你正在浏览EJNMMI Research期刊下所有文献
  • Nanobody: a promising toolkit for molecular imaging and disease therapy.

    abstract::Nanobodies are the recombinant variable domains of heavy-chain-only antibodies, with many unique properties such as small size, excellent solubility, superior stability, quick clearance from blood, and deep tissue penetration. As a result, nanobodies have become a promising tool for the diagnosis and therapy of diseas...

    journal_title:EJNMMI research

    pub_type: 杂志文章,评审


    authors: Bao G,Tang M,Zhao J,Zhu X

    更新日期:2021-01-19 00:00:00

  • The significance of equivocal bone findings in staging PSMA imaging in the preoperative setting: validation of the PSMA-RADS version 1.0.

    abstract:BACKGROUND:Assessing the extent of disease in newly diagnosed prostate cancer (PC) patients is crucial for tailoring an appropriate treatment approach. Prostate-specific membrane antigen (PSMA)-targeted positron emission tomography/computed tomography (PET/CT) reportedly has greater accuracy than conventional imaging f...

    journal_title:EJNMMI research

    pub_type: 杂志文章


    authors: Kuten J,Dekalo S,Mintz I,Yossepowitch O,Mano R,Even-Sapir E

    更新日期:2021-01-06 00:00:00

  • 18F-Fluciclovine PET metabolic imaging reveals prostate cancer tumour heterogeneity associated with disease resistance to androgen deprivation therapy.

    abstract:BACKGROUND:Prostate cancer is highly prevalent worldwide. Androgen deprivation therapy (ADT) remains the treatment of choice for incurable prostate cancer, but majority of patients develop disease recurrence following ADT. There is therefore an urgent need for early detection of treatment resistance. METHODS:Isogenic ...

    journal_title:EJNMMI research

    pub_type: 杂志文章


    authors: Malviya G,Patel R,Salji M,Martinez RS,Repiscak P,Mui E,Champion S,Mrowinska A,Johnson E,AlRasheedi M,Pimlott S,Lewis D,Leung HY

    更新日期:2020-11-25 00:00:00

  • Correction to: Neurologically asymptomatic cerebral oligometastatic prostate carcinoma metastasis identified on [Ga]Ga-THP-PSMA PET/CT.

    abstract::An amendment to this paper has been published and can be accessed via the original article. ...

    journal_title:EJNMMI research

    pub_type: 已发布勘误


    authors: Ross MI,Bird N,Mendichovszky IA,Rimmer YL

    更新日期:2020-10-27 00:00:00

  • Blocking of efflux transporters in rats improves translational validation of brain radioligands.

    abstract:BACKGROUND:Positron emission tomography (PET) is a molecular imaging technique that can be used to investigate the in vivo pharmacology of drugs. Initial preclinical evaluation of PET tracers is often conducted in rodents due to the accessibility of disease models as well as economic considerations. Compared to larger ...

    journal_title:EJNMMI research

    pub_type: 杂志文章


    authors: Shalgunov V,Xiong M,L'Estrade ET,Raval NR,Andersen IV,Edgar FG,Speth NR,Baerentzen SL,Hansen HD,Donovan LL,Nasser A,Peitersen ST,Kjaer A,Knudsen GM,Syvänen S,Palner M,Herth MM

    更新日期:2020-10-19 00:00:00

  • Mode of progression after radioembolization in patients with colorectal cancer liver metastases.

    abstract:BACKGROUND:Radioembolization is an established treatment modality in colorectal cancer patients with liver-dominant disease in a salvage setting. Selection of patients who will benefit most is of vital importance. The aim of this study was to assess response (and mode of progression) at 3 months after radioembolization...

    journal_title:EJNMMI research

    pub_type: 杂志文章


    authors: van Roekel C,Jongen JMJ,Smits MLJ,Elias SG,Koopman M,Kranenburg O,Borel Rinkes IHM,Lam MGEH

    更新日期:2020-09-22 00:00:00

  • A new 68Ga-labeled somatostatin analog containing two iodo-amino acids for dual somatostatin receptor subtype 2 and 5 targeting.

