听力与言语-语言病理学

行为科学

医学伦理学

你正在浏览CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION期刊下所有文献
  • Gut-kidney axis in oxalate homeostasis.

    abstract:PURPOSE OF REVIEW:The gut-kidney axis plays a critical role in oxalate homeostasis, and better understanding of oxalate transport regulatory mechanisms is essential for developing novel therapies. RECENT FINDINGS:Oxalate potentially contributes to chronic kidney disease (CKD) progression, CKD - and end stage renal dis...

    journal_title:Current opinion in nephrology and hypertension

    pub_type: 杂志文章

    doi:10.1097/MNH.0000000000000690

    authors: Alshaikh AE,Hassan HA

    更新日期:2021-03-01 00:00:00

  • WNK4 kinase: role of chloride sensing in the distal convoluted tubule.

    abstract:PURPOSE OF REVIEW:This review focuses on recent efforts in identifying with-no-lysine kinase 4 (WNK4) as a physiological intracellular chloride sensor and exploring regulators of intracellular chloride concentration ([Cl-]i) in the distal convoluted tubule (DCT). RECENT FINDINGS:The discovery of WNK1's chloride-bindin...

    journal_title:Current opinion in nephrology and hypertension

    pub_type: 杂志文章

    doi:10.1097/MNH.0000000000000683

    authors: Chen JC,Lin MX,Cheng CJ

    更新日期:2021-03-01 00:00:00

  • Membranous nephropathy: current understanding of various causes in light of new target antigens.

    abstract:PURPOSE OF REVIEW:Membranous nephropathy is an autoimmune disease caused by antibodies mostly directed to podocyte antigens. PLA2R and THSD7A antigens were described in 2009 and 2014 using classical immunochemical techniques. In the last 2 years, thanks to the combination of laser microdissection of glomeruli and mass ...

    journal_title:Current opinion in nephrology and hypertension

    pub_type: 杂志文章

    doi:10.1097/MNH.0000000000000697

    authors: Ronco P,Debiec H

    更新日期:2021-01-21 00:00:00

  • Novel conservative management of chronic kidney disease via dialysis-free interventions.

    abstract:PURPOSE OF REVIEW:In advanced chronic kidney disease (CKD) patients with progressive uremia, dialysis has traditionally been the dominant treatment paradigm. However, there is increasing interest in conservative and preservative management of kidney function as alternative patient-centered treatment approaches in this ...

    journal_title:Current opinion in nephrology and hypertension

    pub_type: 杂志文章

    doi:10.1097/MNH.0000000000000670

    authors: Zarantonello D,Rhee CM,Kalantar-Zadeh K,Brunori G

    更新日期:2021-01-01 00:00:00

  • Research progress of sirtuins in renal and cardiovascular diseases.

    abstract:PURPOSE OF REVIEW:Sirtuins are a family of nicotinamide adenine dinucleotide+-dependent enzymes catalyzing target protein deacetylation to modulate cellular metabolism, response to oxidative stress and inflammation, senescence, autophagy and apoptosis. In this review, we provide an overview of recent studies regarding ...

    journal_title:Current opinion in nephrology and hypertension

    pub_type: 杂志文章

    doi:10.1097/MNH.0000000000000660

    authors: Wang W,Li J,Cai L

    更新日期:2021-01-01 00:00:00

  • Imaging of renal fibrosis.

    abstract:PURPOSE OF REVIEW:Fibrosis is an important biomarker of chronic kidney injury, and a powerful predictor of renal outcome. Currently, the only method for measuring fibrotic burden is histologic analysis, which requires a kidney biopsy in humans, or kidney removal in animal models. These requirements have not only hinder...

    journal_title:Current opinion in nephrology and hypertension

    pub_type: 杂志文章

    doi:10.1097/MNH.0000000000000650

    authors: Hysi E,Yuen DA

    更新日期:2020-11-01 00:00:00

  • Fluid management in chronic kidney disease: what is too much, what is the distribution, and how to manage fluid overload in patients with chronic kidney disease?

    abstract:PURPOSE OF REVIEW:Assessment of fluid status to reach normovolemia in patients with chronic kidney disease (CKD) continues to be a tough task. Besides clinical observation, technological methods have been introduced, yet, the best approach is still uncertain. The present review looks at fluid overload in CKD from three...

