ISP and PAP4 peptides promote motor functional recovery after peripheral nerve injury.

Abstract:

:Both intracellular sigma peptide (ISP) and phosphatase and tensin homolog agonist protein (PAP4) promote nerve regeneration and motor functional recovery after spinal cord injury. However, the role of these two small peptides in peripheral nerve injury remains unclear. A rat model of brachial plexus injury was established by crush of the C6 ventral root. The rats were then treated with subcutaneous injection of PAP4 (497 µg/d, twice per day) or ISP (11 µg/d, once per day) near the injury site for 21 successive days. After ISP and PAP treatment, the survival of motoneurons was increased, the number of regenerated axons and neuromuscular junctions was increased, muscle atrophy was reduced, the electrical response of the motor units was enhanced and the motor function of the injured upper limbs was greatly improved in rats with brachial plexus injury. These findings suggest that ISP and PAP4 promote the recovery of motor function after peripheral nerve injury in rats. The animal care and experimental procedures were approved by the Laboratory Animal Ethics Committee of Jinan University of China (approval No. 20111008001) in 2011.

journal_name

Neural Regen Res

authors

Lv SQ,Wu W

doi

10.4103/1673-5374.294565

subject

Has Abstract

pub_date

2021-08-01 00:00:00

pages

1598-1605

issue

8

eissn

1673-5374

issn

1876-7958

pii

NeuralRegenRes_2021_16_8_1598_294565

journal_volume

16

pub_type

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