abstract：BACKGROUND:Inclusion of anticancer drugs into biocompatible nanoparticulate carriers decreases the general toxicity and improves the efficacy of clinical treatments due to the reduction of soluble circulating free drug. METHODS:In addition, removal of emerging drug contaminants from wastewaters is a necessity that sho...

journal_title：Current molecular medicine

authors： Fu M,Tayebee R,Saberi S,Nourbakhsh N,Esmaeili E,Maleki B,Vatanpour HR

更新日期：2021-01-10 00:00:00

abstract：:Tumor-derived exosomes contain biological contents such as proteins, lipids, RNA (miRNAs, mRNAs, lncRNA), and DNA for intracellular communication. Meanwhile, studies have shown the role of exosomes in cancer progression, metastasis, and therapeutic resistance. Furthermore, tumor exosomes have received growing attentio...

journal_title：Current molecular medicine

authors： Nooshabadi VT,Arab S

更新日期：2020-11-20 00:00:00

abstract：:Chondroitin sulfate (CS)-glycosaminoglycans (GAGs) are linear, negatively charged polysaccharides attached to CS proteoglycans that make up a major component of biological matrices throughout both central and peripheral tissues. The position of their attached sulfate groups to the CS disaccharide is predicted to influ...

journal_title：Current molecular medicine

authors： Alonge K,Harkewicz R,Guttman M

更新日期：2020-09-15 00:00:00

abstract：:Cancer is one of the most important disorders which is associated with high mortality and high costs of treatment for patients. Despite several efforts, finding, designing and developing, new therapeutic platforms in treatment of cancer patients are still required. Utilization of microorganisms particularly bacteria h...

journal_title：Current molecular medicine

authors： Fathizadeh H,Saffari M,Esmaeili D,Moniri R,Kafil HS

更新日期：2020-08-17 00:00:00

abstract：:The prevalence of insulin resistance and diabetes mellitus is rising globally in epidemic proportions. Diabetes and its complications contribute to significant morbidity and mortality. Increase in sedentary lifestyle and consumption of more energy-dense diet increased the incidence of obesity which is a significant ri...

journal_title：Current molecular medicine

authors： Yaribeygi H,Maleki M,Sathyapalan T,Jamialahmadi T,Sahebkar A

更新日期：2020-08-12 00:00:00

abstract：BACKGROUND:Plasmid DNA has been widely used in vaccination as well as in cell and gene therapy. It exists in multiple isoforms, including supercoiled, nicked or open circular and linear forms. Regulatory agencies recommend having more than 80% of the supercoiled isoform for the bulk release of plasmid products; thus, i...

journal_title：Current molecular medicine

authors： Cook KS,Luo J,Guttman A,Thompson L

更新日期：2020-04-27 00:00:00

abstract：:Pluripotent stem cells (PSCs) are powerful tools for studying developmental biology and neuronal diseases. Conventional differentiation protocols require several intermediate states and different culture conditions, inefficiently generating mixed subtypes of neuronal cells with immature characteristics. Direct program...

journal_title：Current molecular medicine

authors： Gu J,Cromer B,Sumer H

更新日期：2020-04-21 00:00:00

abstract：PURPOSE:A small molecular compound, aminooxy-acetic acid (AOA), has been shown to modulate experimental autoimmune encephalomyelitis (EAE). The current study was designed to investigate whether AOA has a similar effect on the development of experimental autoimmune uveitis (EAU) and to further explore underlying mechani...

journal_title：Current molecular medicine

authors： Mei S,Huang Y,Li N,Xu Z,Xu J,Dai Q,Wu J,Kijlstra A,Yang P,Hou S

更新日期：2020-01-01 00:00:00

abstract：OBJECTIVE:The study aimed to evaluate the preventive effects of hydroxycitric acid（HCA） for stone formation in the glyoxylate-induced mouse model. MATERIALS AND METHODS:Male C57BL/6J mice were divided into a control group, glyoxylate(GOX) 100 mg/kg group, a GOX+HCA 100 mg/kg group, and a GOX+HCA 200 mg/kg group. Blood...

journal_title：Current molecular medicine

authors： Liu X,Yuan P,Sun X,Chen Z

更新日期：2020-01-01 00:00:00

abstract：:Cholesterol is a chameleon bio-molecule in cellular multiplex. It acts as a prelate in almost every cellular compartment with its site specific characteristics viz. regulation of structural veracity and scaffold fluidity of bio-membranes, insulation of electrical transmission in nerves, controlling of genes by making ...

journal_title：Current molecular medicine

authors： Saxena N,Chandra NC

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Persistent hyperlactatemia is associated with greater mortality in shock. Liver is the main site of lactate metabolism. METHOD:In the first part, freshly isolated hepatocytes were incubated in 10% fetal bovine serum William's E medium supplemented with 10 mM lactate. Cells were then exposed to 100 μM ursode...

