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  • Dolutegravir-based regimen for maintenance of viral suppression in people living with HIV: 48-week results in real life setting.

    abstract::To evaluate the efficacy, safety and tolerability of switching to a dolutegravir (DTG)-based regimen in a cohort of virological suppressed HIV-infected patients. The dynamics of total HIV-DNA and levels of high-sensitivity c-reactive protein (hsCRP), interleukin-6 (IL-6), soluble-CD14 (sCD14) and D-Dimer were also ana...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章

    doi:10.1089/AID.2020.0196

    authors: Di Carlo D,Falasca F,Palermo E,Mezzaroma I,Fimiani C,Siccardi G,Celani L,Di Campli FM,d'Ettorre G,Antonelli G,Turriziani O

    更新日期:2021-01-24 00:00:00

  • Impact of plasma IP-10/CXCL10 and RANTES/CCL5 levels on neurocognitive function in HIV treatment naïve patients.

    abstract:BACKGROUND:Immune activation, which is accompanied by the production of proinflammatory cytokines, is a strong predictor of disease progression in HIV infection. Inflammation is critical in neuronal damage linked to HIV-associated neurocognitive disorders. METHODS:We examined the relationship between plasma cytokine l...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章

    doi:10.1089/AID.2020.0203

    authors: Ruhanya V,Jacobs GB,Naidoo S,Paul RH,Joska J,Seedat S,Nyandoro G,Engelbrecht S,Glashoff R

    更新日期:2021-01-20 00:00:00

  • HIV-1 Subtype C Tier 3 Viruses Have Increased Infectivity Compared to Tier 2 Viruses.

    abstract::A primary concern of an antibody-based HIV-1 therapy is the virus' ability to rapidly escape antibody responses. Therefore, we investigated the relationships between antibody neutralization sensitivity, viral phenotype, and infectivity in 13 subtype C viruses using a HeLa transfectant-based assay. We observed that the...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章

    doi:10.1089/AID.2020.0124

    authors: Moyo T,Guleid FH,Schomaker M,Williamson C,Dorfman JR

    更新日期:2020-12-01 00:00:00

  • Micro RNA Targets in HIV Latency: Insights into Novel Layers of Latency Control.

    abstract::Despite the considerable progress that has been made in identifying cellular factors and pathways that contribute to establishment and maintenance of the latent HIV reservoir, it remains the major obstacle to eradicating this virus. Most recently, noncoding genes have been implicated in regulation of HIV expression. I...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章

    doi:10.1089/AID.2020.0150

    authors: Heinson AI,Woo J,Mukim A,White CH,Moesker B,Bosque A,Spina CA,Woelk CH,Macarthur BD,Beliakova-Bethell N

    更新日期:2020-11-10 00:00:00

  • Factors Associated with Nonsuppression of HIV Infection in the Spanish VACH Cohort.

    abstract::We aim to determine the prevalence of HIV nonsuppression and factors associated with it. This is a cross-sectional multicenter study carried out in January 2016 with data of the VACH Cohort, a registry participated by 23 hospitals from most regions of Spain. The prevalence of HIV nonsuppression, defined as HIV RNA ≥20...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章

    doi:10.1089/AID.2020.0016

    authors: Roca B,Spanish VACH Cohort Group.

    更新日期:2020-11-01 00:00:00

  • A Summary of the Fifth Annual Virology Education HIV Microbiome Workshop.

    abstract::In October of 2019, researchers and community members from around the world met at the NIH for the fifth annual International Workshop on Microbiome in HIV. New research was presented on the role of the microbiome on chronic inflammation and vaccine design, interactions of genetics, environment, sexual practice and HI...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章

    doi:10.1089/AID.2020.0121

    authors: Sherrill-Mix S,Connors K,Aldrovandi GM,Brenchley JM,Boucher C,Bushman FD,Collman RG,Dandekar S,Klatt NR,Lagenaur LA,Paredes R,Tachedjian G,Turpin JA,Landay AL,Ghosh M

