Comparison of walking quality variables between incomplete spinal cord injury patients and healthy subjects by using a footscan plantar pressure system.

Abstract:

:The main goal of spinal cord rehabilitation is to restore walking ability and improve walking quality after spinal cord injury (SCI). The spatiotemporal parameters of walking and the parameters of plantar pressure can be obtained using a plantar pressure analysis system. Previous studies have reported step asymmetry in patients with bilateral SCI. However, the asymmetry of other parameters in patients with SCI has not been reported. This was a prospective, cross-sectional study, which included 23 patients with SCI, aged 48.1 ± 14.5 years, and 28 healthy subjects, aged 47.1 ± 9.8 years. All subjects underwent bare foot walking on a plantar pressure measurement device to measure walking speed and spatiotemporal parameters. Compared with healthy subjects, SCI patients had slower walking speed, longer stride time and stance time, larger stance phase percentage, and shorter stride length. The peak pressures under the metatarsal heads and toe were lower in SCI patients than in healthy subjects. In the heel, regional impulse and the contact area percentage in SCI patients were higher than those in healthy subjects. The symmetry indexes of stance time, step length, maximum force, impulse and contact area were increased in SCI patients, indicating a decline in symmetry. The results confirm that the gait quality, including spatiotemporal variables and plantar pressure parameters, and symmetry index were lower in SCI patients compared with healthy subjects. Plantar pressure parameters and symmetry index could be sensitive quantitative parameters to improve gait quality of SCI patients. The protocols were approved by the Clinical Research Ethics Committee of Shengjing Hospital of China Medical University (approval No. 2015PS54J) on August 13, 2015. This trial was registered in the ISRCTN Registry (ISRCTN42544587) on August 22, 2018. Protocol version: 1.0.

journal_name

Neural Regen Res

authors

Yuan XN,Liang WD,Zhou FH,Li HT,Zhang LX,Zhang ZQ,Li JJ

doi

10.4103/1673-5374.244798

subject

Has Abstract

pub_date

2019-02-01 00:00:00

pages

354-360

issue

2

eissn

1673-5374

issn

1876-7958

pii

NeuralRegenRes_2019_14_2_354_244798

journal_volume

14

pub_type

杂志文章
  • Could autophagy dysregulation link neurotropic viruses to Alzheimer's disease?

    abstract::Neurotropic herpesviruses have been associated with the onset and progression of Alzheimer's disease, a common form of dementia that afflicts a large percentage of elderly individuals. Interestingly, among the neurotropic herpesviruses, herpes simplex virus-1, human herpesvirus-6A, and human herpesvirus-6B have been r...

    journal_title:Neural regeneration research

    pub_type: 杂志文章,评审

    doi:10.4103/1673-5374.253508

    authors: Romeo MA,Faggioni A,Cirone M

    更新日期:2019-09-01 00:00:00

  • Inhibition of GABAA-ρ receptors induces retina regeneration in zebrafish.

    abstract::A potential treatment for retinal diseases is to induce an endogenous Müller glia (MG)-derived regenerative response to replace damaged neurons. In contrast to mammalian MG, zebrafish MG are capable of mediating spontaneous regeneration. We seek to define the mechanisms that enable retina regeneration in zebrafish in ...

    journal_title:Neural regeneration research

    pub_type: 杂志文章

    doi:10.4103/1673-5374.286972

    authors: Kent MR,Kara N,Patton JG

    更新日期:2021-02-01 00:00:00

  • A self-made, low-cost infrared system for evaluating the sciatic functional index in mice.

    abstract::The sciatic functional index (SFI) is a popular parameter for peripheral nerve evaluation that relies on footprints obtained with ink and paper. Drawbacks include smearing artefacts and a lack of dynamic information during measurement. Modern applications use digitized systems that can deliver results with less analyt...

    journal_title:Neural regeneration research

    pub_type: 杂志文章

    doi:10.4103/1673-5374.182712

    authors: Fricker L,Penna V,Lampert F,Stark GB,Witzel C,Koulaxouzidis G

    更新日期:2016-05-01 00:00:00

  • Gabapentin inhibits central sensitization during migraine.

    abstract::Peripheral and central sensitizations are phenomena that occur during migraine. The role of pentin, a migraine preventive drug, on central sensitization remains unclear. In this study, a rat model of migraine was established by electrical stimulation of the trigeminal ganglion, and the an-imals were given intragastric...