    abstract:BACKGROUND:Somatostatin receptor (SST) targeting, specifically of the subtype 2 (SST2), with radiolabeled somatostatin analogs, is established for imaging and treatment of neuroendocrine tumors. Owing to the concomitant and heterogeneous expression of several subtypes on the same tumor, analogs targeting more subtypes ...

    journal_title:EJNMMI research

    pub_type: 杂志文章


    authors: Mansi R,Abid K,Nicolas GP,Del Pozzo L,Grouzmann E,Fani M

    更新日期:2020-08-05 00:00:00

  • Phantom and clinical evaluation of bone SPECT/CT image reconstruction with xSPECT algorithm.

    abstract:BACKGROUND:Two novel methods of image reconstruction, xSPECT Quant (xQ) and xSPECT Bone (xB), that use an ordered subset conjugate gradient minimizer (OSCGM) for SPECT/CT reconstruction have been proposed. The present study compares the performance characteristics of xQ, xB, and conventional Flash3D (F3D) reconstructio...

    journal_title:EJNMMI research

    pub_type: 杂志文章


    authors: Miyaji N,Miwa K,Tokiwa A,Ichikawa H,Terauchi T,Koizumi M,Onoguchi M

    更新日期:2020-06-29 00:00:00

  • Long-term Ashtanga yoga practice decreases medial temporal and brainstem glucose metabolism in relation to years of experience.

    abstract:BACKGROUND:Yoga is increasingly popular worldwide with several physical and mental benefits, but the underlying neurobiology remains unclear. Whereas many studies have focused on pure meditational aspects, the triad of yoga includes meditation, postures, and breathing. We conducted a cross-sectional study comparing exp...

    journal_title:EJNMMI research

    pub_type: 杂志文章


    authors: van Aalst J,Ceccarini J,Schramm G,Van Weehaeghe D,Rezaei A,Demyttenaere K,Sunaert S,Van Laere K

    更新日期:2020-05-14 00:00:00

  • VEGF receptor targeted imaging of angiogenic response to limb ischemia in diabetic vs. non-diabetic Yucatan minipigs.

    abstract:BACKGROUND:New therapies to treat diabetic peripheral artery disease (PAD) require target-specific non-invasive imaging modalities to follow efficacy. As a translational study, we performed targeted imaging of receptors for vascular endothelial growth factor (VEGF) in response to anterior femoral artery occlusion (FAO)...

    journal_title:EJNMMI research

    pub_type: 杂志文章


    authors: Johnson LL,Johnson J,Ali Z,Tekabe Y,Ober R,Geist G,McLuckie A,Safarov A,Holland A,Zhang G,Backer M,Backer J

    更新日期:2020-05-12 00:00:00

  • Diagnostic value of PET/CT with 11C-methionine (MET) and 18F-fluorothymidine (FLT) in newly diagnosed glioma based on the 2016 WHO classification.

    abstract:BACKGROUND:The molecular features of isocitrate dehydrogenase (IDH) mutation and chromosome 1p and 19q (1p/19q) codeletion status have pivotal role for differentiating gliomas and have been integrated in the World Health Organization (WHO) classification in 2016. Positron emission tomography (PET) with 3'-deoxy-3'-[18F...

    journal_title:EJNMMI research

    pub_type: 杂志文章


    authors: Ogawa T,Kawai N,Miyake K,Shinomiya A,Yamamoto Y,Nishiyama Y,Tamiya T

    更新日期:2020-05-07 00:00:00

  • Targeted beta therapy of prostate cancer with 177Lu-labelled Miltuximab® antibody against glypican-1 (GPC-1).

    abstract:PURPOSE:Chimeric antibody Miltuximab®, a human IgG1 engineered from the parent antibody MIL-38, is in clinical development for solid tumour therapy. Miltuximab® targets glypican-1 (GPC-1), a cell surface protein involved in tumour growth, which is overexpressed in solid tumours, including prostate cancer (PCa). This st...

    journal_title:EJNMMI research

    pub_type: 杂志文章


    authors: Yeh MC,Tse BWC,Fletcher NL,Houston ZH,Lund M,Volpert M,Stewart C,Sokolowski KA,Jeet V,Thurecht KJ,Campbell DH,Walsh BJ,Nelson CC,Russell PJ

