abstract：:The endometrium undergoes cyclic remodelling throughout the menstrual cycle in preparation for embryo implantation which occurs in a short window during the mid-secretory phase. It is during this short 'receptive window' that the endometrial luminal epithelium acquires adhesive capacity permitting blastocysts firm adh...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Santos LL,Ling CK,Dimitriadis E

更新日期：2020-12-14 00:00:00

abstract：BACKGROUND:Considering that clinical trial studies are limited in polycystic ovary syndrome (PCOS) patients, and there is no consensus on an optimum endometrial preparation protocol for frozen embryo transfer (FET), the present study was designed as a randomized clinical trial to compare the reproductive outcomes follo...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Hosseini-Najarkolaei A,Moini A,Kashani L,Farid Mojtahedi M,Hosseini-Najarkolaee E,Salehi E

更新日期：2020-11-20 00:00:00

abstract：BACKGROUND:Previous caesarean scar pregnancy is one type of ectopic pregnancy in myometrium and fibrous tissue of previous caesarean scar. One of the therapeutic methods of this type of ectopic pregnancy is treatment with methotrexate. Given various findings on the treatment of caesarean scar pregnancy with methotrexat...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Salari N,Kazeminia M,Shohaimi S,Nankali AA,Mohammadi M

更新日期：2020-11-09 00:00:00

abstract：BACKGROUND:Despite significant advances in contraceptive options for women, vasectomy and condoms are the only options available for male contraception. Due to this limitation, the burden of contraception resides on the shoulders of females only. Therefore, there is an urgent need to develop a safe, effective and rever...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Chauhan A,Thaper D,Prabha V

更新日期：2020-09-30 00:00:00

abstract：BACKGROUND:Through this prospective study, we aimed to explore the change of molecular modification after the transient scrotal hyperthermia on human sperm. METHODS:Ten healthy subjects selected with strict screening criteria underwent testicular warming in a 43 °C water bath for 30 min a day for 10 consecutive days. ...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Wu YQ,Rao M,Hu SF,Ke DD,Zhu CH,Xia W

更新日期：2020-08-12 00:00:00

abstract：PURPOSE:To investigate the associations between blastocyst development and the sex ratio (male:female) among singleton live births resulting from single-blastocyst frozen embryo transfer (FET) cycles. METHODS:Patients with singleton live births following the first autologous single FET of non- preimplantation genetic ...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Lou H,Li N,Zhang X,Sun L,Wang X,Hao D,Cui S

更新日期：2020-07-15 00:00:00

abstract：BACKGROUND:The in vitro maturation (IVM) technique has physical and financial benefits, but a lower efficiency and outcome that is still unclear whether it is related to polycystic ovary syndrome (PCOS) itself or the IVM procedure. In this study, we analyzed the clinical and laboratory outcomes of an optimized IVM prot...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Elshewy N,Ji D,Zhang Z,Chen D,Chen B,Xue R,Wu H,Wang J,Zhou P,Cao Y

更新日期：2020-07-15 00:00:00

abstract：:A majority of common metabolic diseases can result in excessive lipolysis, leading to elevated levels of non-esterified fatty acids (NEFAs) in the body fluids. In females, increased NEFA levels in the follicular fluid markedly alter the functions of intrafollicular cells such as granulosa cells (GCs) and oocytes. Ther...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Baddela VS,Sharma A,Vanselow J

更新日期：2020-06-06 00:00:00

abstract：BACKGROUND:Gestational diabetes mellitus (GDM) is a common complication in pregnancy that poses a serious threat to the health of both mother and child. While the specific etiology and pathogenesis of this disease are not fully understood, it is thought to arise due to a combination of insulin resistance, inflammation,...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Wang H,Zhou W,She G,Yu B,Sun L

更新日期：2020-05-20 00:00:00

abstract：:The prolonged lockdown of health services providing high-complexity fertility treatments -as currently recommended by many reproductive medicine entities- is detrimental for society as a whole, and infertility patients in particular. Globally, approximately 0.3% of all infants born every year are conceived using assis...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Alviggi C,Esteves SC,Orvieto R,Conforti A,La Marca A,Fischer R,Andersen CY,Bühler K,Sunkara SK,Polyzos NP,Strina I,Carbone L,Bento FC,Galliano D,Yarali H,Vuong LN,Grynberg M,Drakopoulos P,Xavier P,Llacer J,Neuspil

