Hydroxyethylstarch revisited for acute brain injury treatment.

Abstract:

:Infusion of the colloid hydroxyethylstarch has been used for volume substitution to maintain hemodynamics and microcirculation after e.g., severe blood loss. In the last decade it was revealed that hydroxyethylstarch can aggravate acute kidney injury, especially in septic patients. Because of the serious risk for critically ill patients, the administration of hydroxyethylstarch was restricted for clinical use. Animal studies and recently published in vitro experiments showed that hydroxyethylstarch might exert protective effects on the blood-brain barrier. Since the prevention of blood-brain barrier disruption was shown to go along with the reduction of brain damage after several kinds of insults, we revisit the topic hydroxyethylstarch and discuss a possible niche for the application of hydroxyethylstarch in acute brain injury treatment.

journal_name

Neural Regen Res

authors

Schick MA,Burek M,Förster CY,Nagai M,Wunder C,Neuhaus W

doi

10.4103/1673-5374.300978

subject

Has Abstract

pub_date

2021-07-01 00:00:00

pages

1372-1376

issue

7

eissn

1673-5374

issn

1876-7958

pii

NeuralRegenRes_2021_16_7_1372_300978

journal_volume

16

pub_type

杂志文章,评审
  • Fresh human amniotic membrane effectively promotes the repair of injured common peroneal nerve.

    abstract::Suture and autologous nerve transplantation are the primary therapeutic measures for completely severed nerves. However, imbalances in the microenvironment and adhesion of surrounding tissues can affect the quality of nerve regeneration and repair. Previous studies have shown that human amniotic membrane can promote t...

    journal_title:Neural regeneration research

    pub_type: 杂志文章

    doi:10.4103/1673-5374.262596

    authors: Zhang ZY,Yang J,Fan ZH,Wang DL,Wang YY,Zhang T,Yu LM,Yu CY

    更新日期:2019-12-01 00:00:00

  • Targeting β-secretase with RNAi in neural stem cells for Alzheimer's disease therapy.

    abstract::There are several major pathological changes in Alzheimer's disease, including apoptosis of cholinergic neurons, overactivity or overexpression of β-site amyloid precursor protein cleaving enzyme 1 (BACE1) and inflammation. In this study, we synthesized a 19-nt oligonucleotide targeting BACE1, the key enzyme in amyloi...

    journal_title:Neural regeneration research

    pub_type: 杂志文章

    doi:10.3969/j.issn.1673-5374.2013.33.003

    authors: Liu Z,Li S,Liang Z,Zhao Y,Zhang Y,Yang Y,Wang M,Li F

    更新日期:2013-11-25 00:00:00

  • Protective effect of ginkgo proanthocyanidins against cerebral ischemia/reperfusion injury associated with its antioxidant effects.

    abstract::Proanthocyanidins have been shown to effectively protect ischemic neurons, but its mechanism remains poorly understood. Ginkgo proanthocyanidins (20, 40, 80 mg/kg) were intraperitoneally administered 1, 24, 48 and 72 hours before reperfusion. Results showed that ginkgo proanthocyanidins could effectively mitigate neur...

    journal_title:Neural regeneration research

    pub_type: 杂志文章

    doi:10.4103/1673-5374.194722

    authors: Cao WL,Huang HB,Fang L,Hu JN,Jin ZM,Wang RW

    更新日期:2016-11-01 00:00:00

  • Extracellular vesicles in the diagnosis and treatment of central nervous system diseases.

    abstract::Extracellular vesicles, including exosomes and microvesicles, play a fundamental role in the activity of the nervous system, participating in signal transmission between neurons and providing the interaction of central nervous system with all body systems. In many neurodegenerative diseases, neurons pack toxic substan...

    journal_title:Neural regeneration research

    pub_type: 杂志文章,评审

    doi:10.4103/1673-5374.266908

    authors: Shaimardanova AA,Solovyeva VV,Chulpanova DS,James V,Kitaeva KV,Rizvanov AA

    更新日期:2020-04-01 00:00:00

  • The calmodulin-dependent protein kinase II inhibitor KN-93 protects rat cerebral cortical neurons from N-methyl-D-aspartic acid-induced injury.

    abstract::In this study, primary cultured cerebral cortical neurons of Sprague-Dawley neonatal rats were treated with 0.25, 0.5, and 1.0 μM calmodulin-dependent protein kinase II inhibitor KN-93 after 50 μM N-methyl-D-aspartic acid-induced injury. Results showed that, compared with N-methyl-Daspartic acid-induced injury neurons...

