Abstract:
PURPOSE:Glaucoma is one of the most important reason causes of the blindness, associated with retinal ganglion cells (RGC) death. This process is not fully understood, however apoptosis due to hypoxia is one of the most important processes leading to RGC death. Glaucomatous optic neuropathy is characterized by remodeling of the extracellular matrix due to metalloproteinase activation, which leads to loss of RGC and axons at the optic nerve head. The aim of the study was to evaluate metalloproteinase 9 (MMP-9) and tissue metalloproteinase inhibitor-1 (TIMP-1) expression in the retinal ganglion cells and optic nerve axons in 33 eyes with absolute primary glaucoma. MATERIAL/METHODS:To evaluate MMP-9 and TIMP-1 expression primary polyclonal goat antibodies against MMP-9 and TIMP-1 were used. The control group was composed of 8 cases of eyes enucleated and fixed in the first day after trauma. RESULTS:MMP-9 expression was observed in retinal ganglion cells and in the inner nuclear layer of the retina in all the examined cases. In 28 out of 33 glaucomatous eyes, MMP-9 expression was observed in the proliferating glial cells surrounding the optic nerve axons. TIMP-1 expression was observed in 10 out of 33 glaucomatous eyes, only in retinal ganglion cells. None of the examined injured eyes showed MMP-9 and TIMP-1 expression. CONCLUSIONS:MMP-9 activation rather than TIMP-1 may by associated with the pathomechanism of retinal ganglion cell and optic nerve damage in absolute glaucoma.
journal_name
Adv Med Scijournal_title
Advances in medical sciencesauthors
Zalewska R,Reszeć J,Kisielewski W,Mariak Zdoi
10.1016/j.advms.2015.07.007subject
Has Abstractpub_date
2016-03-01 00:00:00pages
6-10issue
1eissn
1896-1126issn
1898-4002pii
S1896-1126(15)00043-7journal_volume
61pub_type
杂志文章abstract:BACKGROUND:Current risk stratification after acute myocardial infarction (MI) depends on left ventricular ejection fraction. Microvolt T-wave alternans (MTWA) is one of promising markers to predict cardiac events in patients after acute MI treated according to current guidelines. METHODS:In this single center study, 1...
journal_title:Advances in medical sciences
pub_type: 杂志文章
doi:10.2478/v10039-012-0033-7
更新日期:2012-01-01 00:00:00
abstract::Apelin is an endogenous peptide, which is expressed in a vast board of organs such as the brain, placenta, heart, lungs, kidneys, pancreas, testis, prostate and adipose tissues. The apelin receptor, called angiotensin-like-receptor 1 (APJ), is also expressed in the brain, spleen, placenta, heart, liver, intestine, pro...
journal_title:Advances in medical sciences
pub_type: 杂志文章,评审
doi:10.1016/j.advms.2020.02.002
更新日期:2020-03-01 00:00:00
abstract:PURPOSE:Caries, a social ailment, is one of the diseases of civilization of the 20th century. In Poland, the incidence rate of caries is very high both in the young and adults. The major etiological factors of caries are: improper oral hygiene, diet based on carbohydrate-rich and highly processed food products, neglect...
journal_title:Advances in medical sciences
pub_type: 杂志文章
doi:
更新日期:2006-01-01 00:00:00
abstract::Idiopathic retroperitoneal fibrosis (IRF) entirely confined to the pelvic cavity is an extremely rare clinical entity. Herein, is described the case of a 36- year old male who presented with clinical and imaging manifestations of a large pelvic tumor. Exploratory laparotomy revealed a large mass in the right pelvis or...
journal_title:Advances in medical sciences
pub_type: 杂志文章
doi:10.2478/v10039-009-0029-0
更新日期:2009-01-01 00:00:00
abstract:PURPOSE:C-kit positive interstitial cells of Cajal (ICCs) play an important role in the regulation of the smooth muscle motility, acting as pacemakers to provide the slow wave activity in various organs. Recent studies have shown that c-kit positive ICCs are widely distributed in the urinary tract of animals and humans...
