解剖学和形态学

男科学

听力与言语-语言病理学

行为科学

细胞和组织工程学

牙科,口腔外科和医学

皮肤病学

肠胃学和肝脏学

医学伦理学

医学实验室技术

医学,法律

神经影像学

护理

产科医学和妇科医学

周围血管疾病

基本医疗保健

放射学,核医学和医学成像

康复学

兽医学

伦理学

老年医学

心理学,精神分析

  • Clinical application values of neutrophil-to-lymphocyte ratio in intracranial aneurysms.

    abstract::Inflammation plays an important role in the pathogenesis and growth of intracranial aneurysms (IAs). We investigated the clinical value of the neutrophil-to-lymphocyte ratio (NLR) as a marker of systemic subclinical inflammation in patients with IAs. Consecutive patients with IAs who underwent endovascular treatment (...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.202445

    authors: Zhang B,Lin L,Yuan F,Song G,Chang Q,Wu Z,Miao Z,Mo D,Huo X,Liu A

    更新日期:2021-02-01 00:00:00

  • Children as messengers of health knowledge? Impact of health promotion and water infrastructure in schools on facial cleanliness and trachoma in the community.

    abstract:BACKGROUND:Health promotion is essential to the SAFE strategy for trachoma elimination. Schools are a valuable venue for health promotion. However, there is little literature about the impact of health education and water infrastructure in schools on facial cleanliness and trachoma in the community. Our study aimed to ...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章

    doi:10.1371/journal.pntd.0009119

    authors: Chen X,Munoz B,Mkocha H,Wolle MA,K West S

    更新日期:2021-02-01 00:00:00

  • Effect of immunosuppressants on the parasite load developed in, and immune response to, visceral leishmaniasis: A comparative study in a mouse model.

    abstract::The increasing use of immunosuppressants in areas where visceral leishmaniasis (VL) is endemic has increased the number of people susceptible to developing more severe forms of the disease. Few studies have examined the quality of the immune response in immunosuppressed patients or experimental animals with VL. The pr...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章

    doi:10.1371/journal.pntd.0009126

    authors: Bernardo L,Solana JC,Romero-Kauss A,Sánchez C,Carrillo E,Moreno J

    更新日期:2021-02-01 00:00:00

  • Comparative genomic and phenotypic characterization of invasive non-typhoidal Salmonella isolates from Siaya, Kenya.

    abstract::Non-typhoidal Salmonella (NTS) is a major global health concern that often causes bloodstream infections in areas of the world affected by malnutrition and comorbidities such as HIV and malaria. Developing a strategy to control the emergence and spread of highly invasive and antimicrobial resistant NTS isolates requir...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章

    doi:10.1371/journal.pntd.0008991

    authors: Kubicek-Sutherland JZ,Xie G,Shakya M,Dighe PK,Jacobs LL,Daligault H,Davenport K,Stromberg LR,Stromberg ZR,Cheng Q,Kempaiah P,Ong'echa JM,Otieno V,Raballah E,Anyona S,Ouma C,Chain PSG,Perkins DJ,Mukundan H,McMahon BH

    更新日期:2021-02-01 00:00:00

  • ZG16 regulates PD-L1 expression and promotes local immunity in colon cancer.

    abstract::CRC is a heterogeneous disease due to global molecular alterations, including mismatch-repair-deficient (dMMR) and microsatellite instability-high (MSI-H). Immunotherapy has achieved durable responses in a subset of patients with dMMR-MSI-H metastatic CRC. It has been showed that Loss of ZG16 is highly associated with...

    journal_title:Translational oncology

    pub_type: 杂志文章

    doi:10.1016/j.tranon.2020.101003

    authors: Meng H,Ding Y,Liu E,Li W,Wang L

    更新日期:2021-02-01 00:00:00

  • MicroRNA-506-3p increases the response to PARP inhibitors and cisplatin by targeting EZH2/β-catenin in serous ovarian cancers.

    abstract::Chemo-resistance is an important barrier to effective treatment of ovarian cancer. Poly (ADP-ribose) polymerase (PARP) inhibitors are currently promising targeted drugs used to treat BRCA-mutant ovarian cancer. Ovarian cancer patients with BRCA 1/2 mutations appear to benefit better from PARP inhibitors and chemothera...

