abstract：OBJECTIVE:we aimed to investigate the association of smoking cessation with risk of all-cause mortality amongst oldest old people (aged ≥ 80 years). DESIGN:this was a prospective cohort study. SETTING:the Chinese Longitudinal Healthy Longevity Survey, implemented in 23 provinces of China. PARTICIPANTS:a total of 28,...

journal_title：Age and ageing

authors： Wei Y,Lv Y,Zhou J,Gao X,Duan J,Zhao C,Yin Z,Kang Q,Wu B,Chen C,Mao C,Li J,Shi X

更新日期：2021-01-23 00:00:00

abstract：:Delirium is a common presentation in older inpatients with COVID-19, and a risk factor for cognitive decline at discharge. The glaring gaps in the service provision in delirium care, regardless of aetiology, after a hospital admission pre-existed the pandemic, but the pandemic arguably offers an opportunity now to add...

journal_title：Age and ageing

authors： Rahman S,Byatt K

更新日期：2021-01-22 00:00:00

abstract：:In Hong Kong, about 15% of older people (aged 80 and above) live in care homes, one of the highest proportions in the world. During the spread of severe acute respiratory syndrome in 2003, the crude fatality rate for older people in care homes that were infected was 72%. After taking the advice of a team of internatio...

journal_title：Age and ageing

authors： Chow L

更新日期：2021-01-08 00:00:00

abstract：OBJECTIVES:To describe the epidemiology and outcomes of non-traumatic dyspnoea in patients aged 75 years or older presenting to emergency departments (EDs) in the Asia-Pacific region. METHODS:A substudy of a prospective interrupted time series cohort study conducted at three time points in EDs in Australia, New Zealan...

journal_title：Age and ageing

authors： Kelly AM,Keijzers G,Klim S,Craig S,Kuan WS,Holdgate A,Graham CA,Jones P,Laribi S

更新日期：2021-01-08 00:00:00

abstract：BACKGROUND:aspiration pneumonia increases hospitalisation and mortality of older people in residential aged care. OBJECTIVES:determine potentially pathogenic microorganisms in oral specimens of older people with aspiration pneumonia and the effect of professional oral care in reducing aspiration pneumonia risk. DATA ...

journal_title：Age and ageing

authors： Khadka S,Khan S,King A,Goldberg LR,Crocombe L,Bettiol S

更新日期：2021-01-08 00:00:00

abstract：OBJECTIVES:to determine the safety and effect of intravenous iron sucrose on functional outcomes, delirium, nosocomial infections and transfusion requirements in older patients with hip fracture. DESIGN:single-centre randomised, double-blind, placebo-controlled clinical trial. SETTING AND PARTICIPANTS:orthogeriatric ...

journal_title：Age and ageing

authors： Bielza R,Llorente J,Thuissard IJ,Andreu-Vázquez C,Blanco D,Sanjurjo J,López N,Herráez MR,Molano C,Morales A,Arias E,Neira M,Lung A,Escalera J,Portillo L,Larrubia Y,García C,Zambrana F,Gómez Cerezo J

更新日期：2021-01-08 00:00:00

abstract：BACKGROUND:Cognitive health expectancy estimates the proportion of the lifespan that is lived in good cognitive health at the population level. A number of cardiovascular diseases have been identified to be risk factors for cognitive decline and dementia including diabetes, stroke, heart diseases and hypertension. The ...

journal_title：Age and ageing

authors： Zheng L,Matthews FE,Anstey KJ

更新日期：2021-01-08 00:00:00

abstract：BACKGROUND:Frailty was shown to be associated with psychosocial risk factors, but there are few longitudinal data. METHODS:We used data from waves 5 and 6 of the Survey of Health Aging Retirement in Europe (SHARE) to study the contribution of loneliness and social isolation to transitions towards frailty defined accor...

journal_title：Age and ageing

authors： Jarach CM,Tettamanti M,Nobili A,D'avanzo B

更新日期：2021-01-08 00:00:00

abstract：OBJECTIVE:(i) to describe the general practitioner utilisation of health assessments, management plans, coordination of team care arrangements and medication review item numbers within 6 months of an aged care eligibility assessment for home care packages (HCP) and (ii) investigate the impact of health assessments on t...

journal_title：Age and ageing

authors： Visvanathan R,Amare AT,Lang C,Khadka J,Yu S,Beilby J,Wesselingh S,Inacio MC

更新日期：2021-01-08 00:00:00

abstract：OBJECTIVES:The purpose of this paper is to investigate the utilisation of general practice Medicare Benefit Schedule (MBS) services aligned to Comprehensive Geriatric Assessment (CGA) within 6 months of an aged care eligibility assessment and its effects on mortality and transition to permanent residential aged care (P...

