A study of capecitabine metronomic chemotherapy is non-inferior to conventional chemotherapy as maintenance strategy in responders after induction therapy in metastatic colorectal cancer.

abstract：BACKGROUND:Obesity represents a major public health problem and is the fifth leading risk factor for mortality. Morbid obesity is associated with chronic systemic inflammation which increases the risk of comorbidities. Bariatric surgery (BS) is considered an effective intervention for obese patients. However, BS is ass...

journal_title：Trials

authors： Delgado André L,Basso-Vanelli RP,Di Thommazo-Luporini L,Angélica Ricci P,Cabiddu R,Pilon Jürgensen S,Ricardo de Oliveira C,Arena R,Borghi-Silva A

更新日期：2018-10-31 00:00:00

abstract：BACKGROUND:Noncompliance to treatment assignment is an inevitable occurrence in randomized clinical trials (RCTs). Intention to treat (ITT) is generally considered the best method for addressing noncompliance in RCTs. Alternatives to ITT exist, including per protocol (PP), as treated (AT), and instrumental variables (I...

journal_title：Trials

authors： Merrill PD,McClure LA

更新日期：2015-11-17 00:00:00

abstract：BACKGROUND:Multi-centre randomised controlled trials (RCTs) in surgery are challenging. It is particularly difficult to establish standards of surgery and ensure that interventions are delivered as intended. This study developed and tested methods for identifying the key components of surgical interventions and standar...

journal_title：Trials

authors： Blencowe NS,Blazeby JM,Donovan JL,Mills N

更新日期：2015-12-28 00:00:00

abstract：BACKGROUND:Infections are common in nursing home (NH) residents with advanced dementia but are often managed inappropriately. Antimicrobials are extensively prescribed, but frequently with insufficient evidence to support a bacterial infection, promoting the emergence of multidrug-resistant organisms. Moreover, the ben...

journal_title：Trials

authors： Loizeau AJ,D'Agata EMC,Shaffer ML,Hanson LC,Anderson RA,Tsai T,Habtemariam DA,Bergman EH,Carroll RP,Cohen SM,Scott EME,Stevens E,Whyman JD,Bennert EH,Mitchell SL

更新日期：2019-10-15 00:00:00

abstract：BACKGROUND:Bone graft substitutes are widely used for reconstruction of posttraumatic bone defects. However, their clinical significance in comparison to autologous bone grafting, the gold-standard in reconstruction of larger bone defects, still remains under debate. This prospective, randomized, controlled clinical st...

journal_title：Trials

authors： Nusselt T,Hofmann A,Wachtlin D,Gorbulev S,Rommens PM

更新日期：2014-03-08 00:00:00

abstract：BACKGROUND:Chronic back pain continues to be a costly and prevalent condition. The latest NICE guidelines issued in 2009 state that for patients with persistent back pain (of between six weeks and twelve months duration), who are highly distressed and/or disabled and for whom exercise, manual therapy and acupuncture ha...

journal_title：Trials

authors： Pincus T,Anwar S,McCracken L,McGregor A,Graham L,Collinson M,Farrin AJ,OBI Trial Management Team.

更新日期：2013-06-13 00:00:00

abstract：BACKGROUND:Patients taking opioids are known to develop opioid-induced constipation (OIC), which reduces their quality of life. The aim of this study is to compare magnesium oxide with naldemedine and determine which is more effective in preventing OIC. METHODS:This proof-of-concept, prospective, randomized controlled...

journal_title：Trials

authors： Ozaki A,Kessoku T,Iwaki M,Kobayashi T,Yoshihara T,Kato T,Honda Y,Ogawa Y,Imajo K,Higurashi T,Yoneda M,Taguri M,Yamanaka T,Ishiki H,Kobayashi N,Saito S,Ichikawa Y,Nakajima A

更新日期：2020-06-01 00:00:00

abstract：BACKGROUND:Juvenile idiopathic arthritis (JIA)-associated uveitis is a chronic paediatric ocular inflammatory condition that can result in visual impairment. Adalimumab, a tumour necrosis factor (TNF)-alpha inhibitor, effectively controls joint and eye inflammation; however, its long-term use may increase the risk of a...

journal_title：Trials

authors： Acharya NR,Ebert CD,Kelly NK,Porco TC,Ramanan AV,Arnold BF,ADJUST Research Group.