    journal_title:Neural regeneration research

    pub_type: 杂志文章

    doi:10.3969/j.issn.1673-5374.2013.02.002

    authors: Liu X,Ma C,Xing R,Zhang W,Tian B,Li X,Li Q,Zhang Y

    更新日期:2013-01-15 00:00:00

  • Neuroprotective effect of ischemic preconditioning in focal cerebral infarction: relationship with upregulation of vascular endothelial growth factor.

    abstract::Neuroprotection by ischemic preconditioning has been confirmed by many studies, but the precise mechanism remains unclear. In the present study, we performed cerebral ischemic preconditioning in rats by simulating a transient ischemic attack twice (each a 20-minute occlusion of the middle cerebral artery) before induc...

    journal_title:Neural regeneration research

    pub_type: 杂志文章

    doi:10.4103/1673-5374.135313

    authors: Liu Y,Zhu S,Wang Y,Hu J,Xu L,Ding L,Liu G

    更新日期:2014-06-01 00:00:00

  • Nanoparticles carrying neurotrophin-3-modified Schwann cells promote repair of sciatic nerve defects.

    abstract::Schwann cells and neurotrophin-3 play an important role in neural regeneration, but the secretion of neurotrophin-3 from Schwann cells is limited, and exogenous neurotrophin-3 is inactived easily in vivo. In this study, we have transfected neurotrophin-3 into Schwann cells cultured in vitro using nanoparticle liposome...

    journal_title:Neural regeneration research

    pub_type: 杂志文章

    doi:10.3969/j.issn.1673-5374.2013.14.002

    authors: Zong H,Zhao H,Zhao Y,Jia J,Yang L,Ma C,Zhang Y,Dong Y

    更新日期:2013-05-15 00:00:00

  • Quantitative analysis of intraspinal cerebrospinal fluid flow in normal adults.

    abstract::The present study quantitatively analyzed intraspinal cerebrospinal fluid flow patterns in 19 normal adults using fast cine phase-contrast magnetic resonance imaging. Results showed increased downward flow velocity and volume compared with upward flow, and the average downward flow volume of intraspinal cerebrospinal ...

    journal_title:Neural regeneration research

    pub_type: 杂志文章

    doi:10.3969/j.issn.1673-5374.2012.15.007

    authors: Yan L,Liu H,Shang H

    更新日期:2012-05-25 00:00:00

  • Factors predicting sensory and motor recovery after the repair of upper limb peripheral nerve injuries.

    abstract:OBJECTIVE:To investigate the factors associated with sensory and motor recovery after the repair of upper limb peripheral nerve injuries. DATA SOURCES:The online PubMed database was searched for English articles describing outcomes after the repair of median, ulnar, radial, and digital nerve injuries in humans with a ...

    journal_title:Neural regeneration research

    pub_type: 杂志文章

    doi:10.4103/1673-5374.130094

    authors: He B,Zhu Z,Zhu Q,Zhou X,Zheng C,Li P,Zhu S,Liu X,Zhu J

    更新日期:2014-03-15 00:00:00

  • Exogenous platelet-derived growth factor improves neurovascular unit recovery after spinal cord injury.

    abstract::The blood-spinal cord barrier plays a vital role in recovery after spinal cord injury. The neurovascular unit concept emphasizes the relationship between nerves and vessels in the brain, while the effect of the blood-spinal cord barrier on the neurovascular unit is rarely reported in spinal cord injury studies. Mouse ...

    journal_title:Neural regeneration research

    pub_type: 杂志文章

    doi:10.4103/1673-5374.295347

    authors: Ye LX,An NC,Huang P,Li DH,Zheng ZL,Ji H,Li H,Chen DQ,Wu YQ,Xiao J,Xu K,Li XK,Zhang HY

    更新日期:2021-04-01 00:00:00

  • Local inhibition of GABA affects precedence effect in the inferior colliculus.

    abstract::The precedence effect is a prerequisite for faithful sound localization in a complex auditory environment, and is a physiological phenomenon in which the auditory system selectively suppresses the directional information from echoes. Here we investigated how neurons in the inferior colliculus respond to the paired sou...

