Effect of p62 on tau hyperphosphorylation in a rat model of Alzheimer's disease.

abstract：:Amniotic membranes have been widely used in ophthalmology and skin injury repair because of their anti-inflammatory properties. In this study, we measured therapeutic efficacy and determined if amniotic membranes could be used for facial nerve repair. The facial nerves of eight rats were dissected and end-to-end anast...

journal_title：Neural regeneration research

authors： Karaman M,Tuncel A,Sheidaei S,Senol MG,Karabulut MH,Deveci I,Karaman N

更新日期：2013-04-15 00:00:00

abstract：:Molecular mechanisms of the Krüppel-like family of transcription factors (KLFs) have been studied more in proliferating cells than in post-mitotic cells such as neurons. We recently found that KLFs regulate intrinsic axon growth ability in central nervous system (CNS) neurons including retinal ganglion cells, and hipp...

journal_title：Neural regeneration research

authors： Apara A,Goldberg JL

更新日期：2014-08-01 00:00:00

abstract：:Various studies have reported that galanin can promote axonal regeneration of dorsal root ganglion neurons in vitro and inhibit neuropathic pain. However, little is known about its effects on diabetic peripheral neuropathy, and in vivo experimental data are lacking. We hypothesized that repeated applications of exogen...

journal_title：Neural regeneration research

authors： Xu XF,Zhang DD,Liao JC,Xiao L,Wang Q,Qiu W

更新日期：2016-09-01 00:00:00

abstract：:We report a patient with severe ataxia due to Dandy-Walker malformation, who showed functional recovery over 10 months corresponding to a change in a cerebellar peduncle lesion. A 20-month-old female patient who was diagnosed with Dandy-Walker syndrome and six age- and sex-matched healthy control subjects were enrolle...

journal_title：Neural regeneration research

authors： Lee AY,Jang SH,Yeo SS,Lee E,Cho YW,Son SM

更新日期：2013-02-15 00:00:00

abstract：:Neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis are a heterogeneous group of debilitating disorders with multifactorial etiologies and pathogeneses that manifest distinct molecular mechanisms and clinical manifestations with abnormal ...

journal_title：Neural regeneration research

authors： Onyango IG,Bennett JP,Stokin GB

更新日期：2021-08-01 00:00:00

abstract：:The specific and effective α-synuclein RNA interference (RNAi) plasmids, and the α-synuclein-pEGFP recombinant plasmids were co-transfected into human embryonic kidney 293 (HEK293) cells using the lipofectamine method. Using an inverted fluorescence microscope, α-synuclein proteins were observed to aggregate in the cy...

journal_title：Neural regeneration research

authors： Chen T,Liao X,Wen G,Deng Y,Guo M,Long Z,Ouyang F

更新日期：2012-01-15 00:00:00

abstract：:Membrane depolarization induces the release of the serine proteinase tissue-type plasminogen activator (tPA) from the presynaptic terminal of cerebral cortical neurons. Once in the synaptic cleft this tPA promotes the exocytosis and subsequent endocytic retrieval of glutamate-containing synaptic vesicles, and regulate...

journal_title：Neural regeneration research

authors： Jeanneret V,Yepes M

更新日期：2017-03-01 00:00:00

abstract：:Chalcone is a plant metabolite widely found in fruits, vegetables, spices and tea, and has anti-tumor, anti-inflammation, immunomodulation, antibacterial and anti-oxidation activities, as well as many other pharmacological and biological effects. Our team has shown that its analogs have antioxidant activity, and oxida...

journal_title：Neural regeneration research

authors： Wang L,Chen HC,Yang X,Tao JJ,Liang G,Wu JZ,Wu WC,Wang Y,Song ZM,Zhang X

更新日期：2018-09-01 00:00:00

abstract：:TMP269 is a selective class IIA histone deacetylase inhibitor that has a protective effect on the central nervous system, whose specific mechanism of action is unclear. We aimed to reveal the optimal concentration of TMP269 for protecting against cerebral ischemia/reperfusion injury and its neuroprotective mechanism. ...

journal_title：Neural regeneration research

authors： Su L,Liang D,Kuang SY,Dong Q,Han X,Wang Z

更新日期：2020-02-01 00:00:00

abstract：:Acute brain injury caused by subarachnoid hemorrhage is the major cause of poor prognosis. The pathology of subarachnoid hemorrhage likely involves major morphological changes in the microcirculation. However, previous studies primarily used fixed tissue or delayed injury models. Therefore, in the present study, we us...

