Abstract：
:This study compared the difference in brain structure in 12 mine disaster survivors with chronic post-traumatic stress disorder, 7 cases of improved post-traumatic stress disorder symptoms, and 14 controls who experienced the same mine disaster but did not suffer post-traumatic stress disorder, using the voxel-based morphometry method. The correlation between differences in brain structure and post-traumatic stress disorder symptoms was also investigated. Results showed that the gray matter volume was the highest in the trauma control group, followed by the symptoms-improved group, and the lowest in the chronic post-traumatic stress disorder group. Compared with the symptoms-improved group, the gray matter volume in the lingual gyrus of the right occipital lobe was reduced in the chronic post-traumatic stress disorder group. Compared with the trauma control group, the gray matter volume in the right middle occipital gyrus and left middle frontal gyrus was reduced in the symptoms-improved group. Compared with the trauma control group, the gray matter volume in the left superior parietal lobule and right superior frontal gyrus was reduced in the chronic post-traumatic stress disorder group. The gray matter volume in the left superior parietal lobule was significantly positively correlated with the State-Trait Anxiety Inventory subscale score in the symptoms-improved group and chronic post-traumatic stress disorder group (r = 0.477, P = 0.039). Our findings indicate that (1) chronic post-traumatic stress disorder patients have gray matter structural damage in the prefrontal lobe, occipital lobe, and parietal lobe, (2) after post-traumatic stress, the disorder symptoms are improved and gray matter structural damage is reduced, but cannot recover to the trauma-control level, and (3) the superior parietal lobule is possibly associated with chronic post-traumatic stress disorder. Post-traumatic stress disorder patients exhibit gray matter abnormalities.
journal_name
Neural Regen Resjournal_title
Neural regeneration researchauthors
Tan L,Zhang L,Qi R,Lu G,Li L,Liu J,Li Wdoi
10.3969/j.issn.1673-5374.2013.26.001subject
Has Abstractpub_date
2013-09-15 00:00:00pages
2405-14issue
26eissn
1673-5374issn
1876-7958pii
NRR-8-2405journal_volume
8pub_type
杂志文章abstract：:Although Parkinson's disease is the most common neurodegenerative movement disorder, the mechanisms of pathogenesis remain poorly understood. Recent findings have shown that deregulation of the autophagy-lysosome pathway is involved in the pathogenesis of Parkinson's disease. This review summarizes the most recent fin...
journal_title：Neural regeneration research
pub_type： 杂志文章,评审
doi：10.3969/j.issn.1673-5374.2012.02.011
更新日期：2012-01-15 00:00:00
abstract：:There is long-standing debate about sensate versus non-sensate free microvascular flaps among microsurgeons. The principle of connecting not only the vascular supply, but also sensitive nerves, in free tissue transfer is attractive. However, increased operating time and partial spontaneous innervation led to the commo...
journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.3969/j.issn.1673-5374.2012.29.006
更新日期：2012-10-15 00:00:00
abstract：:In this study, we tried to verify the neuroprotective effect of Chrysanthemum indicum Linne (CIL) extract, which has been used as a botanical drug in East Asia, against ischemic damage and to explore the underlying mechanism involving the anti-inflammatory approach. A gerbil was given CIL extract for 7 consecutive day...
journal_title：Neural regeneration research
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doi：10.4103/1673-5374.177735
更新日期：2016-02-01 00:00:00
abstract：:In this study, recombinant baculovirus carrying the microdystrophin and β-catenin genes was used to infect adipose-derived stem cells from a dystrophin-utrophin double knock-out mouse. Results showed that, after baculovirus transgene infection, microdystrophin and β-catenin genes were effectively expressed in adipose-...
journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.3969/j.issn.1673-5374.2012.22.003
更新日期：2012-08-05 00:00:00
abstract：:The three-dimensional (3D) visualization of the functional bundles in the peripheral nerve provides direct and detailed intraneural spatial information. It is useful for selecting suitable surgical methods to repair nerve defects and in optimizing the construction of tissue-engineered nerve grafts. However, there rema...
journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.4103/1673-5374.235307
更新日期：2018-08-01 00:00:00
abstract：:Emerging evidence supports that the stress response to peripheral nerve injury extends beyond the injured neuron, with alterations in associated transcription factors detected both locally and remote to the lesion. Stress-induced nuclear translocation of the transcription factor forkhead class box O3a (FOXO3a) was ini...
journal_title：Neural regeneration research
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abstract：:The sciatic functional index (SFI) is a popular parameter for peripheral nerve evaluation that relies on footprints obtained with ink and paper. Drawbacks include smearing artefacts and a lack of dynamic information during measurement. Modern applications use digitized systems that can deliver results with less analyt...
journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.4103/1673-5374.182712
更新日期：2016-05-01 00:00:00
abstract：:Stem cell transplantation can promote functional restoration following acute spinal cord injury (injury time < 3 months), but the safety and long-term efficacy of this treatment need further exploration. In this study, 25 patients with traumatic spinal cord injury (injury time > 6 months) were treated with human umbil...
journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.3969/j.issn.1673-5374.2013.05.002
更新日期：2013-02-15 00:00:00
abstract：:To facilitate gathering information during a psychiatric interview, some psychiatrists advocate augmenting the interview using drugs. Rather than barbiturates, benzodiazepines have been used for drug-assisted interviews. Dissociative amnesia is one of the indications for these interviews. Herein, we present the case o...
journal_title：Neural regeneration research
pub_type：
doi：10.3969/j.issn.1673-5374.2013.02.012
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abstract：:Septic encephalopathy is a frequent complication of sepsis, but there are few studies examining the role of microRNAs (miRs) in its pathogenesis. In this study, a miR-219 mimic was transfected into rat hippocampal neurons to model miR-219 overexpression. A protective effect of miR-219 was observed for glutamate-induce...
journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.4103/1673-5374.235059
更新日期：2018-07-01 00:00:00
abstract：:The reconstruction of nerve continuity after traumatic nerve injury is the gold standard in hand surgery. Immediate, tension-free, end-to-end nerve suture ensures the best prognosis. The recovery is mostly promising; however, in a few cases, insufficient outcomes in motor or sensory function are observed. Intra- and e...
journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.4103/1673-5374.297081
更新日期：2021-05-01 00:00:00
abstract：:Cerebral ischemia triggers secondary ischemia/reperfusion injury and endoplasmic reticulum stress initiates cell apoptosis. However, the regulatory mechanism of the signaling pathway remains unclear. We hypothesize that the regulatory mechanisms are mediated by the protein kinase-like endoplasmic reticulum kinase/euka...
journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.4103/1673-5374.162755
更新日期：2015-08-01 00:00:00
abstract：:One hundred patients with focal epilepsy were recruited for the present study and their seizures controlled with antiepileptic drugs. The patients then orally received a capsule of tall gastrodis tuber powder, a traditional Chinese drug, and underwent single photon emission computed tomography, long-term electroenceph...
journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.3969/j.issn.1673-5374.2013.03.002
更新日期：2013-01-25 00:00:00
abstract：:Multiple regeneration of axonal buds has been shown to exist during the repair of peripheral nerve injury, which confirms a certain repair potential of the injured peripheral nerve. Therefore, a systematic nerve transposition repair technique has been proposed to treat severe peripheral nerve injury. During nerve tran...
journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.4103/1673-5374.247473
更新日期：2019-04-01 00:00:00
abstract：:Ciliary neurotrophic factor is the only known neurotrophic factor that can promote differentiation of hippocampal neural progenitor cells to glial cells and neurons in adult rats. This process is similar to spontaneous differentiation. Therefore, ciliary neurotrophic factor may be involved in spontaneous differentiati...
journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.3969/j.issn.1673-5374.2013.04.002
更新日期：2013-02-05 00:00:00
abstract：:Preclinical and clinical studies indicate that synthetic psychoactive substances, in addition to having abuse potential, may elicit toxic effects of varying severity at the peripheral and central levels. Nowadays, toxicity induced by synthetic psychoactive substances poses a serious harm for health, since recreational...
journal_title：Neural regeneration research
pub_type： 杂志文章,评审
doi：10.4103/1673-5374.268895
更新日期：2020-05-01 00:00:00
abstract：:Gynostemma (G.) pentaphyllum (Cucurbitaceae) contains various bioactive gypenosides. Ethanol extract from G. pentaphyllum (GP-EX) has been shown to have ameliorative effects on the death of dopaminergic neurons in animal models of Parkinson's disease (PD) induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine- and 6-...
journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.4103/1673-5374.265557
更新日期：2020-02-01 00:00:00
abstract：OBJECTIVE:To identify global research trends in three therapies for children with cerebral palsy. DATA RETRIEVAL:We performed a bibliometric analysis of studies on therapies for children with cerebral palsy from 2002 to 2011 retrieved from Web of Science. SELECTION CRITERIA: INCLUSION CRITERIA:(a) peer-reviewed publ...
journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.3969/j.issn.1673-5374.2012.33.009
更新日期：2012-11-25 00:00:00
abstract：:Alzheimer's disease is the leading cause of dementia. Its increased prevalence in developed countries, due to the sharp rise in ageing populations, presents one of the costliest challenges to modern medicine. In order to find disease-modifying therapies to confront this challenge, a more complete understanding of the ...
