听力与言语-语言病理学

行为科学

医学伦理学

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  • How to bridle a neutrophil.

    abstract::Recent high-dimensional technologies have enabled the characterization of heterogeneity in the neutrophil compartment at an unprecedented resolution. In this review, we discuss the emerging notion of heterogeneity within the neutrophil pool, and provide a detailed account of evolving concepts in the field. We place sp...

    journal_title:Current opinion in immunology

    pub_type: 杂志文章,评审

    doi:10.1016/j.coi.2020.08.003

    authors: Rubio-Ponce A,Hidalgo A,Ballesteros I

    更新日期:2020-10-07 00:00:00

  • Immunotherapy in allergic diseases - improved understanding and innovation for enhanced effectiveness.

    abstract::Allergen immunotherapy leads to tolerance through multiple mechanisms that include tolerogenic dendritic cells and T and B regulatory cells. These induced cellular populations produce mediators to skew the immune response to a tolerogenic milieu that, among others, results in IgG4 blocking antibodies formation and low...

    journal_title:Current opinion in immunology

    pub_type: 杂志文章,评审

    doi:10.1016/j.coi.2020.02.005

    authors: Mitsias DI,Xepapadaki P,Makris M,Papadopoulos NG

    更新日期:2020-10-01 00:00:00

  • Deciphering flavivirus-host interactions using quantitative proteomics.

    abstract::Flaviviruses are a group of important emerging and re-emerging human pathogens that cause worldwide epidemics with thousands of deaths annually. Flaviviruses are small, enveloped, positive-sense, single-stranded RNA viruses that are obligate intracellular pathogens, relying heavily on host cell machinery for productiv...

    journal_title:Current opinion in immunology

    pub_type: 杂志文章,评审

    doi:10.1016/j.coi.2020.06.002

    authors: Li M,Ramage H,Cherry S

    更新日期:2020-10-01 00:00:00

  • Role of the NF-κB system in context-specific tuning of the inflammatory gene response.

    abstract::The canonical NF-κB pathway instructs the expression of inflammatory genes by the RelA:p50 transcription factor in response to diverse cell-activating stimuli. However, this mainstay RelA:p50 transcriptional output must also be curated so as to provide for stimulus-type-specific and cell-type-specific inflammatory res...

    journal_title:Current opinion in immunology

    pub_type: 杂志文章,评审

    doi:10.1016/j.coi.2020.08.005

    authors: Chawla M,Roy P,Basak S

    更新日期:2020-09-05 00:00:00

  • Sensing and clearance of apoptotic cells.

    abstract::Macrophages specifically engulf apoptotic cells but not healthy cells. Phosphatidylserine (PtdSer) is localized at the inner leaflet of plasma membranes as a result of the action of flippases (ATP11A and 11C). When cells undergo apoptosis, caspase 3 cleaves and inactivates the flippases, while simultaneously cleaving ...

    journal_title:Current opinion in immunology

    pub_type: 杂志文章,评审

    doi:10.1016/j.coi.2020.07.007

    authors: Nagata S,Segawa K

    更新日期:2020-08-24 00:00:00

  • T cell analysis in vaccination.

    abstract::A major problem in the analysis of vaccine candidates is the lack of any agreed upon surrogates of efficacy, which means that for diseases that depend on a strong T cell response (HIV, TB especially) the only option is to perform an efficacy trial, involving thousands of subjects, enormous costs, and years before the ...

    journal_title:Current opinion in immunology

    pub_type: 杂志文章,评审

    doi:10.1016/j.coi.2020.05.002

    authors: Davis MM

    更新日期:2020-08-01 00:00:00

  • Mesenchymal perivascular cells in immunity and disease.

    abstract::The mesenchymal microenvironment is increasingly recognized as a major player in immunity. Here we focus on mesenchymal cells located within or in proximity to the blood vessels wall, which include pericytes, adventitial fibroblasts and mesenchymal stromal cells. We discuss recent evidence that these cells play a role...