journal_title：Age and ageing

authors： Visvanathan R,Amare AT,Wesselingh S,Inacio MC

更新日期：2020-12-23 00:00:00

abstract：BACKGROUND:The electronic Frailty Index (eFI) has been developed in primary care settings. The Hospital Frailty Risk Score (HFRS) was derived using secondary care data. OBJECTIVE:Compare the two different tools for identifying frailty in older people admitted to hospital. DESIGN AND SETTING:Retrospective cohort study...

journal_title：Age and ageing

authors： Hollinghurst J,Housley G,Watkins A,Clegg A,Gilbert T,Conroy SP

更新日期：2020-11-30 00:00:00

abstract：BACKGROUND:There is little evidence about the utilization of healthcare services and disease recognition in the older population, which was urged to self-isolate during the COVID-19 lockdowns. OBJECTIVES:We aimed to describe the utilization of physician consultations, specialist referrals, hospital admissions, and the...

journal_title：Age and ageing

authors： Michalowsky B,Hoffmann W,Bohlken J,Kostev K

更新日期：2020-11-17 00:00:00

abstract：BACKGROUND AND PURPOSE:The benefit of endovascular thrombectomy (EVT) among nonagenarians (90 years or older) is poorly documented. We aimed to investigate the clinical and imaging factors associated with good outcomes and mortality at 90 days in nonagenarians undergoing EVT for acute ischemic stroke (AIS). METHODS:Da...

journal_title：Age and ageing

authors： Derraz I,Benali A,Ahmed R,Cagnazzo F,Dargazanli C,Gascou G,Riquelme C,Corti L,Lefevre PH,Bonafe A,Arquizan C,Costalat V

更新日期：2020-11-17 00:00:00

abstract：INTRODUCTION:Age limits for diagnostics and treatments have been largely removed and replaced by an active diagnostic and treatment practice among the oldest old and has led to concerns about potential overtreatment during the last years of life. METHODS:Use of prescription medication in the last years of life was ass...

journal_title：Age and ageing

authors： Pedersen JK,Jensen TM,Waldorff FB,Søndergaard J,Christensen K

更新日期：2020-10-23 00:00:00

abstract：BACKGROUND:Using Newcastle 85+ Study data, we investigated transitions between frailty states from age 85 to 90 years and whether multi-morbidities and socioeconomic status (SES) modify transitions. METHODS:The Newcastle 85+ Study is a prospective, longitudinal cohort study of all people born in 1921 in Newcastle and ...

journal_title：Age and ageing

authors： Mendonça N,Kingston A,Yadegarfar M,Hanson H,Duncan R,Jagger C,Robinson L

更新日期：2020-10-23 00:00:00

abstract：BACKGROUND:COVID-19 has disproportionately affected older people. OBJECTIVE:The objective of this paper to investigate whether frailty is associated with all-cause mortality in older hospital inpatients, with COVID-19. DESIGN:Cohort study. SETTING:Secondary care acute hospital. PARTICIPANTS:Participants included ar...

journal_title：Age and ageing

authors： Aw D,Woodrow L,Ogliari G,Harwood R

更新日期：2020-10-23 00:00:00

abstract：BACKGROUND:Hypertension is a risk factor for both cardiovascular and cerebrovascular disease, with an increasing incidence with advancing patient age. Exercise interventions have the potential to reduce blood pressure in older adults, however, rates of exercise uptake and adherence are low, with 'lack of time' a common...

journal_title：Age and ageing

authors： Herrod PJJ,Lund JN,Phillips BE

更新日期：2020-10-17 00:00:00

abstract：BACKGROUND:dementia is associated with an excess risk of death but mortality after chronic subdural hematoma (CSDH) evacuation in older people with dementia is unknown. We assessed the association between dementia and 1-year case-fatality in older persons undergoing CSDH evacuation. METHODS:we conducted a nationwide F...

journal_title：Age and ageing

authors： Tommiska P,Korja M,Siironen J,Kaprio J,Raj R

更新日期：2020-10-06 00:00:00

abstract：OBJECTIVES:this study investigated the prospective associations of accelerometer assessed daily steps with subsequent depressive symptoms in older adults. METHODS:a 2-year prospective study was performed in the community. A total of 285 older adults ≥65 years (mean age = 74.5) attended the baseline assessment in 2012....

journal_title：Age and ageing

authors： Hsueh MC,Stubbs B,Lai YJ,Sun CK,Chen LJ,Ku PW

更新日期：2020-09-25 00:00:00

abstract：BACKGROUND:frailty is a dynamic condition for which a range of interventions are available. Health state utilities are values that represent the strength of an individual's preference for specific health states, and are used in economic evaluation. This is a topic yet to be examined in detail for frailty. Likewise, lit...

journal_title：Age and ageing

authors： Thompson MQ,Theou O,Ratcliffe J,Tucker GR,Adams RJ,Walters SJ,Visvanathan R