更新日期：2020-10-27 00:00:00

abstract：BACKGROUND:Depression is a debilitating and costly disease for our society, especially in the case of treatment-resistant depression (TRD). Repetitive transcranial magnetic stimulation (rTMS) is an effective adjuvant therapy in treatment-resistant unipolar and non-psychotic depression. It can be applied according to tw...

journal_title：Trials

authors： Bulteau S,Laurin A,Volteau C,Dert C,Lagalice L,Schirr-Bonnans S,Bukowski N,Guitteny M,Simons L,Cabelguen C,Pichot A,Tessier F,Bonnin A,Lepage A,ACOUSTIM Investigators Group.,HUGOPSY Network.,Vanelle JM,Sauvaget A,Rich

更新日期：2020-04-05 00:00:00

abstract：BACKGROUND:Classroom-based stuttering intervention addressing negative peer attitudes, perceptions, teasing and bullying of children who stutter (CWS) is required as part of holistic stuttering management because of its occurrence in primary school. This study was conducted in 2017, in 10 primary schools in the Western...

journal_title：Trials

authors： Mallick R,Kathard H,Borhan ASM,Pillay M,Thabane L

更新日期：2018-11-29 00:00:00

abstract：BACKGROUND:Maternal and perinatal mortality are major problems for which progress in sub-Saharan Africa has been inadequate, even though childbirth services are available, even in the poorest countries. Reducing them is the aim of two of the main Millennium Development Goals. Many initiatives have been undertaken to re...

journal_title：Trials

authors： Dumont A,Fournier P,Fraser W,Haddad S,Traore M,Diop I,Gueye M,Gaye A,Couturier F,Pasquier JC,Beaudoin F,Lalonde A,Hatem M,Abrahamowicz M

更新日期：2009-09-18 00:00:00

abstract：BACKGROUND:Bone microarchitecture is a significant determinant of bone strength. So far, the assessment of bone microarchitecture has required bone biopsies, limiting its utilization in clinical practice to one single skeletal site. With the advance of high-resolution imaging techniques, non-invasive in vivo measuremen...

journal_title：Trials

authors： Richert L,Uebelhart B,Engelhardt M,Azria M,Rizzoli R

更新日期：2008-04-13 00:00:00

abstract：BACKGROUND:Tackling neonatal mortality is essential for the achievement of the child survival millennium development goal. There are just under 4 million neonatal deaths, accounting for 38% of the 10.8 million deaths among children younger than 5 years of age taking place each year; 99% of these occur in low- and middl...

journal_title：Trials

authors： Kirkwood BR,Manu A,Tawiah-Agyemang C,ten Asbroek G,Gyan T,Weobong B,Lewandowski RE,Soremekun S,Danso S,Pitt C,Hanson K,Owusu-Agyei S,Hill Z

更新日期：2010-05-17 00:00:00

abstract：BACKGROUND:The burden of acute gastroenteritis on children and their families continues to be enormous. Probiotics, defined as viable microbial preparations that have a beneficial effect on the health of the host, represent a rapidly expanding field. Although clinical trials in children with gastroenteritis have been p...

journal_title：Trials

authors： Freedman SB,Williamson-Urquhart S,Schuh S,Sherman PM,Farion KJ,Gouin S,Willan AR,Goeree R,Johnson DW,Black K,Schnadower D,Gorelick MH,Pediatric Emergency Research Canada (PERC) Gastroenteritis Study Group.

