abstract：BACKGROUND:Abnormal glutamate and GABA (gamma-aminobutyric acid) levels have been found in the early phase of schizophrenia and may underlie cognitive deficits. However, the association between cognitive function and levels of glutamatergic metabolites and GABA has not been investigated in a large group of antipsychoti...

journal_title：Biological psychiatry

authors： Bojesen KB,Broberg BV,Fagerlund B,Jessen K,Thomas MB,Sigvard A,Tangmose K,Nielsen MØ,Andersen GS,Larsson HBW,Edden RAE,Rostrup E,Glenthøj BY

更新日期：2021-02-01 00:00:00

abstract：BACKGROUND:Schizophrenia (SCZ) is a neurodevelopmental disorder with a progressive, prolonged course. Early prevention for SCZ is promising but overall lacks support from preclinical evidence. Previous studies have tested environmental enrichment (EE) in certain models of SCZ and discovered a broadly beneficial effect ...

journal_title：Biological psychiatry

authors： Zhu X,Grace AA

更新日期：2021-02-01 00:00:00

abstract：:There is no definitive neural marker of suicidal thoughts and behaviors (STBs) or nonsuicidal self-injury (NSSI), and relative to adults, research in youth is more limited. This comprehensive review focuses on magnetic resonance imaging studies reporting structural and functional neural correlates of STBs and NSSI in ...

journal_title：Biological psychiatry

authors： Auerbach RP,Pagliaccio D,Allison GO,Alqueza KL,Alonso MF

更新日期：2021-01-15 00:00:00

abstract：BACKGROUND:The development of adaptive implicit and explicit emotion regulation skills is crucial for mental health. Adolescence and emerging adulthood are periods of heightened risk for psychopathology associated with emotion dysregulation, and neurodevelopmental mechanisms have been proposed to account for this incre...

journal_title：Biological psychiatry

authors： Pozzi E,Vijayakumar N,Rakesh D,Whittle S

更新日期：2021-01-15 00:00:00

abstract：:The neuroimaging community has witnessed a paradigm shift in biomarker discovery from using traditional univariate brain mapping approaches to multivariate predictive models, allowing the field to move toward a translational neuroscience era. Regression-based multivariate models (hereafter "predictive modeling") provi...

journal_title：Biological psychiatry

authors： Sui J,Jiang R,Bustillo J,Calhoun V

更新日期：2020-12-01 00:00:00

abstract：BACKGROUND:Positron emission tomography studies have demonstrated less dopamine D2/3 receptor availability and blunted psychostimulant-induced dopamine release in cocaine-dependent subjects (CDSs). No studies in CDSs have reported the in vivo status of D2/3 and dopamine release in the cortex. Basic and functional imagi...

journal_title：Biological psychiatry

authors： Narendran R,Mason NS,Himes ML,Frankle WG

更新日期：2020-11-15 00:00:00

abstract：BACKGROUND:Recent research suggests that immune dysregulation in pregnancy could be a risk factor for anxiety and depression symptoms in offspring. Whereas animal studies have demonstrated the importance of the link between perinatal cytokines and abnormal behaviors in offspring, human epidemiological studies in this a...

journal_title：Biological psychiatry

authors： Galera C,Barbosa S,Collet O,Khalfallah O,Aouizerate B,Sutter-Dalley AL,Koehl M,Capuron L,Van der Waerden J,Melchior M,Côté S,Heude B,Glaichenhaus N,Davidovic L,EDEN Mother–Child Cohort Study Group.

更新日期：2020-10-24 00:00:00

abstract：BACKGROUND:Immune signaling pathways influence neurodevelopment and are hypothesized to contribute to the etiology of autism spectrum disorder (ASD). We aimed to assess risk of ASD in relation to levels of neonatal acute phase proteins (APPs), key components of innate immune function, measured in neonatal dried blood s...

journal_title：Biological psychiatry

authors： Gardner RM,Lee BK,Brynge M,Sjöqvist H,Dalman C,Karlsson H

更新日期：2020-09-10 00:00:00

abstract：:The categorical approach to defining schizophrenia spectrum disorders requires meeting established criteria. To advance early identification and intervention in young people, the field has progressed to studying help-seeking individuals who are at clinical high risk based on subthreshold psychosis spectrum symptoms, a...