更新日期：2020-09-16 00:00:00

abstract：BACKGROUND:Frailty is increasingly used to risk stratify older people, but across specialised services there is no standardised approach. The aim of this study was to assess if the Hospital Frailty Risk Score (HFRS) could describe outcomes for older people within English specialised services. DESIGN:A retrospective co...

journal_title：Age and ageing

authors： Imam T,Konstant-Hambling R,Fluck R,Hall N,Palmer J,Conroy S

更新日期：2020-09-08 00:00:00

abstract：BACKGROUND:the number of older people living in residential and nursing care homes is rising. Loneliness is a major problem for older people, but little is known about the prevalence of loneliness amongst older people living in care homes. AIM:to undertake a systematic review of literature on the prevalence of moderat...

journal_title：Age and ageing

authors： Gardiner C,Laud P,Heaton T,Gott M

更新日期：2020-08-24 00:00:00

abstract：BACKGROUND:Diabetes management has not been evaluated in French nursing homes (NHs) for 10 years. OBJECTIVES:The present study aimed to compare the management of diabetes with guidelines in older patients living in NHs. DESIGN:Observational, retrospective and multicentre study carried out in 13 NH in the Cote d'Or re...

journal_title：Age and ageing

authors： Quilot E,Petit JM,Vergès B,Bouillet B

更新日期：2020-08-24 00:00:00

abstract：:Lyme disease is an infectious disease caused by the Borrelia burgdorferi spirochetes and other related species that are transmitted through an infected tick bite. We report the case of an older patient presenting with bilateral facial palsy due to Lyme disease. Multiple non-specific clinical signs preceded facial pals...

journal_title：Age and ageing

authors： Méreaux JL,Hébant B,Magne N,Quesney G,Lefaucheur R

更新日期：2020-08-24 00:00:00

abstract：BACKGROUND:Multi-morbidity and polypharmacy increase the risk of non-trivial adverse drug reactions (ADRs) in older people during hospitalization. Despite this, there are no established interventions for hospital-acquired ADR prevention. METHODS:We undertook a pragmatic, multi-national, parallel arm prospective random...

journal_title：Age and ageing

authors： O'Mahony D,Gudmundsson A,Soiza RL,Petrovic M,Jose Cruz-Jentoft A,Cherubini A,Fordham R,Byrne S,Dahly D,Gallagher P,Lavan A,Curtin D,Dalton K,Cullinan S,Flanagan E,Shiely F,Samuelsson O,Sverrisdottir A,Subbarayan S,V

更新日期：2020-07-01 00:00:00

abstract：BACKGROUND:delirium is a frequent complication of hospital admission for older people and can be reduced by multicomponent interventions, but implementation and delivery of such interventions is challenging. OBJECTIVE:to investigate fidelity to the prevention of delirium system of care within a multicentre, pragmatic,...

journal_title：Age and ageing

authors： Smith J,Green J,Siddiqi N,Inouye SK,Collinson M,Farrin A,Young J

更新日期：2020-07-01 00:00:00

abstract：IMPORTANCE:risk factors for delirium in hospital inpatients are well established, but less is known about whether delirium occurring in the community or during an emergency admission to hospital care might be predicted from routine primary-care records. OBJECTIVES:identify risk factors in primary-care electronic healt...

journal_title：Age and ageing

authors： Bowman K,Jones L,Masoli J,Mujica-Mota R,Strain D,Butchart J,Valderas JM,Fortinsky RH,Melzer D,Delgado J

更新日期：2020-04-27 00:00:00

abstract：OBJECTIVE:to develop a model to predict one- and three-year mortality in patients with dementia attending a hospital, through hospital admission or day/memory clinic. DESIGN:we constructed a cohort of dementia patients through data linkage of three Dutch national registers: the hospital discharge register (HDR), the p...

journal_title：Age and ageing

authors： van de Vorst IE,Golüke NMS,Vaartjes I,Bots ML,Koek HL

更新日期：2020-04-27 00:00:00

abstract：:Sporadic Creutzfeld-Jakob disease (CJD) is a rare neurodegenerative disorder. It is uniformly fatal. Clinical signs include myoclonus, visual disturbances, cerebellar ataxia, akinetic mutism and pyramidal/extrapyramidal signs in addition to a rapidly progressive dementia. Premortem diagnosis is challenging due to the ...

journal_title：Age and ageing

authors： Podger H,Ipe A

更新日期：2020-04-27 00:00:00

abstract：INTRODUCTION:ageing is accompanied by impairments in immune responses due to remodelling of the immune system (immunesenescence). Additionally, a decline in habitual physical activity has been reported in older adults. We have recently published that specific features of immunesenescence, such as thymic involution and ...

journal_title：Age and ageing

authors： Bartlett DB,Duggal NA

更新日期：2020-04-27 00:00:00

abstract：BACKGROUND:a large number of studies have explored factors related to self- and informant ratings of quality of life in people with dementia, but many studies have had relatively small sample sizes and mainly focused on health conditions and dementia symptoms. The aim of this study is to compare self- and informant-rat...

journal_title：Age and ageing

authors： Wu YT,Nelis SM,Quinn C,Martyr A,Jones IR,Victor CR,Knapp M,Henderson C,Hindle JV,Jones RW,Kopelman MD,Morris RG,Pickett JA,Rusted JM,Thom JM,Litherland R,Matthews FE,Clare L,IDEAL Programme team.