journal_title：Current molecular medicine

authors： Wang L,He HW,Zhou X,Long Y

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Lauric acid (LA) has antimicrobial effects and the potential to replace antibiotics in feeds to prevent postweaning diarrhea and increase overall swine productivity. The effects of lauric acid on the intestinal epithelial cells remain unclear. METHODS AND RESULTS:This study investigates the effects of LA on...

journal_title：Current molecular medicine

authors： Yang Y,Huang J,Li J,Yang H,Yin Y

更新日期：2020-01-01 00:00:00

abstract：OBJECTIVE:This study aims to investigate the effect of morphine with naloxone on intestinal peristalsis and the number of interstitial cells of Cajal (ICC) in colon tissues of rabbits. METHODS:Thirty rabbits were randomly divided into five groups (n=6, each group): saline control group (NS group), low concentration of...

journal_title：Current molecular medicine

authors： Yang H,Jin XJ,Luo H,Li YH

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Colorectal cancer (CRC) is the third most common cancer worldwide and the third leading cause of cancer-related death. It is a heterogeneous disease that develops through different genetic and epigenetic mechanisms. To date, no comprehensive systematic review investigating genetic risk factors for familial a...

journal_title：Current molecular medicine

authors： Sidenna M,Bux R,Fadl T,Ozbek U,Zayed H

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:In this study, the antioxidant property of new synthesized azomethins has been investigated as theoretical and experimental. METHODS AND RESULTS:Density functional theory (DFT) was employed to investigate the Bond Dissociation Enthalpy (BDE), Mulliken Charges, NBO analysis, Ionization Potential (IP), Electr...

journal_title：Current molecular medicine

authors： Shahab S,Sheikhi M,Filippovich L,Dikusar E,Pazniak A,Rouhani M,Kumar R

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Liver kinase B1 (LKB1)/5'-adenosine monophosphate-activated protein kinase (AMPK) signaling, a metabolic checkpoint, plays a neuro-protective role in the pathogenesis of Alzheimer's disease (AD). Amyloid-β (Aβ) acts as a classical biomarker of AD. The aim of the present study was to explore whether berberine...

journal_title：Current molecular medicine

authors： Cai ZY,Wang CL,Lu TT,Yang WM

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Osteoporosis is a systemic skeletal disease characterized by low bone mineral density. Vitamin D metabolism may play a pivotal role in its pathophysiology. OBJECTIVES:To determine the association between Vitamin D receptor gene polymorphisms and bone density, as well as its relation to biochemical markers o...

journal_title：Current molecular medicine

authors： Taha IM,Allah AMA,El Tarhouny S

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:In vertebrates, cilium is crucial for Hedgehog signaling transduction. Forkhead box transcriptional factor FoxF1 is reported to be associated with Sonic Hedgehog (Shh) signaling in many cases. However, the role of FoxF1 in cilium remains unknown. Here, we showed an essential role of FoxF1 in the regulation o...

journal_title：Current molecular medicine

authors： Huang L,Tjakra M,Luo D,Wen L,Lei D,Wang J,Yin T,Zhang X,Huang J,Wang Y,Wang G

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Interleukins IL1ß/IL18 and Inflammasome NLRP1/NLRP3 polymorphisms can change the course of multiple human diseases, both inflammatory as infectious. SNPs these proteins were associated with the constructive activation of the Inflammasome and excessive production of IL-1β induce a serious autoinflammatory dis...

journal_title：Current molecular medicine

authors： de Almeida E,Frantz SR,Cesar P,Tarragô AM,de Amorim Xabregas L,Garcia NP,Costa AG,de Paula EV,Malheiro A

更新日期：2019-01-01 00:00:00

abstract：PURPOSE:Retinal ganglion cells (RGCs) apoptosis is a common characteristic of optic neuropathies. p53-induced protein with a death domain (PIDD) is a well-known regulator of genotoxic stress-induced apoptosis, which is constitutively cleaved into three main fragments: PIDD-N, PIDD-C and PIDD-CC. Thus, we aim to determi...

journal_title：Current molecular medicine

authors： Zhang M,Chen L,Xu F,Jiang L,Yan W,Kunwar B,Tang F,Yang K,Shen C,Huang H,Lv J,Qin C,Wu X,Zeng S,Li M,Zhong S,Chen Q

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Obesity is a chronic condition associated with poorer cognitive functioning. Wisconsin Card Sorting Test (WCST) is a useful tool for evaluating executive functions. In this study, we assessed the association between dopaminergic gene polymorphisms: DAT1 (SLC6A3), COMTVal158Met, DRD4 (48-bp variable number of...