    journal_title:Neural regeneration research

    pub_type: 杂志文章

    doi:10.3969/j.issn.1673-5374.2013.32.003

    authors: Zhang Y,Shao G,Zhang W,Li S,Niu J,Hu D,Yang M,Ji X

    更新日期:2013-11-15 00:00:00

  • HLA class II alleles and risk for peripheral neuropathy in type 2 diabetes patients.

    abstract::The potential impact of human leukocyte antigen (HLA) genotype variations on development of diabetic peripheral neuropathy (DPN) is not well determined. This study aimed to identify the association of HLA class II alleles with DPN in type 2 diabetes (T2D) patients. Totally 106 T2D patients, 49 with DPN and 57 without ...

    journal_title:Neural regeneration research

    pub_type: 杂志文章

    doi:10.4103/1673-5374.194756

    authors: Marzban A,Kiani J,Hajilooi M,Rezaei H,Kahramfar Z,Solgi G

    更新日期:2016-11-01 00:00:00

  • Sensory reinnervation of free flaps in reconstruction of the breast and the upper and lower extremities.

    abstract::There is long-standing debate about sensate versus non-sensate free microvascular flaps among microsurgeons. The principle of connecting not only the vascular supply, but also sensitive nerves, in free tissue transfer is attractive. However, increased operating time and partial spontaneous innervation led to the commo...

    journal_title:Neural regeneration research

    pub_type: 杂志文章

    doi:10.3969/j.issn.1673-5374.2012.29.006

    authors: Sinis N,Lamia A,Gudrun H,Schoeller T,Werdin F

    更新日期:2012-10-15 00:00:00

  • Constraint-induced movement therapy promotes motor function recovery and downregulates phosphorylated extracellular regulated protein kinase expression in ischemic brain tissue of rats.

    abstract::Motor function impairment is a common outcome of stroke. Constraint-induced movement therapy (CIMT) involving intensive use of the impaired limb while restraining the unaffected limb is widely used to overcome the effects of 'learned non-use' and improve limb function after stroke. However, the underlying mechanism of...

    journal_title:Neural regeneration research

    pub_type: 杂志文章

    doi:10.4103/1673-5374.172319

    authors: Zhang B,He Q,Li YY,Li C,Bai YL,Hu YS,Zhang F

    更新日期:2015-12-01 00:00:00

  • Optimal concentration of necrostatin-1 for protecting against hippocampal neuronal damage in mice with status epilepticus.

    abstract::Hippocampal neurons undergo various forms of cell death after status epilepticus. Necrostatin-1 specifically inhibits necroptosis mediated by receptor interacting protein kinase 1 (RIP1) and RIP3 receptors. However, there are no reports of necroptosis in mouse models of status epilepticus. Therefore, in this study, we...

    journal_title:Neural regeneration research

    pub_type: 杂志文章

    doi:10.4103/1673-5374.268903

    authors: Lin DQ,Cai XY,Wang CH,Yang B,Liang RS

    更新日期:2020-05-01 00:00:00

  • Neuroprotective effects of Buyang Huanwu decoction on cerebral ischemia-induced neuronal damage.

    abstract::Among the various treatment methods for stroke, increasing attention has been paid to traditional Chinese medicines. Buyang Huanwu decoction is a commonly used traditional Chinese medicine for the treatment of stroke. This paper summarizes the active components of the Chinese herb, which is composed of Huangqi (Radix ...

    journal_title:Neural regeneration research

    pub_type: 杂志文章

    doi:10.4103/1673-5374.141791

    authors: Mu Q,Liu P,Hu X,Gao H,Zheng X,Huang H

    更新日期:2014-09-01 00:00:00

  • Differential protein expression in spinal cord tissue of a rabbit model of spinal cord ischemia/reperfusion injury.

    abstract::New Zealand rabbits were randomly divided into an ischemia group (occlusion of the abdominal aorta for 60 minutes), an ischemia-reperfusion group (occlusion of the abdominal aorta for 60 minutes followed by 48 hours of reperfusion) and a sham-surgery group. Two-dimensional gel electrophoresis detected 49 differentiall...

    journal_title:Neural regeneration research

    pub_type: 杂志文章

    doi:10.3969/j.issn.1673-5374.2012.20.002

    authors: Gao Q,Liang Y,Yang X,Liu G,Li X,Zhu B,Liu J,Yang M,Xia W,Dong J,Jiao J

    更新日期:2012-07-15 00:00:00

  • Endothelial progenitor cell-conditioned medium promotes angiogenesis and is neuroprotective after spinal cord injury.

