听力与言语-语言病理学

行为科学

医学伦理学

你正在浏览CIRCULATION期刊下所有文献
  • Achieving Optimal Population Cardiovascular Health Requires an Interdisciplinary Team and a Learning Healthcare System: A Scientific Statement From the American Heart Association.

    abstract::Population cardiovascular health, or improving cardiovascular health among patients and the population at large, requires a redoubling of primordial and primary prevention efforts as declines in cardiovascular disease mortality have decelerated over the past decade. Great potential exists for healthcare systems-based ...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIR.0000000000000913

    authors: Foraker RE,Benziger CP,DeBarmore BM,Cené CW,Loustalot F,Khan Y,Anderson CAM,Roger VL,American Heart Association Council on Epidemiology and Prevention; Council on Arteriosclerosis, Thrombosis and Vascular Biology; and Council on Lifestyl

    更新日期:2021-01-12 00:00:00

  • Exercise Training-Induced Repolarization Abnormalities Masquerading as Congenital Long QT Syndrome.

    abstract:BACKGROUND:The diagnosis of long QT syndrome (LQTS) is rather straightforward. We were surprised by realizing that, despite long-standing experience, we were making occasional diagnostic errors by considering as affected subjects who, over time, resulted as not affected. These individuals were all actively practicing s...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.120.048916

    authors: Dagradi F,Spazzolini C,Castelletti S,Pedrazzini M,Kotta MC,Crotti L,Schwartz PJ

    更新日期:2020-12-22 00:00:00

  • Association of Baseline and Longitudinal Changes in Body Composition Measures With Risk of Heart Failure and Myocardial Infarction in Type 2 Diabetes: Findings From the Look AHEAD Trial.

    abstract:BACKGROUND:Intentional weight loss is associated with lower risk of heart failure (HF) and atherosclerotic cardiovascular disease among patients with type 2 diabetes. However, the contribution of baseline measures and longitudinal changes in fat mass (FM), lean mass (LM), and waist circumference (WC) to the risk of HF ...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.120.050941

    authors: Patel KV,Bahnson JL,Gaussoin SA,Johnson KC,Pi-Sunyer X,White U,Olson KL,Bertoni AG,Kitzman DW,Berry JD,Pandey A,Look AHEAD Research Group.

    更新日期:2020-12-22 00:00:00

  • BMP9 and BMP10 Act Directly on Vascular Smooth Muscle Cells for Generation and Maintenance of the Contractile State.

    abstract::Background: Vascular smooth muscle cells (VSMCs) show a remarkable phenotypic plasticity allowing acquisition of contractile or synthetic states but critical information is missing about the physiological signals, promoting formation and maintenance of contractile VSMCs in vivo. BMP9 and BMP10 are known to regulate en...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.120.047375

    authors: Wang L,Rice M,Swist S,Kubin T,Wu F,Wang S,Kraut S,Weissmann N,Böttger T,Wheeler M,Schneider A,Braun T

    更新日期:2020-12-18 00:00:00

  • Epigenetic Reader BRD4 (Bromodomain-Containing Protein 4) Governs Nucleus-Encoded Mitochondrial Transcriptome to Regulate Cardiac Function.

    abstract:BACKGROUND:BET (bromodomain and extraterminal) epigenetic reader proteins, in particular BRD4 (bromodomain-containing protein 4), have emerged as potential therapeutic targets in a number of pathological conditions, including cancer and cardiovascular disease. Small-molecule BET protein inhibitors such as JQ1 have demo...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.120.047239

    authors: Kim SY,Zhang X,Schiattarella GG,Altamirano F,Ramos TAR,French KM,Jiang N,Szweda PA,Evers BM,May HI,Luo X,Li H,Szweda LI,Maracaja-Coutinho V,Lavandero S,Gillette TG,Hill JA