    journal_title:Neural regeneration research

    pub_type: 杂志文章

    doi:10.4103/1673-5374.128250

    authors: Wang Y,Wang N,Wang D,Jia J,Liu J,Xie Y,Wen X,Li X

    更新日期:2014-02-15 00:00:00

  • L-3-n-butylphthalide protects against vascular dementia via activation of the Akt kinase pathway.

    abstract::As a neuroprotective drug for the treatment of ischemic stroke, 3-n-butylphthalide, a celery seed extract, has been approved by the State Food and Drug Administration of China as a clinical therapeutic drug for ischemic stroke patients. L-3-n-butylphthalide possesses significant efficacy in the treatment of acute isch...

    journal_title:Neural regeneration research

    pub_type: 杂志文章

    doi:10.3969/j.issn.1673-5374.2013.19.001

    authors: Huai Y,Dong Y,Xu J,Meng N,Song C,Li W,Lv P

    更新日期:2013-07-05 00:00:00

  • Brain-derived neurotrophic factor protects against acrylamide-induced neuronal and synaptic injury via the TrkB-MAPK-Erk1/2 pathway.

    abstract::Acrylamide has been shown to be neurotoxic. Brain-derived neurotrophic factor (BDNF) can alleviate acrylamide-induced synaptic injury; however, the underlying mechanism remains unclear. In this study, dibutyryl-cyclic adenosine monophosphate-induced mature human neuroblastoma (NB-1) cells were exposed with 0-100 μg/mL...

    journal_title:Neural regeneration research

    pub_type: 杂志文章

    doi:10.4103/1673-5374.286976

    authors: Chen X,Xiao JW,Cao P,Zhang Y,Cai WJ,Song JY,Gao WM,Li B

    更新日期:2021-01-01 00:00:00

  • Inflammation and apoptosis accelerate progression to irreversible atrophy in denervated intrinsic muscles of the hand compared with biceps: proteomic analysis of a rat model of obstetric brachial plexus palsy.

    abstract::In treating patients with obstetric brachial plexus palsy, we noticed that denervated intrinsic muscles of the hand become irreversibly atrophic at a faster than denervated biceps. In a rat model of obstetric brachial plexus palsy, denervated intrinsic musculature of the forepaw entered the irreversible atrophy far ea...

    journal_title:Neural regeneration research

    pub_type: 杂志文章

    doi:10.4103/1673-5374.272619

    authors: Yu XH,Wu JX,Chen L,Gu YD

    更新日期:2020-07-01 00:00:00

  • Differentiation of rhesus adipose stem cells into dopaminergic neurons.

    abstract::LIM homeobox transcription factor 1a (Lmx1a) has the capacity to initiate the development program of neuronal cells and promote the differentiation of embryonic stem cells into dopaminergic neurons. In this study, rhesus adipose stem cells were infected with recombinant adenovirus carrying the Lmx1a gene and co-cultur...

    journal_title:Neural regeneration research

    pub_type: 杂志文章

    doi:10.3969/j.issn.1673-5374.2012.34.001

    authors: Zhou Y,Sun M,Li H,Yan M,Xie T

    更新日期:2012-12-05 00:00:00

  • Decoding brain responses to pixelized images in the primary visual cortex: implications for visual cortical prostheses.

    abstract::Visual cortical prostheses have the potential to restore partial vision. Still limited by the low-resolution visual percepts provided by visual cortical prostheses, implant wearers can currently only "see" pixelized images, and how to obtain the specific brain responses to different pixelized images in the primary vis...

    journal_title:Neural regeneration research

    pub_type: 杂志文章

    doi:10.4103/1673-5374.167761

    authors: Guo BB,Zheng XL,Lu ZG,Wang X,Yin ZQ,Hou WS,Meng M

    更新日期:2015-10-01 00:00:00

  • Inhibiting endogenous tissue plasminogen activator enhanced neuronal apoptosis and axonal injury after traumatic brain injury.

    abstract::Tissue plasminogen activator is usually used for the treatment of acute ischemic stroke, but the role of endogenous tissue plasminogen activator in traumatic brain injury has been rarely reported. A rat model of traumatic brain injury was established by weight-drop method. The tissue plasminogen activator inhibitor ne...

