Scaffoldless tissue-engineered nerve conduit promotes peripheral nerve regeneration and functional recovery after tibial nerve injury in rats.

abstract：:Type 2 diabetes-associated with impaired insulin/insulin-like growth factor-1 (IGF1) signaling (IIS)-is a risk factor for cognitive impairment and dementia including Alzheimer's disease (AD). The insulin receptor substrate (IRS) proteins are major components of IIS, which transmit upstream signals via the insulin rece...

journal_title：Neural regeneration research

authors： Tanokashira D,Fukuokaya W,Taguchi A

更新日期：2019-08-01 00:00:00

abstract：:Various studies have reported that galanin can promote axonal regeneration of dorsal root ganglion neurons in vitro and inhibit neuropathic pain. However, little is known about its effects on diabetic peripheral neuropathy, and in vivo experimental data are lacking. We hypothesized that repeated applications of exogen...

journal_title：Neural regeneration research

authors： Xu XF,Zhang DD,Liao JC,Xiao L,Wang Q,Qiu W

更新日期：2016-09-01 00:00:00

abstract：:Hippocampal neurons undergo various forms of cell death after status epilepticus. Necrostatin-1 specifically inhibits necroptosis mediated by receptor interacting protein kinase 1 (RIP1) and RIP3 receptors. However, there are no reports of necroptosis in mouse models of status epilepticus. Therefore, in this study, we...

journal_title：Neural regeneration research

authors： Lin DQ,Cai XY,Wang CH,Yang B,Liang RS

更新日期：2020-05-01 00:00:00

abstract：:Genome-wide studies have reported that Parkinson's disease is associated with abnormal expression of various growth factors. In this study, male C57BL/6 mice aged 10 weeks were used to establish Parkinson's disease models using an intraperitoneal injection of 60 mg/kg 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. 28 d...

journal_title：Neural regeneration research

authors： Wang AQ,Kong LN,Meng MZ,Zhao XH,Chen S,Wang XT

更新日期：2019-08-01 00:00:00

abstract：:Neurotropic herpesviruses have been associated with the onset and progression of Alzheimer's disease, a common form of dementia that afflicts a large percentage of elderly individuals. Interestingly, among the neurotropic herpesviruses, herpes simplex virus-1, human herpesvirus-6A, and human herpesvirus-6B have been r...

journal_title：Neural regeneration research

authors： Romeo MA,Faggioni A,Cirone M

更新日期：2019-09-01 00:00:00

abstract：:In the present study, we used immunohistochemistry and western blot analysis to examine changes in the levels and cellular localization of iron, heavy chain ferritin (ferritin-H), and transferrin in the gerbil hippocampal CA1 region from 30 minutes to 7 days following transient forebrain ischemia. Relative to sham con...

journal_title：Neural regeneration research

authors： Yoo DY,Yoo KY,Park JH,Kwon HJ,Jung HY,Kim JW,Choi GM,Moon SM,Kim DW,Yoon YS,Won MH,Hwang IK

更新日期：2016-06-01 00:00:00

abstract：:An increasing amount of evidence demonstrates the anti-aging effect of Heshouwu in pill form. In this study, a subacute aging rat model was established by continuous intraperitoneal injection of D-galactose and treated with Heshouwu decoction (a Chinese herb for tonifying the kidney, comprising Heshouwu pill, Herba Ep...

journal_title：Neural regeneration research

authors： Niu S,Kou S,Zhou X,Ding L

更新日期：2012-07-25 00:00:00

abstract：:The study illustrates that graphene oxide nanosheets can endow materials with continuous electrical conductivity for up to 4 weeks. Conductive nerve scaffolds can bridge a sciatic nerve injury and guide the growth of neurons; however, whether the scaffolds can be used for the repair of spinal cord nerve injuries remai...

journal_title：Neural regeneration research

authors： Yang B,Wang PB,Mu N,Ma K,Wang S,Yang CY,Huang ZB,Lai Y,Feng H,Yin GF,Chen TN,Hu CS

更新日期：2021-09-01 00:00:00

abstract：:White adipose tissue (WAT) stores energy and also plays an important endocrine role in producing adipokines for communication with the peripheral and central nervous system. WAT consists of the major lipogenic unilocular adipocytes and the minor populations of beige and brite multilocular adipocytes. These multilocula...

journal_title：Neural regeneration research

authors： Lee A,Ziouzenkova O

更新日期：2019-02-01 00:00:00

abstract：:The present study analyzed the anatomical association between intracranial subarachnoid space and the cervical lymphatic system. X-ray contrast medium and Microfil(®) (Microfil compounds fill and opacify microvascular and other spaces of non-surviving animals and post-mortem tissue under physiological injection pressu...