    更新日期:2020-12-15 00:00:00

  • Myocardial Infarction in the ISCHEMIA Trial: Impact of Different Definitions on Incidence, Prognosis, and Treatment Comparisons.

    abstract::Background: In ISCHEMIA, an initial invasive strategy did not significantly reduce rates of cardiovascular events or all-cause mortality compared with a conservative strategy in patients with stable ischemic heart disease and moderate/severe myocardial ischemia. The most frequent component of composite cardiovascular ...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.120.047987

    authors: Chaitman BR,Alexander KP,Cyr DD,Berger JS,Reynolds HR,Bangalore S,Boden WE,Lopes RD,Demkow M,Perna GP,Riezebos RK,McFalls EO,Banerjee S,Bagai A,Gosselin G,O'Brien SM,Rockhold FW,Waters DD,Thygesen KA,Stone GW,Whit

    更新日期:2020-12-03 00:00:00

  • Left Ventricular Unloading Is Associated With Lower Mortality in Patients With Cardiogenic Shock Treated With Venoarterial Extracorporeal Membrane Oxygenation: Results From an International, Multicenter Cohort Study.

    abstract:BACKGROUND:Venoarterial extracorporeal membrane oxygenation (VA-ECMO) is increasingly used to treat cardiogenic shock. However, VA-ECMO might hamper myocardial recovery. The Impella unloads the left ventricle. This study aimed to evaluate whether left ventricular unloading in patients with cardiogenic shock treated wit...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.120.048792

    authors: Schrage B,Becher PM,Bernhardt A,Bezerra H,Blankenberg S,Brunner S,Colson P,Cudemus Deseda G,Dabboura S,Eckner D,Eden M,Eitel I,Frank D,Frey N,Funamoto M,Goßling A,Graf T,Hagl C,Kirchhof P,Kupka D,Landmesser U,Li

    更新日期:2020-12-01 00:00:00

  • Effect of Empagliflozin on Left Ventricular Volumes in Patients with Type 2 Diabetes, or Prediabetes, and Heart Failure with Reduced Ejection Fraction (SUGAR-DM-HF).

    abstract:BACKGROUND:Sodium-glucose cotransporter 2 inhibitors reduce the risk of heart failure hospitalization and cardiovascular death in patients with heart failure and reduced ejection fraction (HFrEF). However, their effects on cardiac structure and function in HFrEF are uncertain. METHODS:We designed a multicenter, random...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.120.052186

    authors: Lee MMY,Brooksbank KJM,Wetherall K,Mangion K,Roditi G,Campbell RT,Berry C,Chong V,Coyle L,Docherty KF,Dreisbach JG,Labinjoh C,Lang NN,Lennie V,McConnachie A,Murphy CL,Petrie CJ,Petrie JR,Speirits IA,Sourbron S,Wel

    更新日期:2020-11-13 00:00:00

  • Adult Advanced Life Support: 2020 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations.

    abstract::This 2020 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations for advanced life support includes updates on multiple advanced life support topics addressed with 3 different types of reviews. Topics were prioritized on the basis of both recen...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIR.0000000000000893

    authors: Berg KM,Soar J,Andersen LW,Böttiger BW,Cacciola S,Callaway CW,Couper K,Cronberg T,D'Arrigo S,Deakin CD,Donnino MW,Drennan IR,Granfeldt A,Hoedemaekers CWE,Holmberg MJ,Hsu CH,Kamps M,Musiol S,Nation KJ,Neumar RW,Nic

    更新日期:2020-10-20 00:00:00

  • Identification of Long Noncoding RNA H19 as a New Biomarker and Therapeutic Target in Right Ventricular Failure in Pulmonary Arterial Hypertension.

