解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Nanobodies are the recombinant variable domains of heavy-chain-only antibodies, with many unique properties such as small size, excellent solubility, superior stability, quick clearance from blood, and deep tissue penetration. As a result, nanobodies have become a promising tool for the diagnosis and therapy of diseas...
journal_title:EJNMMI research
pub_type: 杂志文章,评审
doi:10.1186/s13550-021-00750-5
更新日期:2021-01-19 00:00:00
abstract:BACKGROUND:Assessing the extent of disease in newly diagnosed prostate cancer (PC) patients is crucial for tailoring an appropriate treatment approach. Prostate-specific membrane antigen (PSMA)-targeted positron emission tomography/computed tomography (PET/CT) reportedly has greater accuracy than conventional imaging f...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-020-00745-8
更新日期:2021-01-06 00:00:00
abstract:BACKGROUND:Prostate cancer is highly prevalent worldwide. Androgen deprivation therapy (ADT) remains the treatment of choice for incurable prostate cancer, but majority of patients develop disease recurrence following ADT. There is therefore an urgent need for early detection of treatment resistance. METHODS:Isogenic ...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-020-00728-9
更新日期:2020-11-25 00:00:00
abstract::An amendment to this paper has been published and can be accessed via the original article. ...
journal_title:EJNMMI research
pub_type: 已发布勘误
doi:10.1186/s13550-020-00719-w
更新日期:2020-10-27 00:00:00
abstract:BACKGROUND:Positron emission tomography (PET) is a molecular imaging technique that can be used to investigate the in vivo pharmacology of drugs. Initial preclinical evaluation of PET tracers is often conducted in rodents due to the accessibility of disease models as well as economic considerations. Compared to larger ...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-020-00718-x
更新日期:2020-10-19 00:00:00
abstract:BACKGROUND:Radioembolization is an established treatment modality in colorectal cancer patients with liver-dominant disease in a salvage setting. Selection of patients who will benefit most is of vital importance. The aim of this study was to assess response (and mode of progression) at 3 months after radioembolization...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-020-00697-z
更新日期:2020-09-22 00:00:00
abstract:BACKGROUND:Somatostatin receptor (SST) targeting, specifically of the subtype 2 (SST2), with radiolabeled somatostatin analogs, is established for imaging and treatment of neuroendocrine tumors. Owing to the concomitant and heterogeneous expression of several subtypes on the same tumor, analogs targeting more subtypes ...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-020-00677-3
更新日期:2020-08-05 00:00:00
abstract:BACKGROUND:Two novel methods of image reconstruction, xSPECT Quant (xQ) and xSPECT Bone (xB), that use an ordered subset conjugate gradient minimizer (OSCGM) for SPECT/CT reconstruction have been proposed. The present study compares the performance characteristics of xQ, xB, and conventional Flash3D (F3D) reconstructio...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-020-00659-5
更新日期:2020-06-29 00:00:00
abstract:BACKGROUND:Yoga is increasingly popular worldwide with several physical and mental benefits, but the underlying neurobiology remains unclear. Whereas many studies have focused on pure meditational aspects, the triad of yoga includes meditation, postures, and breathing. We conducted a cross-sectional study comparing exp...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-020-00636-y
更新日期:2020-05-14 00:00:00
abstract:BACKGROUND:New therapies to treat diabetic peripheral artery disease (PAD) require target-specific non-invasive imaging modalities to follow efficacy. As a translational study, we performed targeted imaging of receptors for vascular endothelial growth factor (VEGF) in response to anterior femoral artery occlusion (FAO)...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-020-00626-0
更新日期:2020-05-12 00:00:00
abstract:BACKGROUND:The molecular features of isocitrate dehydrogenase (IDH) mutation and chromosome 1p and 19q (1p/19q) codeletion status have pivotal role for differentiating gliomas and have been integrated in the World Health Organization (WHO) classification in 2016. Positron emission tomography (PET) with 3'-deoxy-3'-[18F...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-020-00633-1
更新日期:2020-05-07 00:00:00
abstract:PURPOSE:Chimeric antibody Miltuximab®, a human IgG1 engineered from the parent antibody MIL-38, is in clinical development for solid tumour therapy. Miltuximab® targets glypican-1 (GPC-1), a cell surface protein involved in tumour growth, which is overexpressed in solid tumours, including prostate cancer (PCa). This st...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-020-00637-x
更新日期:2020-05-07 00:00:00
abstract:BACKGROUND:Given the increasing clinical use of PET/MRI, potential risks to patients from simultaneous exposure to ionising radiation and (electro)magnetic fields should be thoroughly investigated as a precaution. With this aim, the genotoxic potential of 2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG) and a strong static m...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-020-00625-1
更新日期:2020-04-28 00:00:00
abstract:PURPOSE:To investigate the added value and diagnostic accuracy of 68Ga-PSMA PET/CT versus bone scintigraphy (BS) for bone metastasis detection at the primary staging of prostate cancer (PCa). METHODS:Inclusion criteria involved consecutive patients with newly diagnosed intermediate- to high-risk PCa, who had undergone...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-020-00618-0
