An entertainment-education approach to prevent COVID-19 spread: study protocol for a multi-site randomized controlled trial.

abstract：BACKGROUND:Orthodontic treatment is commonly undertaken in young people, with over 40% of children in the UK needing treatment and currently one third having treatment, at a cost to the National Health Service in England and Wales of £273 million each year. Most current research about orthodontic care does not consider...

journal_title：Trials

authors： Tsichlaki A,O'Brien K,Johal A,Marshman Z,Benson P,Colonio Salazar FB,Fleming PS

更新日期：2017-08-04 00:00:00

abstract：BACKGROUND:The aim of this study is to demonstrate that capecitabine metronomic chemotherapy is non-inferior to capecitabine conventional chemotherapy as maintenance treatment, in patients who have responded to 16-18 weeks first-line chemotherapy in metastatic colorectal cancer (mCRC). METHODS:The study design is a pr...

journal_title：Trials

authors： Shi M,Ma T,Xi W,Jiang J,Wu J,Zhou C,Yang C,Zhu Z,Zhang J

更新日期：2020-03-06 00:00:00

abstract：BACKGROUND:Diabetic distal symmetric polyneuropathy (DSPN) is one of the most common microvascular complications of diabetes mellitus, and it has become a major public health problem worldwide because of its high and increasing prevalence, morbidity, and disability rate. The current medications for DSPN are not entirel...

journal_title：Trials

authors： Jin,Huang WJ,Meng X,Yang F,Zheng YJ,Bao Q,Zhang MZ,Yang YN,Ni Q,Lian FM,Tong XL

更新日期：2017-12-29 00:00:00

abstract：BACKGROUND:After major abdominal surgery (MAS), 20% of patients endure major complications, which require invasive treatment and are associated with increased morbidity and mortality. A quality control algorithm after major abdominal surgery aimed at early identification of patients at risk of developing major complica...

journal_title：Trials

authors： Straatman J,Cuesta MA,Schreurs WH,Dwars BJ,Cense HA,Rijna H,Sonneveld DJ,den Boer FC,de Lange-de Klerk ES,van der Peet DL

更新日期：2015-08-28 00:00:00

abstract：BACKGROUND:Adverse effects such as fatigue, pain, erythema, nausea and vomiting are commonly known in patients undergoing irradiation (RT) alone or in combination with chemotherapy (RCHT). Patients suffering from these symptoms are limited in their daily life and their quality of life (QOL) is often reduced. As address...

journal_title：Trials

authors： Asadpour R,Kessel KA,Bruckner T,Sertel S,Combs SE

更新日期：2017-08-29 00:00:00

abstract：BACKGROUND:Contrast-induced nephropathy (CIN) is a serious clinical problem associated with increased morbidity and mortality, particularly in patients with chronic renal insufficiency. Although some agents including hydration with saline are being prescribed to prevent renal deterioration in these high risk patients, ...

journal_title：Trials

authors： Park K,Chung WY,Seo JB,Kim SH,Zo JH,Kim MA,Park YB

更新日期：2010-12-20 00:00:00

abstract：BACKGROUND:Hospital mortality for patients with sepsis has recently declined, but sepsis survivors still suffer from significant long-term mortality and morbidity. There are limited data that support effective strategies to address post-discharge management of patients hospitalized with sepsis. METHODS:The Improving M...

journal_title：Trials

authors： Kowalkowski M,Chou SH,McWilliams A,Lashley C,Murphy S,Rossman W,Papali A,Heffner A,Russo M,Burke L,Gibbs M,Taylor SP,Atrium Health ACORN Investigators.

更新日期：2019-11-29 00:00:00

abstract：BACKGROUND:The United Nations Millennium Development Goals include targets for the health of children under five years old. Poor health is linked to poverty and microfinance initiatives are economic interventions that may improve health by breaking the cycle of poverty. However, there is a lack of reliable evidence to ...

journal_title：Trials

authors： Ojha S,Szatkowski L,Sinha R,Yaron G,Fogarty A,Allen S,Choudhary S,Smyth AR

更新日期：2014-07-23 00:00:00

abstract：BACKGROUND:Low back pain is highly prevalent and a major source of disability worldwide. Spa therapy is frequently used to treat low back pain, but the associated level of evidence for efficacy is insufficient. To fill this knowledge gap, this protocol proposes an appropriately powered, prospective, evaluator-blinded, ...

journal_title：Trials

authors： Forestier R,Suehs C,Françon A,Marty M,Genevay S,Sellam J,Chauveton C,Erol Forestier FB,Molinari N

更新日期：2020-05-11 00:00:00

abstract：BACKGROUND:Qualitative methods are increasingly used to study the process of clinical trials and patients understanding of the rationale for trials, randomisation and reasons for taking part or refusing. Patients' understandings are inevitably influenced by the recruiting clinician's understanding of the trial, yet rel...

journal_title：Trials

authors： Ziebland S,Featherstone K,Snowdon C,Barker K,Frost H,Fairbank J

更新日期：2007-01-27 00:00:00

abstract：BACKGROUND:Respiratory support following postoperative extubation is of major importance to prevent hypoxemia and subsequent respiratory failure and reintubation. High-flow nasal cannula oxygen (HFNC) delivers a flow-dependent positive airway pressure and improves oxygenation by increasing end-expiratory lung volume. W...