更新日期：2020-05-13 00:00:00

abstract：BACKGROUND:A limited number of publications have assessed the prevalence of hypertension (HTN) in polycystic ovary syndrome (PCOS) patients with inconclusive results. Since in general populations the occurrence of hypertension is related to age per se, we investigated the prevalence (P) / relative risk (RR) of HTN in p...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Amiri M,Ramezani Tehrani F,Behboudi-Gandevani S,Bidhendi-Yarandi R,Carmina E

更新日期：2020-03-17 00:00:00

abstract：BACKGROUND:Pregnant women have high serum concentrations of sex steroid hormones, which are major regulators of paracrine and autocrine responses for many maternal and placental functions. The main purpose of this study was to compare patients with preeclampsia and patients with uncomplicated pregnancies in terms of se...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Lan KC,Lai YJ,Cheng HH,Tsai NC,Su YT,Tsai CC,Hsu TY

更新日期：2020-02-18 00:00:00

abstract：:Sexual health is strictly related with general health in both genders. In presence of a sexual dysfunction, the expert in sexual medicine aims to discover the specific weight of the physical and psychological factors can cause or con-cause the sexual problem. At the same time, a sexual dysfunction can represent a mark...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Mollaioli D,Ciocca G,Limoncin E,Di Sante S,Gravina GL,Carosa E,Lenzi A,Jannini EAF

更新日期：2020-02-17 00:00:00

abstract：BACKGROUND:In young women with poor ovarian response, luteal-phase ovarian stimulation (LPOS) is a potential method for collecting competent oocytes. The aim of this study was to assess the efficacy of LPOS compared with follicular phase ovarian stimulation (FPOS) in young women with poor ovarian response (POR). METHO...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Llácer J,Moliner B,Luque L,Bernabéu A,Lledó B,Castillo JC,Guerrero J,Ten J,Bernabéu R

更新日期：2020-02-07 00:00:00

abstract：:LINE1 retrotransposons are mobile DNA elements that copy and paste themselves into new sites in the genome. To ensure their evolutionary success, heritable new LINE-1 insertions accumulate in cells that can transmit genetic information to the next generation (i.e., germ cells and embryonic stem cells). It is our hypot...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Lou C,Goodier JL,Qiang R

更新日期：2020-01-21 00:00:00

abstract：BACKGROUND:This study was aimed at screening out the potential key genes and pathways associated with gestational diabetes mellitus (GDM). METHODS:The GSE70493 dataset used for this study was obtained from the Gene Expression Omnibus database. Differentially expressed genes (DEGs) in the placental tissue of women with...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Wang Y,Yu H,Liu F,Song X

更新日期：2019-11-29 00:00:00

abstract：BACKGROUND:The aim of this study was to explore the impact of endometrial thickness change after progesterone administration on pregnancy outcome in patients transferred with single frozen-thawed blastocyst. METHODS:This observational cohort study included a total of 3091 patients undergoing their first frozen-thawed ...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Bu Z,Yang X,Song L,Kang B,Sun Y

更新日期：2019-11-25 00:00:00

abstract：BACKGROUND:Previous studies have demonstrated that progestin-primed ovarian stimulation (PPOS) protocol was a feasible and efficient method in in vitro fertilization (IVF) cycle. However, its application in women with advanced age has not been determined yet. The purpose of this study was to investigate its efficacy in...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Peng Q,Cao X,Wang J,Wang L,Xu J,Ji X,Liu S,Zhu J,Dong X

更新日期：2019-11-09 00:00:00

abstract：BACKGROUND:Peripheral and uterine natural killer cells (pNK and uNK cells) are key players in the establishment and maintenance of pregnancy and are disturbed in patients with recurrent miscarriage (RM). Different immunologic risk factors have been proposed between patients with primary RM (pRM, no previous live birth)...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Toth B,Vomstein K,Togawa R,Böttcher B,Hudalla H,Strowitzki T,Daniel V,Kuon RJ

更新日期：2019-08-31 00:00:00

abstract：BACKGROUND:Endometriosis is an estrogen dependent, inflammatory disorder occurring in 5-10% of reproductive-aged women. Women with endometriosis have a lower body mass index (BMI) and decreased body fat compared to those without the disease, yet few studies have focused on the metabolic abnormalities in adipose tissue ...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Zolbin MM,Mamillapalli R,Nematian SE,Goetz L,Taylor HS

