Abstract：
:Thalidomide is an effective drug for the treatment of ankylosing spondylitis but might induce peripheral neuropathy. This major adverse reaction has attracted much concern. The current study aimed to observe the incidence of thalidomide-induced peripheral neuropathy among ankylosing spondylitis patients for 1 year after treatment. In this study, 207 ankylosing spondylitis cases received thalidomide treatment, while 116 ankylosing spondylitis cases received other treatments. Results showed that the incidence of thalidomide-induced peripheral neuropathy in the thalidomide group was higher than that in the non-thalidomide group. There was no significant difference in the incidence of neuropathy between the < 6 months medication and ≥ 6 months medication groups. There were no differences in the mean age, gender, or daily dose between the two groups. The incidence of peripheral neuropathy among patients receiving 25, 50, 75, or 100 mg thalidomide per day was 4.6%, 8.5%, 17.1%, 21.7%, respectively. The incidence was significantly different between the groups receiving 25 mg and 100 mg thalidomide. In conclusion, thalidomide can induce peripheral neuropathy within 1 year after treatment of ankylosing spondylitis; however, age and gender have no obvious impact on the incidence of peripheral neuropathy. The incidence of peripheral neuropathy is associated with increasing daily doses of thalidomide.
journal_name
Neural Regen Resjournal_title
Neural regeneration researchauthors
Xue HX,Fu WY,Cui HD,Yang LL,Zhang N,Zhao LJdoi
10.4103/1673-5374.156988subject
Has Abstractpub_date
2015-05-01 00:00:00pages
814-8issue
5eissn
1673-5374issn
1876-7958pii
NRR-10-814journal_volume
10pub_type
杂志文章abstract：:The G-protein-coupled purinergic receptor P2Y2 (P2RY2) plays an important role in the mechanism of atherosclerosis, which is relevant to ischemic stroke. This retrospective case-control study aimed to assess the relationship between P2RY2 gene polymorphisms and ischemic stroke risk in the northern Han Chinese populati...
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journal_title：Neural regeneration research
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journal_title：Neural regeneration research
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更新日期：2018-09-01 00:00:00
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journal_title：Neural regeneration research
pub_type： 杂志文章,评审
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journal_title：Neural regeneration research
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pub_type： 杂志文章,评审
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journal_title：Neural regeneration research
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更新日期：2012-05-25 00:00:00
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