    abstract:BACKGROUND:Right ventricular (RV) function is the major determinant for both functional capacity and survival in patients with pulmonary arterial hypertension (PAH). Despite the recognized clinical importance of preserving RV function, the subcellular mechanisms that govern the transition from a compensated to a decomp...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.120.047626

    authors: Omura J,Habbout K,Shimauchi T,Wu WH,Breuils-Bonnet S,Tremblay E,Martineau S,Nadeau V,Gagnon K,Mazoyer F,Perron J,Potus F,Lin JH,Zafar H,Kiely DG,Lawrie A,Archer SL,Paulin R,Provencher S,Boucherat O,Bonnet S

    更新日期:2020-10-13 00:00:00

  • The Safety and Efficacy of Aspirin Discontinuation on a Background of a P2Y12 Inhibitor in Patients After Percutaneous Coronary Intervention: A Systematic Review and Meta-Analysis.

    abstract:BACKGROUND:Dual antiplatelet therapy with aspirin and a P2Y12 inhibitor has been shown to reduce the risk of major adverse cardiovascular events (MACE) compared with aspirin alone after percutaneous coronary intervention (PCI) or acute coronary syndrome but with increased risk of bleeding. The safety of discontinuing a...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.120.046251

    authors: O'Donoghue ML,Murphy SA,Sabatine MS

    更新日期:2020-08-11 00:00:00

  • Bone Marrow Endothelial Cells Regulate Myelopoiesis in Diabetes Mellitus.

    abstract:BACKGROUND:Diabetes mellitus is a prevalent public health problem that affects about one-third of the US population and leads to serious vascular complications with increased risk for coronary artery disease. How bone marrow hematopoiesis contributes to diabetes mellitus complications is incompletely understood. We inv...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.120.046038

    authors: Hoyer FF,Zhang X,Coppin E,Vasamsetti SB,Modugu G,Schloss MJ,Rohde D,McAlpine CS,Iwamoto Y,Libby P,Naxerova K,Swirski FK,Dutta P,Nahrendorf M

    更新日期:2020-07-21 00:00:00

  • Use of Administrative Claims to Assess Outcomes and Treatment Effect in Randomized Clinical Trials for Transcatheter Aortic Valve Replacement: Findings From the EXTEND Study.

    abstract:BACKGROUND:Whether passively collected data can substitute for adjudicated outcomes to reproduce the magnitude and direction of treatment effect observed in cardiovascular clinical trials is not well known. METHODS:We linked adults ≥65 years of age in the HiR (US CoreValve Pivotal High Risk) and SURTAVI trials (Surgic...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.120.046159

    authors: Strom JB,Faridi KF,Butala NM,Zhao Y,Tamez H,Valsdottir LR,Brennan JM,Shen C,Popma JJ,Kazi DS,Yeh RW

    更新日期:2020-07-21 00:00:00

  • The Science Underlying COVID-19: Implications for the Cardiovascular System.

    abstract::The coronavirus disease 2019 (COVID-19) pandemic has affected health and economy worldwide on an unprecedented scale. Patients have diverse clinical outcomes, but those with preexisting cardiovascular disease, hypertension, and related conditions incur disproportionately worse outcome. The high infectivity of severe a...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.120.047549

    authors: Liu PP,Blet A,Smyth D,Li H

    更新日期:2020-07-07 00:00:00

  • Cardiac Amyloidosis: Evolving Diagnosis and Management: A Scientific Statement From the American Heart Association.

    abstract::Transthyretin amyloid cardiomyopathy (ATTR-CM) results in a restrictive cardiomyopathy caused by extracellular deposition of transthyretin, normally involved in the transportation of the hormone thyroxine and retinol-binding protein, in the myocardium. Enthusiasm about ATTR-CM has grown as a result of 3 simultaneous a...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIR.0000000000000792

    authors: Kittleson MM,Maurer MS,Ambardekar AV,Bullock-Palmer RP,Chang PP,Eisen HJ,Nair AP,Nativi-Nicolau J,Ruberg FL,American Heart Association Heart Failure and Transplantation Committee of the Council on Clinical Cardiology.