    更新日期:2020-05-07 00:00:00

  • Double-strand breaks in lymphocyte DNA of humans exposed to [18F]fluorodeoxyglucose and the static magnetic field in PET/MRI.

    abstract:BACKGROUND:Given the increasing clinical use of PET/MRI, potential risks to patients from simultaneous exposure to ionising radiation and (electro)magnetic fields should be thoroughly investigated as a precaution. With this aim, the genotoxic potential of 2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG) and a strong static m...

    journal_title:EJNMMI research

    pub_type: 杂志文章


    authors: Brix G,Günther E,Rössler U,Endesfelder D,Kamp A,Beer A,Eiber M

    更新日期:2020-04-28 00:00:00

  • Added value of 68Ga-PSMA PET/CT for the detection of bone metastases in patients with newly diagnosed prostate cancer and a previous 99mTc bone scintigraphy.

    abstract:PURPOSE:To investigate the added value and diagnostic accuracy of 68Ga-PSMA PET/CT versus bone scintigraphy (BS) for bone metastasis detection at the primary staging of prostate cancer (PCa). METHODS:Inclusion criteria involved consecutive patients with newly diagnosed intermediate- to high-risk PCa, who had undergone...

    journal_title:EJNMMI research

    pub_type: 杂志文章


    authors: Zacho HD,Ravn S,Afshar-Oromieh A,Fledelius J,Ejlersen JA,Petersen LJ

    更新日期:2020-04-08 00:00:00

  • Kinetic analysis of HER2-binding ABY-025 Affibody molecule using dynamic PET in patients with metastatic breast cancer.

    abstract:BACKGROUND:High expression of human epidermal growth factor receptor type 2 (HER2) represents an aggressive subtype of breast cancer. Anti-HER2 treatment requires a theragnostic approach wherein sufficiently high receptor expression in biopsy material is mandatory. Heterogeneity and discordance of HER2 expression betwe...

    journal_title:EJNMMI research

    pub_type: 杂志文章


    authors: Alhuseinalkhudhur A,Lubberink M,Lindman H,Tolmachev V,Frejd FY,Feldwisch J,Velikyan I,Sörensen J

    更新日期:2020-03-23 00:00:00

  • 68Ga-PSMA PET/CT in radioactive iodine-refractory differentiated thyroid cancer and first treatment results with 177Lu-PSMA-617.

    abstract:BACKGROUND:Differentiated thyroid carcinoma (DTC) is the most common type of thyroid cancer. Treatment with surgery, radioactive iodine (RAI), and TSH suppression is effective in most patients. Five to 15% of patients become RAI refractory and need alternative therapy; however, treatment options are limited. 68Ga-PSMA ...

    journal_title:EJNMMI research

    pub_type: 杂志文章


    authors: de Vries LH,Lodewijk L,Braat AJAT,Krijger GC,Valk GD,Lam MGEH,Borel Rinkes IHM,Vriens MR,de Keizer B

    更新日期:2020-03-06 00:00:00

  • Interobserver agreement of [68Ga]Ga-PSMA-11 PET/CT images interpretation in men with newly diagnosed prostate cancer.

    abstract:BACKGROUND:Prostate-specific membrane antigen (PSMA) ligand PET/CT has already provided promising results in prostate cancer (PC) imaging, yet simple and reproductible reporting criteria are still lacking. This study aimed at retrospectively evaluating interobserver agreement of [68Ga]Ga-PSMA-11 PET/CT images interpret...

    journal_title:EJNMMI research

    pub_type: 杂志文章


    authors: Derwael C,Lavergne O,Lovinfosse P,Nechifor V,Salvé M,Waltregny D,Hustinx R,Withofs N

    更新日期:2020-02-28 00:00:00

  • Kinetic modeling of 68Ga-PSMA-11 and validation of simplified methods for quantification in primary prostate cancer patients.

    abstract:BACKGROUND:The positron emission tomography (PET) ligand 68Ga-Glu-urea-Lys(Ahx)-HBED-CC (68Ga-PSMA-11) targets the prostate-specific membrane antigen (PSMA), upregulated in prostate cancer cells. Although 68Ga-PSMA-11 PET is widely used in research and clinical practice, full kinetic modeling has not yet been reported ...