更新日期：2019-04-15 00:00:00

abstract：BACKGROUND:Women with Polycystic Ovary Syndrome (PCOS) present a heterogeneous reproductive and metabolic profile with an increased lifetime risk of Type 2 Diabetes (T2D). Early biomarkers of these metabolic disturbances in PCOS women have not been identified. The abundance of circulating insulin gene promotor cell-fre...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Udesen PB,Sørensen AE,Joglekar MV,Hardikar AA,Wissing MLM,Englund AM,Dalgaard LT

更新日期：2019-04-05 00:00:00

abstract：BACKGROUND:The fibrinolytic system and its inhibitors play a number of roles, apart from their function in blood haemostasis and thrombosis, namely in ovarian folliculogenesis and in ovulation. Plasminogen is converted to active plasmin at the time of follicular rupture through a decrease in plasminogen activator inhib...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Burchall GF,Pouniotis DS,Teede HJ,Ranasinha S,Walters KA,Piva TJ

更新日期：2019-03-16 00:00:00

abstract：BACKGROUND:Infertile men have higher levels of semen reactive oxygen species (ROS) than fertile men. High levels of semen ROS can cause sperm dysfunction, sperm DNA damage and reduced male reproductive potential. This study investigated the effects of supplementation with N-acetyl-cysteine (NAC) on the sperm quality, c...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Jannatifar R,Parivar K,Roodbari NH,Nasr-Esfahani MH

更新日期：2019-02-16 00:00:00

abstract：BACKGROUND:Despite being born with a significant number of primordial cells which representing the ancestor cells of the germ-line, women experience a depletion of ovarian reserve and sub-fertility mid-way into their healthy lives. The poor ovarian response is a substantial limiting factor amplified with higher materna...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Khan HL,Bhatti S,Suhail S,Gul R,Awais A,Hamayun H,Enver F,Abbas S,Hassan Z,Nisar R,Sardar S,Asif W

更新日期：2019-02-11 00:00:00

abstract：BACKGROUND:In assisted reproductive technology, prediction of treatment failure remains a great challenge. The development of more sensitive assays for measuring anti-Müllerian hormone (AMH) has allowed for the possibility to investigate if a lower threshold of AMH can be established predicting very limited or no respo...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Grynnerup AG,Løssl K,Pilsgaard F,Lunding SA,Storgaard M,Bogstad JW,Prætorius L,Zedeler A,Bungum L,Nyboe Andersen A,Pinborg A

更新日期：2019-01-11 00:00:00

abstract：BACKGROUND:There is limited literature investigating the effects of body mass index (BMI) and androgen level on in vitro fertilization (IVF) outcomes with a gonadotropin-releasing hormone (GnRH)-antagonist protocol in polycystic ovary syndrome (PCOS). Androgen-related variation in the effect of body mass index (BMI) on...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Yang W,Yang R,Lin M,Yang Y,Song X,Zhang J,Yang S,Song Y,Li J,Pang T,Deng F,Zhang H,Wang Y,Li R,Jiao J

更新日期：2018-11-19 00:00:00

abstract：BACKGROUND:Spontaneous abortion is one of the most common complications in early pregnancy. A preventive test to identify women who will experience a miscarriage, even before first symptoms occur, is not established. Activation of maternal immunological tolerance seems to be essential for early fetal development and va...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Freis A,Schlegel J,Daniel V,Jauckus J,Strowitzki T,Germeyer A

更新日期：2018-09-28 00:00:00

abstract：BACKGROUND:The injection of estradiol valerate in female rats induces polycystic ovary syndrome, which is characterized by polycystic ovaries, anovulation, and hyperandrogenism. These characteristics have been associated with an increase in the ovarian concentration of norepinephrine, which occurs before establishing t...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Espinoza JA,Alvarado W,Venegas B,Domínguez R,Morales-Ledesma L

更新日期：2018-09-07 00:00:00

abstract：BACKGROUND:The association of recombinant FSH plus recombinant LH in 2:1 ratio may be used not only to induce ovulation in anovulatory women with hypogonadotropic hypogonadism but also to achieve multiple follicular developments in human IVF. The aim of this analysis was to estimate the cost-effectiveness of Controlled...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Mennini FS,Marcellusi A,Viti R,Bini C,Carosso A,Revelli A,Benedetto C

更新日期：2018-07-18 00:00:00

abstract：BACKGROUND:To examine the effects of IVF, ICSI and FET, as well as in vitro culture, on the safety of offspring, this study was conducted from the perspective of genetic imprinting to investigate whether assisted reproductive technology would influence the parental and maternal imprinting genes. METHODS:Eighteen foetu...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Ji M,Wang X,Wu W,Guan Y,Liu J,Wang J,Liu W,Shen C