    journal_title:Neural regeneration research

    pub_type: 杂志文章

    doi:10.4103/1673-5374.266914

    authors: Zhao JJ,Liu ZW,Wang B,Huang TQ,Guo D,Zhao YL,Song JN

    更新日期:2020-04-01 00:00:00

  • Rosmarinic acid elicits neuroprotection in ischemic stroke via Nrf2 and heme oxygenase 1 signaling.

    abstract::Rosmarinic acid (RA) can elicit a neuroprotective effect against ischemic stroke, but the precise molecular mechanism remains poorly understood. In this study, an experimental ischemic stroke model was established in CD-1 mice (Beijing Vital River Laboratory Animal Technology, Beijing, China) by occluding the right mi...

    journal_title:Neural regeneration research

    pub_type: 杂志文章

    doi:10.4103/1673-5374.241463

    authors: Cui HY,Zhang XJ,Yang Y,Zhang C,Zhu CH,Miao JY,Chen R

    更新日期:2018-12-01 00:00:00

  • Offspring of rats with cerebral hypoxia-ischemia manifest cognitive dysfunction in learning and memory abilities.

    abstract::Neonatal hypoxic-ischemic encephalopathy is a serious neurological disease, often resulting in long-term neurodevelopmental disorders among surviving children. However, whether these neurodevelopmental issues can be passed to offspring remains unclear. The right common carotid artery of 7-day-old parental-generation r...

    journal_title:Neural regeneration research

    pub_type: 杂志文章

    doi:10.4103/1673-5374.276359

    authors: Xue LL,Wang F,Niu RZ,Tan YX,Liu J,Jin Y,Ma Z,Zhang ZB,Jiang Y,Chen L,Xia QJ,Chen JJ,Wang TH,Xiong LL

    更新日期:2020-09-01 00:00:00

  • The novel chalcone analog L2H17 protects retinal ganglion cells from oxidative stress-induced apoptosis.

    abstract::Chalcone is a plant metabolite widely found in fruits, vegetables, spices and tea, and has anti-tumor, anti-inflammation, immunomodulation, antibacterial and anti-oxidation activities, as well as many other pharmacological and biological effects. Our team has shown that its analogs have antioxidant activity, and oxida...

    journal_title:Neural regeneration research

    pub_type: 杂志文章

    doi:10.4103/1673-5374.237140

    authors: Wang L,Chen HC,Yang X,Tao JJ,Liang G,Wu JZ,Wu WC,Wang Y,Song ZM,Zhang X

    更新日期:2018-09-01 00:00:00

  • Redistribution of nerve strain enables end-to-end repair under tension without inhibiting nerve regeneration.

    abstract::End-to-end repair under no or low tension leads to improved outcomes for transected nerves with short gaps, compared to repairs with a graft. However, grafts are typically used to enable a tension-free repair for moderate to large gaps, as excessive tension can cause repairs to fail and catastrophically impede recover...

    journal_title:Neural regeneration research

    pub_type: 杂志文章

    doi:10.4103/1673-5374.251338

    authors: Howarth HM,Alaziz T,Nicolds B,O'Connor S,Shah SB

    更新日期:2019-07-01 00:00:00

  • Mechanism of delayed encephalopathy after acute carbon monoxide poisoning.

    abstract::Many hypotheses exist regarding the mechanism underlying delayed encephalopathy after acute carbon monoxide poisoning (DEACMP), including the inflammation and immune-mediated damage hypothesis and the cellular apoptosis and direct neuronal toxicity hypothesis; however, no existing hypothesis provides a satisfactory ex...

    journal_title:Neural regeneration research

    pub_type: 杂志文章

    doi:10.4103/1673-5374.284995

    authors: Huang YQ,Peng ZR,Huang FL,Yang AL

    更新日期:2020-12-01 00:00:00

  • Spinal cord injury drives chronic brain changes.

    abstract::Only a few studies have considered changes in brain structures other than sensory and motor cortex after spinal cord injury, although cognitive impairments have been reported in these patients. Spinal cord injury results in chronic brain neuroinflammation with consequent neurodegeneration and cognitive decline in rode...

    journal_title:Neural regeneration research

    pub_type: 杂志文章,评审

    doi:10.4103/1673-5374.211177

    authors: Jure I,Labombarda F

    更新日期:2017-07-01 00:00:00

  • A paracrine role for white thermogenic adipocytes in innervation: an evidence-based hypothesis.

    abstract::White adipose tissue (WAT) stores energy and also plays an important endocrine role in producing adipokines for communication with the peripheral and central nervous system. WAT consists of the major lipogenic unilocular adipocytes and the minor populations of beige and brite multilocular adipocytes. These multilocula...

