Improving delirium care in the intensive care unit: the design of a pragmatic study.

abstract：BACKGROUND:Evidence increases that a high or a standard dose of tranexamic acid (TA) reduces postpartum bleeding. The TRACES pharmacobiological substudy aims to establish a therapeutic strategy in hemorrhagic (H) Cesarean section (CS) with respect to the intensity of fibrinolysis by using innovative assays. METHOD/DES...

journal_title：Trials

authors： Ducloy-Bouthors AS,Jeanpierre E,Saidi I,Baptiste AS,Simon E,Lannoy D,Duhamel A,Allorge D,Susen S,Hennart B

更新日期：2018-03-01 00:00:00

abstract：BACKGROUND:Rehabilitation after spinal cord injury (SCI) has traditionally involved teaching compensatory strategies for identified impairments and deficits in order to improve functional independence. There is some evidence that regular and intensive activity-based therapies, directed at activation of the paralyzed ex...

journal_title：Trials

authors： Galea MP,Dunlop SA,Davis GM,Nunn A,Geraghty T,Hsueh YS,Churilov L

更新日期：2013-09-11 00:00:00

abstract：BACKGROUND:The lack of approved treatments for the majority of rare diseases is reflective of the unique challenges of orphan drug development. Novel methodologies, including new functionally relevant endpoints, are needed to render the development process more feasible and appropriate for these rare populations and th...

journal_title：Trials

authors： Fields T,Patterson M,Bremova-Ertl T,Belcher G,Billington I,Churchill GC,Davis W,Evans W,Flint S,Galione A,Granzer U,Greenfield J,Karl R,Kay R,Lewi D,Mathieson T,Meyer T,Pangonis D,Platt FM,Tsang L,Verburg C,Fact

更新日期：2021-01-22 00:00:00

abstract：BACKGROUND:Postoperative pulmonary complications (PPCs) are frequent after on-pump cardiac surgery. Cardiac surgery results in a complex pulmonary insult leading to high susceptibility to perioperative pulmonary atelectasis. For technical reasons, ventilator settings interact with the surgical procedure and traditional...

journal_title：Trials

authors： Lagier D,Fischer F,Fornier W,Fellahi JL,Colson P,Cholley B,Jaber S,Baumstarck K,Guidon C,PROVECS investigators and the ARCOTHOVA group.

更新日期：2018-11-13 00:00:00

abstract：BACKGROUND:Sharing interim results by the Data Safety Monitoring Board (DSMB) with non-DSMB members is an issue that can affect trial integrity. It is unclear what should be shared. This study assesses the views of professionals to understand what interim information should be shared at interim, with whom and why. MET...

journal_title：Trials

authors： Borg Debono V,Mbuagbaw L,Paul J,Buckley N,Thabane L

更新日期：2018-05-21 00:00:00

abstract：BACKGROUND:Stroke is a common cause of cognitive impairment and dementia. However, effective strategies for reducing the risk of post-stroke dementia remain undefined. Potential strategies include intensive lowering of blood pressure and/or lipids. METHODS/DESIGN: DESIGN:multi-centre prospective randomised open-label...

journal_title：Trials

authors： Blackburn DJ,Krishnan K,Fox L,Ballard C,Burns A,Ford GA,Mant J,Passmore P,Pocock S,Reckless J,Sprigg N,Stewart R,Wardlaw J,Bath PM

更新日期：2013-11-22 00:00:00

abstract：BACKGROUND:Renal transplantation represents the treatment of choice of end-stage kidney disease. Delayed graft function (DGF) remains the most frequent complication after this procedure, reaching more than 30%. Its prevention is essential as it impedes early- and long-term prognosis of transplantation. Numerous pharmac...

journal_title：Trials

authors： Orban JC,Fontaine E,Cassuto E,Baumstarck K,Leone M,Constantin JM,Ichai C,AzuRéa network.

更新日期：2018-04-17 00:00:00

abstract：BACKGROUND:Intellectual disability (ID) is characterized by limitations in intellectual functioning and adaptive behavior. Adults with ID exhibit higher rates of obesity and poorer health status compared to the general population. Continuity of care and barriers to health-related activities may contribute to the poorer...

journal_title：Trials

authors： Neumeier WH,Guerra N,Thirumalai M,Geer B,Ervin D,Rimmer JH

更新日期：2017-10-23 00:00:00

abstract：BACKGROUND:Recently, catheter-based renal sympathetic denervation (RSD) has been verified to be safely used to substantially reduce the levels of blood pressure, left ventricular hypertrophy, sleep apnea severity and norepinephrine spillover, and improve glucose tolerance. All these pathological changes are recognized ...

journal_title：Trials

authors： Qiu M,Yin Y,Shan Q

更新日期：2013-06-11 00:00:00

abstract：BACKGROUND:Laminoplasty and laminectomy have been used for decades for the treatment of intraspinal space-occupying lesions, spinal stenosis, disc herniation, injuries, etc. After these procedures, patients often experience severe postoperative pain at the surgical site. Intense immediate postoperative pain after many ...