    journal_title:Translational oncology

    pub_type: 杂志文章

    doi:10.1016/j.tranon.2020.100987

    authors: Sun Y,Wu J,Dong X,Zhang J,Meng C,Liu G

    更新日期:2021-02-01 00:00:00

  • Exercise Benefits Meet Cancer Immunosurveillance: Implications for Immunotherapy.

    abstract::Regular exercise reduces the risk of cancer. One potential mechanism for this efficacy is improved antitumor immunity. This is an important issue because evading immune destruction is a hallmark of cancer and immunotherapy is reshaping cancer treatment. Here we review recent developments reported by Wennerberg et al.,...

    journal_title:Trends in cancer

    pub_type: 杂志文章

    doi:10.1016/j.trecan.2020.12.003

    authors: Fiuza-Luces C,Valenzuela PL,Castillo-García A,Lucia A

    更新日期:2021-02-01 00:00:00

  • Extracellular heat shock proteins and cancer: New perspectives.

    abstract::Heat shock proteins (HSPs) are a large family of molecular chaperones aberrantly expressed in cancer. The expression of HSPs in tumor cells has been shown to be implicated in the regulation of apoptosis, immune responses, angiogenesis and metastasis. Given that extracellular vesicles (EVs) can serve as potential sourc...

    journal_title:Translational oncology

    pub_type: 杂志文章,评审

    doi:10.1016/j.tranon.2020.100995

    authors: Albakova Z,Siam MKS,Sacitharan PK,Ziganshin RH,Ryazantsev DY,Sapozhnikov AM

    更新日期:2021-02-01 00:00:00

  • Clinical and pathological significance of programmed cell death 1 (PD-1)/programmed cell death ligand 1 (PD-L1) expression in high grade serous ovarian cancer.

    abstract::We investigated programmed cell death 1 (PD-1) / programmed cell death ligand 1 (PD-L1) expression in high grade serous ovarian cancer (HGSOC) and its relationship to tumor infiltrating lymphocytes (TIL) and prognosis. Formalin fixed paraffin embedded (FFPE) samples of 94 HGSOC cases were included in the study. Immuno...

    journal_title:Translational oncology

    pub_type: 杂志文章

    doi:10.1016/j.tranon.2020.100994

    authors: Baş Y,Koç N,Helvacı K,Koçak C,Akdeniz R,Şahin HHK

    更新日期:2021-02-01 00:00:00

  • Emerging Players in Prostate Cancer-Bone Niche Communication.

    abstract::Patients with advanced prostate cancer (PCa) frequently develop skeletal metastases that are associated with fractures, disability, and increased mortality. Within the bone metastatic niche, mutual interactions between tumor cells and osteoblasts have been proposed as major contributors of osteotropism by PCa. Here, w...

    journal_title:Trends in cancer

    pub_type: 杂志文章,评审

    doi:10.1016/j.trecan.2020.09.006

    authors: Furesi G,Rauner M,Hofbauer LC

    更新日期:2021-02-01 00:00:00

  • Surgical tracheotomy.

    abstract::In spite of the ever-increasing hyper-specialization of gastro-intestinal surgeons, some surgical emergency procedures, such as tracheotomy, need to be mastered. The need for tracheotomy is sometimes so urgent that one cannot wait for a specialized surgeon to arrive or to transport the patient elsewhere. Even though p...

    journal_title:Journal of visceral surgery

    pub_type: 杂志文章

    doi:10.1016/j.jviscsurg.2020.10.002

    authors: Gaubert N,Crambert A,Malgras B

    更新日期:2021-02-01 00:00:00

  • Effects of Smartphone-Based Interventions on Physical Activity in Children and Adolescents: Systematic Review and Meta-analysis.

    abstract:BACKGROUND:About 70% of children and adolescents worldwide do not meet the recommended level of physical activity (PA), which is closely associated with physical, psychological, and cognitive well-being. Nowadays, the use of technologies to change PA is of interest due to the need for novel, more effective intervention...

    journal_title:JMIR mHealth and uHealth

    pub_type: 杂志文章,评审

    doi:10.2196/22601

    authors: He Z,Wu H,Yu F,Fu J,Sun S,Huang T,Wang R,Chen D,Zhao G,Quan M

    更新日期:2021-02-01 00:00:00

  • Effect of physical exercise in bariatric surgery patients: protocol of a randomized controlled clinical trial.