    abstract::Endothelial progenitor cells secrete a variety of growth factors that inhibit inflammation, promote angiogenesis and exert neuroprotective effects. Therefore, in this study, we investigated whether endothelial progenitor cell-conditioned medium might have therapeutic effectiveness for the treatment of spinal cord inju...

    journal_title:Neural regeneration research

    pub_type: 杂志文章

    doi:10.4103/1673-5374.232484

    authors: Wang T,Fang X,Yin ZS

    更新日期:2018-05-01 00:00:00

  • The choroid plexus-cerebrospinal fluid interface in Alzheimer's disease: more than just a barrier.

    abstract::The choroid plexus is a complex structure which hangs inside the ventricles of the brain and consists mainly of choroid plexus epithelial (CPE) cells surrounding fenestrated capillaries. These CPE cells not only form an anatomical barrier, called the blood-cerebrospinal fluid barrier (BCSFB), but also present an activ...

    journal_title:Neural regeneration research

    pub_type: 杂志文章,评审

    doi:10.4103/1673-5374.180372

    authors: Balusu S,Brkic M,Libert C,Vandenbroucke RE

    更新日期:2016-04-01 00:00:00

  • Neurological recovery and antioxidant effects of resveratrol in rats with spinal cord injury: a meta-analysis.

    abstract:Objective:To critically assess the neurological recovery and antioxidant effects of resveratrol in rat models of spinal cord injury. Data sources:Using "spinal cord injury", "resveratrol" and "animal experiment" as the main search terms, all studies on the treatment of spinal cord injury in rats by resveratrol were se...

    journal_title:Neural regeneration research

    pub_type: 杂志文章

    doi:10.4103/1673-5374.266064

    authors: Xu BP,Yao M,Li ZJ,Tian ZR,Ye J,Wang YJ,Cui XJ

    更新日期:2020-03-01 00:00:00

  • Quantitative analysis of intraspinal cerebrospinal fluid flow in normal adults.

    abstract::The present study quantitatively analyzed intraspinal cerebrospinal fluid flow patterns in 19 normal adults using fast cine phase-contrast magnetic resonance imaging. Results showed increased downward flow velocity and volume compared with upward flow, and the average downward flow volume of intraspinal cerebrospinal ...

    journal_title:Neural regeneration research

    pub_type: 杂志文章

    doi:10.3969/j.issn.1673-5374.2012.15.007

    authors: Yan L,Liu H,Shang H

    更新日期:2012-05-25 00:00:00

  • Photoacoustic treatment mitigates cognitive dysfunction in a model of sleep-wake rhythm disturbance.

    abstract::Sleep-wake rhythm disturbances, which are characterized by abnormal sleep timing or duration, are associated with cognitive dysfunction. Photoacoustic treatments including light and sound stimulation have been found to be effective in modulating sleep patterns and improving cognitive behavior in abnormal sleep-wake pa...

    journal_title:Neural regeneration research

    pub_type: 杂志文章

    doi:10.4103/1673-5374.270415

    authors: Xing F,Fang X,Gong XD,Zhao X,Du Y,Ma ZL,Gu XP,Xia TJ

    更新日期:2020-06-01 00:00:00

  • Sequencing analysis of matrix metalloproteinase 7-induced genetic changes in Schwann cells.

    abstract::Previous research revealed the positive activity of matrix metalloproteinase 7 (MMP7) on migration and myelin regeneration of Schwann cells (SCs). However, understanding of the molecular changes and biological activities induced by increased amounts of MMP7 in SCs remains limited. To better understand the underlying m...

    journal_title:Neural regeneration research

    pub_type: 杂志文章

    doi:10.4103/1673-5374.282263

    authors: Lu PJ,Wang G,Cai XD,Zhang P,Wang HK

    更新日期:2020-11-01 00:00:00

  • Does hemispheric lateralization influence therapeutic effects of transcranial direct current stimulation?

    abstract::This study investigated the effect of transcranial direct current stimulation (tDCS) polarity depending on lateralized function of task property in normal individuals performing visuomotor and simple repetitive tasks. Thirty healthy participants with no neurological disorders were recruited to participate in this stud...

    journal_title:Neural regeneration research

    pub_type: 杂志文章

    doi:10.4103/1673-5374.175057

    authors: Kwon YH,Kang KW,Lee NK,Son SM

    更新日期:2016-01-01 00:00:00

  • Neuroprotective effects of atorvastatin against cerebral ischemia/reperfusion injury through the inhibition of endoplasmic reticulum stress.