    更新日期:2020-11-01 00:00:00

  • HIV-1 Genetic Diversity and High Prevalence of Pretreatment Drug Resistance in Tianjin, China.

    abstract::Diversity of genotypes and prevalence of pretreatment drug resistance (PDR) are challenges for the epidemic control and vaccine development of HIV-1. However, little is known about the situation in Tianjin. Blood samples were collected from newly diagnosed, antiretroviral treatment (ART)-naive HIV/AIDS patients from J...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章

    doi:10.1089/AID.2020.0056

    authors: Zeng R,Ren D,Gong X,Wei M,Gao L,Yu A,Zhang D,Mi Y,Ma P

    更新日期:2020-10-01 00:00:00

  • New Knowledge About CCR5, HIV Infection, and Disease Progression: Is "Old" Still Valuable?

    abstract::C-C chemokine receptor (CCR) 5 (CCR5) is the main HIV-1 coreceptor involved in virus entry and cell-to-cell spread during acute and chronic infections: such CCR5 and T cell tropic viruses are adapted to and replicate in CD4+ memory T cells. Polymorphisms in CCR5 regulate CCR5 expression, which, in turn, influences HIV...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章

    doi:10.1089/AID.2020.0060

    authors: Mehlotra RK

    更新日期:2020-10-01 00:00:00

  • What HIV in the Brain Can Teach Us About SARS-CoV-2 Neurological Complications?

    abstract::Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the etiologic agent of COVID-19, a disease that as of July 10, 2020, has infected >12 million people and killed >500,000. COVID-19 infection leads to acute respiratory distress syndrome in a subset of patients and is a primary driver of acute morbidity in...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章

    doi:10.1089/AID.2020.0161

    authors: Al-Harthi L,Campbell E,Schneider JA,Bennett DA

    更新日期:2020-08-10 00:00:00

  • Short Communication: Elevated Labile Iron Levels in CD4 and CD8 T Cells from HIV-Positive Individuals with Undetectable Viral Load.

    abstract::Iron is a key factor at various stages of HIV life cycle and determines the progression of HIV infection. Data about cellular labile iron pool (LIP) in the settings of contemporary antiretroviral therapy (cART) are lacking. Yet LIP is directly related to the generation of reactive oxygen species, and may contribute to...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章

    doi:10.1089/AID.2020.0010

    authors: Emilova R,Manolov V,Todorova Y,Yancheva N,Alexiev I,Nikolova M

    更新日期:2020-07-01 00:00:00

  • HIV-1 Central Nervous System Compartmentalization and Cytokine Interplay in Non-Subtype B HIV-1 Infections in Nigeria and Malawi.

    abstract::HIV-1 compartmentalization in the central nervous system (CNS) and its contribution to neurological disease have been well documented. Previous studies were conducted among people infected with subtypes B or C where CNS compartmentalization has been observed when comparing viral sequences in the blood to virus in cere...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章

    doi:10.1089/AID.2019.0245

    authors: Adewumi OM,Dukhovlinova E,Shehu NY,Zhou S,Council OD,Akanbi MO,Taiwo B,Ogunniyi A,Robertson K,Kanyama C,Hosseinipour MC,Swanstrom R

    更新日期:2020-06-01 00:00:00

  • HIV Care Among Elderly Population: Systematic Review and Meta-Analysis.

    abstract::Elderly people living with HIV are increasing. At present in the United States, nearly half of newly diagnosed HIV-infected people are aged >50 years. Diagnosis and treatment of HIV-infected elderly patients tends to be delayed by several health care factors as several life-threatening diseases are common in elderly p...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章

    doi:10.1089/AID.2019.0098

    authors: Bhatta M,Nandi S,Dutta N,Dutta S,Saha MK

    更新日期:2020-06-01 00:00:00

  • Predictors for Poor Linkage to Care Among Hospitalized Persons Living with HIV and Co-Occurring Substance Use Disorder.

