Regulation of neuronal bioenergetics as a therapeutic strategy in neurodegenerative diseases.

Abstract:

:Neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis are a heterogeneous group of debilitating disorders with multifactorial etiologies and pathogeneses that manifest distinct molecular mechanisms and clinical manifestations with abnormal protein dynamics and impaired bioenergetics. Mitochondrial dysfunction is emerging as an important feature in the etiopathogenesis of these age-related neurodegenerative diseases. The prevalence and incidence of these diseases is on the rise with the increasing global population and average lifespan. Although many therapeutic approaches have been tested, there are currently no effective treatment routes for the prevention or cure of these diseases. We present the current status of our knowledge and understanding of the involvement of mitochondrial dysfunction in these diseases and highlight recent advances in novel therapeutic strategies targeting neuronal bioenergetics as potential approach for treating these diseases.

journal_name

Neural Regen Res

authors

Onyango IG,Bennett JP,Stokin GB

doi

10.4103/1673-5374.303007

subject

Has Abstract

pub_date

2021-08-01 00:00:00

pages

1467-1482

issue

8

eissn

1673-5374

issn

1876-7958

pii

NeuralRegenRes_2021_16_8_1467_303007

journal_volume

16

pub_type

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