abstract：PURPOSE:Ulcerative colitis (UC) carries a high risk of developing colorectal cancer (CRC). FK506-binding protein 51 (FKBP51) is a key regulator of glucocorticoid resistance and inflammatory tumor microenvironment. This study aimed to investigate the role of FKBP51 in UC-CRC prognosis. MATERIALS AND METHODS:The FKBP51 ...

journal_title：Advances in medical sciences

authors： Xia Z,Zhang G,Wang C,Feng Y

更新日期：2021-01-15 00:00:00

abstract：PURPOSE:Non-alcoholic fatty liver disease (NAFLD) is increasingly being recognized in the pediatric population, therefore, the search for non-invasive parameters to predict progression of NAFLD is of great interest. The aim of this study was to assess serum concentration of sCD36 in children with obesity and to determi...

journal_title：Advances in medical sciences

authors： Bobrus-Chociej A,Wasilewska N,Harasim-Symbor E,Flisiak-Jackiewicz M,Wojtkowska M,Chabowski A,Lebensztejn D

更新日期：2020-12-01 00:00:00

abstract：PURPOSE:Glioblastoma is the most common and the deadliest brain cancer. The aim of this study was to analyze the impact of resveratrol and its five analogs: 3,4,4'-trimethoxy, 3,4,2'-trimethoxy, 3,4,2',4'-tetramethoxy, 3,4,2',6'-tetramethoxy and 3,4,2',4',6'-pentamethoxy-trans-stilbenes (MS) on human glioblastoma T98G ...

journal_title：Advances in medical sciences

authors： Majchrzak-Celińska A,Zielińska-Przyjemska M,Wierzchowski M,Kleszcz R,Studzińska-Sroka E,Kaczmarek M,Paluszczak J,Cielecka-Piontek J,Krajka-Kuźniak V

更新日期：2020-11-22 00:00:00

abstract：PURPOSE:In this multicenter retrospective analysis of the Polish Myeloma Group we assessed the real-life application of allogeneic transplantations (alloHCT) in multiple myeloma (MM) outside clinical trials in Poland. METHODS:Anonymized clinical data of patients who underwent alloHCT were retrospectively collected fro...

journal_title：Advances in medical sciences

authors： Gołos A,Gil L,Puła B,Boguradzki P,Hałaburda K,Sawicki W,Sobczyk-Kruszelnicka M,Helbig G,Dybko J,Jurczyszyn A,Dębek S,Warzocha K,Jamroziak K

更新日期：2020-09-01 00:00:00

abstract：PURPOSE:The primary aim of this study is to compare the clinical course and laboratory parameters of acute cholecystitis in patients with diabetes vs. patients without diabetes. MATERIALS AND METHODS:The study involved patients who underwent emergency cholecystectomy in the Department of General, Endocrine and Transpl...

journal_title：Advances in medical sciences

authors： Łącka M,Obłój P,Spychalski P,Łaski D,Rostkowska O,Wieszczy P,Kobiela J

更新日期：2020-09-01 00:00:00

abstract：PURPOSE:We aimed to examine the polymorphism of the promoter and exon 5 of the TNFSF11 gene and their impact on bone mineral density (BMD) and the frequency of bone fractures. TNFSF11 encodes the receptor activator of the NF-kB ligand (RANKL), a key regulator of bone metabolism and osteoporosis drug targets. BMD is an ...

journal_title：Advances in medical sciences

authors： Wawrzyniak A,Skrzypczak-Zielinska M,Krela-Kazmierczak I,Michalak M,Marszalek D,Marcinkowska M,Zakerska-Banaszak O,Slomski R

更新日期：2020-09-01 00:00:00

abstract：:Apelin is an endogenous peptide, which is expressed in a vast board of organs such as the brain, placenta, heart, lungs, kidneys, pancreas, testis, prostate and adipose tissues. The apelin receptor, called angiotensin-like-receptor 1 (APJ), is also expressed in the brain, spleen, placenta, heart, liver, intestine, pro...

journal_title：Advances in medical sciences

authors： Masoumi J,Jafarzadeh A,Khorramdelazad H,Abbasloui M,Abdolalizadeh J,Jamali N

更新日期：2020-03-01 00:00:00

abstract：PURPOSE:The aim of this study was to check the pro-apoptotic mechanism of prosthetic reconstruction on epithelial cells of the oral mucosa. PATIENTS AND METHODS:The research was carried out on the saliva of healthy patients using prostheses. The sample swabs were stained using the May-Grünwald-Giemsa method and proces...