journal_title：Neural regeneration research
pub_type： 杂志文章,评审
doi：10.4103/1673-5374.272571
更新日期：2020-07-01 00:00:00
abstract：:Both intracellular sigma peptide (ISP) and phosphatase and tensin homolog agonist protein (PAP4) promote nerve regeneration and motor functional recovery after spinal cord injury. However, the role of these two small peptides in peripheral nerve injury remains unclear. A rat model of brachial plexus injury was establi...
journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.4103/1673-5374.294565
更新日期：2021-08-01 00:00:00
abstract：:Membrane depolarization induces the release of the serine proteinase tissue-type plasminogen activator (tPA) from the presynaptic terminal of cerebral cortical neurons. Once in the synaptic cleft this tPA promotes the exocytosis and subsequent endocytic retrieval of glutamate-containing synaptic vesicles, and regulate...
journal_title：Neural regeneration research
pub_type： 杂志文章,评审
doi：10.4103/1673-5374.202924
更新日期：2017-03-01 00:00:00
abstract：:As total life expectancy increases, the prevalence of age-related diseases such as diabetes and Alzheimer's disease is also increasing. Many hypotheses about Alzheimer's disease have been developed, including cholinergic neuron damage, oxidative stress, and inflammation. Acetylcholine is a major neurotransmitter in th...
journal_title：Neural regeneration research
pub_type： 杂志文章,评审
doi：10.4103/1673-5374.245467
更新日期：2019-03-01 00:00:00
abstract：:Magnesium (Mg) wire has been shown to be biodegradable and have anti-inflammatory properties. It can induce Schwann cells to secrete nerve growth factor and promote the regeneration of nerve axons after central nervous system injury. We hypothesized that biodegradable Mg wire may enhance compressed peripheral nerve re...
journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.4103/1673-5374.197146
更新日期：2016-12-01 00:00:00
abstract：:A potential treatment for retinal diseases is to induce an endogenous Müller glia (MG)-derived regenerative response to replace damaged neurons. In contrast to mammalian MG, zebrafish MG are capable of mediating spontaneous regeneration. We seek to define the mechanisms that enable retina regeneration in zebrafish in ...
journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.4103/1673-5374.286972
更新日期：2021-02-01 00:00:00
abstract：:Epithelial-specific ETS-1 (ESE1), a member of the ETS transcription factor family, is widely expressed in multiple tissues and performs various functions in inflammation. During neuroinflammation, ESE1 promotes neuronal apoptosis; however, the expression and biological functions of ESE1 remain unclear after cerebral i...
journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.4103/1673-5374.249232
更新日期：2019-05-01 00:00:00
abstract：:In this study, we hypothesized that total flavonoid of Litsea coreana leve (TFLC) protects against focal cerebral ischemia/reperfusion injury. TFLC (25, 50, 100 mg/kg) was administered orally to a rat model of focal ischemia/reperfusion injury, while the free radical scavenging agent, edaravone, was used as a positive...
journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.3969/j.issn.1673-5374.2013.34.003
更新日期：2013-12-05 00:00:00
abstract：:The present study investigated the influence of anti-estrogen treatment (fulvestrant) on pituitary adenoma cell line GH3 biological activity, the estrogen receptor α pathway, the WnT pathway, and mechanisms of decreased Wnt inhibitory factor-1 expression in GH3 cells. Results showed that fulvestrant suppressed GH3 cel...
journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.3969/j.issn.1673-5374.2012.04.008
更新日期：2012-02-05 00:00:00
abstract：:Botulinum toxin type A is a potent muscle relaxant that blocks the transmission and release of acetylcholine at the neuromuscular junction. Intramuscular injection of botulinum toxin type A has served as an effective and safe therapy for strabismus and focal dystonia. However, muscular weakness is temporary and after ...
journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.4103/1673-5374.139479
更新日期：2014-08-15 00:00:00
abstract：:Among the various treatment methods for stroke, increasing attention has been paid to traditional Chinese medicines. Buyang Huanwu decoction is a commonly used traditional Chinese medicine for the treatment of stroke. This paper summarizes the active components of the Chinese herb, which is composed of Huangqi (Radix ...
journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.4103/1673-5374.141791
更新日期：2014-09-01 00:00:00
abstract：:Fimbria-fornix transection induces both exogenous and endogenous neural stem cells to differentiate into neurons in the hippocampus. This indicates that the denervated hippocampus provides an environment for neuronal differentiation of neural stem cells. However, the pathways and mechanisms in this process are still u...
journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.4103/1673-5374.180744
更新日期：2016-04-01 00:00:00