    journal_title:Current opinion in nephrology and hypertension

    pub_type: 杂志文章

    doi:10.1097/MNH.0000000000000640

    authors: de Ruiter A,Bello A,Braam B

    更新日期:2020-11-01 00:00:00

  • Waiting times in renal transplant candidates with a history of malignancy: time for a change?

    abstract:PURPOSE OF REVIEW:With the aging population of kidney transplant candidates, a history of malignancy is an increasingly prevalent finding. Tumors can constitute a contraindication for transplantation or can lead to a delay of acceptance to the waiting-list. Current waiting time guidelines mainly refer to early data col...

    journal_title:Current opinion in nephrology and hypertension

    pub_type: 杂志文章

    doi:10.1097/MNH.0000000000000652

    authors: Bojic M,Watschinger C,Reiter T,Watschinger B

    更新日期:2020-11-01 00:00:00

  • Tubular effects of sodium-glucose cotransporter 2 inhibitors: intended and unintended consequences.

    abstract:PURPOSE OF REVIEW:Sodium-glucose cotransporter 2 (SGLT2) inhibitors are antihyperglycemic drugs that act by inhibiting renal sodium-glucose cotransport. Here we present new insights into 'off target', or indirect, effects of SGLT2 inhibitors. RECENT FINDINGS:SGLT2 inhibition causes an acute increase in urinary glucose...

    journal_title:Current opinion in nephrology and hypertension

    pub_type: 杂志文章

    doi:10.1097/MNH.0000000000000632

    authors: Dominguez Rieg JA,Xue J,Rieg T

    更新日期:2020-09-01 00:00:00

  • Genetic variants of mineral metabolism in health and disease.

    abstract:PURPOSE OF REVIEW:Disturbances in mineral metabolism are common among individuals with chronic kidney disease and have consistently been associated with cardiovascular and bone disease. The current review aims to describe the current knowledge of the genetic aspects of mineral metabolism disturbances and to suggest dir...

    journal_title:Current opinion in nephrology and hypertension

    pub_type: 杂志文章

    doi:10.1097/MNH.0000000000000612

    authors: Robinson-Cohen C

    更新日期:2020-07-01 00:00:00

  • Lessons from rodent gastric bypass model of enteric hyperoxaluria.

    abstract:PURPOSE OF REVIEW:The aim of the article is to review studies on bone health and oxalate metabolism/therapeutics in the obese rodent model of Roux-en-Y gastric bypass (RYGB) and examine pathways to decrease procedural morbidity. RECENT FINDINGS:Compared with controls, RYGB rodents have up to 40-fold more fat in their ...

    journal_title:Current opinion in nephrology and hypertension

    pub_type: 杂志文章

    doi:10.1097/MNH.0000000000000613

    authors: Kwenda EP,Rabley AK,Canales BK

    更新日期:2020-07-01 00:00:00

  • Epigenomics and the kidney.

    abstract:PURPOSE OF REVIEW:Epigenetic modifications are reversible changes to a cell's DNA or histones that alter gene expression but not DNA sequence. The present review will explore epigenomic profiling and bioinformatics techniques for the study of kidney development and disease. RECENT FINDINGS:Reversible DNA and histone m...

    journal_title:Current opinion in nephrology and hypertension

    pub_type: 杂志文章

    doi:10.1097/MNH.0000000000000602

    authors: Wilson PC,Ledru N,Humphreys BD

    更新日期:2020-05-01 00:00:00

  • PPARγ and RhoBTB1 in hypertension.

    abstract:PURPOSE OF REVIEW:This review provides an up-to-date understanding of how peroxisome proliferator activated receptor γ (PPARγ) exerts its cardioprotective effect in the vasculature through its activation of novel PPARγ target genes in endothelium and vascular smooth muscle. RECENT FINDINGS:In vascular endothelial cell...

    journal_title:Current opinion in nephrology and hypertension

    pub_type: 杂志文章,评审

    doi:10.1097/MNH.0000000000000579

    authors: Fang S,Sigmund CD

    更新日期:2020-03-01 00:00:00

  • Microbiome modulation to correct uremic toxins and to preserve kidney functions.

