Abstract:
PURPOSE:Ulcerative colitis (UC) carries a high risk of developing colorectal cancer (CRC). FK506-binding protein 51 (FKBP51) is a key regulator of glucocorticoid resistance and inflammatory tumor microenvironment. This study aimed to investigate the role of FKBP51 in UC-CRC prognosis. MATERIALS AND METHODS:The FKBP51 expression was measured by immunohistochemistry, qRT-PCR and western blot in control and tumor-containing tissues from UC-CRC patients. H&E staining was used to analyze the inflammatory status of each sample. The relationship between FKBP51 expression and UC-CRC prognosis was assessed by Kaplan-Meier curves and Mann-Whitney U test, and receiver-operating characteristic curves were generated to clarify the role of FKBP51 in predicting survival period and recurrence of UC-CRC patients. RESULTS:The FKBP51 expression was significantly (p < 0.01) increased by 36.3% in tumor-containing tissues compared to control tissues in UC-CRC patients. Nuclear enrichment of FKBP51 in tumor-containing tissues was significantly (p < 0.001) increased by 78.5%. The UC-CRC patients with higher levels of FKBP51 expression ratio between tumor-containing tissues and control tissues had shorter survival periods, but greater neutrophil invasion and neutrophils to lymphocytes ratio (NLR) in peripheral blood. Moreover, the FKBP51 expression ratio was more helpful in predicting the survival periods and recurrence in the UC-CRC patients than the NLR in peripheral blood. CONCLUSIONS:The FKBP51 expression ratio between tumor-containing tissue and control tissue may be an important biomarker of inflammatory tumor microenvironment and more helpful for the UC-CRC prognosis.
journal_name
Adv Med Scijournal_title
Advances in medical sciencesauthors
Xia Z,Zhang G,Wang C,Feng Ydoi
10.1016/j.advms.2021.01.003subject
Has Abstractpub_date
2021-01-15 00:00:00pages
89-97issue
1eissn
1896-1126issn
1898-4002pii
S1896-1126(21)00003-1journal_volume
66pub_type
杂志文章abstract:PURPOSE:HCV chronic infection still presents a very serious epidemiological and clinical problem. Apart from its cytopathic effect on liver parenchyma, its detrimental effect on lipid and carbohydrate metabolism has recently been emphasized. The aim of the study was to assess lipid and carbohydrate parameters in childr...
journal_title:Advances in medical sciences
pub_type: 杂志文章
doi:10.2478/v10039-011-0048-5
更新日期:2011-01-01 00:00:00
abstract:PURPOSE:The question of whether or not non-sporadic breast malignancies have different immunohistochemical features than sporadic malignancies has not been investigated previously. Consequently, the purpose of this study was to compare the expression of E-cadherin (EC) in breast cancer patients with positive and negati...
journal_title:Advances in medical sciences
pub_type: 杂志文章
doi:10.2478/v10039-008-0007-y
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abstract:BACKGROUND:Current risk stratification after acute myocardial infarction (MI) depends on left ventricular ejection fraction. Microvolt T-wave alternans (MTWA) is one of promising markers to predict cardiac events in patients after acute MI treated according to current guidelines. METHODS:In this single center study, 1...
journal_title:Advances in medical sciences
pub_type: 杂志文章
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journal_title:Advances in medical sciences
pub_type: 杂志文章
doi:10.1016/j.advms.2015.06.004
更新日期:2015-09-01 00:00:00
abstract::In recent years, a constant growth of knowledge and clinical applications of stem cells have been observed. Mesenchymal stromal cells, also described as mesenchymal stem cells (MSCs) represent a particular cell type for research and therapy because of their ability to differentiate into mesodermal lineage cells. The m...
journal_title:Advances in medical sciences
pub_type: 杂志文章,评审
doi:10.2478/ams-2013-0007
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journal_title:Advances in medical sciences
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doi:10.1016/j.advms.2015.12.001
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journal_title:Advances in medical sciences
pub_type: 杂志文章
doi:10.1016/j.advms.2014.10.005
更新日期:2015-03-01 00:00:00
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journal_title:Advances in medical sciences
pub_type: 杂志文章
doi:
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journal_title:Advances in medical sciences
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journal_title:Advances in medical sciences
pub_type: 杂志文章
doi:10.1016/j.advms.2013.07.001
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journal_title:Advances in medical sciences
pub_type: 杂志文章,评审
doi:10.2478/v10039-008-0037-5
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journal_title:Advances in medical sciences
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doi:10.2478/ams-2013-0025
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journal_title:Advances in medical sciences
pub_type: 杂志文章
doi:10.1016/j.advms.2013.08.003
更新日期:2014-03-01 00:00:00
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journal_title:Advances in medical sciences
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doi:10.1016/j.advms.2017.08.001
更新日期:2018-03-01 00:00:00
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journal_title:Advances in medical sciences
pub_type: 杂志文章
doi:10.2478/v10039-008-0014-z
更新日期:2008-01-01 00:00:00
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journal_title:Advances in medical sciences
pub_type: 杂志文章
doi:10.1016/j.advms.2014.04.002
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journal_title:Advances in medical sciences
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doi:10.2478/v10039-009-0006-7
更新日期:2009-01-01 00:00:00
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journal_title:Advances in medical sciences
pub_type: 杂志文章
doi:10.1016/j.advms.2016.06.005
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journal_title:Advances in medical sciences
pub_type: 杂志文章
doi:10.1016/j.advms.2013.10.002
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journal_title:Advances in medical sciences
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journal_title:Advances in medical sciences
pub_type: 杂志文章
doi:
更新日期:2006-01-01 00:00:00
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journal_title:Advances in medical sciences
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doi:
更新日期:2006-01-01 00:00:00
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journal_title:Advances in medical sciences
pub_type: 杂志文章
doi:10.2478/v10039-008-0047-3
更新日期:2008-01-01 00:00:00
abstract::Lung cancer causes an estimated 1.6 million deaths each year, being the leading cause of cancer-related deaths in the world. Late diagnosis and, in some cases, the high aggressiveness of the tumour result in low overall five-year survival rates of 12% among men and 7% among women. The cure is most likely in early-stag...
journal_title:Advances in medical sciences
pub_type: 杂志文章,评审
doi:10.1016/j.advms.2017.12.002
更新日期:2018-09-01 00:00:00
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journal_title:Advances in medical sciences
pub_type: 杂志文章,评审
doi:10.1016/j.advms.2016.08.001
更新日期:2017-03-01 00:00:00
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journal_title:Advances in medical sciences
pub_type: 杂志文章
doi:10.2478/ams-2013-0010
更新日期:2013-01-01 00:00:00
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journal_title:Advances in medical sciences
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doi:10.2478/v10039-012-0080-0
更新日期:2013-01-01 00:00:00
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journal_title:Advances in medical sciences
pub_type: 杂志文章
doi:10.2478/v10039-011-0010-6
更新日期:2011-01-01 00:00:00
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journal_title:Advances in medical sciences
pub_type: 杂志文章
doi:
更新日期:2006-01-01 00:00:00