解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract:BACKGROUND:Bariatric surgery is an effective approach to weight loss and long-term comorbidity resolution. Although recommended in several guidelines, supervised exercise has not been systematically prescribed after bariatric surgery. The aim of this study is to determine the effects of two types of exercise, moderate-...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-021-05056-4
更新日期:2021-02-01 00:00:00
abstract:BACKGROUND:Depression is seriously affecting the physical and mental health of young people worldwide. Subthreshold depression, as an early stage of depression, is essential for early prevention and treatment of depression. Tai Chi, as a traditional Chinese mind-body therapy, may become an alternative intervention. How...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-021-05054-6
更新日期:2021-01-30 00:00:00
abstract:BACKGROUND:The effects of restrictive fluid therapy combined with controlled hypotension in the elderly on systemic oxygen metabolism and renal function are clinical concerns. The aim of this study was to evaluate blood loss, oxygen metabolism, and renal function in different levels of controlled hypotension induced by...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-020-05015-5
更新日期:2021-01-28 00:00:00
abstract:BACKGROUND:The lack of approved treatments for the majority of rare diseases is reflective of the unique challenges of orphan drug development. Novel methodologies, including new functionally relevant endpoints, are needed to render the development process more feasible and appropriate for these rare populations and th...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-020-05009-3
更新日期:2021-01-22 00:00:00
abstract:BACKGROUND:Chronic nonspecific low back pain (CNSLBP) troubles approximately 30% of people worldwide. Silver needle therapy (SNT) is a treatment method to relieve soft tissue pain through heating. Therefore, this study aimed to observe the effects of SNT on CNSLBP. METHODS:In this study, 100 patients were randomly div...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-021-05040-y
更新日期:2021-01-21 00:00:00
abstract:BACKGROUND:Several drugs are being repurposed for the treatment of the coronavirus disease 2019 (COVID-19) pandemic based on in vitro or early clinical findings. As these drugs are being used in varied regimens and dosages, it is important to enable synthesis of existing safety data from clinical trials. However, avail...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-021-05024-y
更新日期:2021-01-15 00:00:00
abstract:BACKGROUND:Increasingly, genomics is informing clinical practice, but challenges remain for medical professionals lacking genetics expertise, and in access to and clinical utility of genomic testing for minority and underrepresented populations. The latter is a particularly pernicious problem due to the historical lack...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-020-04953-4
更新日期:2021-01-14 00:00:00
abstract:BACKGROUND:Spinal manipulative therapy is commonly used in the treatment of adolescent idiopathic scoliosis. Some therapists also rely on physiotherapeutic scoliosis-specific exercise (PSSE). Combining these two modalities seems reasonable, but the effectiveness of this combination has never been rigorously tested. Her...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-020-05000-y
更新日期:2021-01-14 00:00:00
abstract:BACKGROUND:Active surveillance (AS) is the disease management option of choice for low-risk prostate cancer. Despite this, men with low-risk prostate cancer (LRPC) find management decisions distressing and confusing. We developed Navigate, an online decision aid to help men and their partners make management decisions ...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-020-04986-9
更新日期:2021-01-11 00:00:00
abstract::Adaptations to the gold standard randomised controlled trial (RCT) have been introduced to decrease trial costs and avoid high sample sizes. To facilitate development of precision medicine algorithms that aim to optimise treatment allocation for individual patients, we propose a new RCT adaptation termed the nested-pr...
journal_title:Trials
pub_type: 信件
doi:10.1186/s13063-020-04965-0
更新日期:2021-01-06 00:00:00
abstract:BACKGROUND:In the presence of heterogeneous treatment effects, it is desirable to divide patients into subgroups based on their expected response to treatment. This is formalised via a personalised treatment recommendation: an algorithm that uses biomarker measurements to select treatments. It could be that multiple, r...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-020-04901-2
更新日期:2021-01-06 00:00:00
abstract:BACKGROUND:The application of artificial intelligence (AI) in healthcare is an area of immense interest. The high profile of 'AI in health' means that there are unusually strong drivers to accelerate the introduction and implementation of innovative AI interventions, which may not be supported by the available evidence...
journal_title:Trials
pub_type: 信件
doi:10.1186/s13063-020-04951-6
更新日期:2021-01-06 00:00:00
abstract:BACKGROUND:Entertainment-education (E-E) media can improve behavioral intent toward health-related practices. In the era of COVID-19, millions of people can be reached by E-E media without requiring any physical contact. We have designed a short, wordless, animated video about preventive COVID-19 behaviors that can be ...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-020-04942-7
更新日期:2020-12-15 00:00:00
abstract:BACKGROUND:Burnout is an occupational syndrome that leads to mental health problems, job turnover, and patient safety events. Those caring for critically ill patients are especially susceptible due to high patient mortality, long hours, and regular encounters with trauma and ethical issues. Interventions to prevent bur...