更新日期:2020-04-08 00:00:00
abstract:BACKGROUND:High expression of human epidermal growth factor receptor type 2 (HER2) represents an aggressive subtype of breast cancer. Anti-HER2 treatment requires a theragnostic approach wherein sufficiently high receptor expression in biopsy material is mandatory. Heterogeneity and discordance of HER2 expression betwe...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-020-0603-9
更新日期:2020-03-23 00:00:00
abstract:BACKGROUND:Differentiated thyroid carcinoma (DTC) is the most common type of thyroid cancer. Treatment with surgery, radioactive iodine (RAI), and TSH suppression is effective in most patients. Five to 15% of patients become RAI refractory and need alternative therapy; however, treatment options are limited. 68Ga-PSMA ...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-020-0610-x
更新日期:2020-03-06 00:00:00
abstract:BACKGROUND:Prostate-specific membrane antigen (PSMA) ligand PET/CT has already provided promising results in prostate cancer (PC) imaging, yet simple and reproductible reporting criteria are still lacking. This study aimed at retrospectively evaluating interobserver agreement of [68Ga]Ga-PSMA-11 PET/CT images interpret...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-020-0596-4
更新日期:2020-02-28 00:00:00
abstract:BACKGROUND:The positron emission tomography (PET) ligand 68Ga-Glu-urea-Lys(Ahx)-HBED-CC (68Ga-PSMA-11) targets the prostate-specific membrane antigen (PSMA), upregulated in prostate cancer cells. Although 68Ga-PSMA-11 PET is widely used in research and clinical practice, full kinetic modeling has not yet been reported ...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-020-0594-6
更新日期:2020-02-24 00:00:00
abstract:BACKGROUND:There is a growing interest in the use of F-18 FDG PET-CT to monitor tuberculosis (TB) treatment response. Tuberculosis lung lesions are often complex and diffuse, with dynamic changes during treatment and persisting metabolic activity after apparent clinical cure. This poses a challenge in quantifying scan-...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-020-0591-9
更新日期:2020-02-10 00:00:00
abstract:PURPOSE:Pathological complete response to the neoadjuvant therapy (NAT) for triple negative breast cancer (TNBC) is predictive of prolonged patient survival. Methods for early evaluation of NAT efficiency are still needed, in order to rapidly adjust the therapeutic strategy in case of initial non-response. One option f...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-019-0587-5
更新日期:2020-01-06 00:00:00
abstract:BACKGROUND:Diacetyl-bis(N4-methylthiosemicarbazone), labeled with 64Cu (64Cu-ATSM) has been suggested as a promising tracer for imaging hypoxia. However, various controversial studies highlighted potential pitfalls that may disable its use as a selective hypoxic marker. They also highlighted that the results may be tum...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-019-0586-6
更新日期:2019-12-19 00:00:00
abstract:BACKGROUND:In order to better understand the concept of mechanical dyssynchrony, a promising hallmark of cardiac resynchronization therapy (CRT) response, we investigated its effect on regional myocardial metabolism and myocardial blood flow (MBF) in non-ischemic CRT candidates. RESULTS:Thirty consecutive non-ischemic...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-019-0575-9
更新日期:2019-12-09 00:00:00
abstract:BACKGROUND:Vagus nerve activation impacts inflammation. Therefore, we hypothesized that vagal nerve stimulation (VNS) influenced arterial wall inflammation as measured by 18F-FDG uptake. RESULTS:Ten patients with left-sided VNS for refractory epilepsy were studied during stimulation (VNS-on) and in the hours after sti...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-019-0567-9
更新日期:2019-11-27 00:00:00
abstract:BACKGROUND:Over the last decade, a few radioligands have been developed for PET imaging of brain 5-HT1B receptors. The 5-HT1B receptor is a G-protein-coupled receptor (GPCR) that exists in two different agonist affinity states. An agonist ligand is expected to be more sensitive towards competition from another agonist,...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-019-0570-1
更新日期:2019-11-21 00:00:00
abstract:BACKGROUND:Amyloid PET plays a vital role in detecting the accumulation of in vivo amyloid-β (Aβ). The quantification of Aβ accumulation has been widely performed using the region of interest (ROI)-based mean cortical standardized uptake value ratio (mcSUVR). However, voxel-based statistical analysis has not been well ...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-019-0561-2
更新日期:2019-09-18 00:00:00
abstract:BACKGROUND:The aim of this study was to evaluate the prognostic value of positron emission tomography (PET) parameters and the PET texture features of fluorine 18-fluorodeoxyglucose ([18F]FDG) uptake on pretreatment PET/computed tomography (CT) in patients with locally advanced salivary gland carcinoma treated with int...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-019-0555-0
更新日期:2019-09-11 00:00:00
abstract:BACKGROUND:Image-guided surgery may improve surgical outcome for colorectal cancer patients. Here, we evaluated the feasibility of a pretargeting strategy for multimodal imaging in colorectal cancer using an anti-carcinoembryonic antigen (CEA) x anti-histamine-succinyl-glycine (HSG) bispecific antibody (TF2) in conjunc...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-019-0551-4