    abstract:PURPOSE OF REVIEW:The association between dysbiosis and CKD is well established. This review focuses on the current understanding of microbiome, in normal individuals and CKD patients, in order to hypothesize how to correct uremic toxins levels and preserve the renal function and reduce associated comorbidities. Here w...

    journal_title:Current opinion in nephrology and hypertension

    pub_type: 杂志文章

    doi:10.1097/MNH.0000000000000565

    authors: Caggiano G,Cosola C,Di Leo V,Gesualdo M,Gesualdo L

    更新日期:2020-01-01 00:00:00

  • Conservative vs. preservative management of chronic kidney disease: similarities and distinctions.

    abstract:PURPOSE OF REVIEW:Dialysis has been the prevailing treatment paradigm in advanced chronic kidney disease (CKD) for patients ineligible for or unlikely to receive kidney transplantation. As dialysis may neither offer survival benefit nor improved quality of life in certain groups, there has been increasing interest in c...

    journal_title:Current opinion in nephrology and hypertension

    pub_type: 杂志文章

    doi:10.1097/MNH.0000000000000573

    authors: Rhee CM,Nguyen DV,Nyamathi A,Kalantar-Zadeh K

    更新日期:2020-01-01 00:00:00

  • Skin autofluorescence: an emerging biomarker in persons with kidney disease.

    abstract:PURPOSE OF REVIEW:Skin autofluorescence (SAF) is a measure of the accumulation of advanced glycation end-products (AGEs) proposed to act as a marker of 'cumulative metabolic stress'. This article discusses mechanisms of AGE formation and reviews published literature on SAF as a biomarker and risk factor across the spec...

    journal_title:Current opinion in nephrology and hypertension

    pub_type: 杂志文章,评审

    doi:10.1097/MNH.0000000000000549

    authors: Viramontes Hörner D,Taal MW

    更新日期:2019-11-01 00:00:00

  • When are you too old to get a kidney transplants?

    abstract:PURPOSE OF REVIEW:With the increasing incidence and prevalence of ESRD in the elderly, we are now transplanting more elderly patients. Although we know from previous reports that transplantation provides increased survival advantage and/or quality of life when compared to being on dialysis, we also know that transplant...

    journal_title:Current opinion in nephrology and hypertension

    pub_type: 杂志文章,评审

    doi:10.1097/MNH.0000000000000548

    authors: Kodali L,Turner A

    更新日期:2019-11-01 00:00:00

  • Recent developments in the management of acute and chronic hyponatremia.

    abstract:PURPOSE OF REVIEW:The aim of the study is to review recent studies on the management of acute and chronic hyponatremia. RECENT FINDINGS:In acute symptomatic hyponatremia, bolus infusion of hypertonic saline improves hyponatremia and neurological status more quickly than continuous infusion. In chronic hyponatremia, ne...

    journal_title:Current opinion in nephrology and hypertension

    pub_type: 杂志文章,评审

    doi:10.1097/MNH.0000000000000528

    authors: Hoorn EJ,Spasovski G

    更新日期:2019-09-01 00:00:00

  • Recent advances of biosensors for hypertension and nephrology.

    abstract:PURPOSE OF REVIEW:Hypertension (HTN) and chronic kidney disease (CKD) are significant problems. With recent advances in technologies, biosensors have shown a great potential to provide better home monitoring in hypertension (HTN), medication compliance, diagnostic device for kidney disease, CKD/end-stage renal disease ...

    journal_title:Current opinion in nephrology and hypertension

    pub_type: 杂志文章,评审

    doi:10.1097/MNH.0000000000000517

    authors: Park SH,Zhang Y,Rogers JA,Gallon L

    更新日期:2019-07-01 00:00:00

  • Recent evidence for direct oral anticoagulants in chronic kidney disease.

    abstract:PURPOSE OF REVIEW:The direct oral anticoagulants (DOACs) have emerged as an effective and safe alternative to vitamin K antagonists (VKAs) for stroke and venous thromboembolism (VTE) prevention. However, patients with chronic kidney disease (CKD) experience an increase in the risk of both thromboembolism and bleeding, ...