journal_title：Trials

authors： Shrestha N,Wu L,Wang X,Jia W,Luo F

更新日期：2020-05-05 00:00:00

abstract：BACKGROUND:Allergic rhinitis is a chronic illness, affecting 10 to 40% of the worldwide population. Chinese herbal medicines, the treatment of allergic rhinitis, adopted thousands of years in ancient China, has recently raised much attention among researchers globally. This study evaluates the effects of two Chinese he...

journal_title：Trials

authors： Chan RY,Chien WT

更新日期：2014-07-02 00:00:00

abstract：BACKGROUND:In people with chronic obstructive pulmonary disease (COPD), limb-muscle dysfunction is one of the most troublesome systemic manifestations of the disease, which at the functional level is evidenced by reduced strength and endurance of limb muscles. Improving limb-muscle function is an important therapeutic ...

journal_title：Trials

authors： Frykholm E,Klijn P,Saey D,van Hees HWH,Stål P,Sandström T,Sörlin A,Maltais F,Nyberg A

更新日期：2019-01-03 00:00:00

abstract：BACKGROUND:Sub-threshold depression is common, impairs functioning, and increases the risk of developing major depression. Although psychological treatments have been investigated for sub-threshold depression, they are costly. A less costly alternative could be an educational health promotion campaign about effective s...

journal_title：Trials

authors： Morgan AJ,Jorm AF,Mackinnon AJ

更新日期：2011-01-13 00:00:00

abstract：BACKGROUND:The perimenopausal period refers to the interval when women's menstrual cycles become irregular and is characterized by an increased risk of depressive symptoms. Use of homeopathy to treat depression is widespread but there is a lack of clinical trials about its efficacy in depression in peri- and postmenopa...

journal_title：Trials

authors： Macías-Cortés Edel C,Aguilar-Faisal L,Asbun-Bojalil J

更新日期：2013-04-23 00:00:00

abstract：BACKGROUND:Burns and the associated wound care procedures can be extremely painful and anxiety-provoking for children. Burn injured children and adolescents are therefore at greater risk of experiencing a range of psychological reactions, in particular posttraumatic stress disorder, which can persist for months to year...

journal_title：Trials

authors： Chester SJ,Stockton K,De Young A,Kipping B,Tyack Z,Griffin B,Chester RL,Kimble RM

更新日期：2016-04-29 00:00:00

abstract：BACKGROUND:Previous research has suggested an association between more liberal red blood cell (RBC) transfusion and greater risk of further bleeding and mortality following acute upper gastrointestinal bleeding (AUGIB). METHODS AND DESIGN:The Transfusion in Gastrointestinal Bleeding (TRIGGER) trial is a pragmatic clus...

journal_title：Trials

authors： Kahan BC,Jairath V,Murphy MF,Doré CJ

更新日期：2013-07-10 00:00:00

abstract：BACKGROUND:Frozen shoulder (FS) is a musculoskeletal condition of poorly understood etiology that results in shoulder pain and large mobility deficits. Despite some physical therapy interventions, such as joint mobilization and exercise, having shown therapeutic benefit, a definitive treatment does not currently exist....

journal_title：Trials

authors： Lluch-Girbés E,Dueñas L,Mena-Del Horno S,Luque-Suarez A,Navarro-Ledesma S,Louw A

更新日期：2019-08-13 00:00:00

abstract：BACKGROUND:Tracheal intubation with the patient in the lateral position is difficult because the laryngeal view is compromised during direct laryngoscopy. Flexible video endoscopes may facilitate intubation even when laryngeal views are poor on direct laryngoscopy because the patients are positioned laterally. Thus, th...

journal_title：Trials

authors： Gao Y,Lin B,Huang J,Lin X,Lin C

更新日期：2019-03-15 00:00:00

abstract：BACKGROUND:Anaemia following hip fracture is common. Approximately 30 to 45% of patients have haemoglobin concentrations below population norms on admission, and around 10% are severely anaemic. Anaemia on admission, and in the postoperative period, is associated with poor outcomes with regard to mobility, postoperativ...

journal_title：Trials

authors： Rowlands M,Forward DP,Sahota O,Moppett IK

更新日期：2013-09-09 00:00:00

abstract：BACKGROUND:Callus is one of the most common foot skin complaints experienced by people of all ages. These painful and unsightly lesions often result in disability. The 'gold standard' of treatment is scalpel debridement by a trained specialist; however, people also seek over-the-counter remedies. There is a lack of cli...

journal_title：Trials

authors： Hashmi F,Nester CJ,Wright CR,Lam S

更新日期：2016-05-17 00:00:00

abstract：BACKGROUND:Depression and bipolar disorder are associated with reduced neural plasticity and deficits in memory, attention and executive function. Drug treatments for these affective disorders have insufficient clinical effects in a large group and fail to reverse cognitive deficits. There is thus a need for more effec...