更新日期：2020-04-27 00:00:00

abstract：BACKGROUND:exposures in childhood and adolescence may impact the development of diseases and symptoms in late life. However, evidence from low- and middle-income countries is scarce. In this cross-sectional study, we examined the association of early life risk factors with frailty amongst older adults using a large, na...

journal_title：Age and ageing

authors： Li Y,Xue QL,Odden MC,Chen X,Wu C

更新日期：2020-02-27 00:00:00

abstract：BACKGROUND:there are around 100,000 new stroke cases and over a million people living with its consequences annually in the UK. This has large impacts on health and social care, unpaid carers and lost productivity. We aimed to estimate associated costs. METHODS:we estimated 2014/2015 annual mean cost per person and ag...

journal_title：Age and ageing

authors： Patel A,Berdunov V,Quayyum Z,King D,Knapp M,Wittenberg R

更新日期：2020-02-27 00:00:00

abstract：BACKGROUND:fall-risk assessment with fall-prevention intervention referral for at-risk groups to avoid falls could be cost-effective from a care-payer perspective. AIMS:to model the cost-effectiveness of a fall-risk assessment (QTUG compared to TUG) with referral to one of four fall-prevention interventions (Otago, Fa...

journal_title：Age and ageing

authors： Franklin M,Hunter RM

更新日期：2019-12-01 00:00:00

abstract：:Deprescribing has gained interest recently, driven by an ageing population seeing an increasing number living with multiple long-term conditions. This, coupled with disease-specific guidelines derived from clinical trials in younger people, has led to an increase in exposure to polypharmacy and the associated therapeu...

journal_title：Age and ageing

authors： Woodford HJ,Fisher J

更新日期：2019-11-01 00:00:00

abstract：BACKGROUND:two common anti-diabetic treatments used are sitagliptin and sulphonylureas however evidence examining their comparative effectiveness in older people is limited. OBJECTIVE:to evaluate effectiveness of sitagliptin vs sulphonylureas when added to metformin in older (aged ≥75) vs younger people (18-75). DESI...

journal_title：Age and ageing

authors： Sharma M,Nazareth I,Petersen I

更新日期：2019-09-01 00:00:00

abstract：BACKGROUND:frequent emergency department (ED) attendance at the end of life disrupts care continuity and contradicts most patients' preference for home-based care. OBJECTIVE:to examine factors associated with frequent (≥3) end of life ED attendances among older people to identify opportunities to improve care. METHOD...

journal_title：Age and ageing

authors： Bone AE,Evans CJ,Henson LA,Gao W,Higginson IJ,BUILDCARE study.

更新日期：2019-09-01 00:00:00

abstract：OBJECTIVE:to evaluate the relationship between serum levels of the soluble Receptor for Advanced Glycation End-products (sRAGE) and mortality in frail and non-frail older adults. METHODS:we studied 691 subjects (141 frail and 550 non-frail) with a median age of 75 years from two population-based cohorts, the Toledo St...

journal_title：Age and ageing

authors： Butcher L,Carnicero JA,Gomez Cabrero D,Dartigues JF,Pérès K,Garcia-Garcia FJ,Rodriguez-Mañas L,Erusalimsky JD,FRAILOMIC Consortium.

更新日期：2019-09-01 00:00:00

abstract：BACKGROUND:The long-term effectiveness of group continence promotion delivered via community organisations on female urinary incontinence, falls and healthy life expectancy remains unknown. METHODS:A pragmatic cluster randomised trial was conducted among 909 women aged 65-98 years with urinary incontinence, recruited ...

journal_title：Age and ageing

authors： Tannenbaum C,Fritel X,Halme A,van den Heuvel E,Jutai J,Wagg A

更新日期：2019-07-01 00:00:00

abstract：:Brucellosis is the most commonly reported zoonosis. Nervous system participation can occur at any stage of the disease either in acute or subacute or chronic form. Isolated nervous system involvement or neurobrucellosis is a relatively rare form of the disease. We describe an unusual case of an older patient with deme...

journal_title：Age and ageing

authors： Spyrou A,Natsis KS,Papamichalis E,Mourtzinos H

更新日期：2019-07-01 00:00:00