    abstract::Persons living with HIV (PLWH) with substance use disorders (SUD) remain a population difficult to engage in HIV care. Project HOPE (Hospital Visits as an Opportunity for Prevention and Engagement), a randomized controlled trial testing patient navigation with/without contingency management for PLWH with SUD, aimed to...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章

    doi:10.1089/AID.2019.0153

    authors: Summers NA,Colasanti JA,Feaster DJ,Armstrong WS,Rodriguez A,Jain MK,Jacobs P,Metsch LR,Del Rio C

    更新日期:2020-05-01 00:00:00

  • Characterization of HIV-1 CRF01_AE env Genes Derived from Recently Infected Indonesian Individuals.

    abstract::To eradicate human immunodeficiency virus type 1 (HIV-1) infection, a comprehensive strategy including preventive vaccine development is needed. Envelope glycoproteins (Env) play a central role in viral infection and are the major targets of humoral immune responses. Therefore, Env is a candidate vaccine antigen, and ...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章

    doi:10.1089/aid.2019.0179

    authors: Sasaki M,Kotaki T,Khairunisa SQ,Tachibana S,Ophinni Y,Hayashi Y,Nasronudin,Kameoka M

    更新日期:2020-03-01 00:00:00

  • Going Beyond Giving Antiretroviral Therapy: Multimorbidity in Older People Aging with HIV in Nigeria.

    abstract::"Graying of HIV epidemic" is observed globally, as people living with HIV (PLWH) are aging, due to effectiveness of antiretrovirals. The normal aging processes and HIV-induced immune dysfunction, are potential mechanisms, driving multimorbidity (MM) in PLWH. MM is the concurrent presence of two or more diseases in a s...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章

    doi:10.1089/AID.2019.0131

    authors: Obimakinde AM,Adebusoye L,Achenbach C,Ogunniyi A,Olaleye D

    更新日期:2020-03-01 00:00:00

  • Mitochondrial Impairment in Well-Suppressed Children with Perinatal HIV-Infection on Antiretroviral Therapy.

    abstract::Mitochondrial impairment is reported in HIV-infected children receiving antiretroviral therapy (ART), as well as those naive to ART. Whether mitochondrial function recovers with early initiation of ART and sustained viral suppression on long-term ART is unclear. In this study, we evaluate mitochondrial markers in well...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章

    doi:10.1089/AID.2018.0182

    authors: Shen J,Liberty A,Shiau S,Strehlau R,Pierson S,Patel F,Wang L,Burke M,Violari A,Coovadia A,Abrams EJ,Arpadi S,Foca M,Kuhn L

    更新日期:2020-01-01 00:00:00

  • The Interplay Between Frailty and Intrinsic Capacity in Aging and HIV Infection.

    abstract::In the context of an emerging aging epidemic affecting people living with HIV (PLWH), we critically discuss existing data regarding two different conceptual models of aging-frailty and intrinsic capacity, respectively, both in a clinical and public health perspective. These constructs have not yet been integrated in t...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章,评审

    doi:10.1089/AID.2019.0157

    authors: Guaraldi G,Milic J

    更新日期:2019-11-01 00:00:00

  • Prevalence and Risk Factors for Human Immunodeficiency Virus Infection Among Female Sex Workers: Distinct Offers of Sexual Services in a Municipality of the Brazilian Amazon.

    abstract::This study determined the prevalence of human immunodeficiency virus (HIV) infection and its associated factors in female sex workers (FSWs) from the municipality of Bragança in the state of Pará, Brazil. A cross-sectional study using a respondent-driven sampling method was used to investigate 137 FSWs. They were inte...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章

    doi:10.1089/AID.2019.0032

    authors: da Costa LM,Raiol NC,Lisboa BLA,Frade PCR,Blandtt LDS,Silva-Oliveira GC,Machado LFA,Martins LC,Oliveira-Filho AB