    abstract::Cerebral ischemia triggers secondary ischemia/reperfusion injury and endoplasmic reticulum stress initiates cell apoptosis. However, the regulatory mechanism of the signaling pathway remains unclear. We hypothesize that the regulatory mechanisms are mediated by the protein kinase-like endoplasmic reticulum kinase/euka...

    journal_title:Neural regeneration research

    pub_type: 杂志文章

    doi:10.4103/1673-5374.162755

    authors: Yang JW,Hu ZP

    更新日期:2015-08-01 00:00:00

  • Transgene expression and differentiation of baculovirus-transduced adipose-derived stem cells from dystrophin-utrophin double knock-out mouse.

    abstract::In this study, recombinant baculovirus carrying the microdystrophin and β-catenin genes was used to infect adipose-derived stem cells from a dystrophin-utrophin double knock-out mouse. Results showed that, after baculovirus transgene infection, microdystrophin and β-catenin genes were effectively expressed in adipose-...

    journal_title:Neural regeneration research

    pub_type: 杂志文章

    doi:10.3969/j.issn.1673-5374.2012.22.003

    authors: Li Q,Zhai Q,Geng J,Zheng H,Chen F,Kong J,Zhang C

    更新日期:2012-08-05 00:00:00

  • Temporal changes in inflammatory mitochondria-enriched microRNAs following traumatic brain injury and effects of miR-146a nanoparticle delivery.

    abstract::MicroRNAs (miRNAs) are small non-coding RNA molecules that regulate post-transcriptional gene expression and contribute to all aspects of cellular function. We previously reported that the activities of several mitochondria-enriched miRNAs regulating inflammation (i.e., miR-142-3p, miR-142-5p, and miR-146a) are altere...

    journal_title:Neural regeneration research

    pub_type: 杂志文章

    doi:10.4103/1673-5374.293149

    authors: Wang WX,Prajapati P,Vekaria HJ,Spry M,Cloud AL,Sullivan PG,Springer JE

    更新日期:2021-03-01 00:00:00

  • Exogenous platelet-derived growth factor improves neurovascular unit recovery after spinal cord injury.

    abstract::The blood-spinal cord barrier plays a vital role in recovery after spinal cord injury. The neurovascular unit concept emphasizes the relationship between nerves and vessels in the brain, while the effect of the blood-spinal cord barrier on the neurovascular unit is rarely reported in spinal cord injury studies. Mouse ...

    journal_title:Neural regeneration research

    pub_type: 杂志文章

    doi:10.4103/1673-5374.295347

    authors: Ye LX,An NC,Huang P,Li DH,Zheng ZL,Ji H,Li H,Chen DQ,Wu YQ,Xiao J,Xu K,Li XK,Zhang HY

    更新日期:2021-04-01 00:00:00

  • DTI and pathological changes in a rabbit model of radiation injury to the spinal cord after 125I radioactive seed implantation.

    abstract::Excessive radiation exposure may lead to edema of the spinal cord and deterioration of the nervous system. Magnetic resonance imaging can be used to judge and assess the extent of edema and to evaluate pathological changes and thus may be used for the evaluation of spinal cord injuries caused by radiation therapy. Rad...

    journal_title:Neural regeneration research

    pub_type: 杂志文章

    doi:10.4103/1673-5374.228758

    authors: Cao X,Fang L,Cui CY,Gao S,Wang TW

    更新日期:2018-03-01 00:00:00

  • Transferrin receptor 1 plays an important role in muscle development and denervation-induced muscular atrophy.

    abstract::Previous studies demonstrate an accumulation of transferrin and transferrin receptor 1 (TfR1) in regenerating peripheral nerves. However, the expression and function of transferrin and TfR1 in the denervated skeletal muscle remain poorly understood. In this study, a mouse model of denervation was produced by complete ...

    journal_title:Neural regeneration research

    pub_type: 杂志文章

    doi:10.4103/1673-5374.301024

    authors: Li Y,Cheng JX,Yang HH,Chen LP,Liu FJ,Wu Y,Fan M,Wu HT

    更新日期:2021-07-01 00:00:00

  • Biodegradable magnesium wire promotes regeneration of compressed sciatic nerves.

