ISP and PAP4 peptides promote motor functional recovery after peripheral nerve injury.

abstract：:Functional recovery after oculomotor nerve injury is very poor. Electrical stimulation has been shown to promote regeneration of injured nerves. We hypothesized that electrical stimulation would improve the functional recovery of injured oculomotor nerves. Oculomotor nerve injury models were created by crushing the ri...

journal_title：Neural regeneration research

authors： Du L,Yang M,Wan L,Wang XH,Li ST

更新日期：2016-10-01 00:00:00

abstract：:Membrane trafficking processes are presumably vital for axonal regeneration after injury, but mechanistic understanding in this regard has been sparse. A recent loss-of-function screen had been carried out for factors important for axonal regeneration by cultured cortical neurons and the results suggested that the act...

journal_title：Neural regeneration research

authors： Yong CQY,Tang BL

更新日期：2019-04-01 00:00:00

abstract：:The study aims to confirm the neuroregenerative effects of bacterial melanin (BM) on central nervous system injury using a special staining method based on the detection of Ca(2+)-dependent acid phosphatase activity. Twenty-four rats were randomly assigned to undergo either unilateral destruction of sensorimotor corte...

journal_title：Neural regeneration research

authors： Petrosyan TR,Ter-Markosyan AS,Hovsepyan AS

更新日期：2016-07-01 00:00:00

abstract：:In this study, we tried to verify the neuroprotective effect of Chrysanthemum indicum Linne (CIL) extract, which has been used as a botanical drug in East Asia, against ischemic damage and to explore the underlying mechanism involving the anti-inflammatory approach. A gerbil was given CIL extract for 7 consecutive day...

journal_title：Neural regeneration research

authors： Yoo KY,Kim IH,Cho JH,Ahn JH,Park JH,Lee JC,Tae HJ,Kim DW,Kim JD,Hong S,Won MH,Kang IJ

更新日期：2016-02-01 00:00:00

abstract：:Molecular mechanisms of the Krüppel-like family of transcription factors (KLFs) have been studied more in proliferating cells than in post-mitotic cells such as neurons. We recently found that KLFs regulate intrinsic axon growth ability in central nervous system (CNS) neurons including retinal ganglion cells, and hipp...

journal_title：Neural regeneration research

authors： Apara A,Goldberg JL

更新日期：2014-08-01 00:00:00

abstract：:Suture and autologous nerve transplantation are the primary therapeutic measures for completely severed nerves. However, imbalances in the microenvironment and adhesion of surrounding tissues can affect the quality of nerve regeneration and repair. Previous studies have shown that human amniotic membrane can promote t...

journal_title：Neural regeneration research

authors： Zhang ZY,Yang J,Fan ZH,Wang DL,Wang YY,Zhang T,Yu LM,Yu CY

更新日期：2019-12-01 00:00:00

abstract：:This study compared the difference in brain structure in 12 mine disaster survivors with chronic post-traumatic stress disorder, 7 cases of improved post-traumatic stress disorder symptoms, and 14 controls who experienced the same mine disaster but did not suffer post-traumatic stress disorder, using the voxel-based m...

journal_title：Neural regeneration research

authors： Tan L,Zhang L,Qi R,Lu G,Li L,Liu J,Li W

更新日期：2013-09-15 00:00:00

abstract：:A potential treatment for retinal diseases is to induce an endogenous Müller glia (MG)-derived regenerative response to replace damaged neurons. In contrast to mammalian MG, zebrafish MG are capable of mediating spontaneous regeneration. We seek to define the mechanisms that enable retina regeneration in zebrafish in ...

journal_title：Neural regeneration research

authors： Kent MR,Kara N,Patton JG

更新日期：2021-02-01 00:00:00

abstract：:The G-protein-coupled purinergic receptor P2Y2 (P2RY2) plays an important role in the mechanism of atherosclerosis, which is relevant to ischemic stroke. This retrospective case-control study aimed to assess the relationship between P2RY2 gene polymorphisms and ischemic stroke risk in the northern Han Chinese populati...

journal_title：Neural regeneration research

authors： Yuan LY,He ZY,Li L,Wang YZ

更新日期：2019-03-01 00:00:00

abstract：:Gelatinases matrix metalloproteinase-2 and matrix metalloproteinase-9 have been shown to mediate claudin-5 and occludin degradation, and play an important regulatory role in blood-brain barrier permeability. This study established a rat model of 1.5-hour middle cerebral artery occlusion with reperfusion. Protein expre...