    abstract:BACKGROUND:Bariatric surgery is an effective approach to weight loss and long-term comorbidity resolution. Although recommended in several guidelines, supervised exercise has not been systematically prescribed after bariatric surgery. The aim of this study is to determine the effects of two types of exercise, moderate-...

    journal_title:Trials

    pub_type: 杂志文章

    doi:10.1186/s13063-021-05056-4

    authors: Herrera-Santelices A,Tabach-Apraiz A,Andaur-Cáceres K,Zamunér AR

    更新日期:2021-02-01 00:00:00

  • Drug resistance of pathogens causing nosocomial infection in orthopedics from 2012 to 2017: a 6-year retrospective study.

    abstract:BACKGROUND:Hospital-acquired infections (HAIs) are an emerging global problem that increases in-hospital mortality, length of stay, and cost. We performed a 6-year retrospective study to provide valuable insight into appropriate antibiotic use in HAI cases. We also aimed to understand how hospitals could reduce pathoge...

    journal_title:Journal of orthopaedic surgery and research

    pub_type: 杂志文章

    doi:10.1186/s13018-021-02234-7

    authors: Yang X,Guo R,Xie B,Lai Q,Xu J,Hu N,Wan L,Dai M,Zhang B

    更新日期:2021-02-01 00:00:00

  • Seasonal malaria chemoprevention in the Sahel subregion of Africa: a cost-effectiveness and cost-savings analysis.

    abstract:BACKGROUND:The intermittent administration of seasonal malaria chemoprevention (SMC) is recommended to prevent malaria among children aged 3-59 months in areas of the Sahel subregion in Africa. However, the cost-effectiveness and cost savings of SMC have not previously been evaluated in large-scale studies. METHODS:We...

    journal_title:The Lancet. Global health

    pub_type: 杂志文章

    doi:10.1016/S2214-109X(20)30475-7

    authors: Gilmartin C,Nonvignon J,Cairns M,Milligan P,Bocoum F,Winskill P,Moroso D,Collins D

    更新日期:2021-02-01 00:00:00

  • Chromobox 4 facilitates tumorigenesis of lung adenocarcinoma through the Wnt/β-catenin pathway.

    abstract::Chromobox 4 (CBX4) is a core component of polycomb-repressive complex 1 with important roles in cancer biology and tissue homeostasis. Aberrant expression of CBX4 has been implicated in several human malignancies. However, its role and underlying mechanisms in the tumorigenesis of lung adenocarcinoma (LUAD) have not b...

    journal_title:Neoplasia (New York, N.Y.)

    pub_type: 杂志文章

    doi:10.1016/j.neo.2020.12.005

    authors: Wang Z,Fang Z,Chen G,Liu B,Xu J,Li F,Li F,Liu H,Zhang H,Sun Y,Tian G,Chen H,Xu G,Zhang L,Hu L,Ji H

    更新日期:2021-02-01 00:00:00

  • Quantifying ADC bystander payload penetration with cellular resolution using pharmacodynamic mapping.

    abstract::With the recent approval of 3 new antibody drug conjugates (ADCs) for solid tumors, this class of drugs is gaining momentum for the targeted treatment of cancer. Despite significant investment, there are still fundamental issues that are incompletely understood. Three of the recently approved ADCs contain payloads exh...

    journal_title:Neoplasia (New York, N.Y.)

    pub_type: 杂志文章

    doi:10.1016/j.neo.2020.12.001

    authors: Khera E,Cilliers C,Smith MD,Ganno ML,Lai KC,Keating TA,Kopp A,Nessler I,Abu-Yousif AO,Thurber GM

    更新日期:2021-02-01 00:00:00

  • Tumor necrosis factor receptor signaling modulates carcinogenesis in a mouse model of breast cancer.

    abstract::Pro-inflammatory conditions have long been associated with mammary carcinogenesis and breast cancer progression. The underlying mechanisms are incompletely understood but signaling of pro-inflammatory cytokine TNFα through its receptors TNFR1 and TNFR2 is a major mediator of inflammation in both obesity and in the res...

