Minocycline targets multiple secondary injury mechanisms in traumatic spinal cord injury.

abstract：:Previous studies demonstrate an accumulation of transferrin and transferrin receptor 1 (TfR1) in regenerating peripheral nerves. However, the expression and function of transferrin and TfR1 in the denervated skeletal muscle remain poorly understood. In this study, a mouse model of denervation was produced by complete ...

journal_title：Neural regeneration research

authors： Li Y,Cheng JX,Yang HH,Chen LP,Liu FJ,Wu Y,Fan M,Wu HT

更新日期：2021-07-01 00:00:00

abstract：:Active Achilles tendon kinesitherapy facilitates the functional recovery of a ruptured Achilles tendon. However, protein expression during the healing process remains a controversial issue. New Zealand rabbits, aged 14 weeks, underwent tenotomy followed immediately by Achilles tendon microsurgery to repair the Achille...

journal_title：Neural regeneration research

authors： Jielile J,Aibai M,Sabirhazi G,Shawutali N,Tangkejie W,Badelhan A,Nuerduola Y,Satewalede T,Buranbai D,Hunapia B,Jialihasi A,Bai J,Kizaibek M

更新日期：2012-12-15 00:00:00

abstract：:A mixture of ibotenic acid and β-amyloid 1-42 was injected into the hippocampus of a rat model of Alzheimer's disease, followed by intragastric administration of a traditional Chinese medicine Buyuan Congnao decoction (main components included radix astragali, radix polygoni multiflori preparata, rhizoma acori talarin...

journal_title：Neural regeneration research

authors： Chen M,Wang J,Ming C

更新日期：2012-03-25 00:00:00

abstract：:Abnormal TAR DNA-binding protein 43 (TDP-43) inclusion bodies can be detected in the degenerative neurons of amyotrophic lateral sclerosis. In this study, we induced chronic oxidative stress injury by applying malonate to cultured mouse cortical motor neurons. In the later stages of the malonate insult, TDP-43 express...

journal_title：Neural regeneration research

authors： Zheng M,Shi Y,Fan D

更新日期：2013-12-15 00:00:00

abstract：:Traumatic brain injury is a major health problem worldwide. Currently, there is no effective treatment to improve neural structural repair and functional recovery of patients in the clinic. Cell transplantation is a potential strategy to repair and regenerate the injured brain. This review article summarized recent de...

journal_title：Neural regeneration research

authors： Sun D

更新日期：2016-01-01 00:00:00

abstract：:The blood brain barrier represents a formidable obstacle for the transport of most systematically administered neurodiagnostics and neurotherapeutics to the brain. Phage display is a high throughput screening strategy that can be used for the construction of nanomaterial peptide libraries. These libraries can be scree...

journal_title：Neural regeneration research

authors： Bakhshinejad B,Karimi M,Khalaj-Kondori M

更新日期：2015-06-01 00:00:00

abstract：:The specific and effective α-synuclein RNA interference (RNAi) plasmids, and the α-synuclein-pEGFP recombinant plasmids were co-transfected into human embryonic kidney 293 (HEK293) cells using the lipofectamine method. Using an inverted fluorescence microscope, α-synuclein proteins were observed to aggregate in the cy...

journal_title：Neural regeneration research

authors： Chen T,Liao X,Wen G,Deng Y,Guo M,Long Z,Ouyang F

更新日期：2012-01-15 00:00:00

abstract：:The three-dimensional (3D) visualization of the functional bundles in the peripheral nerve provides direct and detailed intraneural spatial information. It is useful for selecting suitable surgical methods to repair nerve defects and in optimizing the construction of tissue-engineered nerve grafts. However, there rema...

journal_title：Neural regeneration research

authors： Qi J,Wang WY,Zhong YC,Zhou JM,Luo P,Tang P,He CF,Zhu S,Liu XL,Zhang Y

更新日期：2018-08-01 00:00:00

abstract：:Peripheral and central sensitizations are phenomena that occur during migraine. The role of pentin, a migraine preventive drug, on central sensitization remains unclear. In this study, a rat model of migraine was established by electrical stimulation of the trigeminal ganglion, and the an-imals were given intragastric...

journal_title：Neural regeneration research

authors： Zhang Y,Shao G,Zhang W,Li S,Niu J,Hu D,Yang M,Ji X

更新日期：2013-11-15 00:00:00

abstract：:In the present study, we examined the analgesic effect of repeated electroacupuncture at bilateral Zusanli (ST36) and Yanglingquan (GB34) once a day for 14 consecutive days in a rat model of chronic sciatic nerve constriction injury-induced neuropathic pain. In addition, concomitant changes in calcium/calmodulin-depen...