journal_title：Trials

authors： Futier E,Paugam-Burtz C,Constantin JM,Pereira B,Jaber S

更新日期：2013-10-18 00:00:00

abstract：BACKGROUND:In recent years, cold hypersensitivity in the hands (CHH) has become a common ailment of women in Korea. It can lead to gynecological problems such as irregular menstruation, miscarriage, and infertility. Traditionally, Korean herbal medicine has been the primary treatment method used to balance thermoregula...

journal_title：Trials

authors： Ko Y,Go HY,Cho YY,Shin JH,Kim TH,Choi DJ,Lee JM,Jang JB,Song YK,Ko SG,Sun SH,Jeon CY

更新日期：2017-06-08 00:00:00

abstract：BACKGROUND:Patients with liver cirrhosis have a highly elevated risk of developing bacterial infections that significantly decrease survival rates. One of the most relevant infections is spontaneous bacterial peritonitis (SBP). Recently, NOD2 germline variants were found to be potential predictors of the development of...

journal_title：Trials

authors： Casper M,Mengel M,Fuhrmann C,Herrmann E,Appenrodt B,Schiedermaier P,Reichert M,Bruns T,Engelmann C,Grünhage F,Lammert F,INCA trial group.

更新日期：2015-03-08 00:00:00

abstract：BACKGROUND:Generalised anxiety disorder (GAD) is a chronic and disabling condition with considerable personal and economic impact. Cognitive behavioural therapy (CBT) is a recommended psychological therapy for GAD; however, there are substantial barriers to accessing treatment. Digital CBT, in particular smartphone-del...

journal_title：Trials

authors： Gu J,Miller CB,Henry AL,Espie CA,Davis ML,Stott R,Emsley R,Smits JAJ,Craske M,Saunders KEA,Goodwin G,Carl JR

更新日期：2020-04-23 00:00:00

abstract：BACKGROUND:Transurethral resection of the prostate (TURP) has been the standard operation for benign prostatic obstruction (BPO) for 40 years, with approximately 25,000 procedures performed annually, and has remained largely unchanged. It is generally a successful operation, but has well-documented risks for the patien...

journal_title：Trials

authors： Worthington J,Taylor H,Abrams P,Brookes ST,Cotterill N,Noble SM,Page T,Swami KS,Lane JA,Hashim H

更新日期：2017-04-17 00:00:00

abstract：BACKGROUND:This study is a part of a series of two clinical trials. We consider diabetic polyneuropathy (DPN), a common chronic and progressive complication of diabetes mellitus that has several impacts on individuals' foot health and quality of life. Based on the current trends of self-monitoring and self-care, provid...

journal_title：Trials

authors： Silva EQ,Suda EY,Santos DP,Veríssimo JL,Ferreira JSSP,Cruvinel Júnior RH,Monteiro RL,Sartor CD,Sacco ICN

更新日期：2020-02-13 00:00:00

abstract：BACKGROUND:Atopic dermatitis (AD) is associated with reduced skin microbial diversity and overgrowth of Staphylococcus (S.) aureus. However, the importance of S. aureus colonisation in the complex pathogenesis remains unclear and studies on the effect of anti-staphylococcal therapy in non-infected AD show contradictory...

journal_title：Trials

authors： Totté J,de Wit J,Pardo L,Schuren F,van Doorn M,Pasmans S

更新日期：2017-08-31 00:00:00

abstract：BACKGROUND:Findings suggest approximately one in six people with intellectual disability engage in 'challenging behaviours', which include aggression towards others/property and self-injurious actions. In residential settings, actions of staff members can make challenging behaviours more likely to occur, or make these ...

journal_title：Trials

authors： Randell E,Hastings RP,McNamara R,Knight R,Gillespie D,Taylor Z

更新日期：2017-10-05 00:00:00

abstract：BACKGROUND:The Pneumatic CompREssion for Preventing VENous Thromboembolism (PREVENT) trial evaluates the effect of adjunctive intermittent pneumatic compression (IPC) with pharmacologic thromboprophylaxis compared to pharmacologic thromboprophylaxis alone on venous thromboembolism (VTE) in critically ill adults. METHO...

journal_title：Trials

authors： Arabi Y,Al-Hameed F,Burns KEA,Mehta S,Alsolamy S,Almaani M,Mandourah Y,Almekhlafi GA,Al Bshabshe A,Finfer S,Alshahrani M,Khalid I,Mehta Y,Gaur A,Hawa H,Buscher H,Arshad Z,Lababidi H,Al Aithan A,Jose J,Abdukahil SA

更新日期：2018-03-15 00:00:00

abstract：BACKGROUND:Osteoporosis-related fractures are a significant public health concern. Interventions that increase detection and treatment of osteoporosis, as well as prevention of fractures and falls, are substantially underutilized. This paper outlines the protocol for a pragmatic randomised trial of a multifaceted commu...