journal_title：Biological psychiatry

authors： Taylor JH,Calkins ME,Gur RE

更新日期：2020-08-15 00:00:00

abstract：:The aberrant salience hypothesis proposes that striatal dopamine dysregulation causes misattribution of salience to irrelevant stimuli leading to psychosis. Recently, new lines of preclinical evidence on information coding by subcortical dopamine coupled with computational models of the brain's ability to predict and ...

journal_title：Biological psychiatry

authors： Howes OD,Hird EJ,Adams RA,Corlett PR,McGuire P

更新日期：2020-08-15 00:00:00

abstract：BACKGROUND:Pediatric anxiety disorders involve greater capture of attention by threatening stimuli. However, it is not known if disturbances extend to nonthreatening stimuli, as part of a pervasive disturbance in attention-related brain systems. We hypothesized that pediatric anxiety involves greater capture of attenti...

journal_title：Biological psychiatry

authors： Perino MT,Yu Q,Myers MJ,Harper JC,Baumel WT,Petersen SE,Barch DM,Luby JL,Sylvester CM

更新日期：2020-08-01 00:00:00

abstract：BACKGROUND:22q11.2 deletions and duplications are copy number variations (CNVs) that predispose to developmental neuropsychiatric disorders. Both CNVs are associated with autism spectrum disorder (ASD), while the deletion confers disproportionate risk for schizophrenia. Neurobehavioral profiles associated with these re...

journal_title：Biological psychiatry

authors： Lin A,Vajdi A,Kushan-Wells L,Helleman G,Hansen LP,Jonas RK,Jalbrzikowski M,Kingsbury L,Raznahan A,Bearden CE

更新日期：2020-08-01 00:00:00

abstract：BACKGROUND:Increased physical activity is a common feature of anorexia nervosa (AN). Although high activity levels are associated with greater risk of developing AN, particularly when combined with dieting, most individuals who diet and exercise maintain a healthy body weight. It is unclear why some individuals develop...

journal_title：Biological psychiatry

authors： Beeler JA,Mourra D,Zanca RM,Kalmbach A,Gellman C,Klein BY,Ravenelle R,Serrano P,Moore H,Rayport S,Mingote S,Burghardt NS

更新日期：2020-07-16 00:00:00

abstract：:Psychiatric disorders show high rates of comorbidity and nonspecificity of presenting clinical symptoms, while demonstrating substantial heterogeneity within diagnostic categories. Notably, many of these psychiatric disorders first manifest in youth. We review progress and next steps in efforts to parse heterogeneity ...

journal_title：Biological psychiatry

authors： Kaczkurkin AN,Moore TM,Sotiras A,Xia CH,Shinohara RT,Satterthwaite TD

更新日期：2020-07-01 00:00:00

abstract：BACKGROUND:Obsessive-compulsive disorder (OCD) is a debilitating neuropsychiatric disorder with a genetic risk component, yet identification of high-confidence risk genes has been challenging. In recent years, risk gene discovery in other complex psychiatric disorders has been achieved by studying rare de novo (DN) cod...

journal_title：Biological psychiatry

authors： Cappi C,Oliphant ME,Péter Z,Zai G,Conceição do Rosário M,Sullivan CAW,Gupta AR,Hoffman EJ,Virdee M,Olfson E,Abdallah SB,Willsey AJ,Shavitt RG,Miguel EC,Kennedy JL,Richter MA,Fernandez TV

更新日期：2020-06-15 00:00:00

abstract：BACKGROUND:Twin studies show that age-related change in symptoms of attention-deficit/hyperactivity disorder (ADHD) is heritable. However, we do not know the heritability of the development of the neural substrates underlying the disorder. Here, we estimated the heritability of developmental change in white matter trac...

journal_title：Biological psychiatry

authors： Sudre G,Bouyssi-Kobar M,Norman L,Sharp W,Choudhury S,Shaw P

更新日期：2020-06-13 00:00:00

abstract：BACKGROUND:Genetic studies of schizophrenia have implicated numerous risk loci including several copy number variants (CNVs) of large effect and hundreds of loci of small effect. In only a few cases has a specific gene been clearly identified. Rare CNVs affecting a single gene offer a potential avenue to discovering sc...