    更新日期:2020-07-07 00:00:00

  • Incidence, Microbiology, and Outcomes in Patients Hospitalized With Infective Endocarditis.

    abstract:BACKGROUND:Despite improvements in management, infective endocarditis remains associated with high mortality and morbidity. We describe temporal changes in the incidence, microbiology, and outcomes of infective endocarditis and the effect of changes in national antibiotic prophylaxis guidelines on incident infective en...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.119.044913

    authors: Shah ASV,McAllister DA,Gallacher P,Astengo F,Rodríguez Pérez JA,Hall J,Lee KK,Bing R,Anand A,Nathwani D,Mills NL,Newby DE,Marwick C,Cruden NL

    更新日期:2020-06-23 00:00:00

  • Call to Action to Prevent Venous Thromboembolism in Hospitalized Patients: A Policy Statement From the American Heart Association.

    abstract::Venous thromboembolism (VTE) is a major preventable disease that affects hospitalized inpatients. Risk stratification and prophylactic measures have good evidence supporting their use, but multiple reasons exist that prevent full adoption, compliance, and efficacy that may underlie the persistence of VTE over the past...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIR.0000000000000769

    authors: Henke PK,Kahn SR,Pannucci CJ,Secemksy EA,Evans NS,Khorana AA,Creager MA,Pradhan AD,American Heart Association Advocacy Coordinating Committee.

    更新日期:2020-06-16 00:00:00

  • CSC Expert Consensus on Principles of Clinical Management of Patients With Severe Emergent Cardiovascular Diseases During the COVID-19 Epidemic.

    abstract::In response to the outbreak of coronavirus disease 2019 (COVID-19) in Wuhan, China, the Chinese Society of Cardiology (CSC) issued this consensus statement after consulting with 125 medical experts in the fields of cardiovascular disease and infectious disease. The over-arching principles laid out here are the followi...

    journal_title:Circulation

    pub_type: 共识发展会议,杂志文章

    doi:10.1161/CIRCULATIONAHA.120.047011

    authors: Han Y,Zeng H,Jiang H,Yang Y,Yuan Z,Cheng X,Jing Z,Liu B,Chen J,Nie S,Zhu J,Li F,Ma C

    更新日期:2020-05-19 00:00:00

  • Inherited Thoracic Aortic Disease: New Insights and Translational Targets.

    abstract::Inherited thoracic aortopathies denote a group of congenital conditions that predispose to disease of the thoracic aorta. Aortic wall weakness and abnormal aortic hemodynamic profiles predispose these patients to dilatation of the thoracic aorta, which is generally silent but can precipitate aortic dissection or ruptu...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.119.043756

    authors: Fletcher AJ,Syed MBJ,Aitman TJ,Newby DE,Walker NL

    更新日期:2020-05-12 00:00:00

  • Low-Attenuation Noncalcified Plaque on Coronary Computed Tomography Angiography Predicts Myocardial Infarction: Results From the Multicenter SCOT-HEART Trial (Scottish Computed Tomography of the HEART).

    abstract:BACKGROUND:The future risk of myocardial infarction is commonly assessed using cardiovascular risk scores, coronary artery calcium score, or coronary artery stenosis severity. We assessed whether noncalcified low-attenuation plaque burden on coronary CT angiography (CCTA) might be a better predictor of the future risk ...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.119.044720

    authors: Williams MC,Kwiecinski J,Doris M,McElhinney P,D'Souza MS,Cadet S,Adamson PD,Moss AJ,Alam S,Hunter A,Shah ASV,Mills NL,Pawade T,Wang C,Weir McCall J,Bonnici-Mallia M,Murrills C,Roditi G,van Beek EJR,Shaw LJ,Nicol E

    更新日期:2020-05-05 00:00:00

  • Deficiency of Prebiotic Fiber and Insufficient Signaling Through Gut Metabolite-Sensing Receptors Leads to Cardiovascular Disease.