journal_title：Current molecular medicine

authors： Bieliński M,Lesiewska N,Junik R,Kamińska A,Tretyn A,Borkowska A

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Oxidative stress and chronic hyperglycemia are two major side effects of type 2 diabetes affecting all cell types including mesenchymal stem cells (MSCs). As a cell therapy choice, understanding the behavior of MSCs will provide crucial information for efficient treatment. METHODS:Placental mesenchymal stem...

journal_title：Current molecular medicine

authors： Roohi A,Nikougoftar M,Montazeri H,Navabi S,Shokri F,Ostad SN,Ghahremani MH

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Photoreceptor cell death is a key pathology of retinal degeneration diseases. To date, the molecular mechanisms for this pathological process remain largely unclear. Junctional adhesion molecule-c (Jam-c) has been shown to play important roles in different biological events. However, its effect on retinal ne...

journal_title：Current molecular medicine

authors： Li Y,Zhang F,Lu W,Li X

更新日期：2018-03-09 00:00:00

abstract：BACKGROUND & OBJECTIVE:Interleukin 37 (IL-37) is an important regulator of the anti-inflammatory T-cell response. In this study, we investigated its expression and function in peripheral blood mononuclear cells (PBMCs) of patients with HLA-B27 associated acute anterior uveitis (AAU) and idiopathic AAU. METHODS:15 pati...

journal_title：Current molecular medicine

authors： Zhao B,Zhang S,Chen W,Zhang R,Jiang R,Zhang R,Chen L

更新日期：2018-03-09 00:00:00

abstract：BACKGROUND:The phenotypic severity of β-thalassemia is highly modulated by three genetic modifiers: β-globin (HBB) mutations, co-inheritance of α-thalassemia and polymorphisms in the genes associated with fetal haemoglobin (HbF) production. This study was aimed to evaluate the effect of HbF related polymorphisms mainly...

journal_title：Current molecular medicine

authors： Razak SAA,Murad NAA,Masra F,Chong DLS,Abdullah N,Jalil N,Alauddin H,Sabudin RZAR,Ithnin A,Khai LC,Aziz NA,Muda Z,Ibrahim H,Latiff ZA

更新日期：2018-01-01 00:00:00

abstract：PURPOSE:Protein sumoylation is a well established regulatory mechanism to control many cellular processes such as chromatin structure dynamics, transcriptional regulation of gene expression, cell proliferation and differentiation, cell transformation and carcinogenesis, autophagy and senescence. In the vertebrate visio...

journal_title：Current molecular medicine

authors： Nie Q,Xie J,Gong X,Luo Z,Wang L,Liu F,Xiang JW,Xiao Y,Fu JL,Liu Y,Chen Z,Yang L,Chen H,Gan Y,Li DW

更新日期：2018-01-01 00:00:00

abstract：:Multiple myeloma (MM) is characterized by the clonal proliferation of malignant plasma B-lymphocytes and even as of today, it is an incurable disease. MM accounts for approximately 10% of all hematologic cancers. Its molecular pathogenesis is poorly understood, but the bone marrow microenvironment of tumor cells and g...

journal_title：Current molecular medicine

authors： Kovacs Z,Guttman A

更新日期：2018-01-01 00:00:00

abstract：PURPOSE:Accumulated evidence have well established that protein sumoylation plays multiple roles in various cellular processes. In the vertebrate eye, we and others have demonstrated that sumoylation displays indispensable roles in regulating eye development. Various ocular cell lines including human embryonic cell lin...

journal_title：Current molecular medicine

authors： Liu Y,Zhang L,Tang X,Liu F,Fu JL,Gong XD,Wang L,Nie Q,Xiang JW,Xiao Y,Liu Y,Li DW

更新日期：2018-01-01 00:00:00

abstract：:The world is aging and we must face the challenges that this brings. One of the reasons for the increasing aging of the world's population is the increase in life expectancy and, since we live longer, it is of paramount importance to live well and to prevent age-associated diseases. In this way, it is crucial to impro...

journal_title：Current molecular medicine

authors： Magalhaes S,Goodfellow BJ,Nunes A

更新日期：2018-01-01 00:00:00

abstract：:Visfatin is one of the prominent adipokines secreted by adipose tissue. The level of visfatin increases significantly in persons with obesity owing to increased body mass index (BMI). During obesity, the adipocytes, which populate adipose tissue, undergo hypertrophy and hyperplasia and secrete a number of adipocytokin...

journal_title：Current molecular medicine

authors： Kumari B,Yadav UCS

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Dynamic epigenetic alterations accompanying CD4+ T helper cell differentiation have been implicated in multiple autoimmune diseases. The bromodomain and extra-terminal (BET) proteins are epigenetic regulators that recognize and bind to acetylated histones in chromatin and are targets for pharmacological inhi...

