Phage display: development of nanocarriers for targeted drug delivery to the brain.

abstract：:Neurotropic herpesviruses have been associated with the onset and progression of Alzheimer's disease, a common form of dementia that afflicts a large percentage of elderly individuals. Interestingly, among the neurotropic herpesviruses, herpes simplex virus-1, human herpesvirus-6A, and human herpesvirus-6B have been r...

journal_title：Neural regeneration research

authors： Romeo MA,Faggioni A,Cirone M

更新日期：2019-09-01 00:00:00

abstract：OBJECTIVE:To investigate the factors associated with sensory and motor recovery after the repair of upper limb peripheral nerve injuries. DATA SOURCES:The online PubMed database was searched for English articles describing outcomes after the repair of median, ulnar, radial, and digital nerve injuries in humans with a ...

journal_title：Neural regeneration research

authors： He B,Zhu Z,Zhu Q,Zhou X,Zheng C,Li P,Zhu S,Liu X,Zhu J

更新日期：2014-03-15 00:00:00

abstract：:This study aimed to summarize therapy experience of carotid endarterectomy, carotid endarterectomy combined with Fogarty catheter embolectomy, and hybrid surgery for the treatment of extracranial internal carotid artery occlusion. The study included 65 patients with extracranial internal carotid artery occlusion who u...

journal_title：Neural regeneration research

authors： Jiao L,Song G,Hua Y,Ma Y,Chen Y,Wang Y,Ling F

更新日期：2013-08-15 00:00:00

abstract：:Cattle encephalon glycoside and ignotin (CEGI) injection is known as a multi-target neuroprotective drug that contains numerous liposoluble molecules, such as polypeptides, monosialotetrahexosyl ganglioside (GM-1), free amino acids, hypoxanthine and carnosine. CEGI has been approved by the Chinese State Food and Drug ...

journal_title：Neural regeneration research

authors： Zhong J,Li RW,Wang J,Wang Y,Ge HF,Xian JS,Feng H,Tan L

更新日期：2021-02-01 00:00:00

abstract：:Channelrhodopsin-2 ectopically expressed in the retina can recover the response to blue light in genetically blind mice and rats, but is unable to restore visual function due to optic nerve or optic tract lesions. Long Evans rats at postnatal day 1 were used for primary culture of visual cortical cells, and 24 hours l...

journal_title：Neural regeneration research

authors： Yao J,Hou W,Wang H,Liu H,Weng C,Yin Z

更新日期：2012-06-05 00:00:00

abstract：:The present study investigated the influence of anti-estrogen treatment (fulvestrant) on pituitary adenoma cell line GH3 biological activity, the estrogen receptor α pathway, the WnT pathway, and mechanisms of decreased Wnt inhibitory factor-1 expression in GH3 cells. Results showed that fulvestrant suppressed GH3 cel...

journal_title：Neural regeneration research

authors： Bai J,Wang Y,Li C,Zhang Y

更新日期：2012-02-05 00:00:00

abstract：:[This corrects the article DOI: 10.4103/1673-5374.245480]. ...

journal_title：Neural regeneration research

authors：

更新日期：2019-06-01 00:00:00

abstract：:Excessive radiation exposure may lead to edema of the spinal cord and deterioration of the nervous system. Magnetic resonance imaging can be used to judge and assess the extent of edema and to evaluate pathological changes and thus may be used for the evaluation of spinal cord injuries caused by radiation therapy. Rad...

journal_title：Neural regeneration research

authors： Cao X,Fang L,Cui CY,Gao S,Wang TW

更新日期：2018-03-01 00:00:00

abstract：:Ciliary neurotrophic factor is the only known neurotrophic factor that can promote differentiation of hippocampal neural progenitor cells to glial cells and neurons in adult rats. This process is similar to spontaneous differentiation. Therefore, ciliary neurotrophic factor may be involved in spontaneous differentiati...

journal_title：Neural regeneration research

authors： Ding J,He Z,Ruan J,Liu Y,Gong C,Sun S,Chen H

更新日期：2013-02-05 00:00:00

abstract：:After traumatic brain injury, vasogenic and cytotoxic edema appear sequentially on the involved side. Neuroimaging investigations of edema on the injured side have employed apparent diffusion coefficient measurements in diffusion tensor imaging. We investigated the changes occurring on the injured and uninjured sides ...