    更新日期:2019-09-01 00:00:00

  • Short Communication: Effect of Seminal Plasma on Functions of Monocytes and Granulocytes.

    abstract::Most HIV-1 transmissions occur at mucosae and involve exposure to semen. Semen contains immunomodulatory factors, which inhibit anti-HIV-1 natural killer cell and T cell responses. We demonstrate high concentrations (1:2 dilution) of seminal plasma (SP) inhibit monocyte phagocytosis and anti-HIV-1 Fc-dependent functio...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章

    doi:10.1089/AID.2018.0219

    authors: Selva KJ,Juno JA,Worley MJ,Chung AW,Tachedjian G,Kent SJ,Parsons MS

    更新日期:2019-06-01 00:00:00

  • Multiple HIV-1 Subtypes Were Found Circulating in Shijingshan District of Beijing, China.

    abstract::High level of HIV prevalence was found in some specific areas or populations in China. Shijingshan district was one of the areas with rapid increase of newly reported HIV cases in Beijing, China. Comprehensive investigation on HIV genetic characteristics is necessary in the district. In this study, we enrolled 223 new...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章

    doi:10.1089/AID.2018.0263

    authors: Sun L,Jia L,Liu Y,Han J,Li J,Li H,Li L

    更新日期:2019-05-01 00:00:00

  • Seroprevalence of HTLV-1/2 Among Voluntary Blood Donors in Vietnam.

    abstract::Infection with human T lymphotropic virus (HTLV), although asymptomatic in most cases, can lead to severe illnesses, such as adult T cell leukemia/lymphoma or myelopathy/tropical spastic paraparesis. HTLV can be transmitted by whole-blood (WB) transfusion. The prevalence of HTLV among blood donor populations has not b...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章

    doi:10.1089/AID.2018.0240

    authors: Pham D,Nguyen D,Nguyen TA,Tran C,Tran L,Devare S,Tran A,Bhatnagar S

    更新日期:2019-04-01 00:00:00

  • Mapping of Neutralizing Antibody Epitopes on the Envelope of Viruses Obtained from Plasma Samples Exhibiting Broad Cross-Clade Neutralization Potential Against HIV-1.

    abstract::Several broadly neutralizing antibodies (bNAbs) that can target HIV strains with large degrees of variability have recently been identified. However, efforts to induce synthesis of such bNAbs that can protect against HIV infection have not met with much success. Identification of specific epitopes encoded in the HIV-1...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章

    doi:10.1089/AID.2018.0224

    authors: Cheedarla N,Sundaramurthi JC,Hemalatha B,Anangi B,Nesakumar M,Ashokkumar M,Vidya Vijayan KK,Tripathy SP,Swaminathan S,Vaniambadi SK,Ramanathan DV,Hanna LE

    更新日期:2019-02-01 00:00:00

  • HIV-1-Mediated Suppression of IFN-α Production Is Associated with Inhibition of IRF-7 Translocation and PI3K/akt Pathway in Plasmacytoid Dendritic Cells.

    abstract::Interferon-α (IFN-α) plays a vital role in combating viral infections especially in the early control after infection. However, the HIV infection has shown substantial level of suppression of IFN-α secretion during initial phase of infection. The reasons behind this impairment are still obscure. As plasmacytoid dendri...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章

    doi:10.1089/AID.2018.0136

    authors: Dhamanage AS,Thakar MR,Paranjape RS

    更新日期:2019-01-01 00:00:00

  • Conformation-Dependent Interactions Between HIV-1 Envelope Glycoproteins and Broadly Neutralizing Antibodies.

