and heart failure: a systematic review and meta-analysis.

    abstract:BACKGROUND:Discrepancy exists amongst studies investigating the effect of comorbid heart failure (HF) on the morbidity and mortality of chronic obstructive pulmonary disease (COPD) patients. METHODS:MEDLINE and Embase were searched using a pre-specified search strategy for studies comparing hospitalisation, rehospital...

    journal_title:Respiratory research

    pub_type: 杂志文章,meta分析

    doi:10.1186/s12931-020-1312-7

    authors: Axson EL,Ragutheeswaran K,Sundaram V,Bloom CI,Bottle A,Cowie MR,Quint JK

    更新日期:2020-02-14 00:00:00

  • Trends in prevalence and incidence of chronic respiratory diseases from 1990 to 2017.

    abstract:BACKGROUND:Chronic respiratory diseases (CRDs) are leading causes of morbidity worldwide. However, the spatial and temporal trends in prevalence and incidence of CRDs have not been estimated. METHODS:Based on data from the Global Burden of Diseases, Injuries, and Risk Factors Study 2017, we analyzed the prevalence and...

    journal_title:Respiratory research

    pub_type: 杂志文章

    doi:10.1186/s12931-020-1291-8

    authors: Xie M,Liu X,Cao X,Guo M,Li X

    更新日期:2020-02-11 00:00:00

  • Gender differences in pulmonary arterial hypertension patients with BMPR2 mutation: a meta-analysis.

    abstract:OBJECTIVE:To investigate the differences in the proportions of BMPR2 mutations in familial hereditary pulmonary arterial hypertension (HPAH) and idiopathic pulmonary arterial hypertension (IPAH) between males and females and the relationship between BMPR2 mutation and PAH severity. METHODS:A computer was used to searc...

    journal_title:Respiratory research

    pub_type: 杂志文章,meta分析

    doi:10.1186/s12931-020-1309-2

    authors: Ge X,Zhu T,Zhang X,Liu Y,Wang Y,Zhang W

    更新日期:2020-02-06 00:00:00

  • Epigenetics dysfunction in morbid obesity with or without obstructive sleep apnoea: the EPIMOOSA study.

    abstract:BACKGROUND:Obstructive sleep apnoea (OSA) and morbid obesity (MO), defined by a body mass index ≥35 kg/m2, are two closely related conditions. Recent studies suggest that circulating microRNA (miRNA) plays a potential role in the physiopathology of both conditions. To date, circulating miRNA expression has been studied...

    journal_title:Respiratory research

    pub_type: 杂志文章

    doi:10.1186/s12931-020-1302-9

    authors: Lázaro J,Clavería P,Cabrejas C,Fernando J,Daga B,Ordoñez B,Segura S,Sanz-Rubio D,Marín JM

    更新日期:2020-02-04 00:00:00

  • Decreased expression of a phagocytic receptor Siglec-1 on alveolar macrophages in chronic obstructive pulmonary disease.

    abstract:BACKGROUND:Alveolar macrophages are professional phagocytes that remove microbial pathogens inhaled into the lung. The phagocytic ability is compromised in chronic obstructive pulmonary disease (COPD). However, the molecular mechanisms underlying this defect in phagocytosis are not clearly defined. MATERIALS AND METHO...

    journal_title:Respiratory research

    pub_type: 杂志文章

    doi:10.1186/s12931-020-1297-2

    authors: Tanno A,Fujino N,Yamada M,Sugiura H,Hirano T,Tanaka R,Sano H,Suzuki S,Okada Y,Ichinose M

    更新日期:2020-01-28 00:00:00

  • Gene therapy-emulating small molecule treatments in cystic fibrosis airway epithelial cells and patients.

    abstract:BACKGROUND:Several small molecule corrector and potentiator drugs have recently been licensed for Cystic Fibrosis (CF) therapy. However, other aspects of the disease, especially inflammation, are less effectively treated by these drugs. We hypothesized that small molecule drugs could function either alone or as an adju...

