Abstract：
:Neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis are a heterogeneous group of debilitating disorders with multifactorial etiologies and pathogeneses that manifest distinct molecular mechanisms and clinical manifestations with abnormal protein dynamics and impaired bioenergetics. Mitochondrial dysfunction is emerging as an important feature in the etiopathogenesis of these age-related neurodegenerative diseases. The prevalence and incidence of these diseases is on the rise with the increasing global population and average lifespan. Although many therapeutic approaches have been tested, there are currently no effective treatment routes for the prevention or cure of these diseases. We present the current status of our knowledge and understanding of the involvement of mitochondrial dysfunction in these diseases and highlight recent advances in novel therapeutic strategies targeting neuronal bioenergetics as potential approach for treating these diseases.
journal_name
Neural Regen Resjournal_title
Neural regeneration researchauthors
Onyango IG,Bennett JP,Stokin GBdoi
10.4103/1673-5374.303007subject
Has Abstractpub_date
2021-08-01 00:00:00pages
1467-1482issue
8eissn
1673-5374issn
1876-7958pii
NeuralRegenRes_2021_16_8_1467_303007journal_volume
16pub_type
杂志文章abstract：:[This corrects the article DOI: 10.4103/1673-5374.245480]. ...
journal_title：Neural regeneration research
pub_type： 杂志文章,已发布勘误
doi：10.4103/1673-5374.250633
更新日期：2019-06-01 00:00:00
abstract：:The present study investigated the influence of anti-estrogen treatment (fulvestrant) on pituitary adenoma cell line GH3 biological activity, the estrogen receptor α pathway, the WnT pathway, and mechanisms of decreased Wnt inhibitory factor-1 expression in GH3 cells. Results showed that fulvestrant suppressed GH3 cel...
journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.3969/j.issn.1673-5374.2012.04.008
更新日期：2012-02-05 00:00:00
abstract：:A model of cerebral ischemia and reperfusion was established in mice. Mice were treated with ketamine via intraperitoneal injection immediately following ischemia or ischemia/reperfusion. Ketamine did not remarkably change infarct volume in mice immediately following ischemia, but injection immediately following ische...
journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.3969/j.issn.1673-5374.2012.11.006
更新日期：2012-04-15 00:00:00
abstract：:A significant amount of evidence indicates that microRNAs (miRNAs) play an important role in drug addiction. The nucleus accumbens (NAc) is a critical part of the brain's reward circuit and is involved in a variety of psychiatric disorders, including depression, anxiety, and drug addiction. However, few studies have e...
journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.4103/1673-5374.224374
更新日期：2018-01-01 00:00:00
abstract：:Knowledge of the plasticity of language pathways in patients with low-grade glioma is important for neurosurgeons to achieve maximum resection while preserving neurological function. The current study sought to investigate changes in the ventral language pathways in patients with low-grade glioma located in regions li...
journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.3969/j.issn.1673-5374.2013.07.009
更新日期：2013-03-05 00:00:00
abstract：:Damage to peripheral nerve tissue may cause loss of function in both the nerve and the targeted muscles it innervates. This study compared the repair capability of engineered nerve conduit (ENC), engineered fibroblast conduit (EFC), and autograft in a 10-mm tibial nerve gap. ENCs were fabricated utilizing primary fibr...
journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.4103/1673-5374.215265
更新日期：2017-09-01 00:00:00
abstract：:There are several major pathological changes in Alzheimer's disease, including apoptosis of cholinergic neurons, overactivity or overexpression of β-site amyloid precursor protein cleaving enzyme 1 (BACE1) and inflammation. In this study, we synthesized a 19-nt oligonucleotide targeting BACE1, the key enzyme in amyloi...
journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.3969/j.issn.1673-5374.2013.33.003
更新日期：2013-11-25 00:00:00
abstract：:In this study, human umbilical cord mesenchymal stem cells from full-term neonates born by vaginal delivery were cultured in medium containing 150 mg/mL of brain tissue extracts from Sprague-Dawley rats (to mimic the brain microenvironment). Immunocytochemical analysis demonstrated that the cells differentiated into n...
journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.3969/j.issn.1673-5374.2012.25.001
更新日期：2012-09-05 00:00:00
abstract：:Acrylamide has been shown to be neurotoxic. Brain-derived neurotrophic factor (BDNF) can alleviate acrylamide-induced synaptic injury; however, the underlying mechanism remains unclear. In this study, dibutyryl-cyclic adenosine monophosphate-induced mature human neuroblastoma (NB-1) cells were exposed with 0-100 μg/mL...
journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.4103/1673-5374.286976
更新日期：2021-01-01 00:00:00
abstract：:The electrical excitability of neural networks is influenced by different environmental factors. Effective and simple methods are required to objectively and quantitatively evaluate the influence of such factors, including variations in temperature and pharmaceutical dosage. The aim of this paper was to introduce 'the...
journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.4103/1673-5374.233446
更新日期：2018-06-01 00:00:00
abstract：:Gynostemma (G.) pentaphyllum (Cucurbitaceae) contains various bioactive gypenosides. Ethanol extract from G. pentaphyllum (GP-EX) has been shown to have ameliorative effects on the death of dopaminergic neurons in animal models of Parkinson's disease (PD) induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine- and 6-...
journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.4103/1673-5374.265557
更新日期：2020-02-01 00:00:00
abstract：:The main goal of spinal cord rehabilitation is to restore walking ability and improve walking quality after spinal cord injury (SCI). The spatiotemporal parameters of walking and the parameters of plantar pressure can be obtained using a plantar pressure analysis system. Previous studies have reported step asymmetry i...
journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.4103/1673-5374.244798
更新日期：2019-02-01 00:00:00
abstract：:Alzheimer's disease (AD) is an increasingly pressing worldwide public-health, social, political and economic concern. Despite significant investment in multiple traditional therapeutic strategies that have achieved success in preclinical models addressing the pathological hallmarks of the disease, these efforts have n...
journal_title：Neural regeneration research
pub_type： 杂志文章,评审
doi：10.4103/1673-5374.224362
更新日期：2018-01-01 00:00:00
abstract：:Aquaporin-4 regulates water molecule channels and is important in tissue regulation and water transportation in the brain. Upregulation of aquaporin-4 expression is closely related to cellular edema after early cerebral infarction. Cellular edema and aquaporin-4 expression can be determined by measuring cerebral infar...
journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.4103/1673-5374.160099
更新日期：2015-07-01 00:00:00
abstract：:Astrocytes are specialized and most numerous glial cell type in the central nervous system and play important roles in physiology. Astrocytes are also critically involved in many neural disorders including focal ischemic stroke, a leading cause of brain injury and human death. One of the prominent pathological feature...
journal_title：Neural regeneration research
pub_type： 杂志文章,评审
doi：10.4103/1673-5374.147929
更新日期：2014-12-01 00:00:00
abstract：:Accumulating studies suggest that neuroinflammation characterized by microglial overactivation plays a pivotal role in the pathogenesis of Parkinson's disease. As such, inhibition of microglial overactivation might be a promising treatment strategy to delay the onset or slow the progression of Parkinson's disease. Gin...
journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.4103/1673-5374.257536
更新日期：2019-10-01 00:00:00
abstract：:Decreased expression of brain-derived neurotrophic factor (BDNF) plays an important role in the pathogenesis of Alzheimer's disease, and a typical pathological change in Alzheimer's disease is neurofibrillary tangles caused by hyperphosphorylation of tau. An in vivo model of Alzheimer's disease was developed by inject...
journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.4103/1673-5374.241471
更新日期：2018-12-01 00:00:00
abstract：:Previous studies have demonstrated the protective effect of hypoxic preconditioning on acute cerebral infarction, but the mechanisms underlying this protection remain unclear. To investigate the protective mechanisms of hypoxic preconditioning in relation to its effects on angiogenesis, we induced a photochemical mode...
journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.3969/j.issn.1673-5374.2013.31.002
更新日期：2013-11-05 00:00:00
abstract：:Various studies have reported that galanin can promote axonal regeneration of dorsal root ganglion neurons in vitro and inhibit neuropathic pain. However, little is known about its effects on diabetic peripheral neuropathy, and in vivo experimental data are lacking. We hypothesized that repeated applications of exogen...
journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.4103/1673-5374.191228
更新日期：2016-09-01 00:00:00
abstract：:The three-dimensional (3D) visualization of the functional bundles in the peripheral nerve provides direct and detailed intraneural spatial information. It is useful for selecting suitable surgical methods to repair nerve defects and in optimizing the construction of tissue-engineered nerve grafts. However, there rema...
journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.4103/1673-5374.235307
更新日期：2018-08-01 00:00:00
abstract：:As a neuroprotective drug for the treatment of ischemic stroke, 3-n-butylphthalide, a celery seed extract, has been approved by the State Food and Drug Administration of China as a clinical therapeutic drug for ischemic stroke patients. L-3-n-butylphthalide possesses significant efficacy in the treatment of acute isch...
journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.3969/j.issn.1673-5374.2013.19.001
更新日期：2013-07-05 00:00:00
abstract：:Chronic activation of microglial cells endangers neuronal survival through the release of various proinflammatory and neurotoxic factors. The root of Paeonia lactiflora Pall has been considered useful for the treatment of various disorders in traditional oriental medicine. Paeonol, found in the root of Paeonia lactifl...
journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.3969/j.issn.1673-5374.2013.18.001
更新日期：2013-06-25 00:00:00
abstract：OBJECTIVE:To review published data on the biological characteristics, differentiation and applications of adipose-derived stem cells in ischemic diseases. DATA RETRIEVAL:A computer-based online search of reports published from January 2005 to June 2012 related to the development of adipose-derived stem cells and their...
journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.3969/j.issn.1673-5374.2012.25.011
更新日期：2012-09-05 00:00:00
abstract：:Neural stem/progenitor cell (NSC) transplantation has been shown to effectively improve neurological function in rats with hypoxic-ischemic brain damage. Vascular endothelial growth factor (VEGF) is a signaling protein that stimulates angiogenesis and improves neural regeneration. We hypothesized that transplantation ...
journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.4103/1673-5374.191220
更新日期：2016-09-01 00:00:00
abstract：:In this study, we tried to verify the neuroprotective effect of Chrysanthemum indicum Linne (CIL) extract, which has been used as a botanical drug in East Asia, against ischemic damage and to explore the underlying mechanism involving the anti-inflammatory approach. A gerbil was given CIL extract for 7 consecutive day...
journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.4103/1673-5374.177735
更新日期：2016-02-01 00:00:00
abstract：:[This corrects the article on p. 1386 in vol. 10, PMID: 26604888.]. ...
journal_title：Neural regeneration research
pub_type： 已发布勘误
doi：10.4103/1673-5374.187069
更新日期：2016-07-01 00:00:00
abstract：:Amyloid β peptide binding alcohol dehydrogenase (ABAD) decoy peptide (DP) can competitively antagonize binding of amyloid β peptide to ABAD and inhibit the cytotoxic effects of amyloid β peptide. Based on peptide aptamers, the present study inserted ABAD-DP into the disulfide bond of human thioredoxin (TRX) using mole...
journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.3969/j.issn.1673-5374.2013.01.005
更新日期：2013-01-05 00:00:00
abstract：:Traumatic brain injury can cause loss of neuronal tissue, remote symptomatic epilepsy, and cognitive deficits. However, the mechanisms underlying the effects of traumatic brain injury are not yet clear. Hippocampal excitability is strongly correlated with cognitive dysfunction and remote symptomatic epilepsy. In this ...
journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.4103/1673-5374.238618
更新日期：2018-10-01 00:00:00
abstract：:We report a patient with severe ataxia due to Dandy-Walker malformation, who showed functional recovery over 10 months corresponding to a change in a cerebellar peduncle lesion. A 20-month-old female patient who was diagnosed with Dandy-Walker syndrome and six age- and sex-matched healthy control subjects were enrolle...
journal_title：Neural regeneration research
pub_type：
doi：10.3969/j.issn.1673-5374.2013.05.012
更新日期：2013-02-15 00:00:00
abstract：:Molecular mechanisms of the Krüppel-like family of transcription factors (KLFs) have been studied more in proliferating cells than in post-mitotic cells such as neurons. We recently found that KLFs regulate intrinsic axon growth ability in central nervous system (CNS) neurons including retinal ganglion cells, and hipp...
journal_title：Neural regeneration research
pub_type： 杂志文章,评审
doi：10.4103/1673-5374.139454
更新日期：2014-08-01 00:00:00