    abstract::HIV type 1 (HIV-1) envelope glycoproteins (Env) mediate virus entry and are the target of neutralizing antibodies. Binding of the metastable HIV-1 Env trimer to the CD4 receptor triggers structural rearrangements that mediate Env conformational transitions from a closed conformation to a more open state through an int...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章,评审

    doi:10.1089/AID.2018.0102

    authors: Flemming J,Wiesen L,Herschhorn A

    更新日期:2018-09-01 00:00:00

  • The Mathilde Krim Effect as a Way to Overcome the Matilda Effect.

    abstract::The Matilda effect illustrates how the contributions of women to science have been historically attributed to their male colleagues in some circumstances. This effect may perpetuate and even increase the gender gap we currently face. Recognizing the work of great women who led our way and committed their careers to tr...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章

    doi:10.1089/AID.2018.0082

    authors: Izquierdo-Useros N

    更新日期:2018-09-01 00:00:00

  • Short Communication: Characterization of a New HIV-1 Group N Isolate Originating from a Cameroonian Patient.

    abstract::HIV-1 group N (HIV-1/N) remains rare and mainly restricted to Cameroon. In this study, we report a new HIV-1/N infected case identified during routine HIV screening activities in Yaounde. The genetic characterization of the near full-length genome of this virus strain revealed that it is genetically distinct to all HI...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章

    doi:10.1089/AID.2018.0015

    authors: Tagnouokam Ngoupo PA,Sadeuh-Mba SA,De Oliveira F,Ngo-Malabo ET,Ngono L,Plantier JC,Kfutwah A,Njouom R

    更新日期:2018-07-01 00:00:00

  • Factors Associated with High-Grade Anal Intraepithelial Lesion in HIV-Positive Men in a Southern U.S. City.

    abstract::The incidence of anal cancer is increased in HIV-infected patients compared with the general population. Risk factors associated with the anal cancer precursor, high-grade squamous intraepithelial lesion (HSIL), have not been extensively studied in an urban black population with late-stage HIV disease. We performed a ...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章

    doi:10.1089/AID.2018.0008

    authors: Frank M,Lahiri CD,Nguyen ML,Mehta CC,Mosunjac M,Flowers L

    更新日期:2018-07-01 00:00:00

  • Prevalence of Integrase Strand Transfer Inhibitors Resistance Mutations in Integrase Strand Transfer Inhibitors-Naive and -Experienced HIV-1 Infected Patients: A Single Center Experience.

    abstract::Integrase strand transfer inhibitor (InSTI) resistance rates are low. However, genotypic resistance test (GRT) is not routinely performed in many centers. The aim of this study is to evaluate the prevalence of InSTI-related mutations in our large cohort. We examined all integrase GRTs performed as part of routine clin...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章

    doi:10.1089/AID.2018.0006

    authors: De Francesco MA,Izzo I,Properzi M,Gargiulo F,Caccuri F,Quiros-Roldan E,Castelli F,Caruso A,Focà E

    更新日期:2018-07-01 00:00:00

  • Antiviral Activity of Tenofovir Alafenamide Against HIV-1 Subtypes and Emergence of K65R.

    abstract::Differences in emergence of HIV resistance between subtypes B and C in vitro and potential implications on tenofovir alafenamide efficacy in vivo were evaluated. Dose escalation resistance selections showed K65R emerging earlier for subtype C viruses in vitro, as previously reported. Viral breakthrough experiments at ...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章

    doi:10.1089/AID.2017.0248

    authors: Cox S,Margot N,Miller M,Callebaut C

    更新日期:2018-05-01 00:00:00

  • Characterization of a Novel HIV-1 Circulating Recombinant Form, CRF01_AE/B'/C (CRF96_cpx), in Yunnan, China.