    journal_title:Neoplasia (New York, N.Y.)

    pub_type: 杂志文章

    doi:10.1016/j.neo.2020.12.007

    authors: He L,Bhat K,Duhacheck-Muggy S,Ioannidis A,Zhang L,Nguyen NT,Moatamed NA,Pajonk F

    更新日期:2021-02-01 00:00:00

  • Trajectories of anxiety and depressive symptoms during enforced isolation due to COVID-19 in England: a longitudinal observational study.

    abstract:BACKGROUND:There is major concern about the impact of the global COVID-19 outbreak on mental health. Several studies suggest that mental health deteriorated in many countries before and during enforced isolation (ie, lockdown), but it remains unknown how mental health has changed week by week over the course of the COV...

    journal_title:The lancet. Psychiatry

    pub_type: 杂志文章

    doi:10.1016/S2215-0366(20)30482-X

    authors: Fancourt D,Steptoe A,Bu F

    更新日期:2021-02-01 00:00:00

  • Trends in prevalence of blindness and distance and near vision impairment over 30 years: an analysis for the Global Burden of Disease Study.

    abstract:BACKGROUND:To contribute to the WHO initiative, VISION 2020: The Right to Sight, an assessment of global vision impairment in 2020 and temporal change is needed. We aimed to extensively update estimates of global vision loss burden, presenting estimates for 2020, temporal change over three decades between 1990-2020, an...

    journal_title:The Lancet. Global health

    pub_type: 杂志文章

    doi:10.1016/S2214-109X(20)30425-3

    authors: GBD 2019 Blindness and Vision Impairment Collaborators.,Vision Loss Expert Group of the Global Burden of Disease Study.

    更新日期:2021-02-01 00:00:00

  • The acceptability and feasibility of using a 3D body size scale to initiate conversations about weight in toddlerhood: a mixed-methods study.

    abstract:BACKGROUND:Health Care Professionals struggle to initiate conversations about overweight in toddlerhood. A novel 3D body size scale (3D BSS) may facilitate engagement with this topic during pediatric appointments. OBJECTIVES:To explore barriers and facilitators to using the 3D BSS through a mixed-methods design. METH...

    journal_title:Pediatric obesity

    pub_type: 杂志文章

    doi:10.1111/ijpo.12715

    authors: Tommerup K,Smith AD,Evans EH,Croker H,Steptoe A,Tovee MJ,Fildes A,Llewellyn C

    更新日期:2021-02-01 00:00:00

  • Physical Health in Adults Born With Cleft Lip and/or Palate: A Whole of Life Survey in the United Kingdom.

    abstract:OBJECTIVES:Previous research in the field of cleft lip and/or palate (CL/P) has indicated a high prevalence of common health concerns, functional difficulties, and additional conditions known to affect long-term physical health, cognitive development, and psychological well-being. The aim of the present study was to ex...

    journal_title:The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association

    pub_type: 杂志文章

    doi:10.1177/1055665620944758

    authors: Ardouin K,Davis S,Stock NM

    更新日期:2021-02-01 00:00:00

  • Safety and effectiveness of Omnitrope® in patients with growth hormone deficiency: snapshot analysis of PATRO Adults study in the Italian population.

    abstract:PURPOSE:PATRO adults is an ongoing, multicenter, observational, post-marketing surveillance study aimed at investigating the long-term safety (primary endpoint) and effectiveness (secondary endpoint) of the recombinant human growth hormone (rhGH) Omnitrope® during routine clinical practice. This report describes data f...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/s40618-020-01308-3

    authors: Arosio M,Arnaldi G,Gasco V,Giavoli C,Puxeddu E,Vettor R,Ambrosio MR,Gallinari P,Zouater H,Fedeli P,Ferone D

    更新日期:2021-02-01 00:00:00

  • Psychological impact of the COVID-19 pandemic within institutional quarantine and isolation centres and its sociodemographic correlates in Qatar: a cross-sectional study.

    abstract:SETTING:The State of Qatar has had one of the highest COVID-19 infection rates globally and has used state-managed quarantine and isolation centres to limit the spread of infection. Quarantine and isolation have been shown to negatively affect the mental health of individuals. Qatar has a unique population, with around...