journal_title：Neural regeneration research

authors： Liu H,Ni Z,Chen Y,Wang D,Qi Y,Zhang Q,Wang S

更新日期：2012-04-05 00:00:00

abstract：:Botulinum toxin type A is a potent muscle relaxant that blocks the transmission and release of acetylcholine at the neuromuscular junction. Intramuscular injection of botulinum toxin type A has served as an effective and safe therapy for strabismus and focal dystonia. However, muscular weakness is temporary and after ...

journal_title：Neural regeneration research

authors： Jiang H,Xiang Y,Hu X,Cai H

更新日期：2014-08-15 00:00:00

abstract：:The motor relearning program can significantly improve various functional disturbance induced by ischemic cerebrovascular diseases. However, its mechanism of action remains poorly understood. In injured brain tissues, glial fibrillary acidic protein and neurofilament protein changes can reflect the condition of injure...

journal_title：Neural regeneration research

authors： Yin Y,Gu Z,Pan L,Gan L,Qin D,Yang B,Guo J,Hu X,Wang T,Feng Z

更新日期：2013-06-05 00:00:00

abstract：:The G-protein-coupled purinergic receptor P2Y2 (P2RY2) plays an important role in the mechanism of atherosclerosis, which is relevant to ischemic stroke. This retrospective case-control study aimed to assess the relationship between P2RY2 gene polymorphisms and ischemic stroke risk in the northern Han Chinese populati...

journal_title：Neural regeneration research

authors： Yuan LY,He ZY,Li L,Wang YZ

更新日期：2019-03-01 00:00:00

abstract：:For decades visual field defects were considered irreversible because it was thought that in the visual system the regeneration potential of the neuronal tissues is low. Nevertheless, there is always some potential for partial recovery of the visual field defect that can be achieved through induction of neuroplasticit...

journal_title：Neural regeneration research

authors： Sabel BA,Gao Y,Antal A

更新日期：2020-10-01 00:00:00

abstract：:A survivin siRNA expression vector was transfected into glioma U-87MG cells and these cells were then treated with paclitaxel. The results showed that survivin-specific siRNA combined with paclitaxel treatment synergistically inhibited glioma U-87MG cell proliferation and promoted apoptosis. This treatment also inhibi...

journal_title：Neural regeneration research

authors： Xie Y,Liu Y,Shen W,Zhang B,Liu Q

更新日期：2012-05-05 00:00:00

abstract：:Puerarin is a natural isoflavone isolated from plants of the genus Pueraria and functions as a protector against cerebral ischemia. We hypothesized that puerarin can be involved in the repair of peripheral nerve injuries. To test this hypothesis, doses of 10, 5, or 2.5 mg/kg per day puerarin (8-(β-D-Glucopyranosyl-7-h...

journal_title：Neural regeneration research

authors： Wu M,Zhao G,Yang X,Peng C,Zhao J,Liu J,Li R,Gao Z

更新日期：2014-03-15 00:00:00

abstract：:Paired immunoglobulin-like receptor B (PirB) is a functional receptor of myelin-associated inhibitors for axonal regeneration and synaptic plasticity in the central nervous system, and thus suppresses nerve regeneration. The regulatory effect of PirB on injured nerves has received a lot of attention. To better underst...

journal_title：Neural regeneration research

authors： Peng WS,Qi C,Zhang H,Gao ML,Wang H,Ren F,Li XQ

更新日期：2015-07-01 00:00:00

abstract：:Previous studies have indicated that electrical stimulation of the cerebellar fastigial nucleus in rats may reduce brain infarct size, increase the expression of Ku70 in cerebral ischemia/reperfusion area, and decrease the number of apoptotic neurons. However, the anti-apoptotic mechanism of Ku70 remains unclear. In t...

journal_title：Neural regeneration research

authors： Liu J,Li J,Yang Y,Wang X,Zhang Z,Zhang L

更新日期：2014-04-01 00:00:00

abstract：:Lentivirus carrying the Atoh1 gene can infect Corti's organ and express a hair-like cell surface marker in the supporting cell area. However, expression of the gene carried by adenovirus is instantaneous, which undoubtedly limits its clinical application. Lentivirus acts as a carrier that can stably and continuously e...

journal_title：Neural regeneration research

authors： Pan S,Wan J,Liu S,Zhang S,Xiong H,Zhou J,Xiong W,Yu K,Fu Y

更新日期：2013-06-15 00:00:00

abstract：:Both matrix biochemistry and neurotrophic factors are known to modulate neurite outgrowth and pathfinding; however, the interplay between these two factors is less studied. While previous work has shown that the biochemical identity of the matrix can alter the outgrowth of neurites in response to neurotrophins, the im...