journal_title：Biological psychiatry

authors： Szatkiewicz JP,Fromer M,Nonneman RJ,Ancalade N,Johnson JS,Stahl EA,Rees E,Bergen SE,Hultman CM,Kirov G,O'Donovan M,Owen M,Holmans P,Sklar P,Sullivan PF,Purcell SM,Crowley JJ,Ruderfer DM

更新日期：2020-04-15 00:00:00

abstract：BACKGROUND:Schizophrenia risk is associated with both genetic and environmental risk factors. Furthermore, cognitive abnormalities are established core characteristics of schizophrenia. We aim to assess whether a classification approach encompassing risk factors, cognition, and their associations can discriminate patie...

journal_title：Biological psychiatry

authors： Antonucci LA,Pergola G,Pigoni A,Dwyer D,Kambeitz-Ilankovic L,Penzel N,Romano R,Gelao B,Torretta S,Rampino A,Trojano M,Caforio G,Falkai P,Blasi G,Koutsouleris N,Bertolino A

更新日期：2020-04-15 00:00:00

abstract：BACKGROUND:Major prevention trials for Alzheimer's disease (AD) are now focusing on multidomain lifestyle interventions. However, the exact combination of behavioral factors related to AD pathology remains unclear. In 2 cohorts of cognitively unimpaired individuals at risk of AD, we examined which combinations of perso...

journal_title：Biological psychiatry

authors： Pichet Binette A,Vachon-Presseau É,Morris J,Bateman R,Benzinger T,Collins DL,Poirier J,Breitner JCS,Villeneuve S,Dominantly Inherited Alzheimer Network (DIAN).,PREVENT-AD Research Group.

更新日期：2020-02-06 00:00:00

abstract：BACKGROUND:The study of Turner syndrome (TS) offers a unique window of opportunity for advancing scientific knowledge of how X chromosome gene imprinting, epigenetic factors, hormonal milieu, and chronologic age affect brain development in females. METHODS:We described brain growth trajectories in 55 girls with TS and...

journal_title：Biological psychiatry

authors： O'Donoghue S,Green T,Ross JL,Hallmayer J,Lin X,Jo B,Huffman LC,Hong DS,Reiss AL

更新日期：2020-01-15 00:00:00

abstract：BACKGROUND:Impaired neuromotor development is often one of the earliest observations in children with autism spectrum disorder (ASD). We investigated whether a genetic predisposition to developmental disorders was associated with nonoptimal neuromotor development during infancy and examined the genetic correlation betw...

journal_title：Biological psychiatry

authors： Serdarevic F,Tiemeier H,Jansen PR,Alemany S,Xerxa Y,Neumann A,Robinson E,Hillegers MHJ,Verhulst FC,Ghassabian A

更新日期：2020-01-15 00:00:00

abstract：:Since the isolation of morphine from the opium poppy over 200 years ago, the molecular basis of opioid action has remained the subject of intense inquiry. The identification of specific receptors responsible for opioid function and the discovery of many chemically diverse molecules with unique opioid-like efficacies h...

journal_title：Biological psychiatry

authors： Manglik A

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Despite the twofold higher prevalence of major depressive and posttraumatic stress disorders in women compared with men, most clinical and preclinical studies have focused on male subjects. We used an ethological murine model to study several cardinal symptoms of affective disorders in the female targets of ...

journal_title：Biological psychiatry

authors： Newman EL,Covington HE 3rd,Suh J,Bicakci MB,Ressler KJ,DeBold JF,Miczek KA

更新日期：2019-11-01 00:00:00

abstract：BACKGROUND:Many polymorphisms in dopamine genes are reported to affect cognitive, imaging, or clinical phenotypes. It is often inferred or assumed that such associations are causal, mediated by a direct effect of the polymorphism on the gene product itself. However, the supporting evidence is not always clear. METHODS...

journal_title：Biological psychiatry

authors： Tunbridge EM,Narajos M,Harrison CH,Beresford C,Cipriani A,Harrison PJ

更新日期：2019-10-15 00:00:00

abstract：:Schizophrenia is a debilitating mental illness that affects approximately 1% of the world's population. Despite much research in its neurobiology to aid in developing new treatments, little progress has been made. One system that has not received adequate attention is the kappa opioid system and its potential role in ...