    journal_title:BMJ open

    pub_type: 杂志文章

    doi:10.1136/bmjopen-2020-045794

    authors: Reagu S,Wadoo O,Latoo J,Nelson D,Ouanes S,Masoodi N,Karim MA,Iqbal Y,Al Abdulla S,Al Nuaimi SK,Abdelmajid AAB,Al Samawi MS,Khoodoruth MAS,Khoodoruth WNC,Al-Maslamani MARS,Alabdulla M

    更新日期:2021-01-31 00:00:00

  • Scoping review protocol: bladder cancer in Nigeria: what are the gaps in clinical care and research?

    abstract:INTRODUCTION:Bladder cancer (BC) is the 10th common cancer worldwide and ranks seventh in Nigeria. This scoping review aims to identify the gaps in clinical care and research of BC in Nigeria as part of the development of a larger national research programme aiming to improve outcomes and care of BC. METHODS AND ANALY...

    journal_title:BMJ open

    pub_type: 杂志文章

    doi:10.1136/bmjopen-2020-041894

    authors: Kibaru J,Kotecha P,Iya AM,Russell B,Abdullahi M,Alhassan SU,Mustapha MI,Bryan RT,Van Hemelrijck M

    更新日期:2021-01-31 00:00:00

  • PD-1 siRNA-Encapsulated Solid Lipid Nanoparticles Downregulate PD-1 Expression by Macrophages and Inhibit Tumor Growth : PD-1 siRNA-Encapsulated Solid Lipid Nanoparticles.

    abstract::The present study was designed to test the hypothesis that programmed cell death-1 (PD-1) siRNA can downregulate PD-1 expression in macrophages in culture and in tumor tissues in mice and inhibit tumor growth in a mouse model. PD-1 siRNA was encapsulated in solid lipid nanoparticles (SLNs), and the physical properties...

    journal_title:AAPS PharmSciTech

    pub_type: 杂志文章

    doi:10.1208/s12249-021-01933-y

    authors: Hanafy MS,Hufnagel S,Trementozzi AN,Sakran W,Stachowiak JC,Koleng JJ,Cui Z

    更新日期:2021-01-31 00:00:00

  • Genetic, epigenetic, and environmental factors controlling oxytocin receptor gene expression.

    abstract:BACKGROUND:The neuropeptide oxytocin regulates mammalian social behavior. Disruptions in oxytocin signaling are a feature of many psychopathologies. One commonly studied biomarker for oxytocin involvement in psychiatric diseases is DNA methylation at the oxytocin receptor gene (OXTR). Such studies focus on DNA methylat...

    journal_title:Clinical epigenetics

    pub_type: 杂志文章

    doi:10.1186/s13148-021-01017-5

    authors: Danoff JS,Wroblewski KL,Graves AJ,Quinn GC,Perkeybile AM,Kenkel WM,Lillard TS,Parikh HI,Golino HF,Gregory SG,Carter CS,Bales KL,Connelly JJ

    更新日期:2021-01-30 00:00:00

  • Transcriptomic and Functional Analyses of Mitochondrial Dysfunction in Pressure Overload-Induced Right Ventricular Failure.

    abstract::Background In complex congenital heart disease patients such as those with tetralogy of Fallot, the right ventricle (RV) is subject to pressure overload, leading to RV hypertrophy and eventually RV failure. The mechanisms that promote the transition from stable RV hypertrophy to RV failure are unknown. We evaluated th...

    journal_title:Journal of the American Heart Association

    pub_type: 杂志文章

    doi:10.1161/JAHA.120.017835

    authors: Hwang HV,Sandeep N,Nair RV,Hu DQ,Zhao M,Lan IS,Fajardo G,Matkovich SJ,Bernstein D,Reddy S

    更新日期:2021-01-30 00:00:00

  • The effectiveness of Tai Chi on the depressive symptom of young adults with subthreshold depression: a study protocol for a randomized controlled trial.

    abstract:BACKGROUND:Depression is seriously affecting the physical and mental health of young people worldwide. Subthreshold depression, as an early stage of depression, is essential for early prevention and treatment of depression. Tai Chi, as a traditional Chinese mind-body therapy, may become an alternative intervention. How...