    abstract:BACKGROUND:High blood pressure (BP) continues to be a major, poorly controlled but modifiable risk factor for cardiovascular death. Among key Western lifestyle factors, a diet poor in fiber is associated with prevalence of high BP. The impact of lack of prebiotic fiber and the associated mechanisms that lead to higher ...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.119.043081

    authors: Kaye DM,Shihata WA,Jama HA,Tsyganov K,Ziemann M,Kiriazis H,Horlock D,Vijay A,Giam B,Vinh A,Johnson C,Fiedler A,Donner D,Snelson M,Coughlan MT,Phillips S,Du XJ,El-Osta A,Drummond G,Lambert GW,Spector TD,Valdes AM

    更新日期:2020-04-28 00:00:00

  • The Prognostic Significance of Quantitative Myocardial Perfusion: An Artificial Intelligence-Based Approach Using Perfusion Mapping.

    abstract:BACKGROUND:Myocardial perfusion reflects the macro- and microvascular coronary circulation. Recent quantitation developments using cardiovascular magnetic resonance perfusion permit automated measurement clinically. We explored the prognostic significance of stress myocardial blood flow (MBF) and myocardial perfusion r...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.119.044666

    authors: Knott KD,Seraphim A,Augusto JB,Xue H,Chacko L,Aung N,Petersen SE,Cooper JA,Manisty C,Bhuva AN,Kotecha T,Bourantas CV,Davies RH,Brown LAE,Plein S,Fontana M,Kellman P,Moon JC

    更新日期:2020-04-21 00:00:00

  • Outcomes of Transcatheter Aortic Valve Replacement in Patients With Bicuspid Aortic Valve Disease: A Report From the Society of Thoracic Surgeons/American College of Cardiology Transcatheter Valve Therapy Registry.

    abstract:BACKGROUND:Patients with bicuspid aortic valve (AV) stenosis were excluded from the pivotal evaluations of transcatheter AV replacement (TAVR) devices. We sought to evaluate the outcomes of TAVR in patients with bicuspid AV stenosis in comparison with those with tricuspid AV stenosis. METHODS:We used data from the Soc...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.119.040333

    authors: Halim SA,Edwards FH,Dai D,Li Z,Mack MJ,Holmes DR,Tuzcu EM,Thourani VH,Harrison JK,Brennan JM

    更新日期:2020-03-31 00:00:00

  • Sudden Cardiac Arrest Survivorship: A Scientific Statement From the American Heart Association.

    abstract::Cardiac arrest systems of care are successfully coordinating community, emergency medical services, and hospital efforts to improve the process of care for patients who have had a cardiac arrest. As a result, the number of people surviving sudden cardiac arrest is increasing. However, physical, cognitive, and emotiona...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIR.0000000000000747

    authors: Sawyer KN,Camp-Rogers TR,Kotini-Shah P,Del Rios M,Gossip MR,Moitra VK,Haywood KL,Dougherty CM,Lubitz SA,Rabinstein AA,Rittenberger JC,Callaway CW,Abella BS,Geocadin RG,Kurz MC,American Heart Association Emergency Cardiovasc

    更新日期:2020-03-24 00:00:00

  • The Effect of Coconut Oil Consumption on Cardiovascular Risk Factors: A Systematic Review and Meta-Analysis of Clinical Trials.

    abstract:BACKGROUND:Coconut oil is high in saturated fat and may, therefore, raise serum cholesterol concentrations, but beneficial effects on other cardiovascular risk factors have also been suggested. Therefore, we conducted a systematic review of the effect of coconut oil consumption on blood lipids and other cardiovascular ...

    journal_title:Circulation

    pub_type: 杂志文章,meta分析

    doi:10.1161/CIRCULATIONAHA.119.043052

    authors: Neelakantan N,Seah JYH,van Dam RM

    更新日期:2020-03-10 00:00:00

  • Slowing Progression of Cardiovascular Calcification With SNF472 in Patients on Hemodialysis: Results of a Randomized Phase 2b Study.