    journal_title:EJNMMI research

    pub_type: 杂志文章


    authors: Ringheim A,Campos Neto GC,Anazodo U,Cui L,da Cunha ML,Vitor T,Martins KM,Miranda ACC,de Barboza MF,Fuscaldi LL,Lemos GC,Colombo Junior JR,Baroni RH

    更新日期:2020-02-24 00:00:00

  • Quantitative 18F-FDG PET-CT scan characteristics correlate with tuberculosis treatment response.

    abstract:BACKGROUND:There is a growing interest in the use of F-18 FDG PET-CT to monitor tuberculosis (TB) treatment response. Tuberculosis lung lesions are often complex and diffuse, with dynamic changes during treatment and persisting metabolic activity after apparent clinical cure. This poses a challenge in quantifying scan-...

    journal_title:EJNMMI research

    pub_type: 杂志文章


    authors: Malherbe ST,Chen RY,Dupont P,Kant I,Kriel M,Loxton AG,Smith B,Beltran CGG,van Zyl S,McAnda S,Abrahams C,Maasdorp E,Doruyter A,Via LE,Barry CE 3rd,Alland D,Richards SG,Ellman A,Peppard T,Belisle J,Tromp G,Ronache

    更新日期:2020-02-10 00:00:00

  • [18F]ML-10 PET imaging fails to assess early response to neoadjuvant chemotherapy in a preclinical model of triple negative breast cancer.

    abstract:PURPOSE:Pathological complete response to the neoadjuvant therapy (NAT) for triple negative breast cancer (TNBC) is predictive of prolonged patient survival. Methods for early evaluation of NAT efficiency are still needed, in order to rapidly adjust the therapeutic strategy in case of initial non-response. One option f...

    journal_title:EJNMMI research

    pub_type: 杂志文章


    authors: Jouberton E,Schmitt S,Chautard E,Maisonial-Besset A,Roy M,Radosevic-Robin N,Chezal JM,Miot-Noirault E,Bouvet Y,Cachin F

    更新日期:2020-01-06 00:00:00

  • 64Cu-ATSM/64Cu-Cl2 and their relationship to hypoxia in glioblastoma: a preclinical study.

    abstract:BACKGROUND:Diacetyl-bis(N4-methylthiosemicarbazone), labeled with 64Cu (64Cu-ATSM) has been suggested as a promising tracer for imaging hypoxia. However, various controversial studies highlighted potential pitfalls that may disable its use as a selective hypoxic marker. They also highlighted that the results may be tum...

    journal_title:EJNMMI research

    pub_type: 杂志文章


    authors: Pérès EA,Toutain J,Paty LP,Divoux D,Ibazizène M,Guillouet S,Barré L,Vidal A,Cherel M,Bourgeois M,Bernaudin M,Valable S

    更新日期:2019-12-19 00:00:00

  • Low septal to lateral wall 18F-FDG ratio is highly associated with mechanical dyssynchrony in non-ischemic CRT candidates.

    abstract:BACKGROUND:In order to better understand the concept of mechanical dyssynchrony, a promising hallmark of cardiac resynchronization therapy (CRT) response, we investigated its effect on regional myocardial metabolism and myocardial blood flow (MBF) in non-ischemic CRT candidates. RESULTS:Thirty consecutive non-ischemic...

    journal_title:EJNMMI research

    pub_type: 杂志文章


    authors: Degtiarova G,Claus P,Duchenne J,Cvijic M,Schramm G,Nuyts J,Voigt JU,Gheysens O

    更新日期:2019-12-09 00:00:00

  • Short-term discontinuation of vagal nerve stimulation alters 18F-FDG blood pool activity: an exploratory interventional study in epilepsy patients.

    abstract:BACKGROUND:Vagus nerve activation impacts inflammation. Therefore, we hypothesized that vagal nerve stimulation (VNS) influenced arterial wall inflammation as measured by 18F-FDG uptake. RESULTS:Ten patients with left-sided VNS for refractory epilepsy were studied during stimulation (VNS-on) and in the hours after sti...

    journal_title:EJNMMI research

    pub_type: 杂志文章


    authors: Boswijk E,Franssen R,Vijgen GHEJ,Wierts R,van der Pol JAJ,Mingels AMA,Cornips EMJ,Majoie MHJM,van Marken Lichtenbelt WD,Mottaghy FM,Wildberger JE,Bucerius J