journal_title：Neural regeneration research

authors： Xu Q,Liu T,Chen S,Gao Y,Wang J,Qiao L,Liu J

更新日期：2012-06-25 00:00:00

abstract：:The present study investigated the influence of anti-estrogen treatment (fulvestrant) on pituitary adenoma cell line GH3 biological activity, the estrogen receptor α pathway, the WnT pathway, and mechanisms of decreased Wnt inhibitory factor-1 expression in GH3 cells. Results showed that fulvestrant suppressed GH3 cel...

journal_title：Neural regeneration research

authors： Bai J,Wang Y,Li C,Zhang Y

更新日期：2012-02-05 00:00:00

abstract：:Previous animal studies have shown that stromal cell-derived factor-1 (SDF-1)/CXC chemokine receptor-4 (CXCR4) signaling pathway plays an important role in the targeted migration of bone marrow-derived mesenchymal stem cells (BMSCs) to the injured area. In the present study, we aimed to investigate the potential role ...

journal_title：Neural regeneration research

authors： Peyvandi AA,Roozbahany NA,Peyvandi H,Abbaszadeh HA,Majdinasab N,Faridan M,Niknazar S

更新日期：2018-01-01 00:00:00

abstract：:The blood-spinal cord barrier plays a vital role in recovery after spinal cord injury. The neurovascular unit concept emphasizes the relationship between nerves and vessels in the brain, while the effect of the blood-spinal cord barrier on the neurovascular unit is rarely reported in spinal cord injury studies. Mouse ...

journal_title：Neural regeneration research

authors： Ye LX,An NC,Huang P,Li DH,Zheng ZL,Ji H,Li H,Chen DQ,Wu YQ,Xiao J,Xu K,Li XK,Zhang HY

更新日期：2021-04-01 00:00:00

abstract：OBJECTIVE:To analyze international research trends in hepatic encephalopathy and examine the role of neuroelectrophysiology and neuroimaging in diagnosis of hepatic encephalopathy. DATA RETRIEVAL:We performed a bibliometric analysis of studies on hepatic encephalopathy published during 2002-2011 retrieved from Web of ...

journal_title：Neural regeneration research

authors： Li N

更新日期：2012-12-05 00:00:00

abstract：:Mental practice is a new rehabilitation method that refers to the mental rehearsal of motor imagery content with the goal of improving motor performance. However, the relationship between activated regions and motor recovery after mental practice training is not well understood. In this study, 15 patients who suffered...

journal_title：Neural regeneration research

authors： Liu H,Song L,Zhang T

更新日期：2014-08-01 00:00:00

abstract：:A survivin siRNA expression vector was transfected into glioma U-87MG cells and these cells were then treated with paclitaxel. The results showed that survivin-specific siRNA combined with paclitaxel treatment synergistically inhibited glioma U-87MG cell proliferation and promoted apoptosis. This treatment also inhibi...

journal_title：Neural regeneration research

authors： Xie Y,Liu Y,Shen W,Zhang B,Liu Q

更新日期：2012-05-05 00:00:00

abstract：:Preclinical and clinical studies indicate that synthetic psychoactive substances, in addition to having abuse potential, may elicit toxic effects of varying severity at the peripheral and central levels. Nowadays, toxicity induced by synthetic psychoactive substances poses a serious harm for health, since recreational...

journal_title：Neural regeneration research

authors： Costa G,De Luca MA,Piras G,Marongiu J,Fattore L,Simola N

更新日期：2020-05-01 00:00:00

abstract：:The motor relearning program can significantly improve various functional disturbance induced by ischemic cerebrovascular diseases. However, its mechanism of action remains poorly understood. In injured brain tissues, glial fibrillary acidic protein and neurofilament protein changes can reflect the condition of injure...

journal_title：Neural regeneration research

authors： Yin Y,Gu Z,Pan L,Gan L,Qin D,Yang B,Guo J,Hu X,Wang T,Feng Z

更新日期：2013-06-05 00:00:00

abstract：:Three male patients were diagnosed with new cortical infarctions of the right parietal lobe on the basis of head magnetic resonance imaging; high-intensity signals indicating lesions in the right parietal lobe were noted on diffusion-weighted images at admission. Two of them presented with left hand weakness, and one ...

journal_title：Neural regeneration research

authors： Li F,Jia Y

更新日期：2012-04-25 00:00:00

abstract：:This review summarizes and describes the use of curcumin in diagnosis, prevention, and treatment of Alzheimer's disease. For diagnosis of Alzheimer's disease, amyloid-β and highly phosphorylated tau protein are the major biomarkers. Curcumin was developed as an early diagnostic probe based on its natural fluorescence ...