journal_title：Advances in medical sciences

authors： Domian N,Surażyński A,Szarmach J,Piotrowska Ż,Kasacka I

更新日期：2020-03-01 00:00:00

abstract：PURPOSE:Lipoxygenases (LOX) have been implicated in carcinogenesis, however both pro- and anti-carcinogenic effects have been reported in different cancer models. Using transgenic mice, which specifically overexpress human 15-lipoxygenase (ALOX15) in endothelial cells (EC), we previously demonstrated significant inhibi...

journal_title：Advances in medical sciences

authors： Sultan M,Ben-Shushan D,Peled M,Kamari Y,Isman S,Barshack I,Kuban RJ,Kühn H,Harats D,Shaish A

更新日期：2020-03-01 00:00:00

abstract：PURPOSE:To determine reference values and tolerance limits of between-side differences for the calibers of the common femoral artery (CFA), superficial femoral artery (SFA), popliteal artery (PA), dorsalis pedis artery (DPA), and posterior tibial artery (PTA). MATERIALS AND METHODS:Calibers of arteries, defined as the...

journal_title：Advances in medical sciences

authors： Kubarewicz KJ,Ustymowicz A,Czyzewska D,Kaminski MJ,Sledziewski R,Krejza J

更新日期：2020-03-01 00:00:00

abstract：PURPOSE:Accumulating evidence has linked long noncoding RNAs (lncRNAs) to autoimmune and inflammatory disorders. This study aimed to detect the expression levels of five lncRNAs (lnc0640, lnc3643, lnc5150, lnc7514 and lncagf) in peripheral blood mononuclear cells (PBMCs) of patients with systemic lupus erythematosus (S...

journal_title：Advances in medical sciences

authors： Wang JB,Li J,Zhang TP,Lv TT,Li LJ,Wu J,Leng RX,Fan YG,Pan HF,Ye DQ

更新日期：2019-09-01 00:00:00

abstract：:Adhesive molecules are responsible for the cell-cell interaction and the surrounding intercellular environment creating normal tissue architecture. The role of adhesion proteins in cancer refers to angiogenesis, loss of tissue continuity, and deprivation of intercellular contact with the extracellular matrix, promotin...

journal_title：Advances in medical sciences

authors： Lewczuk Ł,Pryczynicz A,Guzińska-Ustymowicz K

更新日期：2019-09-01 00:00:00

abstract：PURPOSE:Chronic obstructive pulmonary disease is the most common chronic lung disease, which may be caused by different pathological processes, including inflammation. Furthermore, signs of changes in thyroid hormone levels are found in some patients. Deiodinases (DIOs) are selenoproteins (enzymes) involved in the synt...

journal_title：Advances in medical sciences

authors： Gałecka E,Kumor-Kisielewska A,Górski P

更新日期：2019-09-01 00:00:00

abstract：PURPOSE:Cerebral metastases develop in 10-30% of patients with breast cancer (BC) and in around 3.3 to 4% of patients with ovarian cancer (OC). The aim of the multicenter study is to investigate the correlation between the expression of estrogen alpha receptors (ERα), progesterone receptors (PR), human epidermal growth...

journal_title：Advances in medical sciences

authors： Szarszewska M,Markowska A,Jach R,Marszałek A,Filas V,Bednarek W,Olejek A,Tomczak P,Sajdak S,Nowak-Markwitz E,Jaszczyńska-Nowinka K,Stanisławiak-Rudowicz J,Gryboś A,Chudecka-Głaz A,Gryboś M,Adamska K,Ramlau R,Markowska J

更新日期：2019-09-01 00:00:00

abstract：PURPOSE:The biggest problem with the occurrence of breast cancer is late diagnosis, which is associated with high mortality rates. The aim of the study was to appraise the number of circulating endothelial precursors and the concentration of vascular endothelial growth factor A (VEGF-A) and the soluble forms of its rec...

journal_title：Advances in medical sciences

authors： Zarychta E,Rhone P,Bielawski K,Michalska M,Rość D,Ruszkowska-Ciastek B

更新日期：2019-09-01 00:00:00

abstract：PURPOSE:Vascular endothelial growth factor is an important factor in promoting angiogenesis in malignant processes, matrix metalloproteinase-9 in the degradation of extracellular matrix, which enhances metastasis, and tissue inhibitor of metalloproteinase-1 is its inhibitor. The aim of this study was to investigate the...