更新日期：2018-07-05 00:00:00

abstract：BACKGROUND:Pregnancy-associated plasma protein-A2 (PAPP-A2) is consistently upregulated in the placentae of pregnancies complicated by preeclampsia and fetal growth restriction. The causes and significance of this upregulation remain unknown, but it has been hypothesized that it is a compensatory response to improve pl...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Christians JK,Lennie KI,Huicochea Munoz MF,Binning N

更新日期：2018-06-12 00:00:00

abstract：BACKGROUND:Serum leptin levels are augmented in obese infertile men and in men with azoospermia. They also correlate inversely with sperm concentration, motility and normal forms. The mechanisms underlying the adverse effects of excess leptin on male reproductive function remain unclear. The present study aimed to eval...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Wang X,Zhang X,Hu L,Li H

更新日期：2018-05-31 00:00:00

abstract：BACKGROUND:Male factor infertility is quite common as 30-50% of infertility cases are due to sperm defects. The high sperm DNA fragmentation is one of the causes of male factor infertility. Many factors cause sperm DNA fragmentation and could be testicular or post-testicular. The purpose of this study was to assess rel...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Al Omrani B,Al Eisa N,Javed M,Al Ghedan M,Al Matrafi H,Al Sufyan H

更新日期：2018-05-19 00:00:00

abstract：BACKGROUND:Hatching is crucial for mammalian embryo implantation, since difficulties during this process can lead to implantation failure, ectopic pregnancy and consequent infertility. Despite years of intensive researches, how internal and external factors affecting embryo hatch are still largely unclear. METHODS:The...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Zhan S,Cao S,Du H,Sun Y,Li L,Ding C,Zheng H,Huang J

更新日期：2018-04-21 00:00:00

abstract：OBJECTIVE:To assess the effectiveness and safety of omega-3 fatty acid for patients with PCOS. METHODS:In this meta-analysis, data from randomized controlled trials were obtained to assess the effects of omega-3 fatty acid versus placebo or western medicine in women with PCOS. The study's registration number is CRD420...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Yang K,Zeng L,Bao T,Ge J

更新日期：2018-03-27 00:00:00

abstract：BACKGROUND:Endometriosis is a known cause of infertility. Differences in immune tolerance caused by regulatory T cells (Tregs) and transforming growth factor-β (TGF-β) are thought to be involved in the pathology of endometriosis. Evidence has indicated that Tregs can be separated into three functionally and phenotypica...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Hanada T,Tsuji S,Nakayama M,Wakinoue S,Kasahara K,Kimura F,Mori T,Ogasawara K,Murakami T

更新日期：2018-02-01 00:00:00

abstract：BACKGROUND:L-carnitine (LC), and its acetylated form, acetyl L-carnitine (ALC), have immense functional capabilities to regulate the oxidative and metabolic status of the female reproductive system. The vulnerability of this system to free radicals demand for advanced strategies to combat them. For this purpose, the 'q...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Agarwal A,Sengupta P,Durairajanayagam D

更新日期：2018-01-26 00:00:00

abstract：BACKGROUND:The published results regarding lymphocytes immunotherapy for unexplained recurrent miscarriage (uRM) patients are conflicting due to different screening criteria and therapeutic protocols. The objective of the present study is to evaluate the effectiveness of immunotherapy using low-dose lymphocytes in pati...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Liu M,Zhen X,Song H,Chen J,Sun X,Li X,Zhou J,Yan G,Ding L,Sun H

更新日期：2017-12-16 00:00:00

abstract：:Decidualization is an intricate biological process where extensive morphological, functional, and genetic changes take place in endometrial stromal cells to support the development of an implanting blastocyst. Deficiencies in decidualization are associated with pregnancy complications and reproductive diseases. Decidu...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Ni N,Li Q

更新日期：2017-10-13 00:00:00

abstract：BACKGROUND:Morphometric and morphokinetic evaluation of in vitro cultured human embryos allows evaluation without time restriction and reduces intra- and inter-observer variability. Even though these technologies have been reported to improve the quality of cleavage stage embryo evaluation during fresh culture, possibl...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Fernandez Gallardo E,Spiessens C,D'Hooghe T,Debrock S

更新日期：2017-10-03 00:00:00