journal_title:Trials
pub_type: 杂志文章,随机对照试验
doi:10.1186/s13063-020-04929-4
更新日期:2020-12-11 00:00:00
abstract:INTRODUCTION:Sample size calculations require assumptions regarding treatment response and variability. Incorrect assumptions can result in under- or overpowered trials, posing ethical concerns. Sample size re-estimation (SSR) methods investigate the validity of these assumptions and increase the sample size if necessa...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-020-04931-w
更新日期:2020-12-04 00:00:00
abstract:BACKGROUND:Approximately 2 million children are hospitalized each year in the United States, with more than three-quarters of non-elective hospitalizations admitted through emergency departments (EDs). Direct admission, defined as admission to hospital without first receiving care in the hospital's ED, may offer benefi...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-020-04889-9
更新日期:2020-11-30 00:00:00
abstract:BACKGROUND:Cardiovascular diseases (CVDs) remain the leading causes of morbidity and mortality in the world. Hypertension is an important and prevalent cardiovascular risk factor. The present study will be conducted to investigate the effect of barberry as a cardio-protective fruit on the blood pressure in patients wit...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-020-04918-7
更新日期:2020-11-27 00:00:00
abstract:BACKGROUND:College is an exciting but also challenging time with an increased risk for mental health issues. Only a minority of the college students concerned get professional help, a problem that might be improvable by internet- and mobile-based interventions (IMIs). However, adherence of IMIs is a concern. While guid...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-020-04868-0
更新日期:2020-11-26 00:00:00
abstract:OBJECTIVES:Patients with diabetes are - compared to people without diabetes - at increased risk of worse outcomes from COVID-19 related pneumonia during hospitalization. We aim to investigate whether telemetric continuous glucose monitoring (CGM) in quarantined hospitalized patients with diabetes and confirmed SARS-CoV...
journal_title:Trials
pub_type: 信件,随机对照试验
doi:10.1186/s13063-020-04872-4
更新日期:2020-11-25 00:00:00
abstract:BACKGROUND:Pharmacological therapies of proven efficacy in coronavirus disease 2019 (COVID-19) are still lacking. We have identified IFNβ-1a as the most promising drug to be repurposed for COVID-19. The rationale relies on the evidence of IFNβ anti-viral activity in vitro against SARS-CoV-2 and animal models resembling...
journal_title:Trials
pub_type: 杂志文章,随机对照试验
doi:10.1186/s13063-020-04864-4
更新日期:2020-11-23 00:00:00
abstract:OBJECTIVES:Primary Objective • To assess the efficacy of herbal extracts in boosting innate immunity of patients with COVID-19 infection. Secondary Objectives • To assess the efficacy of herbal extracts in restoring respiratory health • To assess the efficacy of Cap. IP in early recovery of patients and decline in vira...
journal_title:Trials
pub_type: 信件,随机对照试验
doi:10.1186/s13063-020-04906-x
更新日期:2020-11-23 00:00:00
abstract:OBJECTIVES:To assess the effect of prone positioning therapy on intubation rate in awake patients with COVID-19 and acute respiratory failure. TRIAL DESIGN:This is a two-center parallel group, superiority, randomized (1:1 allocation ratio) controlled trial. PARTICIPANTS:All patients admitted to the Hospital Civil de ...
journal_title:Trials
pub_type: 信件,随机对照试验
doi:10.1186/s13063-020-04882-2
更新日期:2020-11-23 00:00:00
abstract:OBJECTIVES:The GETAFIX trial will test the hypothesis that favipiravir is a more effective treatment for COVID-19 infection in patients who have early stage disease, compared to current standard of care. This study will also provide an important opportunity to investigate the safety and tolerability of favipiravir, the...
journal_title:Trials
pub_type: 信件,多中心研究,随机对照试验
doi:10.1186/s13063-020-04891-1
更新日期:2020-11-19 00:00:00
abstract:OBJECTIVES:Primary Objective: To determine the feasibility of delivering a protocolised, remote, online, Eye Movement Desensitisation and Reprocessing (EMDR) intervention, within 12-weeks of hospital discharge, for adult survivors of Covid-19 related critical illness. Secondary objectives: To investigate whether remote...
journal_title:Trials
pub_type: 信件
doi:10.1186/s13063-020-04805-1
更新日期:2020-11-17 00:00:00
abstract:OBJECTIVES:Assessing the effect of surfactant on clinical outcome in patients with COVID-19 under mechanical ventilation TRIAL DESIGN: Single centre, two arm, parallel group (1:1 allocation ratio), randomised superiority trial with blinded care and outcome assessment. PARTICIPANTS:Inclusion criteria: Adult COVID-19 pa...
journal_title:Trials
pub_type: 信件
doi:10.1186/s13063-020-04815-z
更新日期:2020-11-11 00:00:00
abstract:BACKGROUND:This is a phase II randomised, double-blind, sham-controlled trial to evaluate the effectiveness and tolerability of repetitive transcranial magnetic stimulation for preventive treatment of episodic migraine amongst migraine subjects. METHODS:Subjects age 18 to 60 years will undergo a baseline evaluation to...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-020-04832-y
更新日期:2020-11-11 00:00:00
abstract:BACKGROUND:The FIRST-ABC trial comprises of two pragmatic, multicentre, parallel groups, non-inferiority randomised clinical trials designed to evaluate the clinical non-inferiority of first-line use of high flow nasal cannula (HFNC) to continuous positive airway pressure (CPAP) in critically ill children who require n...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-020-04818-w
更新日期:2020-10-31 00:00:00
abstract:OBJECTIVES:To assess the impact of adding statin (atorvastatin) and/or aspirin on clinical deterioration in patients infected with SARS-CoV-2 who require hospitalisation. The safety of these drugs in COVID-19 patients will also be evaluated. TRIAL DESIGN:This is a single-centre, prospective, four-arm parallel design, ...