更新日期：2014-05-14 00:00:00

abstract：BACKGROUND:Incomplete recovery from facial palsy results in social and physical disabilities, and the medical options for the sequelae of Bell's palsy are limited. Acupuncture is widely used for Bell's palsy patients in East Asia, but its efficacy is unclear. METHODS:We performed a randomized controlled trial includin...

journal_title：Trials

authors： Kwon HJ,Choi JY,Lee MS,Kim YS,Shin BC,Kim JI

更新日期：2015-06-03 00:00:00

abstract：BACKGROUND:Delirium prevalence in the intensive care unit (ICU) is high. Numerous psychotropic agents are used to manage delirium in the ICU with limited data regarding their efficacy or harms. METHODS/DESIGN:This is a randomized controlled trial of 428 patients aged 18 and older suffering from delirium and admitted t...

journal_title：Trials

authors： Campbell NL,Khan BA,Farber M,Campbell T,Perkins AJ,Hui SL,Abernathy G,Buckley J,Sing R,Tricker J,Zawahiri M,Boustani MA

更新日期：2011-06-06 00:00:00

abstract：BACKGROUND:Tobacco smoking remains the leading preventable cause of death in the US. A hospital admission provides smokers with a unique opportunity to stop smoking because it requires temporary tobacco abstinence while illness may enhance motivation to quit. Hospital interventions must continue post-discharge to incre...

journal_title：Trials

authors： Rigotti NA,Schnitzer K,Davis EM,Regan S,Chang Y,Kelley JHK,Notier AE,Gilliam K,Douaihy A,Levy DE,Singer DE,Tindle HA

更新日期：2020-04-16 00:00:00

abstract：BACKGROUND:The physical and mental health of college students tends to continuously decline around the world. Since they are in a significant transition period which presents opportunities and challenges in health promotion, it is important to improve their health in this period. As a traditional Chinese exercise form ...

journal_title：Trials

authors： Zheng G,Li M,Lan X,Yan X,Lin Q,Chen L,Tao J,Zheng X,Li J,Chen B,Fang Q

更新日期：2013-12-05 00:00:00

abstract：BACKGROUND:Systematic use of observational pain tools has been advocated as a means to improve pain management for care home residents with dementia. Pain experts suggest that any observational tool should be used as part of a comprehensive pain management protocol, which should include score interpretation and verific...

journal_title：Trials

authors： Liu JY,Lai C

更新日期：2014-03-13 00:00:00

abstract：BACKGROUND:Photobiomodulation using low-level laser therapy (LLLT) has been tested as a new technique to optimize recovery of patients with traumatic brain injury (TBI). The aim of this study is to evaluate inhibitory attentional control after 18 sessions of active LLLT and compare with the placebo group (sham LLLT). O...

journal_title：Trials

authors： Poiani GDCR,Zaninotto AL,Carneiro AMC,Zangaro RA,Salgado ASI,Parreira RB,de Andrade AF,Teixeira MJ,Paiva WS

更新日期：2018-01-08 00:00:00

abstract：BACKGROUND:Necrotizing enterocolitis (NEC) is the leading cause of death among preterm infants born at < 30 weeks' gestation. The incidence of NEC is reduced when infants are fed human milk. However, in many neonatal intensive care units (NICUs), it is standard practice to freeze and/or pasteurize human milk, which dea...

journal_title：Trials

authors： Sun H,Cao Y,Han S,Cheng R,Liu L,Liu J,Xia S,Zhang J,Li Z,Cheng X,Yang C,Pan X,Li L,Ding X,Wang R,Wu M,Li X,Shi L,Xu F,Yu F,Pan J,Zhang X,Li L,Yang J,Li M,Yan C,Zhou Q,Lu J,Wei M,Wang L,Yang L,

更新日期：2020-02-11 00:00:00

abstract：BACKGROUND:The serious mental illness Health Improvement Profile [HIP] is a brief pragmatic tool, which enables mental health nurses to work together with patients to screen physical health and take evidence-based action when variables are identified to be at risk. Piloting has demonstrated clinical utility and accepta...

journal_title：Trials

authors： White J,Gray RJ,Swift L,Barton GR,Jones M

更新日期：2011-07-04 00:00:00

abstract：:Following the South African case, Treatment Action Campaign and Others v Minister of Health and Others, the use of 'pilot' studies to investigate interventions already proven efficacious, offered free of charge to government, but confined by the government to a small part of the population, may violate children's righ...