journal_title：Current molecular medicine

authors： Hu X,Schewitz-Bowers LP,Lait PJP,Copland DA,Stimpson ML,Li JJ,Liu Y,Dick AD,Lee RWJ,Wei L

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Overexpression of MDA-9/Syntenin occurs in multiple human cancer cell lines and is associated with higher grade of tumor classification, invasiveness and metastasis. In some cases, its role in cancer biology depends on relationships between MDA-9/Syntenin and NF-κB. OBJECTIVE:This study aims to analyze the ...

journal_title：Current molecular medicine

authors： Notarbartolo M,Labbozzetta M,Pojero F,D'Alessandro N,Poma P

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Macrophages undergo polarization or activation in response to environmental stimuli, an essential process for proper immune response. Meanwhile, excessive activation of macrophages causes autoimmune diseases. It is therefore crucial to prevent over-activation of macrophage in order to maintain the proper imm...

journal_title：Current molecular medicine

authors： Zou Y,Chen Q,Ye Z,Li X,Ju R

更新日期：2017-12-07 00:00:00

abstract：BACKGROUND:Four-and-a-half LIM domains protein 1 (FHL1) mutations are associated with human myopathies. However, the function of this protein in skeletal development remains unclear. METHODS:Whole-mount in situ hybridization and embryo immunostaining were performed. RESULTS:Zebrafish Fhl1A is the homologue of human F...

journal_title：Current molecular medicine

authors： Chen F,Yuan W,Mo X,Zhuang J,Wang Y,Chen J,Jiang Z,Zhu X,Zeng Q,Wan Y,Li F,Shi Y,Cao L,Fan X,Luo S,Ye X,Chen Y,Dai G,Gao J,Wang X,Xie H,Zhu P,Li Y,Wu X

更新日期：2017-01-01 00:00:00

abstract：PURPOSE:Ubiquitin is involved in cell proliferation and differentiation, and the objective of this study is to investigate the potential of dominant negative Ubiquitin (Ub) with a lysine to tryptophan mutation at the 6 position (K6W) through an adenoviral expression vector in the prevention of posterior capsule opacifi...

journal_title：Current molecular medicine

authors： Bao X,Hou M,Peng R,Luo F,Wu M

更新日期：2017-01-01 00:00:00

abstract：:Prostate cancer is one of the most difficult cancers to treat especially when it becomes hormone resistant such as castrate resistant prostate cancer (CRPC) and subsequent metastatic CRPC. Apart from the genetic alterations in prostate cancer, epigenetic modifications also play an important role in the development and...

journal_title：Current molecular medicine

authors： Giudice A,Montella M,Boccellino M,Crispo A,D'Arena G,Bimonte S,Facchini G,Ciliberto G,Botti G,Quagliuolo L,Caraglia M,Capunzo M

更新日期：2017-01-01 00:00:00

abstract：:The currently available knowledge of factors that dictate the development and progression as well as the clinical outcome of colorectal cancers (CRC) is mainly derived from Western countries. Considerable number of publications document different incidence rates and contrasting clinical features of CRC in various grou...

journal_title：Current molecular medicine

authors： Abdel-Rahman WM,Faris ME,Peltomaki P

更新日期：2017-01-01 00:00:00

abstract：:Carcinoma-associated fibroblasts (CAFs) are activated fibroblasts during development of several cancer types, and therefore emerge as an attractive therapeutic target for cancer therapy. Drugs such as PT-100 and sibrotuzumab that block the functions of CAFs have already been in clinical trials. However, these drugs ex...

journal_title：Current molecular medicine

authors： Xu Y,Zhou X,Mei M,Ren Y

更新日期：2017-01-01 00:00:00

abstract：:The testes are one of the most delicate organs in the male body and highly susceptible to the exogenous influences capable of inducing cell damage. Cancer therapies are well known to negatively affect the male reproductive tract with a severe impairment of spermatogenesis and infertility. The present work aimed to sys...

journal_title：Current molecular medicine

authors： Silva AM,Correia S,Socorro S,Maia CJ

更新日期：2016-01-01 00:00:00

abstract：:Fibromyalgia (FM) is a prevalent disorder defined by the presence of chronic widespread pain in association with fatigue, sleep disturbances and cognitive dysfunction. Recent studies indicate that bipolar spectrum disorders frequently co-occur in individuals with FM. Furthermore, shared pathophysiological mechanisms a...

journal_title：Current molecular medicine

authors： Bortolato B,Berk M,Maes M,McIntyre RS,Carvalho AF

更新日期：2016-01-01 00:00:00