更新日期:2019-09-04 00:00:00
abstract:BACKGROUND:In a colorectal cancer xenograft model, we investigated the therapeutic effect of metformin on tumor hypoxia with [18F]flortanidazole ([18F]HX4) small-animal positron emission tomography (μPET). We also assessed the additive effect of metformin on long-term radiotherapy outcome and we studied the potential o...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-019-0543-4
更新日期:2019-08-02 00:00:00
abstract:BACKGROUND:18F-FDG PET/CT has proven to be a reliable tool for therapy monitoring in sarcoidosis. Previous PET studies investigated the SUVmax as a marker for disease activity. Total lung glycolysis (TLuG) is a new tool, quantifying the glycolysis of the entire lung. Since SUVmax represents the maximum activity in only...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-019-0505-x
更新日期:2019-06-13 00:00:00
abstract:BACKGROUND:In molecular imaging and nuclear medicine, theranostic agents that integrate radionuclide pairs are successfully being used for individualized care, which has led to rapidly growing interest in their continued development. These compounds, which are radiolabeled with one radionuclide for imaging and a chemic...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-019-0515-8
更新日期:2019-05-16 00:00:00
abstract:PURPOSE:We have developed a multi-modal imaging approach for SIRT, combining 99mTc-MAA SPECT/CT and/or 90Y PET, 18F-FDG PET/CT, and contrast-enhanced CBCT for voxel-based dosimetry, as a tool for treatment planning and verification. For radiation dose prediction calculations, a segmentation of the total liver volume an...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-019-0485-x
更新日期:2019-02-20 00:00:00
abstract:BACKGROUND:The G-protein-coupled receptor 44 (GPR44) is a beta cell-restricted target that may serve as a marker for beta cell mass (BCM) given the development of a suitable PET ligand. METHODS:The binding characteristics of the selected candidate, AZ12204657, at human GPR44 were determined using in vitro ligand bindi...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-018-0465-6
更新日期:2018-12-27 00:00:00
abstract:BACKGROUND:Gastrin-releasing peptide receptor antagonists have promise in theranostics of several highly incident tumours, including prostate and breast. This study presents the first human dosimetry of 68Ga-NODAGA-MJ9 in the first five consecutive patients with recurrent prostate cancer included in a dual-tracer posit...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-018-0462-9
更新日期:2018-12-12 00:00:00
abstract:BACKGROUND:HEPES is a favorable buffer for 68Ga-complexations in radiochemical laboratories. The drawback of this buffer is its prescribed limit of 200 μg per recommended application volume in the final formulation. Currently, a TLC test according to the European Pharmacopoeia (Ph. Eur.) has to be performed for quantif...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-018-0449-6
更新日期:2018-10-23 00:00:00
abstract:BACKGROUND:Erlotinib is an epidermal growth factor receptor (EGFR)-targeting tyrosine kinase inhibitor approved for treatment of non-small cell lung cancer. The wide inter-individual pharmacokinetic (PK) variability of erlotinib may impact treatment outcome and/or toxicity. Recent in vivo studies reported a nonlinear u...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-018-0434-0
更新日期:2018-08-16 00:00:00
abstract:BACKGROUND:Off-target binding in the choroid plexus (CP) may cause spill-in of the tau PET tracer [18F] flortaucipir into the adjacent hippocampus region. The impact of this spill-in on hippocampal uptake was assessed using a novel partial volume correction method (PVC). METHODS:PVC was performed on 20 [18F] flortauci...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-018-0432-2
更新日期:2018-08-15 00:00:00
abstract:BACKGROUND:In contrast to ordered subset expectation maximization (OSEM), block sequential regularized expectation maximization (BSREM) positron emission tomography (PET) reconstruction algorithms can run until full convergence while controlling image quality and noise. Recent studies with BSREM and 18F-FDG PET reporte...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-018-0414-4
更新日期:2018-07-27 00:00:00
abstract:BACKGROUND:Merkel cell carcinoma (MCC) is an aggressive neuroendocrine skin tumor. Currently, 18F-fluoro-deoxy-glucose (18F-FDG) PET/CT is the functional imaging modality of choice. Few data are available on the use of 68Ga-somatostatin analogs. The aim of our study was to evaluate and compare the diagnostic performanc...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-018-0423-3
更新日期:2018-07-21 00:00:00
abstract:BACKGROUND:The potential of the D-isomerization of 4-borono-2-18F-fluoro-phenylalanine (18F-FBPA) to improve its target tumor to non-target normal brain tissue ratio (TBR) was evaluated in rat brain glioma and compared with those of L- and D-11C-methyl-tyrosine (11C-CMT). The L- or D-isomer of 18F-FBPA was injected int...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-018-0404-6
更新日期:2018-06-13 00:00:00
abstract:INTRODUCTION:The NMDA receptor radiotracer [18F]GE-179 has been used with 90-min scans and arterial plasma input functions. We explored whether (1) arterial blood sampling is avoidable and (2) shorter scans are feasible. METHODS:For 20 existing [18F]GE-179 datasets, we generated (1) standardised uptake values (SUVs) o...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-018-0396-2
更新日期:2018-06-11 00:00:00