journal_title：Trials

authors： Oduwo E,Edwards SJ

更新日期：2014-07-16 00:00:00

abstract：BACKGROUND:The high co-morbidity of mental disorders, particularly depression, with non-communicable diseases (NCDs) such as cardiovascular disease (CVD), is concerning given the rising burden of NCDs globally, and the role depression plays in confounding prevention and treatment of NCDs. The objective of this randomis...

journal_title：Trials

authors： Petersen I,Bhana A,Folb N,Thornicroft G,Zani B,Selohilwe O,Petrus R,Mntambo N,Georgeu-Pepper D,Kathree T,Lund C,Lombard C,Bachmann M,Gaziano T,Levitt N,Fairall L,PRIME-SA research team.

更新日期：2018-03-22 00:00:00

abstract：BACKGROUND:Tetramethylpyrazine (TMP), an active ingredient in the traditional Chinese herbal medicine Rhizoma Chuanxiong, has been used clinically for the prevention and treatment of cardiovascular disease. The benefits of TMP are largely attributed to its anti-oxidative and vasodilative properties. However, the effica...

journal_title：Trials

authors： Chen Y,He W,Ouyang H,Liu C,Hong C,Wang T,Yang K,Lu W,Wang J

更新日期：2019-12-16 00:00:00

abstract：BACKGROUND:Among clinical trials of interventions that aim to modify time spent on mechanical ventilation for critically ill patients there is considerable inconsistency in chosen outcomes and how they are measured. The Core Outcomes in Ventilation Trials (COVenT) study aims to develop a set of core outcomes for use in...

journal_title：Trials

authors： Blackwood B,Ringrow S,Clarke M,Marshall J,Rose L,Williamson P,McAuley D

更新日期：2015-08-20 00:00:00

abstract：BACKGROUND:Chronic subdural haematoma (CSDH) is a common neurosurgical condition, typically treated with surgical drainage of the haematoma. However, surgery is associated with mortality and morbidity, including up to 20% recurrence of the CSDH. Steroids, such as dexamethasone, have been identified as a potential thera...

journal_title：Trials

authors： Kolias AG,Edlmann E,Thelin EP,Bulters D,Holton P,Suttner N,Owusu-Agyemang K,Al-Tamimi YZ,Gatt D,Thomson S,Anderson IA,Richards O,Whitfield P,Gherle M,Caldwell K,Davis-Wilkie C,Tarantino S,Barton G,Marcus HJ,Chari A

更新日期：2018-12-04 00:00:00

abstract：BACKGROUND:There is a strong evidence base for the benefits of parenting interventions for parents without severe mental illness (SMI). As the impact of maternal SMI can be significant on child development, mothers need support to maximise outcomes for themselves and their children. Some mothers with SMI require admiss...

journal_title：Trials

authors： Wittkowski A,Cartwright K,Emsley R,Bee P,Calam R,Cross C,Abel KM,Reid H

更新日期：2018-09-10 00:00:00

abstract：BACKGROUND:Ventilator-associated pneumonia (VAP) is one of the most common and severe hospital-adquired infections, and multidrugresistant gram-negative bacilli (MDR-GNB) constitute the main etiology in many countries. Inappropriate empiric antimicrobial treatment is associated with increased mortality. In this context...

journal_title：Trials

authors： Rosso-Fernández C,Garnacho-Montero J,Antonelli M,Dimopoulos G,Cisneros JM,MagicBullet study group.

更新日期：2015-03-20 00:00:00

abstract：BACKGROUND:In studies comparing different prosthetic treatment concepts the repeated loss of teeth was chosen as the primary outcome. The resulting data appear to represent a data structure of recurrent events. However, the application of an existing method for recurrent events is far from straightforward. Often only t...

journal_title：Trials

authors： Diebner HH,Marré B,Roeder I,Walter MH

更新日期：2016-05-17 00:00:00