    journal_title:Current opinion in nephrology and hypertension

    pub_type: 杂志文章,评审

    doi:10.1097/MNH.0000000000000493

    authors: Ha JT,Badve SV,Jun M

    更新日期:2019-05-01 00:00:00

  • Diagnosis of monogenic chronic kidney diseases.

    abstract:PURPOSE OF REVIEW:The purpose of this review is to emphasize that single gene disorders are an important and sometimes unrecognized cause of progressive chronic kidney disease. We provide an overview of the benefits of making a genetic diagnosis, the currently available genetic testing methods and examples of diseases ...

    journal_title:Current opinion in nephrology and hypertension

    pub_type: 杂志文章,评审

    doi:10.1097/MNH.0000000000000486

    authors: Armstrong ME,Thomas CP

    更新日期:2019-03-01 00:00:00

  • The case for cautious consumption: NSAIDs in chronic kidney disease.

    abstract:PURPOSE OF REVIEW:Strong epidemiological and pathologic evidence associates NSAIDs with kidney disease, both acute and chronic. Hence, the usage of NSAIDs has decreased in patients with, or at risk for, chronic kidney disease (CKD). Coupled with this has been a rise in use of opioids and other non-NSAID alternatives, w...

    journal_title:Current opinion in nephrology and hypertension

    pub_type: 杂志文章,评审

    doi:10.1097/MNH.0000000000000473

    authors: Sriperumbuduri S,Hiremath S

    更新日期:2019-03-01 00:00:00

  • Dilemmas and challenges in apolipoprotein L1 nephropathy research.

    abstract:PURPOSE OF REVIEW:The purpose of this mini-review is to highlight some unresolved questions and controversies in the evolving story of apolipoprotein L1 (APOL1) nephropathy. RECENT FINDINGS:We highlight studies that introduce complexity in unraveling the mechanisms whereby APOL1 risk variant alleles cause disease. The...

    journal_title:Current opinion in nephrology and hypertension

    pub_type: 杂志文章,评审

    doi:10.1097/MNH.0000000000000462

    authors: Kruzel-Davila E,Skorecki K

    更新日期:2019-01-01 00:00:00

  • Methylglyoxal stress, the glyoxalase system, and diabetic chronic kidney disease.

    abstract:PURPOSE OF REVIEW:Chronic kidney disease (CKD) remains a serious diabetic complication despite the use of widely employed interventions such as angiotensin-converting enzyme inhibitors and glucose-lowering treatments. Accumulation of methylglyoxal, a highly reactive glucose metabolite and a major precursor in the forma...

    journal_title:Current opinion in nephrology and hypertension

    pub_type: 杂志文章,评审

    doi:10.1097/MNH.0000000000000465

    authors: Hanssen NMJ,Stehouwer CDA,Schalkwijk CG

    更新日期:2019-01-01 00:00:00

  • Leveraging pragmatic clinical trial design to advance phosphate management in end-stage renal disease.

    abstract:PURPOSE OF REVIEW:Phosphate lowering toward the normal range is advocated and widely practiced in patients with end-stage renal disease receiving dialysis. This approach is guided by basic science data and large observational studies that have demonstrated a consistent association between hyperphosphatemia and adverse ...

    journal_title:Current opinion in nephrology and hypertension

    pub_type: 杂志文章,评审

    doi:10.1097/MNH.0000000000000460

    authors: Wald R,Thorpe KE,Walsh MW

    更新日期:2019-01-01 00:00:00

  • Personalized medicine in diabetic kidney disease: a novel approach to improve trial design and patient outcomes.

    abstract:PURPOSE OF REVIEW:In the last decade many attempts have been made to reduce the high residual risk of end-stage kidney disease and cardiovascular disease in patients with diabetic kidney disease by targeting a variety of risk markers. Subsequent analyses revealed that the variation in individual drug response to the te...

    journal_title:Current opinion in nephrology and hypertension

    pub_type: 杂志文章,评审

    doi:10.1097/MNH.0000000000000447

    authors: Idzerda NMA,Pena MJ,Heerspink HJL

    更新日期:2018-11-01 00:00:00

  • Expanding deceased donor kidney transplantation: medical risk, infectious risk, hepatitis C virus, and HIV.