    journal_title:Neural regeneration research

    pub_type: 杂志文章,评审

    doi:10.4103/1673-5374.244777

    authors: Lee A,Ziouzenkova O

    更新日期:2019-02-01 00:00:00

  • Neuroprotective effects of atorvastatin against cerebral ischemia/reperfusion injury through the inhibition of endoplasmic reticulum stress.

    abstract::Cerebral ischemia triggers secondary ischemia/reperfusion injury and endoplasmic reticulum stress initiates cell apoptosis. However, the regulatory mechanism of the signaling pathway remains unclear. We hypothesize that the regulatory mechanisms are mediated by the protein kinase-like endoplasmic reticulum kinase/euka...

    journal_title:Neural regeneration research

    pub_type: 杂志文章

    doi:10.4103/1673-5374.162755

    authors: Yang JW,Hu ZP

    更新日期:2015-08-01 00:00:00

  • Acrylamide inhibits nerve sprouting induced by botulinum toxin type A.

    abstract::Botulinum toxin type A is a potent muscle relaxant that blocks the transmission and release of acetylcholine at the neuromuscular junction. Intramuscular injection of botulinum toxin type A has served as an effective and safe therapy for strabismus and focal dystonia. However, muscular weakness is temporary and after ...

    journal_title:Neural regeneration research

    pub_type: 杂志文章

    doi:10.4103/1673-5374.139479

    authors: Jiang H,Xiang Y,Hu X,Cai H

    更新日期:2014-08-15 00:00:00

  • Mash1 efficiently reprograms rat astrocytes into neurons.

    abstract::To date, it remains poorly understood whether astrocytes can be easily reprogrammed into neurons. Mash1 and Brn2 have been previously shown to cooperate to reprogram fibroblasts into neurons. In this study, we examined astrocytes from 2-month-old Sprague-Dawley rats, and found that Brn2 was expressed, but Mash1 was no...

    journal_title:Neural regeneration research

    pub_type: 杂志文章

    doi:10.4103/1673-5374.125326

    authors: Ding D,Xu L,Xu H,Li X,Liang Q,Zhao Y,Wang Y

    更新日期:2014-01-01 00:00:00

  • Influence of endogenous ciliary neurotrophic factor on neural differentiation of adult rat hippocampal progenitors.

    abstract::Ciliary neurotrophic factor is the only known neurotrophic factor that can promote differentiation of hippocampal neural progenitor cells to glial cells and neurons in adult rats. This process is similar to spontaneous differentiation. Therefore, ciliary neurotrophic factor may be involved in spontaneous differentiati...

    journal_title:Neural regeneration research

    pub_type: 杂志文章

    doi:10.3969/j.issn.1673-5374.2013.04.002

    authors: Ding J,He Z,Ruan J,Liu Y,Gong C,Sun S,Chen H

    更新日期:2013-02-05 00:00:00

  • Modified insulin-like growth factor 1 containing collagen-binding domain for nerve regeneration.

    abstract::Insulin-like growth factor 1 (IGF-1) is a potential nutrient for nerve repair. However, it is impractical as a therapy because of its limited half-life, rapid clearance, and limited target specificity. To achieve targeted and long-lasting treatment, we investigated the addition of a binding structure by fusing a colla...

    journal_title:Neural regeneration research

    pub_type: 杂志文章

    doi:10.4103/1673-5374.226400

    authors: Li JA,Zhao CF,Li SJ,Zhang J,Li ZH,Zhang Q,Yang XY,Zan CF

    更新日期:2018-02-01 00:00:00

  • Photoacoustic treatment mitigates cognitive dysfunction in a model of sleep-wake rhythm disturbance.

    abstract::Sleep-wake rhythm disturbances, which are characterized by abnormal sleep timing or duration, are associated with cognitive dysfunction. Photoacoustic treatments including light and sound stimulation have been found to be effective in modulating sleep patterns and improving cognitive behavior in abnormal sleep-wake pa...

    journal_title:Neural regeneration research

    pub_type: 杂志文章

    doi:10.4103/1673-5374.270415

    authors: Xing F,Fang X,Gong XD,Zhao X,Du Y,Ma ZL,Gu XP,Xia TJ

    更新日期:2020-06-01 00:00:00