    abstract:BACKGROUND:The high cardiovascular morbidity and mortality in patients with end-stage kidney disease could be partially caused by extensive cardiovascular calcification. SNF472, intravenous myo-inositol hexaphosphate, selectively inhibits the formation and growth of hydroxyapatite. METHODS:This double-blind, placebo-c...

    journal_title:Circulation

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1161/CIRCULATIONAHA.119.044195

    authors: Raggi P,Bellasi A,Bushinsky D,Bover J,Rodriguez M,Ketteler M,Sinha S,Salcedo C,Gillotti K,Padgett C,Garg R,Gold A,Perelló J,Chertow GM

    更新日期:2020-03-03 00:00:00

  • Cumulative Blood Pressure Exposure During Young Adulthood and Mobility and Cognitive Function in Midlife.

    abstract:BACKGROUND:High blood pressure (BP) is a known risk factor for mobility and cognitive impairment in older adults. This study tested the association of cumulative BP exposure from young adulthood to midlife with gait and cognitive function in midlife. Furthermore, we tested whether these associations were modified by ce...

    journal_title:Circulation

    pub_type: 杂志文章,多中心研究

    doi:10.1161/CIRCULATIONAHA.119.042502

    authors: Mahinrad S,Kurian S,Garner CR,Sedaghat S,Nemeth AJ,Moscufo N,Higgins JP,Jacobs DR Jr,Hausdorff JM,Lloyd-Jones DM,Sorond FA

    更新日期:2020-03-03 00:00:00

  • Recommendations for Cardiovascular Health and Disease Surveillance for 2030 and Beyond: A Policy Statement From the American Heart Association.

    abstract::The release of the American Heart Association's 2030 Impact Goal and associated metrics for success underscores the importance of cardiovascular health and cardiovascular disease surveillance systems for the acquisition of information sufficient to support implementation and evaluation. The aim of this policy statemen...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIR.0000000000000756

    authors: Roger VL,Sidney S,Fairchild AL,Howard VJ,Labarthe DR,Shay CM,Tiner AC,Whitsel LP,Rosamond WD,American Heart Association Advocacy Coordinating Committee.

    更新日期:2020-03-03 00:00:00

  • Deficiency of Cardiac Natriuretic Peptide Signaling Promotes Peripartum Cardiomyopathy-Like Remodeling in the Mouse Heart.

    abstract:BACKGROUND:The maternal circulatory system and hormone balance both change dynamically during pregnancy, delivery, and the postpartum period. Although atrial natriuretic peptides and brain natriuretic peptides produced in the heart control circulatory homeostasis through their common receptor, NPR1, the physiologic and...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.119.039761

    authors: Otani K,Tokudome T,Kamiya CA,Mao Y,Nishimura H,Hasegawa T,Arai Y,Kaneko M,Shioi G,Ishida J,Fukamizu A,Osaki T,Nagai-Okatani C,Minamino N,Ensho T,Hino J,Murata S,Takegami M,Nishimura K,Kishimoto I,Miyazato M,Hara

    更新日期:2020-02-18 00:00:00

  • Sex-Specific Trends in Acute Myocardial Infarction Within an Integrated Healthcare Network, 2000 Through 2014.

    abstract:BACKGROUND:In recent decades, the rates of incident acute myocardial infarction (AMI) have declined in the United States, yet disparities by sex remain. In an integrated healthcare delivery system, we examined temporal trends in incident AMI among women and men. METHODS:We identified hospitalized AMI among members ≥35...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.119.044738

    authors: Mefford MT,Li BH,Qian L,Reading SR,Harrison TN,Scott RD,Cavendish JJ,Jacobsen SJ,Kanter MH,Woodward M,Reynolds K