    journal_title:Trials

    pub_type: 杂志文章

    doi:10.1186/s13063-021-05054-6

    authors: Xie X,Song J,Zhu J,Han M,He Y,Huang J,Tao J,Wu J

    更新日期:2021-01-30 00:00:00

  • Quantitative assessment of left ventricular longitudinal function and myocardial deformation in Duchenne muscular dystrophy patients.

    abstract:BACKGROUND:Duchenne muscular dystrophy (DMD) manifests in males mainly by skeletal muscle impairment, but also by cardiac dysfunction. The assessment of the early phases of cardiac involvement using echocardiography is often very difficult to perform in these patients. The aim of the study was to use cardiac magnetic r...

    journal_title:Orphanet journal of rare diseases

    pub_type: 杂志文章

    doi:10.1186/s13023-021-01704-9

    authors: Panovský R,Pešl M,Máchal J,Holeček T,Feitová V,Juříková L,Masárová L,Pešlová E,Opatřil L,Mojica-Pisciotti ML,Kincl V

    更新日期:2021-01-30 00:00:00

  • Talar fracture: epidemiology, treatment and results in a multicenter series.

    abstract:INTRODUCTION:Talar fracture is rare. Treatment is surgical for neck and/or body fractures with displacement. The aims of the present study were to collect epidemiological data on talar fractures, and to assess the impact of trauma via various functional scores and radiographic impact in the medium term. HYPOTHESIS:Dis...

    journal_title:Orthopaedics & traumatology, surgery & research : OTSR

    pub_type: 杂志文章

    doi:10.1016/j.otsr.2021.102835

    authors: Sautet P,Roussignol X,Loubignac F,Rochwerger RA,Pidhorz L,French Society of Orthopedic Surgery and Traumatology (SoFCOT).

    更新日期:2021-01-29 00:00:00

  • Identification and validation of methylated differentially expressed miRNAs and immune infiltrate profile in EBV-associated gastric cancer.

    abstract:BACKGROUND:The recent discovery of cancer/tissue specificity of miRNA has indicated its great potential as a therapeutic target. In Epstein-Barr virus-associated gastric cancer (EBVaGC), host genes are affected by extensive DNA methylation, including miRNAs. However, the role of methylated miRNA in the development of E...

    journal_title:Clinical epigenetics

    pub_type: 杂志文章

    doi:10.1186/s13148-020-00989-0

    authors: Zhu M,Liang Q,Chen T,Kong Q,Ye G,Yu S,Li X,He Q,Liu H,Hu Y,Yu J,Li G

    更新日期:2021-01-29 00:00:00

  • Role of antenatal plasma cytomegalovirus DNA levels on pregnancy outcome and HIV-1 vertical transmission among mothers in the University of Zimbabwe birth cohort study (UZBCS).

    abstract:INTRODUCTION:Despite being a leading infectious cause of childhood disability globally, testing for cytomegalovirus (CMV) infections in pregnancy is generally not done in Sub-Sahara Africa (SSA), where breastfeeding practice is almost universal. Whilst CMV and human immunodeficiency virus (HIV) are both endemic in SSA,...

    journal_title:Virology journal

    pub_type: 杂志文章

    doi:10.1186/s12985-021-01494-3

    authors: Duri K,Chimhuya S,Gomo E,Munjoma PT,Chandiwana P,Yindom LM,Mhandire K,Ziruma A,Mtapuri-Zinyowera S,Mazengera LR,Misselwitz B,Gumbo FZ,Jordi S,Rowland-Jones S,for (UZBCS) The U Z Birth Cohort Study Team.

    更新日期:2021-01-29 00:00:00

  • Pulse-Controlled Amplification-A new powerful tool for on-site diagnostics under resource limited conditions.

    abstract:BACKGROUND:Molecular diagnostics has become essential in the identification of many infectious and neglected diseases, and the detection of nucleic acids often serves as the gold standard technique for most infectious agents. However, established techniques like polymerase chain reaction (PCR) are time-consuming labora...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章

    doi:10.1371/journal.pntd.0009114

    authors: Müller K,Daßen S,Holowachuk S,Zwirglmaier K,Stehr J,Buersgens F,Ullerich L,Stoecker K

    更新日期:2021-01-29 00:00:00

  • Investigational Studies on a Hit Compound Cyclopropane-Carboxylic Acid Derivative Targeting O-Acetylserine Sulfhydrylase as a Colistin Adjuvant.