    更新日期:2019-11-27 00:00:00

  • Potential for imaging the high-affinity state of the 5-HT1B receptor: a comparison of three PET radioligands with differing intrinsic activity.

    abstract:BACKGROUND:Over the last decade, a few radioligands have been developed for PET imaging of brain 5-HT1B receptors. The 5-HT1B receptor is a G-protein-coupled receptor (GPCR) that exists in two different agonist affinity states. An agonist ligand is expected to be more sensitive towards competition from another agonist,...

    journal_title:EJNMMI research

    pub_type: 杂志文章


    authors: Lindberg A,Arakawa R,Nogami T,Nag S,Schou M,Elmore CS,Farde L,Pike VW,Halldin C

    更新日期:2019-11-21 00:00:00

  • Voxel-based statistical analysis and quantification of amyloid PET in the Japanese Alzheimer's disease neuroimaging initiative (J-ADNI) multi-center study.

    abstract:BACKGROUND:Amyloid PET plays a vital role in detecting the accumulation of in vivo amyloid-β (Aβ). The quantification of Aβ accumulation has been widely performed using the region of interest (ROI)-based mean cortical standardized uptake value ratio (mcSUVR). However, voxel-based statistical analysis has not been well ...

    journal_title:EJNMMI research

    pub_type: 杂志文章


    authors: Akamatsu G,Ikari Y,Ohnishi A,Matsumoto K,Nishida H,Yamamoto Y,Senda M,Japanese Alzheimer’s Disease Neuroimaging Initiative.

    更新日期:2019-09-18 00:00:00

  • Texture analysis of pretreatment [18F]FDG PET/CT for the prognostic prediction of locally advanced salivary gland carcinoma treated with interstitial brachytherapy.

    abstract:BACKGROUND:The aim of this study was to evaluate the prognostic value of positron emission tomography (PET) parameters and the PET texture features of fluorine 18-fluorodeoxyglucose ([18F]FDG) uptake on pretreatment PET/computed tomography (CT) in patients with locally advanced salivary gland carcinoma treated with int...

    journal_title:EJNMMI research

    pub_type: 杂志文章


    authors: Wu WJ,Li ZY,Dong S,Liu SM,Zheng L,Huang MW,Zhang JG

    更新日期:2019-09-11 00:00:00

  • A pretargeted multimodal approach for image-guided resection in a xenograft model of colorectal cancer.

    abstract:BACKGROUND:Image-guided surgery may improve surgical outcome for colorectal cancer patients. Here, we evaluated the feasibility of a pretargeting strategy for multimodal imaging in colorectal cancer using an anti-carcinoembryonic antigen (CEA) x anti-histamine-succinyl-glycine (HSG) bispecific antibody (TF2) in conjunc...

    journal_title:EJNMMI research

    pub_type: 杂志文章


    authors: Elekonawo FMK,Lütje S,Franssen GM,Bos DL,Goldenberg DM,Boerman OC,Rijpkema M

    更新日期:2019-09-04 00:00:00

  • Effects of metformin on tumor hypoxia and radiotherapy efficacy: a [18F]HX4 PET imaging study in colorectal cancer xenografts.

    abstract:BACKGROUND:In a colorectal cancer xenograft model, we investigated the therapeutic effect of metformin on tumor hypoxia with [18F]flortanidazole ([18F]HX4) small-animal positron emission tomography (μPET). We also assessed the additive effect of metformin on long-term radiotherapy outcome and we studied the potential o...

    journal_title:EJNMMI research

    pub_type: 杂志文章


    authors: De Bruycker S,Vangestel C,Staelens S,Wyffels L,Detrez J,Verschuuren M,De Vos WH,Pauwels P,Van den Wyngaert T,Stroobants S

    更新日期:2019-08-02 00:00:00

  • Quantification of pulmonary disease activity in sarcoidosis measured with 18F-FDG PET/CT: SUVmax versus total lung glycolysis.

    abstract:BACKGROUND:18F-FDG PET/CT has proven to be a reliable tool for therapy monitoring in sarcoidosis. Previous PET studies investigated the SUVmax as a marker for disease activity. Total lung glycolysis (TLuG) is a new tool, quantifying the glycolysis of the entire lung. Since SUVmax represents the maximum activity in only...