journal_title：Neural regeneration research

authors： Xin H,Liang W,Mang J,Lin L,Guo N,Zhang F,Xu Z

更新日期：2012-11-05 00:00:00

abstract：:In peripheral artery disease patients, the blood supply directed to the lower limbs is reduced. This results in severe limb ischemia and thereby enhances pain sensitivity in lower limbs. The painful perception is induced and exaggerate during walking, and is relieved by rest. This symptom is termed by intermittent cla...

journal_title：Neural regeneration research

authors： Qin L,Li J

更新日期：2021-04-01 00:00:00

abstract：:At 8 weeks after intragastric administration of icariin to senescence-accelerated mice (P8 strain), Morris water maze results showed that escape latency was shortened, and the number of platform crossings was increased. Immunohistochemical staining and western blot assay detected significantly increased levels of cycl...

journal_title：Neural regeneration research

authors： Zhang Z,Zhang T,Dong K

更新日期：2012-04-25 00:00:00

abstract：:The choroid plexus is a complex structure which hangs inside the ventricles of the brain and consists mainly of choroid plexus epithelial (CPE) cells surrounding fenestrated capillaries. These CPE cells not only form an anatomical barrier, called the blood-cerebrospinal fluid barrier (BCSFB), but also present an activ...

journal_title：Neural regeneration research

authors： Balusu S,Brkic M,Libert C,Vandenbroucke RE

更新日期：2016-04-01 00:00:00

abstract：:Angelica sinensis has antioxidative and neuroprotective effects. In the present study, we aimed to determine the neuroprotective effect of polysaccharides isolated from Angelica sinensis. In a preliminary experiment, Angelica sinensis polysaccharides not only protected PC12 neuronal cells from H2O2-induced cytotoxicit...

journal_title：Neural regeneration research

authors： Lei T,Li H,Fang Z,Lin J,Wang S,Xiao L,Yang F,Liu X,Zhang J,Huang Z,Liao W

更新日期：2014-02-01 00:00:00

abstract：:Previous animal studies have shown that stromal cell-derived factor-1 (SDF-1)/CXC chemokine receptor-4 (CXCR4) signaling pathway plays an important role in the targeted migration of bone marrow-derived mesenchymal stem cells (BMSCs) to the injured area. In the present study, we aimed to investigate the potential role ...

journal_title：Neural regeneration research

authors： Peyvandi AA,Roozbahany NA,Peyvandi H,Abbaszadeh HA,Majdinasab N,Faridan M,Niknazar S

更新日期：2018-01-01 00:00:00

abstract：:Intrinsically disordered proteins, such as tau or α-synuclein, have long been associated with a dysfunctional role in neurodegenerative diseases. In Alzheimer's and Parkinson's' diseases, these proteins, sharing a common chemical-physical pattern with alternating hydrophobic and hydrophilic domains rich in prolines, a...

journal_title：Neural regeneration research

authors： Caminati G,Procacci P

更新日期：2020-12-01 00:00:00

abstract：:Rosmarinic acid (RA) can elicit a neuroprotective effect against ischemic stroke, but the precise molecular mechanism remains poorly understood. In this study, an experimental ischemic stroke model was established in CD-1 mice (Beijing Vital River Laboratory Animal Technology, Beijing, China) by occluding the right mi...

journal_title：Neural regeneration research

authors： Cui HY,Zhang XJ,Yang Y,Zhang C,Zhu CH,Miao JY,Chen R

更新日期：2018-12-01 00:00:00

abstract：:The iron chelator deferoxamine has been shown to inhibit ferroptosis in spinal cord injury. However, it is unclear whether deferoxamine directly protects neurons from ferroptotic cell death. By comparing the survival rate and morphology of primary neurons and SH-SY5Y cells exposed to erastin, it was found that these c...

journal_title：Neural regeneration research

authors： Zhang Y,Fan BY,Pang YL,Shen WY,Wang X,Zhao CX,Li WX,Liu C,Kong XH,Ning GZ,Feng SQ,Yao X

更新日期：2020-08-01 00:00:00

abstract：:This study aimed to detect the difference in resting cerebral activities between ischemic stroke patients and healthy participants, define the abnormal site, and provide new evidence for pathological mechanisms, clinical diagnosis, prognosis prediction and efficacy evaluation of ischemic stroke. At present, the majori...

journal_title：Neural regeneration research

authors： Wu P,Zeng F,Li YX,Yu BL,Qiu LH,Qin W,Li J,Zhou YM,Liang FR

更新日期：2015-05-01 00:00:00

abstract：:The accumulation of myelin debris may be a major contributor to the inflammatory response after diffuse axonal injury. In this study, we examined the accumulation and clearance of myelin debris in a rat model of diffuse axonal injury. Oil Red O staining was performed on sections from the cerebral cortex, hippocampus a...