journal_title：Advances in medical sciences

authors： Zajkowska M,Gacuta E,Kozłowska S,Lubowicka E,Głażewska EK,Chrostek L,Szmitkowski M,Pawłowski P,Zbucka-Krętowska M,Ławicki S

更新日期：2019-03-01 00:00:00

abstract：PURPOSE:Adaptation of the colorimetric method for the determination of β-d-galactosidase, β-d-glucuronidase and α-l-fucosidase activities in serums from hemolyzed blood, the material currently being discarded. MATERIALS AND METHODS:The materials included serums from hemolyzed and non-hemolyzed blood, obtained from 26 ...

journal_title：Advances in medical sciences

authors： Chojnowska S,Ptaszyńska-Sarosiek I,Kępka A,Szajda SD,Waszkiewicz N,Zwierz K

更新日期：2018-09-01 00:00:00

abstract：:Lung cancer causes an estimated 1.6 million deaths each year, being the leading cause of cancer-related deaths in the world. Late diagnosis and, in some cases, the high aggressiveness of the tumour result in low overall five-year survival rates of 12% among men and 7% among women. The cure is most likely in early-stag...

journal_title：Advances in medical sciences

authors： Ostrowski M,Marjański T,Rzyman W

更新日期：2018-09-01 00:00:00

abstract：PURPOSE:To determine the time point at which thrombocytopenia after TAVI procedure is an indicator of the worst prognosis, with special consideration of perioperative platelet and coagulation activation as its potential causes. METHODS:Thirty two patients (mean age 78.5±7.9years, 62% females) qualified for TAVI proced...

journal_title：Advances in medical sciences

authors： Mitrosz M,Kazimierczyk R,Chlabicz M,Sobkowicz B,Waszkiewicz E,Lisowska A,Dobrzycki S,Musial WJ,Hirnle T,Kaminski KA,Tycinska AM

更新日期：2018-03-01 00:00:00

abstract：PURPOSE:The objective of this study was to evaluate thevitamin D concentration in patients with recurrent respiratory infections with or without immunoglobulin G, A or M (IgG, IgA, IgM) deficiency, and to find a correlation between the vitamin D concentration and the response to hepatitis B vaccination. MATERIALS AND ...

journal_title：Advances in medical sciences

authors： Dąbrowska-Leonik N,Bernatowska E,Pac M,Filipiuk W,Mulawka J,Pietrucha B,Heropolitańska-Pliszka E,Bernat-Sitarz K,Wolska-Kuśnierz B,Mikołuć B

更新日期：2018-03-01 00:00:00

abstract：PURPOSE:The purpose of this study was to test the influence of a barbituric acid derivative acting as a catalyst and small amounts of pyrolytic silica in acrylic resins on color stability, solubility and sorption of a composite. MATERIALS AND METHODS:A series of two-component powder/liquid resin systems were prepared....

journal_title：Advances in medical sciences

authors： Raszewski Z,Jałbrzykowski M

更新日期：2017-09-01 00:00:00

abstract：PURPOSE:Arterial hypertension (aHT) is the leading risk factor for morbidity and mortality worldwide. Blood pressure (BP) deviation at rest is well defined and accompanies risk for cardiovascular events and cardiovascular mortality. A growing body of evidence emphasises that an exaggerated blood pressure response (EBPR...

journal_title：Advances in medical sciences

authors： Keller K,Stelzer K,Ostad MA,Post F

更新日期：2017-09-01 00:00:00

abstract：PURPOSE:Defining the level of protective factors in saliva of patients suffering from decompensated type 2 diabetes. MATERIAL AND METHODS:50 Patients with diagnosis of decompensated type 2 diabetes, including 32 women and 18 men at the age of 57.9±9.2 years. The control group consisted of 50 people among whom there we...

journal_title：Advances in medical sciences

authors： Chorzewski M,Orywal K,Sierpinska T,Golebiewska M

更新日期：2017-09-01 00:00:00

abstract：PURPOSE:Existing anti-epileptic drugs (AED) have limited efficiency in many patients, necessitating the search for alternative approaches such as stem cell therapy. We report the use of autologous patient-derived mesenchymal stem cells (MSC) as a therapeutic agent in symptomatic drug-resistant epilepsy in a Phase I ope...