    journal_title:Current opinion in immunology

    pub_type: 杂志文章,评审

    doi:10.1016/j.coi.2020.03.009

    authors: Benabid A,Peduto L

    更新日期:2020-05-06 00:00:00

  • Stromal cell control of conventional and ectopic germinal centre reactions.

    abstract::The germinal centre (GC) is a specialized cellular structure that forms in response to antigenic stimulation. It generates long-term humoral immunity through the production of memory B cells and long-lived antibody-secreting plasma cells. Conventional GCs form within secondary lymphoid organs, where networks of specia...

    journal_title:Current opinion in immunology

    pub_type: 杂志文章,评审

    doi:10.1016/j.coi.2020.03.007

    authors: Silva-Cayetano A,Linterman MA

    更新日期:2020-04-20 00:00:00

  • Selection in the germinal center.

    abstract::Germinal centers (GCs) are well known for their important role in shaping the secondary B cell repertoire to generate antibodies capable of binding with high-affinity and specificity to foreign antigens. Somatic hypermutation of the Ig variable region genes in GC B cells represents a highly efficient mechanism for gen...

    journal_title:Current opinion in immunology

    pub_type: 杂志文章,评审

    doi:10.1016/j.coi.2019.11.001

    authors: Lau AW,Brink R

    更新日期:2020-04-01 00:00:00

  • Plant NLR-triggered immunity: from receptor activation to downstream signaling.

    abstract::Innate immune perception is the first line of inducible defense against invading pathogens. Plants lack specialized circulating immune cells. Therefore, diverse cell types are able to recognize and respond to pathogens. Surface-localized and intracellular plant innate immune receptors are capable of recognizing divers...

    journal_title:Current opinion in immunology

    pub_type: 杂志文章,评审

    doi:10.1016/j.coi.2019.12.007

    authors: Lolle S,Stevens D,Coaker G

    更新日期:2020-02-01 00:00:00

  • Epithelial cells: liaisons of immunity.

    abstract::The surface and lining tissues of our body are exposed to the external environment, and as such these epithelial tissues must form structural barriers able to defend against microbes, environmental toxins, and mechanical stress. Their cells are equipped to detect a diverse array of surface perturbations, and then laun...

    journal_title:Current opinion in immunology

    pub_type: 杂志文章,评审

    doi:10.1016/j.coi.2019.11.004

    authors: Larsen SB,Cowley CJ,Fuchs E

    更新日期:2020-02-01 00:00:00

  • Autoimmune complications of cancer immunotherapy.

    abstract::Immunotherapy of cancer with blockade of inhibitory immune checkpoints and adoptive cell therapies have led to impressive clinical responses in several cancers. However, with increasing utilization of these therapies, immune-related adverse events have emerged as a major obstacle. Herein I discuss recent insights into...

    journal_title:Current opinion in immunology

    pub_type: 杂志文章,评审

    doi:10.1016/j.coi.2019.08.004

    authors: Dhodapkar KM

    更新日期:2019-12-01 00:00:00

  • Spatial and functional heterogeneity of follicular helper T cells in autoimmunity.

    abstract::Follicular helper T cells provide signals that promote B cell development, proliferation, and production of affinity matured and appropriately isotype switched antibodies. In addition to their classical locations within B cell follicles and germinal centers therein, B cell helper T cells are also found in extrafollicu...

    journal_title:Current opinion in immunology

    pub_type: 杂志文章,评审

    doi:10.1016/j.coi.2019.06.005

    authors: Seth A,Craft J

    更新日期:2019-12-01 00:00:00

  • Regulation of oral immune tolerance by the microbiome in food allergy.

    abstract::The steep rise in the incidence and prevalence of food allergy (FA) in the last few decades have focused attention of environmental mechanisms which act to promote disease, chief among which is the microbiome. Recent studies have now established the presence of pathogenic dysbiosis in FA that could be precipitated by ...