    更新日期:2020-02-18 00:00:00

  • Endothelial Cell-Derived Interleukin-18 Released During Ischemia Reperfusion Injury Selectively Expands T Peripheral Helper Cells to Promote Alloantibody Production.

    abstract:BACKGROUND:Ischemia reperfusion injury (IRI) predisposes to the formation of donor-specific antibodies, a factor contributing to chronic rejection and late allograft loss. METHODS:We describe a mechanism underlying the correlative association between IRI and donor-specific antibodies by using humanized models and pati...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.119.042501

    authors: Liu L,Fang C,Fu W,Jiang B,Li G,Qin L,Rosenbluth J,Gong G,Xie CB,Yoo P,Tellides G,Pober JS,Jane-Wit D

    更新日期:2020-02-11 00:00:00

  • An International, Multicentered, Evidence-Based Reappraisal of Genes Reported to Cause Congenital Long QT Syndrome.

    abstract:BACKGROUND:Long QT syndrome (LQTS) is the first described and most common inherited arrhythmia. Over the last 25 years, multiple genes have been reported to cause this condition and are routinely tested in patients. Because of dramatic changes in our understanding of human genetic variation, reappraisal of reported gen...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.119.043132

    authors: Adler A,Novelli V,Amin AS,Abiusi E,Care M,Nannenberg EA,Feilotter H,Amenta S,Mazza D,Bikker H,Sturm AC,Garcia J,Ackerman MJ,Hershberger RE,Perez MV,Zareba W,Ware JS,Wilde AAM,Gollob MH

    更新日期:2020-02-11 00:00:00

  • A Novel Role of Cyclic Nucleotide Phosphodiesterase 10A in Pathological Cardiac Remodeling and Dysfunction.

    abstract:BACKGROUND:Heart failure is a leading cause of death worldwide. Cyclic nucleotide phosphodiesterases (PDEs), through degradation of cyclic nucleotides, play critical roles in cardiovascular biology and disease. Our preliminary screening studies have revealed PDE10A upregulation in the diseased heart. However, the roles...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.119.042178

    authors: Chen S,Zhang Y,Lighthouse JK,Mickelsen DM,Wu J,Yao P,Small EM,Yan C

    更新日期:2020-01-21 00:00:00

  • Dietary Cholesterol and Cardiovascular Risk: A Science Advisory From the American Heart Association.

    abstract::The elimination of specific dietary cholesterol target recommendations in recent guidelines has raised questions about its role with respect to cardiovascular disease. This advisory was developed after a review of human studies on the relationship of dietary cholesterol with blood lipids, lipoproteins, and cardiovascu...

    journal_title:Circulation

    pub_type: 杂志文章,meta分析

    doi:10.1161/CIR.0000000000000743

    authors: Carson JAS,Lichtenstein AH,Anderson CAM,Appel LJ,Kris-Etherton PM,Meyer KA,Petersen K,Polonsky T,Van Horn L,American Heart Association Nutrition Committee of the Council on Lifestyle and Cardiometabolic Health; Council on Arteriosclero

    更新日期:2020-01-21 00:00:00

  • Critical Role of Cytosolic DNA and Its Sensing Adaptor STING in Aortic Degeneration, Dissection, and Rupture.

    abstract:BACKGROUND:Sporadic aortic aneurysm and dissection (AAD), caused by progressive aortic smooth muscle cell (SMC) loss and extracellular matrix degradation, is a highly lethal condition. Identifying mechanisms that drive aortic degeneration is a crucial step in developing an effective pharmacologic treatment to prevent d...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.119.041460

    authors: Luo W,Wang Y,Zhang L,Ren P,Zhang C,Li Y,Azares AR,Zhang M,Guo J,Ghaghada KB,Starosolski ZA,Rajapakshe K,Coarfa C,Li Y,Chen R,Fujiwara K,Abe JI,Coselli JS,Milewicz DM,LeMaire SA,Shen YH