    abstract::Currently, complex HIV-1 recombinations among the B', C, and CRF01_AE genotypes have frequently arisen in Yunnan, China. A novel HIV-1 complex circulating recombinant form (CRF) consisting of B', C, and CRF01_AE (CRF96_cpx) was recently characterized from three epidemiologically unlinked individuals. Two strains of th...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章

    doi:10.1089/AID.2017.0288

    authors: Miao J,Ran J,Song Y,Liu Y,Gao L,Miao Z,Zhang C,Feng Y,Xia X

    更新日期:2018-04-01 00:00:00

  • Postvaccination C-Reactive Protein and C5/gp41732-744 Antibody Level Fold-Changes Over Baseline Are Independent Predictors of Therapeutic HIV Vaccine Effect in a Phase 2 Clinical Study of Vacc-4x.

    abstract::Therapeutic vaccination has the potential to contribute to functional HIV cure strategies. However, to show functional HIV cure, study participants must be taken off combination antiretroviral therapy (cART). The availability of suitable biomarkers that can predict viral load (VL) or CD4 count outcomes following thera...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章,随机对照试验

    doi:10.1089/AID.2017.0179

    authors: Huang Y,Zhang L,Jolliffe D,Sanchez B,Stjernholm G,Jelmert Ø,Ökvist M,Sommerfelt MA

    更新日期:2018-03-01 00:00:00

  • Characterization of Envelope Surface Glycoprotein from HIV-2 Primary Isolates with Different Coreceptor Usage Profile.

    abstract::The main goal of this work was to identify molecular signatures in envelope surface glycoprotein that may be correlated with coreceptor usage by different human immunodeficiency virus (HIV)-2 strains. From inspection of aligned HIV-2 sequences, we verified that V1/V2 region showed the highest degree of amino acid sequ...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章

    doi:10.1089/AID.2017.0192

    authors: Cerejo P,Santos-Costa Q,Calado M,Espírito-Santo M,Parreira R,Azevedo-Pereira JM

    更新日期:2018-02-01 00:00:00

  • Immunization with Clinical HIV-1 Env Proteins Induces Broad Antibody Dependent Cellular Cytotoxicity-Mediating Antibodies in a Rabbit Vaccination Model.

    abstract::The induction of both neutralizing antibodies and non-neutralizing antibodies with effector functions, for example, antibody-dependent cellular cytotoxicity (ADCC), is desired in the search for effective vaccines against HIV-1. In the pursuit of novel immunogens capable of inducing an efficient antibody response, rabb...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章

    doi:10.1089/AID.2017.0140

    authors: Karlsson I,Borggren M,Jensen SS,Heyndrickx L,Stewart-Jones G,Scarlatti G,Fomsgaard A

    更新日期:2018-02-01 00:00:00

  • Simian Immunodeficiency Virus Infection Increases Blood Ethanol Concentration Duration After Both Acute and Chronic Administration.

    abstract::Alcohol use disorder (AUD) is a frequent comorbidity among people living with HIV/AIDS (PLWHA). Alcohol consumption is a significant predictor of nonadherence to antiretroviral therapy (ART), as well as worsening immunological and virological indicators among PLWHA. Clinical studies indicate that higher viral loads in...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章

    doi:10.1089/AID.2017.0195

    authors: Simon L,Siggins R,Winsauer P,Brashear M,Ferguson T,Mercante D,Song K,Vande Stouwe C,Nelson S,Bagby G,Amedee A,Molina PE

    更新日期:2018-02-01 00:00:00

  • Low Levels of Endothelial Progenitor Cells and Their Association with Systemic Inflammation and Monocyte Activation in Older HIV-Infected Men.

    abstract::Endothelial progenitor cells (EPCs) repair damaged vascular endothelium, and low circulating EPC levels have been associated with cardiovascular disease (CVD). CD34+/KDR+ EPCs are commonly reported in the literature and CD34+/CD133+/KDR+ EPCs are rare in circulation but highly specific for endothelial lineage. HIV-inf...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章

    doi:10.1089/AID.2017.0057

    authors: Seang S,Kelesidis T,Huynh D,Park S,Moe AA,Currier JS,Lake JE

    更新日期:2018-01-01 00:00:00

  • Reduced Expression of Siglec-7, NKG2A, and CD57 on Terminally Differentiated CD56-CD16+ Natural Killer Cell Subset Is Associated with Natural Killer Cell Dysfunction in Chronic HIV-1 Clade C Infection.