journal_title：Advances in medical sciences

authors： Hlebokazov F,Dakukina T,Ihnatsenko S,Kosmacheva S,Potapnev M,Shakhbazau A,Goncharova N,Makhrov M,Korolevich P,Misyuk N,Dakukina V,Shamruk I,Slobina E,Marchuk S

更新日期：2017-09-01 00:00:00

abstract：:Vascular calcification (VC) is highly prevalent in patients with chronic kidney disease (CKD) and is strongly associated with cardiovascular mortality and morbidity. Accumulating evidence over the past decade has challenged the hypothesis of close interaction between bone and VC what raises the possibility of a common...

journal_title：Advances in medical sciences

authors： Znorko B,Oksztulska-Kolanek E,Michałowska M,Kamiński T,Pawlak K

更新日期：2017-03-01 00:00:00

abstract：PURPOSE:Obstructive sleep apnea increases the risk of cardiovascular diseases. Alternations in prostacyclin and thromboxane concentrations and balance could constitute one of mechanisms linking sleep apnea and cardiovascular events. Thus we aimed to assess the concentrations of 6-keto-prostaglandin F1α (6-keto-PGF1α) (...

journal_title：Advances in medical sciences

authors： Mejza F,Kania A,Nastalek P,Nizankowska-Jedrzejczyk A,Nizankowska-Mogilnicka E

更新日期：2016-03-01 00:00:00

abstract：PURPOSE:To evaluate the role of 12/15-lipoxygenase (LOX) in regulation of synthesis of selected eicosanoids in mice sensitized and challenged with Dermatophagoides pteronyssinus (Dp) allergen extract. MATERIALS AND METHODS:Both C57Bl and 12/15-LOX knockout mice were sensitized by 2 intraperitoneal injections and subse...

journal_title：Advances in medical sciences

authors： Sacharzewska E,Bielecki P,Bernatowicz P,Niklinski J,Kowal-Bielecka O,Kowal K

更新日期：2016-03-01 00:00:00

abstract：PURPOSE:The study aimed to determine the effect of OSA and obesity on the plasma levels of adiponectin and the long-term effect of CPAP on its plasma levels and obesity parameters. MATERIAL/METHODS:A prospective observational study included 159 newly diagnosed OSA patients. The cohort was divided into CPAP treated (n=...

journal_title：Advances in medical sciences

authors： Hobzová M,Salzman R,Stejskal D,Zapletalová J,Kolek V

更新日期：2016-03-01 00:00:00

abstract：PURPOSE:The purpose of this study was to investigate the influence of selective agonists of the retinoid receptor X (RXR) and the retinoid acid receptor (RAR) on bone metabolism in rats. METHODS:Thirty six male Wistar rats were divided into three groups: receiving bexarotene, or tazarotene, or to control group. Serum ...

journal_title：Advances in medical sciences

authors： Nowak B,Matuszewska A,Filipiak J,Nikodem A,Merwid-Ląd A,Pieśniewska M,Fereniec-Gołębiewska L,Kwiatkowska J,Szeląg A

更新日期：2016-03-01 00:00:00

abstract：PURPOSE:The aim of the study was to establish whether preoperative serum levels of HE4 and CA125 could be a good predictor for lymphadenectomy in the early stage of endometrioid adenocarcinoma of the uterus. MATERIAL AND METHODS:Preoperative serum HE4 and CA125 were measured in 78 postmenopausal patients treated surgi...

journal_title：Advances in medical sciences

authors： Dobrzycka B,Mackowiak-Matejczyk B,Terlikowska KM,Kinalski M,Terlikowski SJ

更新日期：2016-03-01 00:00:00

abstract：PURPOSE:Glaucoma is one of the most important reason causes of the blindness, associated with retinal ganglion cells (RGC) death. This process is not fully understood, however apoptosis due to hypoxia is one of the most important processes leading to RGC death. Glaucomatous optic neuropathy is characterized by remodeli...

journal_title：Advances in medical sciences

authors： Zalewska R,Reszeć J,Kisielewski W,Mariak Z

更新日期：2016-03-01 00:00:00

abstract：PURPOSE:The aim of the study was to investigate the voice quality parameters in 72 rheumatoid arthritis (RA) patients and their relationships with the clinical manifestations and disease activity. The control group consisted of 30 healthy subjects. MATERIAL AND METHODS:All RA patients were evaluated by extensive clini...