journal_title：Biological psychiatry

authors： Clark SD,Abi-Dargham A

更新日期：2019-10-01 00:00:00

abstract：:The human brain comprises a multiscale network with multiple levels of organization. Neurons with dendritic and axonal connections form the microscale fabric of brain circuitry, and macroscale brain regions and white matter connections form the infrastructure for system-level brain communication and information integr...

journal_title：Biological psychiatry

authors： van den Heuvel MP,Scholtens LH,Kahn RS

更新日期：2019-10-01 00:00:00

abstract：BACKGROUND:Deletions encompassing a four-gene region on chromosome 15 (BP1-BP2 at 15q11.2), seen at a population frequency of 1 in 500, are associated with increased risk for schizophrenia, epilepsy, and other common neurodevelopmental disorders. However, little is known in terms of how these common deletions impact co...

journal_title：Biological psychiatry

authors： Woo YJ,Kanellopoulos AK,Hemati P,Kirschen J,Nebel RA,Wang T,Bagni C,Abrahams BS

更新日期：2019-08-15 00:00:00

abstract：BACKGROUND:Autism spectrum disorder and attention-deficit/hyperactivity disorder (ADHD) are associated with complex changes as revealed by functional magnetic resonance imaging. To date, neuroimaging-based models are not able to characterize individuals with sufficient sensitivity and specificity. Further, although evi...

journal_title：Biological psychiatry

authors： Lake EMR,Finn ES,Noble SM,Vanderwal T,Shen X,Rosenberg MD,Spann MN,Chun MM,Scheinost D,Constable RT

更新日期：2019-08-15 00:00:00

abstract：BACKGROUND:A method that promotes the retrieval of lost long-term memories has not been well established. Histamine in the central nervous system is implicated in learning and memory, and treatment with antihistamines impairs learning and memory. Because histamine H3 receptor inverse agonists upregulate histamine relea...

journal_title：Biological psychiatry

authors： Nomura H,Mizuta H,Norimoto H,Masuda F,Miura Y,Kubo A,Kojima H,Ashizuka A,Matsukawa N,Baraki Z,Hitora-Imamura N,Nakayama D,Ishikawa T,Okada M,Orita K,Saito R,Yamauchi N,Sano Y,Kusuhara H,Minami M,Takahashi H,Ikeg

更新日期：2019-08-01 00:00:00

abstract：BACKGROUND:The basolateral amygdala (BLA) has been widely implicated in the pathophysiology of major depressive disorder. A-kinase anchoring protein 150 (AKAP150) directs kinases and phosphatases to synaptic glutamate receptors, controlling synaptic transmission and plasticity. However, the role of the AKAP150 in the B...

journal_title：Biological psychiatry

authors： Zhou HY,He JG,Hu ZL,Xue SG,Xu JF,Cui QQ,Gao SQ,Zhou B,Wu PF,Long LH,Wang F,Chen JG

更新日期：2019-07-15 00:00:00

abstract：BACKGROUND:Whether paternal age effect on schizophrenia is a causation or just an association due to confounding by selection into late parenthood is still debated. We investigated the association between paternal age and early onset of schizophrenia in offspring, controlling for both paternal and maternal predispositi...

journal_title：Biological psychiatry

authors： Wang SH,Hsiao PC,Yeh LL,Liu CM,Liu CC,Hwang TJ,Hsieh MH,Chien YL,Lin YT,Huang YT,Chen CY,Chandler SD,Faraone SV,Neale B,Glatt SJ,Tsuang MT,Hwu HG,Chen WJ

更新日期：2019-07-01 00:00:00

abstract：BACKGROUND:Psychotic-like experiences (PLEs) during childhood are associated with greater risk of developing a psychotic disorder (and other mental disorders), highlighting the importance of identifying neural correlates of childhood PLEs. Three major cortical networks-the cingulo-opercular network (CON), default mode ...