journal_title:Advances in medical sciences
pub_type: 杂志文章
doi:10.2478/ams-2013-0002
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abstract:PURPOSE:Cerebral metastases develop in 10-30% of patients with breast cancer (BC) and in around 3.3 to 4% of patients with ovarian cancer (OC). The aim of the multicenter study is to investigate the correlation between the expression of estrogen alpha receptors (ERα), progesterone receptors (PR), human epidermal growth...
journal_title:Advances in medical sciences
pub_type: 杂志文章,多中心研究
doi:10.1016/j.advms.2018.12.007
更新日期:2019-09-01 00:00:00
abstract::PET is a successful modality to detect cancer and in recent years has demonstrated a great diagnostic value in large series of tumour types. PET combines high sensitivity and reasonable resolution, and offers the ability to perform whole body scans. 18F-deoxyglucose (FDG)-PET has also been used to diagnose tumours of ...
journal_title:Advances in medical sciences
pub_type: 杂志文章
doi:
更新日期:2006-01-01 00:00:00
abstract::Vascular calcification (VC) is highly prevalent in patients with chronic kidney disease (CKD) and is strongly associated with cardiovascular mortality and morbidity. Accumulating evidence over the past decade has challenged the hypothesis of close interaction between bone and VC what raises the possibility of a common...
journal_title:Advances in medical sciences
pub_type: 杂志文章,评审
doi:10.1016/j.advms.2016.08.001
更新日期:2017-03-01 00:00:00
abstract::In recent years, a constant growth of knowledge and clinical applications of stem cells have been observed. Mesenchymal stromal cells, also described as mesenchymal stem cells (MSCs) represent a particular cell type for research and therapy because of their ability to differentiate into mesodermal lineage cells. The m...
journal_title:Advances in medical sciences
pub_type: 杂志文章,评审
doi:10.2478/ams-2013-0007
更新日期:2013-01-01 00:00:00
abstract::Lung cancer causes an estimated 1.6 million deaths each year, being the leading cause of cancer-related deaths in the world. Late diagnosis and, in some cases, the high aggressiveness of the tumour result in low overall five-year survival rates of 12% among men and 7% among women. The cure is most likely in early-stag...
journal_title:Advances in medical sciences
pub_type: 杂志文章,评审
doi:10.1016/j.advms.2017.12.002
更新日期:2018-09-01 00:00:00
abstract:PURPOSE:To evaluate the serum levels of tumor necrosis factor (TNF) alpha and its soluble receptors in obese children with non-alcoholic fatty liver disease (NAFLD). MATERIAL/METHODS:Fasting serum levels of TNFalpha and its receptors were determined in 45 consecutive obese children with suspected liver disease and 20 ...
journal_title:Advances in medical sciences
pub_type: 杂志文章
doi:10.2478/v10039-010-0008-5
更新日期:2010-01-01 00:00:00
abstract:PURPOSE:In the literature, the manifestations of gastric cancer have been described based on all patients. In recent times, interest has focused on the subgroup of young patients. In the following analysis, the subgroup of young patients (< 50y) is compared with an older reference group (≥ 50y). MATERIAL AND METHODS:B...
journal_title:Advances in medical sciences
pub_type: 杂志文章
doi:10.2478/v10039-012-0052-4
更新日期:2012-01-01 00:00:00
abstract:PURPOSE:The purpose of the studies performed was an attempt to establish a potential relationship between total antioxidant status of unstimulated whole saliva, patients' ages, oral hygiene status and dental caries. MATERIAL AND METHODS:The study involved 120 non-smokers. Mean age of the study subjects was 18.40 ± 1.7...
journal_title:Advances in medical sciences
pub_type: 杂志文章
doi:10.2478/v10039-012-0015-9
更新日期:2012-06-01 00:00:00
abstract:PURPOSE:The aim of this study was to check the pro-apoptotic mechanism of prosthetic reconstruction on epithelial cells of the oral mucosa. PATIENTS AND METHODS:The research was carried out on the saliva of healthy patients using prostheses. The sample swabs were stained using the May-Grünwald-Giemsa method and proces...