    journal_title:Current opinion in immunology

    pub_type: 杂志文章,评审

    doi:10.1016/j.coi.2019.06.001

    authors: Stephen-Victor E,Chatila TA

    更新日期:2019-10-01 00:00:00

  • Contribution of antimicrobials to the development of allergic disease.

    abstract::Antimicrobials represent a broad class of chemicals with the intended purpose of eliminating or controlling the growth of harmful microorganisms. Exposure can occur occupationally or through the use or consumption of consumer products. The use of antimicrobial agents has been associated with an increased incidence of ...

    journal_title:Current opinion in immunology

    pub_type: 杂志文章,评审

    doi:10.1016/j.coi.2019.05.003

    authors: Anderson SE,Weatherly L,Shane HL

    更新日期:2019-10-01 00:00:00

  • Vaccination against atherosclerosis.

    abstract::Atherosclerosis is a chronic inflammatory disease that causes most heart attacks and strokes, making it the biggest killer in the world. Although cholesterol-lowering drugs have dramatically reduced these major adverse cardiovascular events, there remains a high residual risk called inflammatory risk. Atherosclerosis ...

    journal_title:Current opinion in immunology

    pub_type: 杂志文章,评审

    doi:10.1016/j.coi.2019.02.008

    authors: Kobiyama K,Saigusa R,Ley K

    更新日期:2019-08-01 00:00:00

  • Understanding the immunology of Shingrix, a recombinant glycoprotein E adjuvanted herpes zoster vaccine.

    abstract::Herpes zoster is common in older and immune suppressed persons due to diminished VZV-specific cellular immunity. A recombinant herpes zoster vaccine (RZV) consisting of a single VZV glycoprotein and an adjuvant system stimulates robust and persistent VZV-specific antibody and CD4+ T cell responses in these high-risk p...

    journal_title:Current opinion in immunology

    pub_type: 杂志文章,评审

    doi:10.1016/j.coi.2019.02.009

    authors: Heineman TC,Cunningham A,Levin M

    更新日期:2019-08-01 00:00:00

  • Immunological goals for respiratory syncytial virus vaccine development.

    abstract::Defining the immunological goals for respiratory syncytial virus (RSV) vaccination requires understanding of RSV biology and tropism, mechanisms of cell-to-cell spread and immunity, epidemiology, and transmission dynamics. The immunological goals for a particular vaccine would be product-specific based on antigen sele...

    journal_title:Current opinion in immunology

    pub_type: 杂志文章,评审

    doi:10.1016/j.coi.2019.03.005

    authors: Graham BS

    更新日期:2019-08-01 00:00:00

  • Roles for the adaptive immune system in Parkinson's and Alzheimer's diseases.

    abstract::Neurodegenerative diseases, such as Parkinson's and Alzheimer's, affect millions of people and pose major personal and socioeconomic burdens. The causes of neurodegeneration are mostly unknown, although current efforts have described an autoimmune aspect to these diseases. Here we discuss recent findings that shed lig...

    journal_title:Current opinion in immunology

    pub_type: 杂志文章,评审

    doi:10.1016/j.coi.2019.07.004

    authors: Lindestam Arlehamn CS,Garretti F,Sulzer D,Sette A

    更新日期:2019-08-01 00:00:00

  • Heterogeneity and fate choice: T cell exhaustion in cancer and chronic infections.

    abstract::CD8 T cell differentiation is a tightly regulated process generating effector and memory T cells over the course of acute infections. In cancer and chronic infection, this differentiation program is derailed, and antigen-specific CD8 T cells differentiate to a hyporesponsive state generally referred to as T cell exhau...

    journal_title:Current opinion in immunology

    pub_type: 杂志文章,评审

    doi:10.1016/j.coi.2019.04.014

    authors: Philip M,Schietinger A

    更新日期:2019-06-01 00:00:00

  • Mitochondrial antigen presentation: a mechanism linking Parkinson's disease to autoimmunity.