    journal_title:Respiratory research

    pub_type: 杂志文章

    doi:10.1186/s12931-019-1214-8

    authors: Yang Q,Soltis AR,Sukumar G,Zhang X,Caohuy H,Freedy J,Dalgard CL,Wilkerson MD,Pollard HB,Pollard BS

    更新日期:2019-12-21 00:00:00

  • Electronic cigarette vapour increases virulence and inflammatory potential of respiratory pathogens.

    abstract:INTRODUCTION:Bacteria have been extensively implicated in the development of smoking related diseases, such as COPD, by either direct infection or bacteria-mediated inflammation. In response to the health risks associated with tobacco exposure, the use of electronic cigarettes (e-cigs) has increased. This study compare...

    journal_title:Respiratory research

    pub_type: 杂志文章

    doi:10.1186/s12931-019-1206-8

    authors: Gilpin DF,McGown KA,Gallagher K,Bengoechea J,Dumigan A,Einarsson G,Elborn JS,Tunney MM

    更新日期:2019-12-18 00:00:00

  • Exchange protein directly activated by cAMP (Epac) protects against airway inflammation and airway remodeling in asthmatic mice.

    abstract:BACKGROUND:β2 receptor agonists induce airway smooth muscle relaxation by increasing intracellular cAMP production. PKA is the traditional downstream signaling pathway of cAMP. Exchange protein directly activated by cAMP (Epac) was identified as another important signaling molecule of cAMP recently. The role of Epac in...

    journal_title:Respiratory research

    pub_type: 杂志文章

    doi:10.1186/s12931-019-1260-2

    authors: Chen YF,Huang G,Wang YM,Cheng M,Zhu FF,Zhong JN,Gao YD

    更新日期:2019-12-18 00:00:00

  • Determination of rheology and surface tension of airway surface liquid: a review of clinical relevance and measurement techniques.

    abstract::By airway surface liquid, we mean a thin fluid continuum consisting of the airway lining layer and the alveolar lining layer, which not only serves as a protective barrier against foreign particles but also contributes to maintaining normal respiratory mechanics. In recent years, measurements of the rheological proper...

    journal_title:Respiratory research

    pub_type: 杂志文章,评审

    doi:10.1186/s12931-019-1229-1

    authors: Chen Z,Zhong M,Luo Y,Deng L,Hu Z,Song Y

    更新日期:2019-12-04 00:00:00

  • Effects of cigarette smoke on barrier function and tight junction proteins in the bronchial epithelium: protective role of cathelicidin LL-37.

    abstract:BACKGROUND:Airway epithelial barrier function is maintained by the formation of tight junctions (TJs) and adherens junctions (AJs). Inhalation of cigarette smoke causes airway epithelial barrier dysfunction and may contribute to the pathogenesis of chronic lung diseases such as asthma and chronic obstructive pulmonary ...

    journal_title:Respiratory research

    pub_type: 杂志文章

    doi:10.1186/s12931-019-1226-4

    authors: Tatsuta M,Kan-O K,Ishii Y,Yamamoto N,Ogawa T,Fukuyama S,Ogawa A,Fujita A,Nakanishi Y,Matsumoto K

    更新日期:2019-11-09 00:00:00

  • Isolation and characterization of extracellular vesicles from Broncho-alveolar lavage fluid: a review and comparison of different methods.

    abstract::Extracellular vesicles (EVs) are cell-derived membranous vesicles secreted by cells into the extracellular space, which play a role in cell to cell communication. EVs are categorized into 3 groups depending on their size, surface marker, and method of release from the host cell. Recently, EVs have become of interest i...

    journal_title:Respiratory research

    pub_type: 杂志文章,评审

    doi:10.1186/s12931-019-1210-z

    authors: Carnino JM,Lee H,Jin Y

    更新日期:2019-10-30 00:00:00

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