journal_title:Trials
pub_type: 信件
doi:10.1186/s13063-020-04840-y
更新日期:2020-10-30 00:00:00
abstract:BACKGROUND:Juvenile idiopathic arthritis (JIA)-associated uveitis is a chronic paediatric ocular inflammatory condition that can result in visual impairment. Adalimumab, a tumour necrosis factor (TNF)-alpha inhibitor, effectively controls joint and eye inflammation; however, its long-term use may increase the risk of a...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-020-04796-z
更新日期:2020-10-27 00:00:00
abstract:OBJECTIVES:The BCG vaccine, widely used in Brazil in new-borns, induces adjuvant protection for several diseases, including childhood virus infections. BCG activates monocytes and innate memory NK cells which are crucial for the antiviral immune response. Therefore, strategies to prevent COVID-19 in health workers (HW)...
journal_title:Trials
pub_type: 信件,随机对照试验
doi:10.1186/s13063-020-04822-0
更新日期:2020-10-26 00:00:00
abstract:RATIONALE:Aspiration, infections, and fever are common in the first days after stroke, especially in older patients. The occurrence of these complications has been associated with an increased risk of death or dependency. AIMS AND DESIGN:PREvention of Complications to Improve OUtcome in elderly patients with acute Str...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-020-04717-0
更新日期:2020-10-26 00:00:00
abstract:BACKGROUND:Suicide risk among individuals with schizophrenia (SZ) is intractably high, with over 40% of individuals attempting to take their own lives during their lifetime and an estimated 5-10% completing suicide. At present, available pharmacological and psychotherapeutic treatments offer limited risk reduction bene...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-020-04788-z
更新日期:2020-10-21 00:00:00
abstract:BACKGROUND:Equine-assisted therapy is more often practiced with children and adolescents than with the elderly, although individuals in the second half of life could also profit from it. This group, from the age of 50, is characterised by increasing emotional, social, health-related and cognitive changes; a critical li...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-020-04784-3
更新日期:2020-10-15 00:00:00
abstract::An amendment to this paper has been published and can be accessed via the original article. ...
journal_title:Trials
pub_type: 已发布勘误
doi:10.1186/s13063-020-04793-2
更新日期:2020-10-08 00:00:00
abstract:BACKGROUND:Glenohumeral osteoarthritis can, in the most severe cases, require surgery with insertion of a shoulder arthroplasty. A design with a stem in the humeral bone canal is currently regarded as the standard treatment option in patients who have an intact rotator cuff function, but complications related to the st...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-020-04763-8
更新日期:2020-10-07 00:00:00
abstract:BACKGROUND:Osteoarthritis (OA) is a common chronic disease in older adults. Currently, there are no effective therapies to reduce disease severity and progression of knee OA (KOA), particularly in mid- to late-stages. This study aims to examine the effect of methotrexate (MTX) on knee effusion-synovitis and pain in sym...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-020-04687-3
更新日期:2020-09-16 00:00:00
abstract:BACKGROUND:Alcohol use disorder (AUD) is a chronic and relapsing condition for which current pharmacological treatments are only modestly effective. The development of efficacious medications for AUD remains a high research priority with recent emphasis on identifying novel molecular targets for AUD treatment and to ef...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-020-04670-y
更新日期:2020-09-11 00:00:00
abstract:BACKGROUND:Carotid atherosclerosis disease (CAD) is generally associated with the occurrence of cardiovascular and cerebrovascular accidents. However, CAD has not been taken seriously enough in the clinic, which, coupled with the single treatment and prevention of CAD, has led to a generally low level of patient compli...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-020-04709-0
更新日期:2020-09-07 00:00:00
abstract:OBJECTIVES:To investigate the potential efficacy of Acacia Senegal extract Gum Arabic (GA) supplementation as immunomodulatory and anti-inflammatory dietary intervention among newly diagnosed COVID 19 Sudanese patients. To study the effect of GA on the level of cytokines, TNFα, IL8, IL6 IL10, CRP and the viral load. Se...
journal_title:Trials
pub_type: 信件
doi:10.1186/s13063-020-04707-2
更新日期:2020-09-05 00:00:00
abstract:BACKGROUND:Rheumatoid arthritis (RA) is one of the leading chronic inflammatory rheumatism. First-line therapy with synthetic disease-modifying antirheumatic drugs (sDMARD) is insufficiently effective in 40% of cases and these patients are treated with biotherapies. The increased use of these drugs each year is becomin...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-020-04683-7
更新日期:2020-08-31 00:00:00