journal_title：Neural regeneration research

authors： Wen L,Xu J,Zhan T,Wang H,Huang X,Liu W,Yang X,Zhan R

更新日期：2014-11-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to evaluate the effectiveness and safety of stem cell transplantation for spinal cord injury (SCI). DATA SOURCES:PubMed, EMBASE, Cochrane, China National Knowledge Infrastructure, China Science and Technology Journal, Wanfang, and SinoMed databases were systematically searched by co...

journal_title：Neural regeneration research

authors： Fan X,Wang JZ,Lin XM,Zhang L

更新日期：2017-05-01 00:00:00

abstract：:The sciatic functional index (SFI) is a popular parameter for peripheral nerve evaluation that relies on footprints obtained with ink and paper. Drawbacks include smearing artefacts and a lack of dynamic information during measurement. Modern applications use digitized systems that can deliver results with less analyt...

journal_title：Neural regeneration research

authors： Fricker L,Penna V,Lampert F,Stark GB,Witzel C,Koulaxouzidis G

更新日期：2016-05-01 00:00:00

abstract：:LIM homeobox transcription factor 1a (Lmx1a) has the capacity to initiate the development program of neuronal cells and promote the differentiation of embryonic stem cells into dopaminergic neurons. In this study, rhesus adipose stem cells were infected with recombinant adenovirus carrying the Lmx1a gene and co-cultur...

journal_title：Neural regeneration research

authors： Zhou Y,Sun M,Li H,Yan M,Xie T

更新日期：2012-12-05 00:00:00

abstract：:Emerging evidence supports that the stress response to peripheral nerve injury extends beyond the injured neuron, with alterations in associated transcription factors detected both locally and remote to the lesion. Stress-induced nuclear translocation of the transcription factor forkhead class box O3a (FOXO3a) was ini...

journal_title：Neural regeneration research

authors： Hasmatali JCD,De Guzman J,Johnston JM,Noyan H,Juurlink BH,Misra V,Verge VMK

更新日期：2020-12-01 00:00:00

abstract：:The precedence effect is a prerequisite for faithful sound localization in a complex auditory environment, and is a physiological phenomenon in which the auditory system selectively suppresses the directional information from echoes. Here we investigated how neurons in the inferior colliculus respond to the paired sou...

journal_title：Neural regeneration research

authors： Wang Y,Wang N,Wang D,Jia J,Liu J,Xie Y,Wen X,Li X

更新日期：2014-02-15 00:00:00

abstract：:Aquaporin-4 regulates water molecule channels and is important in tissue regulation and water transportation in the brain. Upregulation of aquaporin-4 expression is closely related to cellular edema after early cerebral infarction. Cellular edema and aquaporin-4 expression can be determined by measuring cerebral infar...

journal_title：Neural regeneration research

authors： He ZP,Lu H

更新日期：2015-07-01 00:00:00

abstract：:Curcumin exerts a neuroprotective effect on Alzheimer's disease; however, it is not known whether microRNAs are involved in this protective effect. This study was conducted using swAPP695-HEK293 cells as an Alzheimer's disease cell model. swAPP695-HEK293 cells were treated with 0, 0.5, 1, 2, 5, and 10 μM curcumin for ...

journal_title：Neural regeneration research

authors： Liu HY,Fu X,Li YF,Li XL,Ma ZY,Zhang Y,Gao QC

更新日期：2019-09-01 00:00:00

abstract：:There are several major pathological changes in Alzheimer's disease, including apoptosis of cholinergic neurons, overactivity or overexpression of β-site amyloid precursor protein cleaving enzyme 1 (BACE1) and inflammation. In this study, we synthesized a 19-nt oligonucleotide targeting BACE1, the key enzyme in amyloi...

journal_title：Neural regeneration research

authors： Liu Z,Li S,Liang Z,Zhao Y,Zhang Y,Yang Y,Wang M,Li F

更新日期：2013-11-25 00:00:00

abstract：:Spinal cord injury is a major cause of disability with devastating neurological outcomes and limited therapeutic opportunities, even though there are thousands of publications on spinal cord injury annually. There are two major types of spinal cord injury, transaction of the spinal cord and spinal cord contusion. Both...

journal_title：Neural regeneration research

authors： Ju G,Wang J,Wang Y,Zhao X

更新日期：2014-04-15 00:00:00

abstract：:In this study, we hypothesized that an increase in integrin αvβ3 and its co-activator vascular endothelial growth factor play important neuroprotective roles in ischemic injury. We performed ischemic preconditioning with bilateral common carotid artery occlusion for 5 minutes in C57BL/6J mice. This was followed by isc...

journal_title：Neural regeneration research

authors： Ma XM,Liu M,Liu YY,Ma LL,Jiang Y,Chen XH

更新日期：2016-05-01 00:00:00