journal_title：Trials

authors： Miskowiak KW,Vinberg M,Harmer CJ,Ehrenreich H,Knudsen GM,Macoveanu J,Hansen AR,Paulson OB,Siebner HR,Kessing LV

更新日期：2010-10-13 00:00:00

abstract：BACKGROUND:In a sham-controlled double-blind trial, we aim to establish the efficacy and safety of the local application of laser therapy in patients with diabetes, onychomycosis and risk factors for diabetes-related foot complications. Onychomycosis leads to thickened and distorted nails, which in turn lead to increas...

journal_title：Trials

authors： Nijenhuis-Rosien L,Kleefstra N,Wolfhagen MJ,Groenier KH,Bilo HJ,Landman GW

更新日期：2015-03-22 00:00:00

abstract：BACKGROUND:Intra-operative electrocorticography, based on interictal spikes and spike patterns, is performed to optimize delineation of the epileptogenic tissue during epilepsy surgery. High frequency oscillations (HFOs, 80-500 Hz) have been identified as more precise biomarkers for epileptogenic tissue. The aim of the...

journal_title：Trials

authors： van 't Klooster MA,Leijten FS,Huiskamp G,Ronner HE,Baayen JC,van Rijen PC,Eijkemans MJ,Braun KP,Zijlmans M,HFO study group.

更新日期：2015-09-23 00:00:00

abstract：BACKGROUND:Postoperative atrial fibrillation (POAF) is a common complication following cardiac surgery. POAF is associated with increased morbidity and hospital costs. We herein describe the protocol for a randomized controlled trial to determine if performing a posterior left pericardiotomy prevents POAF after cardiac...

journal_title：Trials

authors： Abouarab AA,Leonard JR,Ohmes LB,Lau C,Rong LQ,Ivascu NS,Pryor KO,Munjal M,Crea F,Massetti M,Sanna T,Girardi LN,Gaudino M

更新日期：2017-12-13 00:00:00

abstract：BACKGROUND:Chest tube insertion is a standard intervention for management of various injuries of the thorax. Quick and accurate execution facilitates efficient therapy without further complications. Here, we propose a new training concept comprised of e-learning elements as well as continuous rating using an objective ...

journal_title：Trials

authors： Friedrich M,Bergdolt C,Haubruck P,Bruckner T,Kowalewski KF,Müller-Stich BP,Tanner MC,Nickel F

更新日期：2017-02-06 00:00:00

abstract：BACKGROUND:Carpal tunnel syndrome (CTS) is the most common form of peripheral nerve injury, affecting approximately 3 % of the population. While surgery is effective in mild and moderate cases, nerve and functional recovery are often not complete in severe cases. Therefore, there is a need for adjuvant methods to impro...

journal_title：Trials

authors： Curran MW,Olson J,Morhart M,Sample D,Chan KM

更新日期：2016-04-14 00:00:00

abstract：BACKGROUND:Published evaluations of successful interventions to prevent falls in people with sight impairment (SI) are limited. The aim of this feasibility study is to optimise the design and investigation of home safety (HS) and home exercise (HE) programmes to prevent falls in older people with SI. METHODS:A communi...

journal_title：Trials

authors： Waterman H,Ballinger C,Brundle C,Chastin S,Gage H,Harper R,Henson D,Laventure B,McEvoy L,Pilling M,Olleveant N,Skelton DA,Stanford P,Todd C

更新日期：2016-09-26 00:00:00

abstract：BACKGROUND:Single-sided deafness (SSD) describes the presence of a unilateral severe to profound sensorineural hearing loss. SSD disrupts spatial hearing and understanding speech in background noise. It has functional, psychological and social consequences. Potential options for rehabilitation include hearing aids and ...

journal_title：Trials

authors： Katiri R,Hall DA,Buggy N,Hogan N,Horobin A,van de Heyning P,Firszt JB,Bruce IA,Kitterick PT

更新日期：2020-03-04 00:00:00

abstract：BACKGROUND:Osteoarthritis often results in prolonged periods of reduced physical activity and is associated with adverse health outcomes, including increased risk of cardiovascular and metabolic diseases. Exercise interventions for patients on the waiting list for arthroplasty can reduce the risk of long-term adverse o...

journal_title：Trials

authors： O'Brien J,Hamilton K,Williams A,Fell J,Mulford J,Cheney M,Wu S,Bird ML

更新日期：2018-08-07 00:00:00

abstract：BACKGROUND:Classroom-based stuttering intervention addressing negative peer attitudes, perceptions, teasing and bullying of children who stutter (CWS) is required as part of holistic stuttering management because of its occurrence in primary school. This study was conducted in 2017, in 10 primary schools in the Western...

journal_title：Trials

authors： Mallick R,Kathard H,Borhan ASM,Pillay M,Thabane L

更新日期：2018-11-29 00:00:00