Hydroxyethylstarch revisited for acute brain injury treatment.

Abstract:

:Infusion of the colloid hydroxyethylstarch has been used for volume substitution to maintain hemodynamics and microcirculation after e.g., severe blood loss. In the last decade it was revealed that hydroxyethylstarch can aggravate acute kidney injury, especially in septic patients. Because of the serious risk for critically ill patients, the administration of hydroxyethylstarch was restricted for clinical use. Animal studies and recently published in vitro experiments showed that hydroxyethylstarch might exert protective effects on the blood-brain barrier. Since the prevention of blood-brain barrier disruption was shown to go along with the reduction of brain damage after several kinds of insults, we revisit the topic hydroxyethylstarch and discuss a possible niche for the application of hydroxyethylstarch in acute brain injury treatment.

journal_name

Neural Regen Res

authors

Schick MA,Burek M,Förster CY,Nagai M,Wunder C,Neuhaus W

doi

10.4103/1673-5374.300978

subject

Has Abstract

pub_date

2021-07-01 00:00:00

pages

1372-1376

issue

7

eissn

1673-5374

issn

1876-7958

pii

NeuralRegenRes_2021_16_7_1372_300978

journal_volume

16

pub_type

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