    abstract::HIV-1 viremia has been shown to induce several phenotypic and functional abnormalities in natural killer (NK) cells. To assess immune defects associated with HIV viremia, we examined NK cell function, differentiation status, and phenotypic alterations based on expression of inhibitory and activating receptors on NK ce...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章

    doi:10.1089/AID.2017.0095

    authors: Zulu MZ,Naidoo KK,Mncube Z,Jaggernath M,Goulder PJR,Ndung'u T,Altfeld M,Thobakgale CF

    更新日期:2017-12-01 00:00:00

  • Evidence for Altered Glutamine Metabolism in Human Immunodeficiency Virus Type 1 Infected Primary Human CD4+ T Cells.

    abstract::Glutamine is a conditionally essential amino acid that is an important metabolic resource for proliferating tissues by acting as a proteinogenic amino acid, a nitrogen donor for biosynthetic reactions and as a substrate for the citric acid or tricarboxylic acid cycle. The human immunodeficiency virus type 1 (HIV-1) pr...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章

    doi:10.1089/AID.2017.0165

    authors: Hegedus A,Kavanagh Williamson M,Khan MB,Dias Zeidler J,Da Poian AT,El-Bacha T,Struys EA,Huthoff H

    更新日期:2017-12-01 00:00:00

  • Analysis of Clinical HIV-1 Strains with Resistance to Maraviroc Reveals Strain-Specific Resistance Mutations, Variable Degrees of Resistance, and Minimal Cross-Resistance to Other CCR5 Antagonists.

    abstract::Maraviroc (MVC) is an allosteric inhibitor of human immunodeficiency virus type 1 (HIV-1) entry, and is the only CCR5 antagonist licensed for use as an anti-HIV-1 therapeutic. It acts by altering the conformation of the CCR5 extracellular loops, rendering CCR5 unrecognizable by the HIV-1 envelope (Env) glycoproteins. ...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章

    doi:10.1089/AID.2017.0097

    authors: Flynn JK,Ellenberg P,Duncan R,Ellett A,Zhou J,Sterjovski J,Cashin K,Borm K,Gray LR,Lewis M,Jubb B,Westby M,Lee B,Lewin SR,Churchill M,Roche M,Gorry PR

    更新日期:2017-12-01 00:00:00

  • Ultra-Deep Sequencing Analysis on HIV Drug-Resistance-Associated Mutations Among HIV-Infected Individuals: First Report from the Philippines.

    abstract::A sharp increase in the number of people living with HIV has been documented in the Philippines. In response, the government has instituted antiretroviral therapy (ART) nationwide through HIV treatment hubs. However, no data presently exist on the status of ART drug-resistance-associated mutations (DRMs). In this stud...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章

    doi:10.1089/AID.2016.0151

    authors: SahBandar IN,Samonte G,Telan E,Siripong N,Belcaid M,Schanzenbach D,Leano S,Chagan-Yasutan H,Hattori T,Shikuma CM,Ndhlovu LC

    更新日期:2017-11-01 00:00:00

  • IL-21 Therapy Controls Immune Activation and Maintains Antiviral CD8+ T Cell Responses in Acute Simian Immunodeficiency Virus Infection.

    abstract::Human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) replicate during acute infection in lymphocytes of the gastrointestinal tract, before disseminating systemically. Localized replication and associated loss of gut-resident CD4+ T cells occur regardless of the portal of entry of the virus (e.g.,...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章

    doi:10.1089/aid.2017.0160

    authors: Méndez-Lagares G,Lu D,Merriam D,Baker CA,Villinger F,Van Rompay KKA,McCune JM,Hartigan-O'Connor DJ

    更新日期:2017-11-01 00:00:00

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