    abstract:PURPOSE OF REVIEW:Due to the organ shortage, which prevents over 90 000 individuals in the United States from receiving life-saving transplants, the transplant community has begun to critically reevaluate whether organ sources that were previously considered too risky provide a survival benefit to waitlist candidates. ...

    journal_title:Current opinion in nephrology and hypertension

    pub_type: 杂志文章,评审

    doi:10.1097/MNH.0000000000000456

    authors: Ruck JM,Segev DL

    更新日期:2018-11-01 00:00:00

  • Which anticoagulants should be used for stroke prevention in non-valvular atrial fibrillation and severe chronic kidney disease?

    abstract:PURPOSE OF REVIEW:Non-valvular atrial fibrillation is common in patients with severe chronic kidney disease (CKD) and historically patients have been treated with vitamin K antagonists (VKA). However, these agents have questionable efficacy and are associated with increased bleeding risk. Non-vitamin K oral anticoagula...

    journal_title:Current opinion in nephrology and hypertension

    pub_type: 杂志文章,评审

    doi:10.1097/MNH.0000000000000443

    authors: Kalra PA,Burlacu A,Ferro CJ,Covic A

    更新日期:2018-11-01 00:00:00

  • Will there still be a role for the originator erythropoiesis-simulating agents after the biosimilars and the hypoxia-inducible factor stabilizers approval?

    abstract:PURPOSE OF REVIEW:To discuss if there will still be a role for the originator ESAs after the already available biosimilars and the approval of HIF stabilizers in the near future. RECENT FINDINGS:Current treatment with erythropoiesis-simulating agents (ESAs) is effective and generally well tolerated, but requires paren...

    journal_title:Current opinion in nephrology and hypertension

    pub_type: 杂志文章,评审

    doi:10.1097/MNH.0000000000000432

    authors: Locatelli F,Del Vecchio L

    更新日期:2018-09-01 00:00:00

  • Iron therapy for managing anaemia in chronic kidney disease.

    abstract:PURPOSE OF REVIEW:Iron deficiency is a major contributory cause to the development of anaemia in chronic kidney disease (CKD), and thus, iron replacement therapy plays a critical role in the management of this condition. The two main routes for administering iron are oral and intravenous, and there have been a number o...

    journal_title:Current opinion in nephrology and hypertension

    pub_type: 杂志文章,评审

    doi:10.1097/MNH.0000000000000436

    authors: Macdougall IC

    更新日期:2018-09-01 00:00:00

  • Role of microRNAs in aldosterone signaling.

    abstract:PURPOSE OF REVIEW:The review describes studies investigating the role of microRNAs in the signaling pathway of the mineralocorticoid hormone, aldosterone. RECENT FINDINGS:Emerging evidence indicates that aldosterone alters the expression of microRNAs in target tissues thereby modulating the expression of key regulator...

    journal_title:Current opinion in nephrology and hypertension

    pub_type: 杂志文章,评审

    doi:10.1097/MNH.0000000000000440

    authors: Butterworth MB

    更新日期:2018-09-01 00:00:00

  • Role of Klotho in bone and implication for CKD.

    abstract:PURPOSE OF REVIEW:Klotho is a transmembrane protein that acts as a co-receptor for fibroblast growth factor 23 (FGF23). Recent investigations have discovered the presence of Klotho in bone-forming osteoblasts and osteocytes. This review summarizes emerging literature on the roles of bone Klotho in mineral and bone meta...

    journal_title:Current opinion in nephrology and hypertension

    pub_type: 杂志文章,评审

    doi:10.1097/MNH.0000000000000423

    authors: Komaba H,Lanske B

    更新日期:2018-07-01 00:00:00

  • Rationale to reduce calcium intake in adult patients with chronic kidney disease.

    abstract:PURPOSE OF REVIEW:Calcium is an essential ion for the maintenance of normal bone health and physiologic functions. The extracellular and intracellular levels of calcium are maintained through hormonal regulation called homeostasis. Balance, the net intake minus excretion of calcium, is maintained by hormonal regulation...

    journal_title:Current opinion in nephrology and hypertension

    pub_type: 杂志文章,评审

    doi:10.1097/MNH.0000000000000416

    authors: Moe SM

    更新日期:2018-07-01 00:00:00

  • Renal effects of cytokines in hypertension.