journal_title：Neural regeneration research

authors： Lu H,Lei X

更新日期：2014-05-01 00:00:00

abstract：:Rosmarinic acid (RA) can elicit a neuroprotective effect against ischemic stroke, but the precise molecular mechanism remains poorly understood. In this study, an experimental ischemic stroke model was established in CD-1 mice (Beijing Vital River Laboratory Animal Technology, Beijing, China) by occluding the right mi...

journal_title：Neural regeneration research

authors： Cui HY,Zhang XJ,Yang Y,Zhang C,Zhu CH,Miao JY,Chen R

更新日期：2018-12-01 00:00:00

abstract：:Cerebral ischemia triggers secondary ischemia/reperfusion injury and endoplasmic reticulum stress initiates cell apoptosis. However, the regulatory mechanism of the signaling pathway remains unclear. We hypothesize that the regulatory mechanisms are mediated by the protein kinase-like endoplasmic reticulum kinase/euka...

journal_title：Neural regeneration research

authors： Yang JW,Hu ZP

更新日期：2015-08-01 00:00:00

abstract：:Traumatic brain injury (TBI) is characterized by primary damage to the brain from the external mechanical force and by subsequent secondary injury due to various molecular and pathophysiological responses that eventually lead to neuronal cell death. Secondary brain injury events may occur minutes, hours, or even days ...

journal_title：Neural regeneration research

authors： Martinez B,Peplow PV

更新日期：2017-11-01 00:00:00

abstract：:Magnetic resonance diffusion tensor imaging has been shown to quantitatively measure the early pathological changes in chronic cervical spondylotic myelopathy. In this study, a novel spongy polyurethane material was implanted in the rat C3-5 epidural space to establish a rat model of chronic cervical spondylotic myelo...

journal_title：Neural regeneration research

authors： Lin E,Long H,Li G,Lei W

更新日期：2013-12-25 00:00:00

abstract：:Paired associative stimulation has been used in stroke patients as an innovative recovery treatment. However, the mechanisms underlying the therapeutic effectiveness of paired associative stimulation on neurological function remain unclear. In this study, rats were randomly divided into middle cerebral occlusion model...

journal_title：Neural regeneration research

authors： Gao BY,Sun CC,Xia GH,Zhou ST,Zhang Y,Mao YR,Liu PL,Zheng Y,Zhao D,Li XT,Xu J,Xu DS,Bai YL

更新日期：2020-11-01 00:00:00

abstract：:Alzheimer's disease (AD) is an increasingly pressing worldwide public-health, social, political and economic concern. Despite significant investment in multiple traditional therapeutic strategies that have achieved success in preclinical models addressing the pathological hallmarks of the disease, these efforts have n...

journal_title：Neural regeneration research

authors： Onyango IG

更新日期：2018-01-01 00:00:00

abstract：:Previous studies have demonstrated that sevoflurane postconditioning can provide neuroprotection after hypoxic-ischemic injury and improve learning and memory function in developing rodent brains. The classical Rice-Vannucci model was used to induce hypoxic-ischemic injury, and newborn (postnatal day 7) rats were trea...

journal_title：Neural regeneration research

authors： Gao QS,Zhang YH,Xue H,Wu ZY,Li C,Zhao P

更新日期：2021-06-01 00:00:00

abstract：:Traumatic brain injury survivors often experience cognitive deficits and neuropsychiatric symptoms. However, the neurobiological mechanisms underlying specific impairments are not fully understood. Advances in neuroimaging techniques (such as diffusion tensor imaging and functional MRI) have given us new insights on s...

journal_title：Neural regeneration research

authors： Xiao H,Yang Y,Xi JH,Chen ZQ

更新日期：2015-12-01 00:00:00

abstract：:In the present study, a rat model of non-traumatic intracerebral hemorrhage was established by type IV collagenase injection into the right globus pallidus. Bax and Bcl-2 expression in tissues surrounding hematomas was significantly increased within 14 days after injury, and it then gradually decreased. Vascular endot...

journal_title：Neural regeneration research

authors： Wang R,Hao D,Shi W,Pu J,Wang Z

更新日期：2012-03-15 00:00:00

abstract：:Microtubule-associated protein 1B plays an important role in axon guidance and neuronal migration. In the present study, we sought to discover the mechanisms underlying microtubule-associated protein 1B mediation of axon guidance and neuronal migration. We exposed bone marrow mesenchymal stem cells to okadaic acid or ...

journal_title：Neural regeneration research

authors： Xia P,Pan S,Cheng J,Yang M,Qi Z,Hou T,Yang X

更新日期：2014-09-15 00:00:00

abstract：:Electroacupuncture has been shown to improve cerebral blood flow in animal models of stroke. However, it is unclear whether electroacupuncture alters miRNA expression in the cortex. In this study, we examined changes in the cerebral cortical miRNA profile, cerebral blood flow and neurological function induced by elect...