journal_title：Trials

authors： Ciaschini PM,Straus SE,Dolovich LR,Goeree RA,Leung KM,Woods CR,Zimmerman GM,Majumdar SR,Spadafora S,Fera LA,Lee HN

更新日期：2008-11-04 00:00:00

abstract：BACKGROUND:The objective of this research was to evaluate data from a randomized clinical trial that tested injectable diacetylmorphine (DAM) and oral methadone (MMT) for substitution treatment, using a multi-domain dichotomous index, with a Bayesian approach. METHODS:Sixty two long-term, socially-excluded heroin inje...

journal_title：Trials

authors： Perea-Milla E,Ayçaguer LC,Cerdà JC,Saiz FG,Rivas-Ruiz F,Danet A,Vallecillo MR,Oviedo-Joekes E

更新日期：2009-08-14 00:00:00

abstract：BACKGROUND:Tinnitus is the perception of a sound in the absence of an objective physical source. Up to now, there is no generally accepted view how these phantom sounds come about, and also no efficient treatment. Patients are turning to complementary or alternative medical therapies, such as acupuncture. Based on the ...

journal_title：Trials

authors： Shi GX,Han LL,Liu LY,Li QQ,Liu CZ,Wang LP

更新日期：2012-11-23 00:00:00

abstract：BACKGROUND:Chronic back pain is a major public health problem and the primary reason patients seek massage treatment. Despite the growing use of massage for chronic low back pain, there have been few studies of its effectiveness. This trial will be the first evaluation of the effectiveness of relaxation massage for chr...

journal_title：Trials

authors： Cherkin DC,Sherman KJ,Kahn J,Erro JH,Deyo RA,Haneuse SJ,Cook AJ

更新日期：2009-10-20 00:00:00

abstract：BACKGROUND:The prevalence of otitis media in Greenlandic children is one of the highest in the world. International studies have shown that otitis-prone children may benefit from tubulation of the tympanic membrane. However, it is unknown whether these results can be applied to Greenlandic children and trials on the ef...

journal_title：Trials

authors： Demant MN,Jensen RG,Jakobsen JC,Gluud C,Homøe P

更新日期：2017-01-19 00:00:00

abstract：BACKGROUND:Resistant hypertension is defined as an uncontrolled blood pressure despite treatment at best-tolerated doses with at least three antihypertensive agents including a diuretic. It is an emerging public health problem. At present clinical trial data on management of resistant hypertension is limited. Managemen...

journal_title：Trials

authors： Constantine GR,Ranasinghe P,Weeratunga P,Weeraratne C,Galappatthy P,Rajapakse S,Senarath U,Katulanda P

更新日期：2017-03-14 00:00:00

abstract：BACKGROUND:Cardiovascular diseases are the major cause of death in the world. Current treatments have not been able to reverse this scenario, creating the need for the development of new therapies. Cell therapies have emerged as an alternative for cardiac diseases of distinct causes in experimental animal studies and m...

journal_title：Trials

authors： Tura BR,Martino HF,Gowdak LH,dos Santos RR,Dohmann HF,Krieger JE,Feitosa G,Vilas-Boas F,Oliveira SA,Silva SA,Bozza AZ,Borojevic R,de Carvalho AC

更新日期：2007-01-18 00:00:00

abstract：BACKGROUND:A high intake of salt is a major risk factor for cardiovascular diseases. Despite decades of effort to reduce salt consumption, the salt intake in China is still considerably above the recommended level. Thus, this study aims to design and implement an intelligent household added salt monitoring system (SALT...

journal_title：Trials

authors： Xian J,Zeng M,Zhu R,Cai Z,Shi Z,Abdullah AS,Zhao Y

更新日期：2020-04-21 00:00:00

abstract：BACKGROUND:Oral mucositis (OM) is the most frequent and debilitating acute side effect associated with head and neck cancer (HNC) treatment. When present, severe OM negatively impacts the quality of life of patients undergoing HNC treatment. Photobiomodulation is a well-consolidated and effective therapy for the treatm...

journal_title：Trials

authors： Martins AFL,Nogueira TE,Morais MO,Oton-Leite AF,Valadares MC,Batista AC,Freitas NMA,Leles CR,Mendonça EF

更新日期：2019-02-01 00:00:00

abstract：BACKGROUND:Previous research has suggested an association between more liberal red blood cell (RBC) transfusion and greater risk of further bleeding and mortality following acute upper gastrointestinal bleeding (AUGIB). METHODS AND DESIGN:The Transfusion in Gastrointestinal Bleeding (TRIGGER) trial is a pragmatic clus...

journal_title：Trials

authors： Kahan BC,Jairath V,Murphy MF,Doré CJ

更新日期：2013-07-10 00:00:00

abstract：BACKGROUND:Coronary heart disease (CHD) has become a common cardiovascular disease that seriously threatens the health of people. As reperfusion in the early phase and drug therapy, especially percutaneous coronary intervention (PCI), have become widely used in the clinic, the mortality of acute myocardial infarction i...

journal_title：Trials

authors： Wang Y,Wang X,Wang J,Li B,Yu R,Hu Y,Li X,Peng G,Zhang M,Zhu M

更新日期：2020-03-20 00:00:00