    journal_title:EJNMMI research

    pub_type: 杂志文章


    authors: Schimmelpennink MC,Vorselaars ADM,Veltkamp M,Keijsers RGM

    更新日期:2019-06-13 00:00:00

  • Photonuclear production, chemistry, and in vitro evaluation of the theranostic radionuclide 47Sc.

    abstract:BACKGROUND:In molecular imaging and nuclear medicine, theranostic agents that integrate radionuclide pairs are successfully being used for individualized care, which has led to rapidly growing interest in their continued development. These compounds, which are radiolabeled with one radionuclide for imaging and a chemic...

    journal_title:EJNMMI research

    pub_type: 杂志文章


    authors: Loveless CS,Radford LL,Ferran SJ,Queern SL,Shepherd MR,Lapi SE

    更新日期:2019-05-16 00:00:00

  • Multi-modal image analysis for semi-automatic segmentation of the total liver and liver arterial perfusion territories for radioembolization.

    abstract:PURPOSE:We have developed a multi-modal imaging approach for SIRT, combining 99mTc-MAA SPECT/CT and/or 90Y PET, 18F-FDG PET/CT, and contrast-enhanced CBCT for voxel-based dosimetry, as a tool for treatment planning and verification. For radiation dose prediction calculations, a segmentation of the total liver volume an...

    journal_title:EJNMMI research

    pub_type: 杂志文章


    authors: Jafargholi Rangraz E,Coudyzer W,Maleux G,Baete K,Deroose CM,Nuyts J

    更新日期:2019-02-20 00:00:00

  • The development of a GPR44 targeting radioligand [11C]AZ12204657 for in vivo assessment of beta cell mass.

    abstract:BACKGROUND:The G-protein-coupled receptor 44 (GPR44) is a beta cell-restricted target that may serve as a marker for beta cell mass (BCM) given the development of a suitable PET ligand. METHODS:The binding characteristics of the selected candidate, AZ12204657, at human GPR44 were determined using in vitro ligand bindi...

    journal_title:EJNMMI research

    pub_type: 杂志文章


    authors: Jahan M,Johnström P,Selvaraju RK,Svedberg M,Winzell MS,Bernström J,Kingston L,Schou M,Jia Z,Skrtic S,Johansson L,Korsgren O,Farde L,Halldin C,Eriksson O

    更新日期:2018-12-27 00:00:00

  • First in-human radiation dosimetry of the gastrin-releasing peptide (GRP) receptor antagonist 68Ga-NODAGA-MJ9.

    abstract:BACKGROUND:Gastrin-releasing peptide receptor antagonists have promise in theranostics of several highly incident tumours, including prostate and breast. This study presents the first human dosimetry of 68Ga-NODAGA-MJ9 in the first five consecutive patients with recurrent prostate cancer included in a dual-tracer posit...

    journal_title:EJNMMI research

    pub_type: 杂志文章


    authors: Gnesin S,Cicone F,Mitsakis P,Van der Gucht A,Baechler S,Miralbell R,Garibotto V,Zilli T,Prior JO

    更新日期:2018-12-12 00:00:00

  • Development and evaluation of a rapid analysis for HEPES determination in 68Ga-radiotracers.

    abstract:BACKGROUND:HEPES is a favorable buffer for 68Ga-complexations in radiochemical laboratories. The drawback of this buffer is its prescribed limit of 200 μg per recommended application volume in the final formulation. Currently, a TLC test according to the European Pharmacopoeia (Ph. Eur.) has to be performed for quantif...

    journal_title:EJNMMI research

    pub_type: 杂志文章


    authors: Pfaff S,Nehring T,Pichler V,Cardinale J,Mitterhauser M,Hacker M,Wadsak W

    更新日期:2018-10-23 00:00:00

  • Impact of rifampicin-inhibitable transport on the liver distribution and tissue kinetics of erlotinib assessed with PET imaging in rats.

    abstract:BACKGROUND:Erlotinib is an epidermal growth factor receptor (EGFR)-targeting tyrosine kinase inhibitor approved for treatment of non-small cell lung cancer. The wide inter-individual pharmacokinetic (PK) variability of erlotinib may impact treatment outcome and/or toxicity. Recent in vivo studies reported a nonlinear u...