journal_title:Advances in medical sciences
pub_type: 杂志文章
doi:10.1016/j.advms.2019.12.010
更新日期:2020-03-01 00:00:00
abstract:PURPOSE:Promoter hypermethylation and reduced expression of many genes have been found in gastric cancer. DNA methyltransferases are enzymes potentially affecting promoter hypermethylation. MATERIAL AND METHODS:We analyzed proteins expression of DNA methyltransferase 1 and 3b by immunohistochemistry in 47 surgically r...
journal_title:Advances in medical sciences
pub_type: 杂志文章
doi:10.1016/j.advms.2014.10.002
更新日期:2015-03-01 00:00:00
abstract:PURPOSE:The excess and deficit of serotonin can be the cause of somatic and mental disorders. The aim of this study was to evaluate serotonin levels in blood and ascitic fluid as well as excretion of 5-hydroxyindoleacetic acid (5-HIAA) in urine in patients with hepatic encephalopathy (HE). MATERIAL AND METHODS:The stu...
journal_title:Advances in medical sciences
pub_type: 杂志文章
doi:10.2478/ams-2013-0010
更新日期:2013-01-01 00:00:00
abstract:PURPOSE:Defining the level of protective factors in saliva of patients suffering from decompensated type 2 diabetes. MATERIAL AND METHODS:50 Patients with diagnosis of decompensated type 2 diabetes, including 32 women and 18 men at the age of 57.9±9.2 years. The control group consisted of 50 people among whom there we...
journal_title:Advances in medical sciences
pub_type: 杂志文章
doi:10.1016/j.advms.2016.06.005
更新日期:2017-09-01 00:00:00
abstract:PURPOSE:To evaluate intravascular xenotransplantation of macroencapsulated pancreatic islet cells in the process of the treatment of diabetes mellitus type 1 without immunosuppressive therapy. MATERIAL AND METHODS:Xenogenic intravascular transplantation was performed in 19 patients with diabetes mellitus (type 1) havi...
journal_title:Advances in medical sciences
pub_type: 杂志文章
doi:10.2478/v10039-008-0045-5
更新日期:2008-01-01 00:00:00
abstract:PURPOSE:Psoriasis is a chronic, recurrent, inflammatory disease. Recent investigations indicate its autoimmune pathogenesis. Apoptosis plays an important role in the development of many autoimmune diseases. The aim of this study was to evaluate the influence of topical treatment of psoriasis on soluble Fas (sFas) and s...
journal_title:Advances in medical sciences
pub_type: 杂志文章
doi:10.1016/j.advms.2014.10.005
更新日期:2015-03-01 00:00:00
abstract::Melanoma is a malignant tumor which is inclined to metastasize promptly into the lymphatic system and other organs such as lung, liver, brain or bone. Therefore early diagnosis remains crucial for improving clinical outcome for melanoma patients. Current chemotherapy and chemo-immunotherapy regimes have shown little c...
journal_title:Advances in medical sciences
pub_type: 杂志文章,评审
doi:10.1016/j.advms.2014.12.002
更新日期:2015-03-01 00:00:00
abstract:PURPOSE:The aim of this prospective randomized trial was to assess the influence of the sequence of pulmonary vessel ligation, during anatomic resection, on long term survival in patients with NSCLC. MATERIAL/METHODS:This prospective randomized study included 385 patients treated surgically with lobectomy or pneumonec...
journal_title:Advances in medical sciences
pub_type: 杂志文章,随机对照试验
doi:10.2478/v10039-012-0061-3
更新日期:2013-01-01 00:00:00
abstract:PURPOSE:The aim of the present study was to assess the effect of tumor advancement and surgery treatment on P-selectin expression (CD 62P), level of sP-selectin and platelet count. MATERIAL AND METHODS:The study involved 27 colorectal cancer patients (CRC). They were divided into two groups: group B1--18 patients (T2-...