    abstract::Antibacterial adjuvants are of great significance, since they allow the therapeutic dose of conventional antibiotics to be lowered and reduce the insurgence of antibiotic resistance. Herein, we report that an O-acetylserine sulfhydrylase (OASS) inhibitor can be used as a colistin adjuvant to treat infections caused by...

    journal_title:ACS infectious diseases

    pub_type: 杂志文章

    doi:10.1021/acsinfecdis.0c00378

    authors: Annunziato G,Spadini C,Franko N,Storici P,Demitri N,Pieroni M,Flisi S,Rosati L,Iannarelli M,Marchetti M,Magalhaes J,Bettati S,Mozzarelli A,Cabassi CS,Campanini B,Costantino G

    更新日期:2021-01-29 00:00:00

  • Risks of poor asthma outcome in 14,405 children and young people in London.

    abstract::This is a 12-month retrospective data analysis (2018/19) of asthma risk factors in 350 North West London general practices. Fourteen thousand four hundred and five of the 482,029 (40% female) children and young people (CYP) had diagnosed asthma. Exacerbations are as follows: (i) 749 (5%) CYP had 797 hospital admission...

    journal_title:NPJ primary care respiratory medicine

    pub_type: 杂志文章

    doi:10.1038/s41533-020-00215-7

    authors: Levy ML

    更新日期:2021-01-29 00:00:00

  • Automatic brain lesion segmentation on standard magnetic resonance images: a scoping review.

    abstract:OBJECTIVES:Medical image analysis practices face challenges that can potentially be addressed with algorithm-based segmentation tools. In this study, we map the field of automatic MR brain lesion segmentation to understand the clinical applicability of prevalent methods and study designs, as well as challenges and limi...

    journal_title:BMJ open

    pub_type: 杂志文章

    doi:10.1136/bmjopen-2020-042660

    authors: Gryska E,Schneiderman J,Björkman-Burtscher I,Heckemann RA

    更新日期:2021-01-29 00:00:00

  • Patient and public priorities for breast cancer research: a qualitative study in the UK.

    abstract:OBJECTIVE:Internationally recognised specialist breast cancer scientists, clinicians and healthcare professionals have published breast cancer research gaps that are informing research funding priorities in the UK and worldwide. We aimed to determine the breast cancer research priorities of the public to compare with t...

    journal_title:BMJ open

    pub_type: 杂志文章

    doi:10.1136/bmjopen-2019-036072

    authors: Boundouki G,Wilson R,Duxbury P,Henderson J,Ballance L,Wray J,Appanah V,Ibrahim I,Harvey J,Kirwan CC,Northwest Breast Research Collaborative.

    更新日期:2021-01-29 00:00:00

  • Adipose-derived cellular therapies prolong graft survival in an allogenic hind limb transplantation model.

    abstract:BACKGROUND:The long-term survival after vascularized composite allotransplantation (VCA) is often limited by systemic rejection as well as the adverse effects of immunosuppressants. The stromal vascular fraction (SVF) can be expanded to produce adipose-derived stem cells (ADSC) which represents a combination of endothe...

    journal_title:Stem cell research & therapy

    pub_type: 杂志文章

    doi:10.1186/s13287-021-02162-7

    authors: Chen J,Wang Y,Hu H,Xiong Y,Wang S,Yang J

    更新日期:2021-01-29 00:00:00

  • Comparative efficacy of pharmacological agents on reducing the risk of major adverse cardiovascular events in the hypertriglyceridemia population: a network meta-analysis.

    abstract:BACKGROUND:Hypertriglyceridemia (HTG) is considered an independent risk factor for major adverse cardiovascular events (MACE). METHODS:This study analyzed the effects of various agents on MACE risk reduction in HTG (serum triglyceride ≥ 150 mg/dl) populations by performing a network meta-analysis. We performed a frequ...

    journal_title:Diabetology & metabolic syndrome

    pub_type: 杂志文章

    doi:10.1186/s13098-021-00626-7

    authors: Qi YY,Yan L,Wang ZM,Wang X,Meng H,Li WB,Chen DC,Li M,Liu J,An ST

    更新日期:2021-01-29 00:00:00

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