journal_title：Neural regeneration research

authors： Chen M,Du ZY,Zheng X,Li DL,Zhou RP,Zhang K

更新日期：2018-04-01 00:00:00

abstract：:Throughout the globe, diabetes mellitus (DM) is increasing in incidence with limited therapies presently available to prevent or resolve the significant complications of this disorder. DM impacts multiple organs and affects all components of the central and peripheral nervous systems that can range from dementia to di...

journal_title：Neural regeneration research

authors： Maiese K

更新日期：2016-03-01 00:00:00

abstract：:White adipose tissue (WAT) stores energy and also plays an important endocrine role in producing adipokines for communication with the peripheral and central nervous system. WAT consists of the major lipogenic unilocular adipocytes and the minor populations of beige and brite multilocular adipocytes. These multilocula...

journal_title：Neural regeneration research

authors： Lee A,Ziouzenkova O

更新日期：2019-02-01 00:00:00

abstract：:Synaptosomal-associated protein-25 is an important factor for synaptic functions and cognition. In this study, subarachnoid hemorrhage models with spatial learning disorder were established through a blood injection into the chiasmatic cistern. Immunohistochemical staining and western blot analysis results showed that...

journal_title：Neural regeneration research

authors： Chen G,Hu T,Li Q,Li J,Jia Y,Wang Z

更新日期：2013-10-15 00:00:00

abstract：:The signaling mechanisms underlying ischemia-induced nerve cell apoptosis are poorly understood. We investigated the effects of apoptosis-related signal transduction pathways following ischemic spinal cord injury, including extracellular signal-regulated kinase (ERK), serine-threonine protein kinase (Akt) and c-Jun N-...

journal_title：Neural regeneration research

authors： Jin M,Yang YW,Cheng WP,Lu JK,Hou SY,Dong XH,Liu SY

更新日期：2015-11-01 00:00:00

abstract：:In treating patients with obstetric brachial plexus palsy, we noticed that denervated intrinsic muscles of the hand become irreversibly atrophic at a faster than denervated biceps. In a rat model of obstetric brachial plexus palsy, denervated intrinsic musculature of the forepaw entered the irreversible atrophy far ea...

journal_title：Neural regeneration research

authors： Yu XH,Wu JX,Chen L,Gu YD

更新日期：2020-07-01 00:00:00

abstract：:Type 2 diabetes-associated with impaired insulin/insulin-like growth factor-1 (IGF1) signaling (IIS)-is a risk factor for cognitive impairment and dementia including Alzheimer's disease (AD). The insulin receptor substrate (IRS) proteins are major components of IIS, which transmit upstream signals via the insulin rece...

journal_title：Neural regeneration research

authors： Tanokashira D,Fukuokaya W,Taguchi A

更新日期：2019-08-01 00:00:00

abstract：:After binding to the estrogen receptor, estrogen can alleviate the toxic effects of beta-amyloid protein, and thereby exert a therapeutic effect on Alzheimer's disease patients. Estrogen can increase the incidence of breast carcinoma and endometrial cancer in post-menopausal women, so it is not suitable for clinical t...

journal_title：Neural regeneration research

authors： Wang H,Si L,Li X,Deng W,Yang H,Yang Y,Fu Y

更新日期：2012-05-15 00:00:00

abstract：:Various studies have reported that galanin can promote axonal regeneration of dorsal root ganglion neurons in vitro and inhibit neuropathic pain. However, little is known about its effects on diabetic peripheral neuropathy, and in vivo experimental data are lacking. We hypothesized that repeated applications of exogen...

journal_title：Neural regeneration research

authors： Xu XF,Zhang DD,Liao JC,Xiao L,Wang Q,Qiu W

更新日期：2016-09-01 00:00:00

abstract：:The iron chelator deferoxamine has been shown to inhibit ferroptosis in spinal cord injury. However, it is unclear whether deferoxamine directly protects neurons from ferroptotic cell death. By comparing the survival rate and morphology of primary neurons and SH-SY5Y cells exposed to erastin, it was found that these c...

journal_title：Neural regeneration research

authors： Zhang Y,Fan BY,Pang YL,Shen WY,Wang X,Zhao CX,Li WX,Liu C,Kong XH,Ning GZ,Feng SQ,Yao X

更新日期：2020-08-01 00:00:00

abstract：:Schwann cell transplantation and hyperbaric oxygen therapy each promote recovery from spinal cord injury, but it remains unclear whether their combination improves therapeutic results more than monotherapy. To investigate this, we used Schwann cell transplantation via the tail vein, hyperbaric oxygen therapy, or their...

journal_title：Neural regeneration research

authors： Peng CG,Zhang SQ,Wu MF,Lv Y,Wu DK,Yang Q,Gu R

更新日期：2015-09-01 00:00:00