journal_title：Biological psychiatry

authors： Karcher NR,O'Brien KJ,Kandala S,Barch DM

更新日期：2019-07-01 00:00:00

abstract：BACKGROUND:The endocannabinoid and neurosteroid systems regulate emotions and stress responses. Activation of peroxisome proliferator-activated receptor (PPAR)-α by the endocannabinoid congener N-palmitoylethanolamine (PEA) regulates pathophysiological systems (e.g., inflammation, oxidative stress) and induces peripher...

journal_title：Biological psychiatry

authors： Locci A,Pinna G

更新日期：2019-06-15 00:00:00

abstract：:There has been an explosion of research on fear extinction in humans in the past 2 decades. This has not only generated major insights, but also brought a new goal into focus: how to maintain extinction memory over time (i.e., extinction retention). We argue that there are still important conceptual and procedural cha...

journal_title：Biological psychiatry

authors： Lonsdorf TB,Merz CJ,Fullana MA

更新日期：2019-06-15 00:00:00

abstract：BACKGROUND:Binge eating and other forms of disordered eating behavior (DEB) are associated with failed inhibitory control. This study investigated the neural correlates of failed inhibitory control as a potential biomarker for DEB. METHODS:The study used prospective longitudinal data from the European IMAGEN study ado...

journal_title：Biological psychiatry

authors： Bartholdy S,O'Daly OG,Campbell IC,Banaschewski T,Barker G,Bokde ALW,Bromberg U,Büchel C,Quinlan EB,Desrivières S,Flor H,Frouin V,Garavan H,Gowland P,Heinz A,Ittermann B,Martinot JL,Paillère Martinot ML,Nees F,Orfano

更新日期：2019-06-01 00:00:00

abstract：BACKGROUND:The neuropeptide oxytocin (OXT) mediates its actions, including anxiolysis, via its G protein-coupled OXT receptor. Within the paraventricular nucleus of the hypothalamus (PVN), OXT-induced anxiolysis is mediated, at least in part, via activation of the mitogen-activated protein kinase pathway following calc...

journal_title：Biological psychiatry

authors： Martinetz S,Meinung CP,Jurek B,von Schack D,van den Burg EH,Slattery DA,Neumann ID

更新日期：2019-05-15 00:00:00

abstract：BACKGROUND:Evidence links infections to mental disorders and suicidal behavior. However, knowledge is sparse regarding less severe infections, anti-infective treatment, and deliberate self-harm. Using nationwide Danish longitudinal registers, we estimated associations between infections treated with anti-infective agen...

journal_title：Biological psychiatry

authors： Gjervig Hansen H,Köhler-Forsberg O,Petersen L,Nordentoft M,Postolache TT,Erlangsen A,Benros ME

更新日期：2019-05-01 00:00:00

abstract：BACKGROUND:A parallel downregulation of brain-derived neurotrophic factor (BDNF) and somatostatin (SST), a marker of inhibitory gamma-aminobutyric acid interneurons that target pyramidal cell dendrites, has been reported in several brain areas of subjects with major depressive disorder (MDD). Rodent genetic studies sug...

journal_title：Biological psychiatry

authors： Oh H,Piantadosi SC,Rocco BR,Lewis DA,Watkins SC,Sibille E

更新日期：2019-03-15 00:00:00

abstract：BACKGROUND:Cerebral myeloarchitecture shows substantial development across childhood and adolescence, and aberrations in these trajectories are relevant for a range of mental disorders. Differential myelination between intracortical and subjacent white matter can be approximated using signal intensities in T1-weighted ...

journal_title：Biological psychiatry

authors： Norbom LB,Doan NT,Alnæs D,Kaufmann T,Moberget T,Rokicki J,Andreassen OA,Westlye LT,Tamnes CK

更新日期：2019-03-01 00:00:00

abstract：BACKGROUND:The ability to stop a suboptimal response is integral to decision making and is commonly impaired across psychiatric disorders. Cortical paired associative stimulation (cPAS) is a form of transcranial magnetic stimulation in which paired pulses can induce plasticity at cortical synapses. Here we used cPAS pr...

journal_title：Biological psychiatry

authors： Kohl S,Hannah R,Rocchi L,Nord CL,Rothwell J,Voon V

更新日期：2019-02-15 00:00:00