    abstract::Parkinson's disease (PD) is caused by the progressive loss of dopaminergic neurons and afflicts millions of people world-wide. The current treatments address only the late motor symptoms, with no cure or preventive therapeutic approaches. The contribution of dysfunctional immune mechanisms in PD has been clearly estab...

    journal_title:Current opinion in immunology

    pub_type: 杂志文章,评审

    doi:10.1016/j.coi.2019.02.004

    authors: Fahmy AM,Boulais J,Desjardins M,Matheoud D

    更新日期:2019-06-01 00:00:00

  • Cellular pathways in the development of human and murine innate lymphoid cells.

    abstract::Innate lymphoid cells (ILCs) are critical to effective immune surveillance against pathogens, have malignant counterparts, and contribute to disease. Thus, it is important to understand ILC development. All ILCs are derived from the common lymphoid progenitor cell; however, the exact mechanisms and signals that initia...

    journal_title:Current opinion in immunology

    pub_type: 杂志文章,评审

    doi:10.1016/j.coi.2018.11.003

    authors: Scoville SD,Freud AG,Caligiuri MA

    更新日期:2019-02-01 00:00:00

  • Neuronal regulation of innate lymphoid cells.

    abstract::The cardinal signs of inflammation suggest a close connection between the nervous system and the immune system. However, the cellular and molecular basis of these interactions remains incompletely defined. Recent research has demonstrated that tissue-resident innate lymphoid cells (ILCs) obtain neuronal signals, parti...

    journal_title:Current opinion in immunology

    pub_type: 杂志文章,评审

    doi:10.1016/j.coi.2018.11.002

    authors: Klose CS,Artis D

    更新日期:2019-02-01 00:00:00

  • Innate lymphoid cell sensing of tissue vitality.

    abstract::Innate lymphoid cells (ILCs) constitute a heterogeneous population of cytokine-secreting cells that colonize different tissues and are heavily reliant on cytokines and other secreted factors for their development, maintenance and effector functions. Most ILCs are tissue resident and differentiate in non-lymphoid perip...

    journal_title:Current opinion in immunology

    pub_type: 杂志文章,评审

    doi:10.1016/j.coi.2018.11.004

    authors: Barrow AD,Colonna M

    更新日期:2019-02-01 00:00:00

  • Crosstalk between type I and II interferons in regulation of myeloid cell responses during bacterial infection.

    abstract::Type I and type II interferons (IFNα/β and IFNγ) are cytokines that play indispensable roles in directing myeloid cell activity during inflammatory and immune responses. Each IFN type binds a distinct receptor (IFNAR or IFNGR) to transduce signals that reshape gene expression and function of myeloid and other cell typ...

    journal_title:Current opinion in immunology

    pub_type: 杂志文章,评审

    doi:10.1016/j.coi.2018.05.014

    authors: Crisler WJ,Lenz LL

    更新日期:2018-10-01 00:00:00

  • The widening spectrum of immunological memory.

    abstract::Immunological memory is broadly understood as the underlying mechanism by which an organism remembers previous encounters with pathogens, aberrant cells, or self-antigens to produce a more rapid or robust secondary response upon re-encounter. This phenomenon is widely accepted as the hallmark feature of the adaptive i...

    journal_title:Current opinion in immunology

    pub_type: 杂志文章,评审

    doi:10.1016/j.coi.2018.05.013

    authors: Lau CM,Sun JC

    更新日期:2018-10-01 00:00:00

  • Helminth-induced regulatory T cells and suppression of allergic responses.

    abstract::Infection with helminths has been associated with lower rates of asthma and other allergic diseases. This has been attributed, in part, to the ability of helminths to induce regulatory T cells that suppress inappropriate immune responses to allergens. Recent compelling evidence suggests that helminths may promote regu...