journal_title:Advances in medical sciences
pub_type: 杂志文章
doi:
更新日期:2006-01-01 00:00:00
abstract:PURPOSE:To evaluate the role of 12/15-lipoxygenase (LOX) in regulation of synthesis of selected eicosanoids in mice sensitized and challenged with Dermatophagoides pteronyssinus (Dp) allergen extract. MATERIALS AND METHODS:Both C57Bl and 12/15-LOX knockout mice were sensitized by 2 intraperitoneal injections and subse...
journal_title:Advances in medical sciences
pub_type: 杂志文章
doi:10.1016/j.advms.2015.11.001
更新日期:2016-03-01 00:00:00
abstract:PURPOSE:Glioblastoma is the most common and the deadliest brain cancer. The aim of this study was to analyze the impact of resveratrol and its five analogs: 3,4,4'-trimethoxy, 3,4,2'-trimethoxy, 3,4,2',4'-tetramethoxy, 3,4,2',6'-tetramethoxy and 3,4,2',4',6'-pentamethoxy-trans-stilbenes (MS) on human glioblastoma T98G ...
journal_title:Advances in medical sciences
pub_type: 杂志文章
doi:10.1016/j.advms.2020.11.001
更新日期:2020-11-22 00:00:00
abstract:PURPOSE:To compare soluble Fas, FasL and Bcl-2 in Graves' disease (GD) and Hashimoto's thyroiditis (HT) to the markers of humoral response: aTPO, aTG and aTSHR. MATERIAL AND METHODS:5 groups of subjects: 1) 14 patients with GD in euthyreosis on methimazol (euGD); 2) 20 patients with hyperthyroid GD (hrGD); 3) 15 patie...
journal_title:Advances in medical sciences
pub_type: 杂志文章
doi:
更新日期:2006-01-01 00:00:00
abstract:PURPOSE:The purpose of this study was to investigate the influence of selective agonists of the retinoid receptor X (RXR) and the retinoid acid receptor (RAR) on bone metabolism in rats. METHODS:Thirty six male Wistar rats were divided into three groups: receiving bexarotene, or tazarotene, or to control group. Serum ...
journal_title:Advances in medical sciences
pub_type: 杂志文章
doi:10.1016/j.advms.2015.09.001
更新日期:2016-03-01 00:00:00
abstract::The increasing demand in studying cellular functions in cultured cells under various levels of oxygen and hydrogen peroxide (H2O2) is only partly fulfilled by conventional approaches such as hypoxia chambers, bolus additions of H2O2 or redox-cycling drugs. This article describes the recently developed enzymatic GOX/CA...
journal_title:Advances in medical sciences
pub_type: 杂志文章
doi:10.2478/v10039-009-0042-3
更新日期:2009-01-01 00:00:00
abstract:PURPOSE:Our question was whether two biochemical markers of preeclampsia, E-selectin and P-selectin, keep their prognostic value in particular stages of labour, or they lose it during labour. MATERIAL AND METHODS:The study group consisted of 36 healthy parturient women who gave physiological births (in control 15 heal...
journal_title:Advances in medical sciences
pub_type: 杂志文章
doi:
更新日期:2007-01-01 00:00:00
abstract:PURPOSE:Response to steroids is included in the diagnostic criteria for IgG4-related sclerosing cholangitis (IgG4-SC). To assess how to appropriately conduct steroid trials for IgG4-related SC, we examined the clinical pictures of steroid responsiveness in IgG4-SC patients. MATERIAL AND METHODS:A total of 29 patients ...
journal_title:Advances in medical sciences
pub_type: 临床试验,杂志文章
doi:10.1016/j.advms.2015.02.006
更新日期:2015-09-01 00:00:00
abstract:PURPOSE:The objective of this study was to evaluate thevitamin D concentration in patients with recurrent respiratory infections with or without immunoglobulin G, A or M (IgG, IgA, IgM) deficiency, and to find a correlation between the vitamin D concentration and the response to hepatitis B vaccination. MATERIALS AND ...
journal_title:Advances in medical sciences
pub_type: 杂志文章
doi:10.1016/j.advms.2017.08.001
更新日期:2018-03-01 00:00:00