    更新日期:2020-01-07 00:00:00

  • Comparison of Events Across Bleeding Scales in the ENGAGE AF-TIMI 48 Trial.

    abstract:BACKGROUND:Numerous scales exist for the classification of major bleeding events. Limited data compare the most commonly used bleeding scales within a single at-risk cohort of patients with atrial fibrillation. Here, we analyze bleeding outcomes according to the ISTH (International Society on Thrombosis and Hemostasis)...

    journal_title:Circulation

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1161/CIRCULATIONAHA.119.041346

    authors: Bergmark BA,Kamphuisen PW,Wiviott SD,Ruff CT,Antman EM,Nordio F,Kuder JF,Mercuri MF,Lanz HJ,Braunwald E,Giugliano RP

    更新日期:2019-11-26 00:00:00

  • Assessment and Treatment of Patients With Type 2 Myocardial Infarction and Acute Nonischemic Myocardial Injury.

    abstract::Although coronary thrombus overlying a disrupted atherosclerotic plaque has long been considered the hallmark and the primary therapeutic target for acute myocardial infarction (MI), multiple other mechanisms are now known to cause or contribute to MI. It is further recognized that an MI is just one of many types of a...

    journal_title:Circulation

    pub_type: 杂志文章,评审

    doi:10.1161/CIRCULATIONAHA.119.040631

    authors: DeFilippis AP,Chapman AR,Mills NL,de Lemos JA,Arbab-Zadeh A,Newby LK,Morrow DA

    更新日期:2019-11-12 00:00:00

  • Paclitaxel-Coated Balloons and Eluting Stents: Is There a Mortality Risk in Patients With Peripheral Artery Disease?

    abstract::Paclitaxel drug-coated balloons and drug-eluting stents became commercially available for the treatment of intermittent claudication in 2015 and 2012, respectively. Both devices demonstrated superiority in limb revascularization compared with non-paclitaxel-coated devices and were rapidly accepted into clinical practi...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.119.041099

    authors: Beckman JA,White CJ

    更新日期:2019-10-15 00:00:00

  • Genome-Wide Analysis of Left Ventricular Image-Derived Phenotypes Identifies Fourteen Loci Associated With Cardiac Morphogenesis and Heart Failure Development.

    abstract:BACKGROUND:The genetic basis of left ventricular (LV) image-derived phenotypes, which play a vital role in the diagnosis, management, and risk stratification of cardiovascular diseases, is unclear at present. METHODS:The LV parameters were measured from the cardiovascular magnetic resonance studies of the UK Biobank. ...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.119.041161

    authors: Aung N,Vargas JD,Yang C,Cabrera CP,Warren HR,Fung K,Tzanis E,Barnes MR,Rotter JI,Taylor KD,Manichaikul AW,Lima JAC,Bluemke DA,Piechnik SK,Neubauer S,Munroe PB,Petersen SE

    更新日期:2019-10-15 00:00:00

  • Unlocking the Secrets of Mitochondria in the Cardiovascular System: Path to a Cure in Heart Failure—A Report from the 2018 National Heart, Lung, and Blood Institute Workshop

    abstract::Mitochondria have emerged as a central factor in the pathogenesis and progression of heart failure, and other cardiovascular diseases, as well, but no therapies are available to treat mitochondrial dysfunction. The National Heart, Lung, and Blood Institute convened a group of leading experts in heart failure, cardiova...

    journal_title:Circulation

    pub_type: 杂志文章,评审

    doi:10.1161/CIRCULATIONAHA.119.040551

    authors: Tian R,Colucci WS,Arany Z,Bachschmid MM,Ballinger SW,Boudina S,Bruce JE,Busija DW,Dikalov S,Dorn GW II,Galis ZS,Gottlieb RA,Kelly DP,Kitsis RN,Kohr MJ,Levy D,Lewandowski ED,McClung JM,Mochly-Rosen D,O'Brien KD,O'R

    更新日期:2019-10-01 00:00:00

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