    journal_title:Current opinion in immunology

    pub_type: 杂志文章,评审

    doi:10.1016/j.coi.2018.05.007

    authors: Logan J,Navarro S,Loukas A,Giacomin P

    更新日期:2018-10-01 00:00:00

  • Shaping a universally broad antibody response to influenza amidst a variable immunoglobulin landscape.

    abstract::One hundred years ago, the 1918 H1N1 Pandemic killed 20 million people worldwide. Despite the introduction of a worldwide surveillance system, large-scale production of influenza vaccines coupled with annual vaccination schemes, influenza remains a major public health concern. Prevention of influenza on a population b...

    journal_title:Current opinion in immunology

    pub_type: 杂志文章,评审

    doi:10.1016/j.coi.2018.04.009

    authors: Andrews SF,McDermott AB

    更新日期:2018-08-01 00:00:00

  • Zika virus vaccines: immune response, current status, and future challenges.

    abstract::Zika virus (ZIKV) is the most recent mosquito-transmitted virus to cause a global health crisis following its entrance into a naïve population in the Western Hemisphere. Once the ZIKV outbreak began investigators rapidly established small and large animal models of pathogenesis, developed a number candidate vaccines u...

    journal_title:Current opinion in immunology

    pub_type: 杂志文章,评审

    doi:10.1016/j.coi.2018.04.024

    authors: Richner JM,Diamond MS

    更新日期:2018-08-01 00:00:00

  • Toward universal influenza virus vaccines: from natural infection to vaccination strategy.

    abstract::Conceptually, a universal influenza vaccine should elicit broadly protective antibody responses targeting highly conserved epitope(s) shared by various virus strains. Strategically directing antibody immunity to the conserved hemagglutinin stalk has recently emerged as a promising approach that is substantiated by the...

    journal_title:Current opinion in immunology

    pub_type: 杂志文章,评审

    doi:10.1016/j.coi.2018.03.020

    authors: Zhao C,Xu J

    更新日期:2018-08-01 00:00:00

  • When designing vaccines, consider the starting material: the human B cell repertoire.

    abstract::Most viral vaccines provide protection from infection through the generation of neutralizing antibodies (nAbs). The repertoire of B cells responding to immunization is the starting material from which nAbs eventually arise. Immunization strategies are increasingly targeting precise B cell specificities to mimic nAbs g...

    journal_title:Current opinion in immunology

    pub_type: 杂志文章,评审

    doi:10.1016/j.coi.2018.08.002

    authors: Havenar-Daughton C,Abbott RK,Schief WR,Crotty S

    更新日期:2018-08-01 00:00:00

  • Harnessing immune history to combat influenza viruses.

    abstract::Individuals are exposed to influenza viruses throughout their lifetime. Accumulating evidence shows the first viruses an individual is exposed to leaves an imprint on the antibody response induced by subsequent drifted and novel influenza viral exposures. Imprinted humoral immunity against influenza viruses relies on ...

    journal_title:Current opinion in immunology

    pub_type: 杂志文章,评审

    doi:10.1016/j.coi.2018.05.010

    authors: Guthmiller JJ,Wilson PC

    更新日期:2018-08-01 00:00:00

  • The purinergic P2X7 ion channel receptor-a 'repair' receptor in bone.

    abstract::A strong skeleton relies on adaptation to varying physical demands and on maintenance of the bone tissue in order to avoid accumulation of micro-damage. In bone, the purinergic P2X7 ion channel receptor is expressed on both cells of the stromal lineage such as the bone forming osteoblasts and the mechano-sensing osteo...

    journal_title:Current opinion in immunology

    pub_type: 杂志文章,评审

    doi:10.1016/j.coi.2018.03.016

    authors: Jørgensen NR

    更新日期:2018-06-01 00:00:00

  • Oncolytic viruses and immunity.

    abstract::Initially, direct oncolysis was thought to be the sole mechanism through which oncolytic viruses (OVs) exert their anti-tumor effect, and the immune system was perceived as the major obstacle in oncolytic virotherapy. Over the last decade, there has been a lot of debate on whether the immune system is a friend or foe ...