    journal_title:EJNMMI research

    pub_type: 杂志文章


    authors: Amor D,Goutal S,Marie S,Caillé F,Bauer M,Langer O,Auvity S,Tournier N

    更新日期:2018-08-16 00:00:00

  • A novel partial volume correction method for accurate quantification of [18F] flortaucipir in the hippocampus.

    abstract:BACKGROUND:Off-target binding in the choroid plexus (CP) may cause spill-in of the tau PET tracer [18F] flortaucipir into the adjacent hippocampus region. The impact of this spill-in on hippocampal uptake was assessed using a novel partial volume correction method (PVC). METHODS:PVC was performed on 20 [18F] flortauci...

    journal_title:EJNMMI research

    pub_type: 杂志文章


    authors: Wolters EE,Golla SSV,Timmers T,Ossenkoppele R,van der Weijden CWJ,Scheltens P,Schwarte L,Schuit RC,Windhorst AD,Barkhof F,Yaqub M,Lammertsma AA,Boellaard R,van Berckel BNM

    更新日期:2018-08-15 00:00:00

  • Quantitative performance and optimal regularization parameter in block sequential regularized expectation maximization reconstructions in clinical 68Ga-PSMA PET/MR.

    abstract:BACKGROUND:In contrast to ordered subset expectation maximization (OSEM), block sequential regularized expectation maximization (BSREM) positron emission tomography (PET) reconstruction algorithms can run until full convergence while controlling image quality and noise. Recent studies with BSREM and 18F-FDG PET reporte...

    journal_title:EJNMMI research

    pub_type: 杂志文章


    authors: Ter Voert EEGW,Muehlematter UJ,Delso G,Pizzuto DA,Müller J,Nagel HW,Burger IA

    更新日期:2018-07-27 00:00:00

  • 18F-FDG and 68Ga-somatostatin analogs PET/CT in patients with Merkel cell carcinoma: a comparison study.

    abstract:BACKGROUND:Merkel cell carcinoma (MCC) is an aggressive neuroendocrine skin tumor. Currently, 18F-fluoro-deoxy-glucose (18F-FDG) PET/CT is the functional imaging modality of choice. Few data are available on the use of 68Ga-somatostatin analogs. The aim of our study was to evaluate and compare the diagnostic performanc...

    journal_title:EJNMMI research

    pub_type: 杂志文章


    authors: Taralli S,Sollini M,Milella M,Perotti G,Filice A,Menga M,Versari A,Rufini V

    更新日期:2018-07-21 00:00:00

  • Evaluation of D-isomers of 4-borono-2-18F-fluoro-phenylalanine and O-11C-methyl-tyrosine as brain tumor imaging agents: a comparative PET study with their L-isomers in rat brain glioma.

    abstract:BACKGROUND:The potential of the D-isomerization of 4-borono-2-18F-fluoro-phenylalanine (18F-FBPA) to improve its target tumor to non-target normal brain tissue ratio (TBR) was evaluated in rat brain glioma and compared with those of L- and D-11C-methyl-tyrosine (11C-CMT). The L- or D-isomer of 18F-FBPA was injected int...

    journal_title:EJNMMI research

    pub_type: 杂志文章


    authors: Kanazawa M,Nishiyama S,Hashimoto F,Kakiuchi T,Tsukada H

    更新日期:2018-06-13 00:00:00

  • Simplifying [18F]GE-179 PET: are both arterial blood sampling and 90-min acquisitions essential?

    abstract:INTRODUCTION:The NMDA receptor radiotracer [18F]GE-179 has been used with 90-min scans and arterial plasma input functions. We explored whether (1) arterial blood sampling is avoidable and (2) shorter scans are feasible. METHODS:For 20 existing [18F]GE-179 datasets, we generated (1) standardised uptake values (SUVs) o...

    journal_title:EJNMMI research

    pub_type: 杂志文章


    authors: McGinnity CJ,Riaño Barros DA,Trigg W,Brooks DJ,Hinz R,Duncan JS,Koepp MJ,Hammers A

    更新日期:2018-06-11 00:00:00

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