    abstract:PURPOSE OF REVIEW:Inflammatory cytokines contribute to the pathogenesis of hypertension through effects on renal blood flow and sodium handling. This review will update recent advances that explore the renal actions of immune cells and cytokines in the pathogenesis of hypertension. RECENT FINDINGS:Populations of cells...

    journal_title:Current opinion in nephrology and hypertension

    pub_type: 杂志文章,评审

    doi:10.1097/MNH.0000000000000385

    authors: Wen Y,Crowley SD

    更新日期:2018-03-01 00:00:00

  • Leukotrienes and kidney diseases.

    abstract:PURPOSE OF REVIEW:This review will critically highlight the role of leukotrienes as mediators of renal diseases and drug nephrotoxicity. It will also discuss the recently identified mechanism of cysteinyl leukotrienes induction and action, and will propose clinical implementation of these findings. RECENT FINDINGS:Sin...

    journal_title:Current opinion in nephrology and hypertension

    pub_type: 杂志文章,评审

    doi:10.1097/MNH.0000000000000381

    authors: Rubinstein M,Dvash E

    更新日期:2018-01-01 00:00:00

  • Ischemic conditioning in solid organ transplantation: is it worth giving your right arm for?

    abstract:PURPOSE OF REVIEW:Ischemia reperfusion injury (IRI) is an inevitable complication in solid organ transplantation. Limiting this injury can increase patient and graft survival and can decrease complications associated with transplantation. We provide an extensive literature review analyzing the available evidence for is...

    journal_title:Current opinion in nephrology and hypertension

    pub_type: 杂志文章,评审

    doi:10.1097/MNH.0000000000000367

    authors: Nadarajah L,Yaqoob MM,McCafferty K

    更新日期:2017-11-01 00:00:00

  • Pregnancy and the kidney transplant recipient.

    abstract:PURPOSE OF REVIEW:The current article reviews the available literature on the incidence, complications, outcomes, and management of pregnancies in kidney transplant recipients. RECENT FINDINGS:Pregnancy can be a reasonable option for women with a kidney transplant. More than 4700 successful pregnancies have been repor...

    journal_title:Current opinion in nephrology and hypertension

    pub_type: 杂志文章,评审

    doi:10.1097/MNH.0000000000000363

    authors: Vijayan M,Pavlakis M

    更新日期:2017-11-01 00:00:00

  • The impact of frailty on outcomes in dialysis.

    abstract:PURPOSE OF REVIEW:Frailty is highly prevalent in the dialysis population and is associated with mortality. Recent studies have suggested that other dialysis outcomes are compromised in frail individuals. While we do not yet have a consensus as to the best measure of frailty, identification of these poor outcomes and th...

    journal_title:Current opinion in nephrology and hypertension

    pub_type: 杂志文章,评审

    doi:10.1097/MNH.0000000000000364

    authors: Sy J,Johansen KL

    更新日期:2017-11-01 00:00:00

  • Digital pathology in nephrology clinical trials, research, and pathology practice.

    abstract:PURPOSE OF REVIEW:In this review, we will discuss (i) how the recent advancements in digital technology and computational engineering are currently applied to nephropathology in the setting of clinical research, trials, and practice; (ii) the benefits of the new digital environment; (iii) how recognizing its challenges...

    journal_title:Current opinion in nephrology and hypertension

    pub_type: 杂志文章,评审

    doi:10.1097/MNH.0000000000000360

    authors: Barisoni L,Hodgin JB

    更新日期:2017-11-01 00:00:00

  • Therapeutic microRNAs in polycystic kidney disease.

    abstract:PURPOSE OF REVIEW:microRNAs (miRNAs) are short noncoding RNAs that function as sequence-specific inhibitors of gene expression. Autosomal dominant polycystic kidney disease (ADPKD) is the most frequent genetic cause of end-stage kidney failure with limited treatment options. The realization that miRNA upregulation, and...

    journal_title:Current opinion in nephrology and hypertension

    pub_type: 杂志文章,评审

    doi:10.1097/MNH.0000000000000333

    authors: Yheskel M,Patel V

    更新日期:2017-07-01 00:00:00

231 条记录 1/6 页 « 123456 »