    journal_title:Current opinion in immunology

    pub_type: 杂志文章,评审

    doi:10.1016/j.coi.2018.03.008

    authors: Chaurasiya S,Chen NG,Fong Y

    更新日期:2018-04-01 00:00:00

  • Next generation natural killer cells for cancer immunotherapy: the promise of genetic engineering.

    abstract::Recent advances in the field of cellular therapy have focused on autologous T cells engineered to express a chimeric antigen receptor (CAR) against tumor antigens. Remarkable responses have been observed in patients receiving autologous CD19-redirected T cells for the treatment of B-lymphoid malignancies. However, the...

    journal_title:Current opinion in immunology

    pub_type: 杂志文章,评审

    doi:10.1016/j.coi.2018.03.013

    authors: Daher M,Rezvani K

    更新日期:2018-04-01 00:00:00

  • Immunomodulation in multiple sclerosis: promises and pitfalls.

    abstract::Multiple sclerosis (MS) afflicts about 2.5 million people globally and poses a major personal and socioeconomic burden. The recognition of MS as an inflammatory disease, characterized by infiltration of immune cells into the central nervous system, has spurred research into the autoimmune etiology of the condition and...

    journal_title:Current opinion in immunology

    pub_type: 杂志文章,评审

    doi:10.1016/j.coi.2017.08.013

    authors: Dendrou CA,Fugger L

    更新日期:2017-12-01 00:00:00

  • Tuberculosis vaccines - perspectives from the NIH/NIAID Mycobacteria vaccine testing program.

    abstract::The development of novel vaccine candidates against infections with Mycobacterium tuberculosis has highlighted our limited understanding of immune mechanisms required to kill M. tuberculosis. The induction of a Th1 immunity is vital, but new studies are required to identify other mechanisms that may be necessary. Nove...

    journal_title:Current opinion in immunology

    pub_type: 杂志文章,评审

    doi:10.1016/j.coi.2017.07.008

    authors: Izzo AA

    更新日期:2017-08-01 00:00:00

  • Properties of the tapasin homologue TAPBPR.

    abstract::The presentation of antigenic peptides by MHC class I molecules plays a vital role in generating T cell responses against infection and cancer. Over the last two decades the central role of tapasin as a peptide editor that influences the loading and optimisation of peptides onto MHC class I molecules has been extensiv...

    journal_title:Current opinion in immunology

    pub_type: 杂志文章,评审

    doi:10.1016/j.coi.2017.04.008

    authors: Neerincx A,Boyle LH

    更新日期:2017-06-01 00:00:00

  • Targeting NK-cell checkpoints for cancer immunotherapy.

    abstract::Natural Killer (NK) cells are cytotoxic lymphocytes specialized in early defense against virus-infected and transformed cells. NK-cell function is regulated by activating and inhibitory surface receptors recognizing their ligands on transformed cells. Modulation of NK numbers and/or function by a variety of agents suc...

    journal_title:Current opinion in immunology

    pub_type: 杂志文章,评审

    doi:10.1016/j.coi.2017.01.003

    authors: Muntasell A,Ochoa MC,Cordeiro L,Berraondo P,López-Díaz de Cerio A,Cabo M,López-Botet M,Melero I

    更新日期:2017-04-01 00:00:00

  • Deconstructing the germinal center, one cell at a time.

    abstract::Successful vaccination relies on driving the immune response towards high specificity, affinity and longevity. Germinal centers facilitate the evolution of antigen-specific B cells by iterative rounds of diversification, selection, and differentiation to memory and plasma cells. Experimental evidence points to B cell ...

    journal_title:Current opinion in immunology

    pub_type: 杂志文章,评审

    doi:10.1016/j.coi.2017.03.007

    authors: Dufaud CR,McHeyzer-Williams LJ,McHeyzer-Williams MG

    更新日期:2017-04-01 00:00:00

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