journal_title：Advances in medical sciences

authors： Kosztyła-Hojna B,Moskal D,Kuryliszyn-Moskal A

更新日期：2015-09-01 00:00:00

abstract：PURPOSE:The aim of the study was to evaluate factors related to bone formation and resorption in Polish children and adolescents with cystic fibrosis and to examine the effect of nutritional status, biochemical parameters and clinical status on bone mineral density. MATERIALS AND METHODS:The study group consisted of 1...

journal_title：Advances in medical sciences

authors： Sands D,Mielus M,Umławska W,Lipowicz A,Oralewska B,Walkowiak J

更新日期：2015-09-01 00:00:00

abstract：PURPOSE:Solid tumors modulate their environment to keep non-malignant stromal cells in a tumor-promoting state. The main cells in the stroma of epithelial derived tumors are cancer associated fibroblasts (CAF) that are critical to tumorigenesis and angiogenesis. CAFs also supply the tumor cells with growth factors and ...

journal_title：Advances in medical sciences

authors： Teichgräber V,Monasterio C,Chaitanya K,Boger R,Gordon K,Dieterle T,Jäger D,Bauer S

更新日期：2015-09-01 00:00:00

abstract：PURPOSE:Response to steroids is included in the diagnostic criteria for IgG4-related sclerosing cholangitis (IgG4-SC). To assess how to appropriately conduct steroid trials for IgG4-related SC, we examined the clinical pictures of steroid responsiveness in IgG4-SC patients. MATERIAL AND METHODS:A total of 29 patients ...

journal_title：Advances in medical sciences

authors： Iwasaki S,Kamisawa T,Koizumi S,Chiba K,Tabata T,Kuruma S,Kishimoto Y,Igarashi Y

更新日期：2015-09-01 00:00:00

abstract：PURPOSE:Desmin regulates function of mitochondria, T-tubular system and cytosolic Ca(2+) transients. We investigated whether desmin remodeling correlates with diastolic dysfunction and whether progressive desmin abnormalities are accompanied by increasing diastolic dysfunction stages. PATIENTS AND METHODS:Eighty five ...

journal_title：Advances in medical sciences

authors： Pawlak A,Gil RJ,Nasierowska-Guttmejer AM,Kasprzak JD

更新日期：2015-03-01 00:00:00

abstract：:Melanoma is a malignant tumor which is inclined to metastasize promptly into the lymphatic system and other organs such as lung, liver, brain or bone. Therefore early diagnosis remains crucial for improving clinical outcome for melanoma patients. Current chemotherapy and chemo-immunotherapy regimes have shown little c...

journal_title：Advances in medical sciences

authors： Stadler S,Weina K,Gebhardt C,Utikal J

更新日期：2015-03-01 00:00:00

abstract：PURPOSE:Promoter hypermethylation and reduced expression of many genes have been found in gastric cancer. DNA methyltransferases are enzymes potentially affecting promoter hypermethylation. MATERIAL AND METHODS:We analyzed proteins expression of DNA methyltransferase 1 and 3b by immunohistochemistry in 47 surgically r...

journal_title：Advances in medical sciences

authors： Ksiâa F,Ziadi S,Dhiab MB,Gacem RB,Trimeche M

更新日期：2015-03-01 00:00:00

abstract：PURPOSE:Psoriasis is a chronic, recurrent, inflammatory disease. Recent investigations indicate its autoimmune pathogenesis. Apoptosis plays an important role in the development of many autoimmune diseases. The aim of this study was to evaluate the influence of topical treatment of psoriasis on soluble Fas (sFas) and s...

journal_title：Advances in medical sciences

authors： Myśliwiec H,Baran A,Myśliwiec P,Górska M,Flisiak I

更新日期：2015-03-01 00:00:00

abstract：PURPOSE:We analyzed the usefulness and prognostic value of intraoperative monitoring for identification of the oculomotor (III) and the abducens (VI) nerve in patients with cavernous sinus meningiomas. MATERIAL/METHODS:43 patients diagnosed with cavernous sinus meningiomas were divided according to their topography. F...

journal_title：Advances in medical sciences

authors： Kaspera W,Adamczyk P,Ślaska-Kaspera A,Ładziński P

更新日期：2015-03-01 00:00:00