journal_title：Neural regeneration research

authors： Yang XM,Chen XH,Lu JF,Zhou CM,Han JY,Chen CH

更新日期：2018-03-01 00:00:00

abstract：:This study investigated the effect of transcranial direct current stimulation (tDCS) polarity depending on lateralized function of task property in normal individuals performing visuomotor and simple repetitive tasks. Thirty healthy participants with no neurological disorders were recruited to participate in this stud...

journal_title：Neural regeneration research

authors： Kwon YH,Kang KW,Lee NK,Son SM

更新日期：2016-01-01 00:00:00

abstract：:This study compared the difference in brain structure in 12 mine disaster survivors with chronic post-traumatic stress disorder, 7 cases of improved post-traumatic stress disorder symptoms, and 14 controls who experienced the same mine disaster but did not suffer post-traumatic stress disorder, using the voxel-based m...

journal_title：Neural regeneration research

authors： Tan L,Zhang L,Qi R,Lu G,Li L,Liu J,Li W

更新日期：2013-09-15 00:00:00

abstract：:Multiple sclerosis is a chronic, inflammatory and degenerative disease of the central nervous system of unknown aetiology although well-defined evidence supports an autoimmune pathogenesis. So far, the exact mechanisms leading to autoimmune diseases are still only partially understood. We know that genetic, epigenetic...

journal_title：Neural regeneration research

authors： Nociti V,Santoro M

更新日期：2021-09-01 00:00:00

abstract：:Minocycline hydrochloride (MH), a semi-synthetic tetracycline derivative, is a clinically available antibiotic and anti-inflammatory drug that also exhibits potent neuroprotective activities. It has been shown to target multiple secondary injury mechanisms in spinal cord injury, via its anti-inflammatory, anti-oxidant...

journal_title：Neural regeneration research

authors： Shultz RB,Zhong Y

更新日期：2017-05-01 00:00:00

abstract：:The present study aimed to explore the mechanism underlying the protective effects of hydrogen sulfide against neuronal damage caused by cerebral ischemia/reperfusion. We established the middle cerebral artery occlusion model in rats via the suture method. Ten minutes after middle cerebral artery occlusion, the animal...

journal_title：Neural regeneration research

authors： Li XJ,Li CK,Wei LY,Lu N,Wang GH,Zhao HG,Li DL

更新日期：2015-06-01 00:00:00

abstract：:The structural plasticity of synaptic terminals contributes to normal nervous system function but also to neural degeneration, in the form of terminal retraction, and regeneration, due to process growth. Synaptic morphological change is mediated through the actin cytoskeleton, which is enriched in axonal and dendritic...

journal_title：Neural regeneration research

authors： Wang W,Townes-Anderson E

更新日期：2016-07-01 00:00:00

abstract：:Recent studies have shown that induced expression of endogenous antioxidative enzymes thr-ough activation of the antioxidant response element/nuclear factor erythroid 2-related factor 2 (Nrf2) pathway may be a neuroprotective strategy. In this study, rat cerebral cortical neurons cultured in vitro were pretreated with...

journal_title：Neural regeneration research

authors： Wu JX,Zhang LY,Chen YL,Yu SS,Zhao Y,Zhao J

更新日期：2015-03-01 00:00:00

abstract：:Ototoxic drugs can be used to produce a loss of cochlear hair cells to create animal models of deafness. However, to the best of our knowledge, there is no report on the establishment of a rat deafness model through the combined application of aminoglycosides and loop diuretics. The aim of this study was to use single...

journal_title：Neural regeneration research

authors： Ma L,Yi HJ,Yuan FQ,Guo WW,Yang SM

更新日期：2015-10-01 00:00:00

abstract：:Neurotropic herpesviruses have been associated with the onset and progression of Alzheimer's disease, a common form of dementia that afflicts a large percentage of elderly individuals. Interestingly, among the neurotropic herpesviruses, herpes simplex virus-1, human herpesvirus-6A, and human herpesvirus-6B have been r...

journal_title：Neural regeneration research

authors： Romeo MA,Faggioni A,Cirone M

更新日期：2019-09-01 00:00:00

abstract：:Angelica sinensis has antioxidative and neuroprotective effects. In the present study, we aimed to determine the neuroprotective effect of polysaccharides isolated from Angelica sinensis. In a preliminary experiment, Angelica sinensis polysaccharides not only protected PC12 neuronal cells from H2O2-induced cytotoxicit...

journal_title：Neural regeneration research

authors： Lei T,Li H,Fang Z,Lin J,Wang S,Xiao L,Yang F,Liu X,Zhang J,Huang Z,Liao W

