Abstract:
:Infusion of the colloid hydroxyethylstarch has been used for volume substitution to maintain hemodynamics and microcirculation after e.g., severe blood loss. In the last decade it was revealed that hydroxyethylstarch can aggravate acute kidney injury, especially in septic patients. Because of the serious risk for critically ill patients, the administration of hydroxyethylstarch was restricted for clinical use. Animal studies and recently published in vitro experiments showed that hydroxyethylstarch might exert protective effects on the blood-brain barrier. Since the prevention of blood-brain barrier disruption was shown to go along with the reduction of brain damage after several kinds of insults, we revisit the topic hydroxyethylstarch and discuss a possible niche for the application of hydroxyethylstarch in acute brain injury treatment.
journal_name
Neural Regen Resjournal_title
Neural regeneration researchauthors
Schick MA,Burek M,Förster CY,Nagai M,Wunder C,Neuhaus Wdoi
10.4103/1673-5374.300978subject
Has Abstractpub_date
2021-07-01 00:00:00pages
1372-1376issue
7eissn
1673-5374issn
1876-7958pii
NeuralRegenRes_2021_16_7_1372_300978journal_volume
16pub_type
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