    abstract::Magnesium (Mg) wire has been shown to be biodegradable and have anti-inflammatory properties. It can induce Schwann cells to secrete nerve growth factor and promote the regeneration of nerve axons after central nervous system injury. We hypothesized that biodegradable Mg wire may enhance compressed peripheral nerve re...

    journal_title:Neural regeneration research

    pub_type: 杂志文章

    doi:10.4103/1673-5374.197146

    authors: Li BH,Yang K,Wang X

    更新日期:2016-12-01 00:00:00

  • Treating Alzheimer's disease with Yizhijiannao granules by regulating expression of multiple proteins in temporal lobe.

    abstract::Yizhijiannao granules have been shown to improve cognitive function in Alzheimer's disease patients. The present study sought to explore the mechanisms involved in the cognitive enhancing effects of Yizhijiannao granule. Senescence-accelerated mouse prone 8 mice with learning and memory disorders were intragastrically...

    journal_title:Neural regeneration research

    pub_type: 杂志文章

    doi:10.4103/1673-5374.137575

    authors: Zhu H,Luo L,Hu S,Dong K,Li G,Zhang T

    更新日期:2014-07-01 00:00:00

  • Neuroprotective effects of statins against amyloid β-induced neurotoxicity.

    abstract::A growing body of evidence suggests that disruption of the homeostasis of lipid metabolism affects the pathogenesis of Alzheimer's disease (AD). In particular, dysregulation of cholesterol homeostasis in the brain has been reported to considerably increase the risk of developing AD. Thus, dysregulation of lipid homeos...

    journal_title:Neural regeneration research

    pub_type: 杂志文章,评审

    doi:10.4103/1673-5374.226379

    authors: Li HH,Lin CL,Huang CN

    更新日期:2018-02-01 00:00:00

  • Brain cell apoptosis and enhancement of nervous excitability in pregnant rats with high plasma levels of homocysteine.

    abstract::Hyperhomocysteinemia is an important risk factor for preeclampsia-eclampsia. This study established a pregnant rat model of hyperhomocysteinemia, in which blood plasma homocysteine concentrations were twice or three times greater than that of normal pregnant rats. TUNEL revealed an increase in the number of apoptotic ...

    journal_title:Neural regeneration research

    pub_type: 杂志文章

    doi:10.3969/j.issn.1673-5374.2012.028.005

    authors: Wang J,Ge J,Yang L,Zhang H,Li X,Xue D

    更新日期:2012-10-05 00:00:00

  • Vascular endothelial growth factor A promotes platelet adhesion to collagen IV and causes early brain injury after subarachnoid hemorrhage.

    abstract::The role of vascular endothelial growth factor A in platelet adhesion in cerebral microvessels in the early stage of subarachnoid hemorrhage remains unclear. In this study, the endovascular puncture method was used to produce a rat model of subarachnoid hemorrhage. Then, 30 minutes later, vascular endothelial growth f...

    journal_title:Neural regeneration research

    pub_type: 杂志文章

    doi:10.4103/1673-5374.257530

    authors: Liu ZW,Zhao JJ,Pang HG,Song JN

    更新日期:2019-10-01 00:00:00

  • Indirubin-3'-monoxime suppresses amyloid-beta-induced apoptosis by inhibiting tau hyperphosphorylation.

    abstract::Indirubin-3'-monoxime is an effective inhibitor of cyclin-dependent protein kinases, and may play an obligate role in neuronal apoptosis in Alzheimer's disease. Here, we found that indirubin-3'-monoxime improved the morphology and increased the survival rate of SH-SY5Y cells exposed to amyloid-beta 25-35 (Aβ25-35), an...

    journal_title:Neural regeneration research

    pub_type: 杂志文章

    doi:10.4103/1673-5374.184500

    authors: Zhang SG,Wang XS,Zhang YD,Di Q,Shi JP,Qian M,Xu LG,Lin XJ,Lu J

    更新日期:2016-06-01 00:00:00

  • Isoflurane-induced neuronal apoptosis in developing hippocampal neurons.

    abstract::We hypothesized that the P2X7 receptor may be the target of isoflurane, so we investigated the roles of the P2X7 receptor and inositol triphosphate receptor in calcium overload and neuronal apoptosis induced by isoflurane in cultured embryonic rat hippocampal neurons. Results showed that isoflurane induced widespread ...

    journal_title:Neural regeneration research

    pub_type: 杂志文章

    doi:10.3969/j.issn.1673-5374.2013.09.007

    authors: Liu H,Dai T,Guo W

    更新日期:2013-03-25 00:00:00