更新日期：2014-02-01 00:00:00

abstract：:Aquaporin-4 regulates water molecule channels and is important in tissue regulation and water transportation in the brain. Upregulation of aquaporin-4 expression is closely related to cellular edema after early cerebral infarction. Cellular edema and aquaporin-4 expression can be determined by measuring cerebral infar...

journal_title：Neural regeneration research

authors： He ZP,Lu H

更新日期：2015-07-01 00:00:00

abstract：:Multiple mononeuropathy is an unusual form of peripheral neuropathy involving two or more nerve trunks. It is a syndrome with many different causes. We reviewed the clinical, electrophysiological and nerve biopsy findings of 14 patients who suffered from multiple mononeuropathy in our clinic between January 2009 and J...

journal_title：Neural regeneration research

authors： Zhang YS,Sun AP,Chen L,Dong RF,Zhong YF,Zhang J

更新日期：2015-01-01 00:00:00

abstract：:Brain structure and cognitive function change in the temporal lobe, hippocampus, and prefrontal cortex of patients with mild cognitive impairment and Alzheimer's disease, and brain network-connection strength, network efficiency, and nodal attributes are abnormal. However, existing research has only analyzed the diffe...

journal_title：Neural regeneration research

authors： Xiang J,Guo H,Cao R,Liang H,Chen J

更新日期：2013-10-25 00:00:00

abstract：:Serum biomarkers may play a reliable role in predicting the outcomes of patients with aneurysmal subarachnoid hemorrhage. This study retrospectively analyzed the relationship between serum biomarkers on admission and outcomes in patients with aneurysmal subarachnoid hemorrhage. We recruited 146 patients with aneurysma...

journal_title：Neural regeneration research

authors： Liu JH,Li XK,Chen ZB,Cai Q,Wang L,Ye YH,Chen QX

更新日期：2017-12-01 00:00:00

abstract：:The motor relearning program can significantly improve various functional disturbance induced by ischemic cerebrovascular diseases. However, its mechanism of action remains poorly understood. In injured brain tissues, glial fibrillary acidic protein and neurofilament protein changes can reflect the condition of injure...

journal_title：Neural regeneration research

authors： Yin Y,Gu Z,Pan L,Gan L,Qin D,Yang B,Guo J,Hu X,Wang T,Feng Z

更新日期：2013-06-05 00:00:00

abstract：:The Na(+)-K(+)-Cl(-) cotransporter 1 and K(+)-Cl(-) cotransporter 2 regulate the levels of intracellular chloride in hippocampal cells. Impaired chloride transport by these proteins is thought to be involved in the pathophysiological mechanisms of mesial temporal lobe epilepsy. Imbalance in the relative expression of ...

journal_title：Neural regeneration research

authors： Cai X,Yang L,Zhou J,Zhu D,Guo Q,Chen Z,Chen S,Zhou L

更新日期：2013-02-25 00:00:00

abstract：:Gelatinases matrix metalloproteinase-2 and matrix metalloproteinase-9 have been shown to mediate claudin-5 and occludin degradation, and play an important regulatory role in blood-brain barrier permeability. This study established a rat model of 1.5-hour middle cerebral artery occlusion with reperfusion. Protein expre...

journal_title：Neural regeneration research

authors： Xin H,Liang W,Mang J,Lin L,Guo N,Zhang F,Xu Z

更新日期：2012-11-05 00:00:00

abstract：:Lentivirus carrying the Atoh1 gene can infect Corti's organ and express a hair-like cell surface marker in the supporting cell area. However, expression of the gene carried by adenovirus is instantaneous, which undoubtedly limits its clinical application. Lentivirus acts as a carrier that can stably and continuously e...

journal_title：Neural regeneration research

authors： Pan S,Wan J,Liu S,Zhang S,Xiong H,Zhou J,Xiong W,Yu K,Fu Y

更新日期：2013-06-15 00:00:00

abstract：:The cornea has unique features that make it a useful model for regenerative medicine studies. It is an avascular, transparent, densely innervated tissue and any pathological changes can be easily detected by slit lamp examination. Corneal sensitivity is provided by the ophthalmic branch of the trigeminal nerve that el...

journal_title：Neural regeneration research

authors： Sacchetti M,Lambiase A

更新日期：2017-08-01 00:00:00

abstract：:Thalidomide is an effective drug for the treatment of ankylosing spondylitis but might induce peripheral neuropathy. This major adverse reaction has attracted much concern. The current study aimed to observe the incidence of thalidomide-induced peripheral neuropathy among ankylosing spondylitis patients for 1 year aft...

journal_title：Neural regeneration research

authors： Xue HX,Fu WY,Cui HD,Yang LL,Zhang N,Zhao LJ

更新日期：2015-05-01 00:00:00