journal_title：Neural regeneration research

authors： Zheng HZ,Jiang W,Zhao XF,Du J,Liu PG,Chang LD,Li WB,Hu HT,Shi XM

更新日期：2016-12-01 00:00:00

abstract：:There are several major pathological changes in Alzheimer's disease, including apoptosis of cholinergic neurons, overactivity or overexpression of β-site amyloid precursor protein cleaving enzyme 1 (BACE1) and inflammation. In this study, we synthesized a 19-nt oligonucleotide targeting BACE1, the key enzyme in amyloi...

journal_title：Neural regeneration research

authors： Liu Z,Li S,Liang Z,Zhao Y,Zhang Y,Yang Y,Wang M,Li F

更新日期：2013-11-25 00:00:00

abstract：:Microglia-associated neuroinflammation plays an important role in the pathophysiology of ischemic stroke. Microglial activation and polarization, and the inflammatory response mediated by these cells play important roles in the development, progression and outcome of brain injury after ischemic stroke. Currently, ther...

journal_title：Neural regeneration research

authors： Zhang W,Tian T,Gong SX,Huang WQ,Zhou QY,Wang AP,Tian Y

更新日期：2021-01-01 00:00:00

abstract：:Previous studies demonstrate an accumulation of transferrin and transferrin receptor 1 (TfR1) in regenerating peripheral nerves. However, the expression and function of transferrin and TfR1 in the denervated skeletal muscle remain poorly understood. In this study, a mouse model of denervation was produced by complete ...

journal_title：Neural regeneration research

authors： Li Y,Cheng JX,Yang HH,Chen LP,Liu FJ,Wu Y,Fan M,Wu HT

更新日期：2021-07-01 00:00:00

abstract：:Rho-associated kinase (ROCK) is a key regulatory protein involved in inflammatory secretion in microglia in the central nervous system. Our previous studies showed that ROCK inhibition enhances phagocytic activity in microglia through the extracellular signal-regulated kinase (ERK) signaling pathway, but its effect on...

journal_title：Neural regeneration research

authors： Fu PC,Tang RH,Yu ZY,Xie MJ,Wang W,Luo X

更新日期：2018-04-01 00:00:00

abstract：:Traumatic brain injury is a major health problem worldwide. Currently, there is no effective treatment to improve neural structural repair and functional recovery of patients in the clinic. Cell transplantation is a potential strategy to repair and regenerate the injured brain. This review article summarized recent de...

journal_title：Neural regeneration research

authors： Sun D

更新日期：2016-01-01 00:00:00

abstract：:In this study, rats were put into traumatic brain injury-induced coma and treated with median nerve electrical stimulation. We explored the wake-promoting effect, and possible mechanisms, of median nerve electrical stimulation. Electrical stimulation upregulated the expression levels of orexin-A and its receptor OX1R ...

journal_title：Neural regeneration research

authors： Feng Z,Zhong YJ,Wang L,Wei TQ

更新日期：2015-04-01 00:00:00

abstract：:In the present study, we examined the analgesic effect of repeated electroacupuncture at bilateral Zusanli (ST36) and Yanglingquan (GB34) once a day for 14 consecutive days in a rat model of chronic sciatic nerve constriction injury-induced neuropathic pain. In addition, concomitant changes in calcium/calmodulin-depen...

journal_title：Neural regeneration research

authors： Xu Q,Liu T,Chen S,Gao Y,Wang J,Qiao L,Liu J

更新日期：2012-06-25 00:00:00

abstract：:Three-dimensional (3D) histology utilizes tissue clearing techniques to turn intact tissues transparent, allowing rapid interrogation of tissue architecture in three dimensions. In this article, we summarized the available tissue clearing methods and classified them according to their physicochemical principles of ope...

journal_title：Neural regeneration research

authors： Lai HM,Ng HM,Wu W

更新日期：2017-01-01 00:00:00

abstract：:Neural stem/progenitor cell (NSC) transplantation has been shown to effectively improve neurological function in rats with hypoxic-ischemic brain damage. Vascular endothelial growth factor (VEGF) is a signaling protein that stimulates angiogenesis and improves neural regeneration. We hypothesized that transplantation ...

journal_title：Neural regeneration research

authors： Yao Y,Zheng XR,Zhang SS,Wang X,Yu XH,Tan JL,Yang YJ

更新日期：2016-09-01 00:00:00