journal_title：Neural regeneration research

authors： Madl CM,Heilshorn SC

更新日期：2015-04-01 00:00:00

abstract：:Rho-associated kinase (ROCK) is a key regulatory protein involved in inflammatory secretion in microglia in the central nervous system. Our previous studies showed that ROCK inhibition enhances phagocytic activity in microglia through the extracellular signal-regulated kinase (ERK) signaling pathway, but its effect on...

journal_title：Neural regeneration research

authors： Fu PC,Tang RH,Yu ZY,Xie MJ,Wang W,Luo X

更新日期：2018-04-01 00:00:00

abstract：:Huntington's disease (HD) is an autosomal-dominant neurodegenerative disease characterized by the selective loss of neurons in the striatum and cortex, leading to progressive motor dysfunction, cognitive decline and behavioral symptoms. HD is caused by a trinucleotide (CAG) repeat expansion in the gene encoding for hu...

journal_title：Neural regeneration research

authors： Colpo GD,Stimming EF,Rocha NP,Teixeira AL

更新日期：2017-09-01 00:00:00

abstract：:Stroke is one of the leading causes of death and disability in adults worldwide, resulting in huge social and financial burdens. Extracts from herbs, especially those used in Chinese medicine, have emerged as new pharmaceuticals for stroke treatment. Here we review the evidence from preclinical studies investigating n...

journal_title：Neural regeneration research

authors： Zhang B,Saatman KE,Chen L

更新日期：2020-03-01 00:00:00

abstract：:The blood-spinal cord barrier plays a vital role in recovery after spinal cord injury. The neurovascular unit concept emphasizes the relationship between nerves and vessels in the brain, while the effect of the blood-spinal cord barrier on the neurovascular unit is rarely reported in spinal cord injury studies. Mouse ...

journal_title：Neural regeneration research

authors： Ye LX,An NC,Huang P,Li DH,Zheng ZL,Ji H,Li H,Chen DQ,Wu YQ,Xiao J,Xu K,Li XK,Zhang HY

更新日期：2021-04-01 00:00:00

abstract：:Electroacupuncture improves depressive behavior faster and with fewer adverse effects than antidepressant medication. However, the antidepressant mechanism of electroacupuncture remains poorly understood. Here, we established a rat model of chronic unpredicted mild stress, and then treated these rats with electroacupu...

journal_title：Neural regeneration research

authors： Duan DM,Tu Y,Liu P,Jiao S

更新日期：2016-10-01 00:00:00

abstract：:The main goal of spinal cord rehabilitation is to restore walking ability and improve walking quality after spinal cord injury (SCI). The spatiotemporal parameters of walking and the parameters of plantar pressure can be obtained using a plantar pressure analysis system. Previous studies have reported step asymmetry i...

journal_title：Neural regeneration research

authors： Yuan XN,Liang WD,Zhou FH,Li HT,Zhang LX,Zhang ZQ,Li JJ

更新日期：2019-02-01 00:00:00

abstract：:Fractional anisotropy values in diffusion tensor imaging can quantitatively reflect the consistency of nerve fibers after brain damage, where higher values generally indicate less damage to nerve fibers. Therefore, we hypothesized that diffusion tensor imaging could be used to evaluate the effect of mild hypothermia o...

journal_title：Neural regeneration research

authors： Jing G,Yao X,Li Y,Xie Y,Li WX,Liu K,Jing Y,Li B,Lv Y,Ma B

更新日期：2014-01-15 00:00:00

abstract：:The choroid plexus is a complex structure which hangs inside the ventricles of the brain and consists mainly of choroid plexus epithelial (CPE) cells surrounding fenestrated capillaries. These CPE cells not only form an anatomical barrier, called the blood-cerebrospinal fluid barrier (BCSFB), but also present an activ...

journal_title：Neural regeneration research

authors： Balusu S,Brkic M,Libert C,Vandenbroucke RE

更新日期：2016-04-01 00:00:00

abstract：:A growing body of evidence suggests that disruption of the homeostasis of lipid metabolism affects the pathogenesis of Alzheimer's disease (AD). In particular, dysregulation of cholesterol homeostasis in the brain has been reported to considerably increase the risk of developing AD. Thus, dysregulation of lipid homeos...

journal_title：Neural regeneration research

authors： Li HH,Lin CL,Huang CN

更新日期：2018-02-01 00:00:00

abstract：:Olive leaves have an antioxidant capacity, and olive leaf extract can protect the blood, spleen and hippocampus in lead-poisoned mice. However, little is known about the effects of olive leaf extract on lead-induced brain injury. This study was designed to determine whether olive leaf extract can inhibit lead-induced ...

journal_title：Neural regeneration research

authors： Wang Y,Wang S,Cui W,He J,Wang Z,Yang X

更新日期：2013-08-05 00:00:00