In vivo observation of cerebral microcirculation after experimental subarachnoid hemorrhage in mice.

abstract：:The intrinsic growth ability of all the neurons declines during development although some may grow better than others. Numerous intracellular signaling proteins and transcription factors have been shown to regulate the intrinsic growth capacity in mature neurons. Among them, PI3 kinase/Akt pathway is important for con...

journal_title：Neural regeneration research

authors： Ohtake Y,Hayat U,Li S

更新日期：2015-09-01 00:00:00

abstract：:Infusion of the colloid hydroxyethylstarch has been used for volume substitution to maintain hemodynamics and microcirculation after e.g., severe blood loss. In the last decade it was revealed that hydroxyethylstarch can aggravate acute kidney injury, especially in septic patients. Because of the serious risk for crit...

journal_title：Neural regeneration research

authors： Schick MA,Burek M,Förster CY,Nagai M,Wunder C,Neuhaus W

更新日期：2021-07-01 00:00:00

abstract：:The role of vascular endothelial growth factor A in platelet adhesion in cerebral microvessels in the early stage of subarachnoid hemorrhage remains unclear. In this study, the endovascular puncture method was used to produce a rat model of subarachnoid hemorrhage. Then, 30 minutes later, vascular endothelial growth f...

journal_title：Neural regeneration research

authors： Liu ZW,Zhao JJ,Pang HG,Song JN

更新日期：2019-10-01 00:00:00

abstract：:Alzheimer's disease is characterized by the extracellular accumulation of the amyloid β in the form of amyloid plaques and the intracellular deposition of the microtubule-associated protein tau in the form of neurofibrillary tangles. Most of the Alzheimer's drugs targeting amyloid β have been failed in clinical trials...

journal_title：Neural regeneration research

authors： Mamun AA,Uddin MS,Mathew B,Ashraf GM

更新日期：2020-08-01 00:00:00

abstract：:Myelin regeneration is indispensably important for patients suffering from several central nervous system (CNS) disorders such as multiple sclerosis (MS) and spinal cord injury (SCI), because it is not only essential for restoring neurophysiology, but also protects denuded axons for secondary degeneration. Understandi...

journal_title：Neural regeneration research

authors： Bhatt A,Fan LW,Pang Y

更新日期：2014-07-15 00:00:00

abstract：:Increasing evidence suggests that food ingested polyphenols can have beneficial effects in neuronal protection acting against oxidative stress and inflammatory injury. Moreover, polyphenols have been reported to promote cognitive functions. Biotransformation of polyphenols is needed to obtain metabolites active in bra...

journal_title：Neural regeneration research

authors： Filosa S,Di Meo F,Crispi S

更新日期：2018-12-01 00:00:00

abstract：:The signaling mechanisms underlying ischemia-induced nerve cell apoptosis are poorly understood. We investigated the effects of apoptosis-related signal transduction pathways following ischemic spinal cord injury, including extracellular signal-regulated kinase (ERK), serine-threonine protein kinase (Akt) and c-Jun N-...

journal_title：Neural regeneration research

authors： Jin M,Yang YW,Cheng WP,Lu JK,Hou SY,Dong XH,Liu SY

更新日期：2015-11-01 00:00:00

abstract：:The γ-aminobutyric acid neurotransmitter in the spinal cord dorsal horn plays an important role in pain modulation through primary afferent-mediated presynaptic inhibition. The weakening of γ-aminobutyric acid-mediated presynaptic inhibition may be an important cause of neuropathic pain. γ-aminobutyric acid-mediated p...

journal_title：Neural regeneration research

authors： Lian Y,Wang Y,Ma K,Zhao L,Zhang Z,Shang Y,Si J,Li L

更新日期：2012-11-15 00:00:00

abstract：:Endothelial progenitor cells secrete a variety of growth factors that inhibit inflammation, promote angiogenesis and exert neuroprotective effects. Therefore, in this study, we investigated whether endothelial progenitor cell-conditioned medium might have therapeutic effectiveness for the treatment of spinal cord inju...

journal_title：Neural regeneration research

authors： Wang T,Fang X,Yin ZS

更新日期：2018-05-01 00:00:00

abstract：:There are several major pathological changes in Alzheimer's disease, including apoptosis of cholinergic neurons, overactivity or overexpression of β-site amyloid precursor protein cleaving enzyme 1 (BACE1) and inflammation. In this study, we synthesized a 19-nt oligonucleotide targeting BACE1, the key enzyme in amyloi...

journal_title：Neural regeneration research

authors： Liu Z,Li S,Liang Z,Zhao Y,Zhang Y,Yang Y,Wang M,Li F

更新日期：2013-11-25 00:00:00

abstract：:Brain structure and cognitive function change in the temporal lobe, hippocampus, and prefrontal cortex of patients with mild cognitive impairment and Alzheimer's disease, and brain network-connection strength, network efficiency, and nodal attributes are abnormal. However, existing research has only analyzed the diffe...

journal_title：Neural regeneration research

authors： Xiang J,Guo H,Cao R,Liang H,Chen J

更新日期：2013-10-25 00:00:00

abstract：:Chronic activation of microglial cells endangers neuronal survival through the release of various proinflammatory and neurotoxic factors. The root of Paeonia lactiflora Pall has been considered useful for the treatment of various disorders in traditional oriental medicine. Paeonol, found in the root of Paeonia lactifl...

journal_title：Neural regeneration research

authors： Nam KN,Woo BC,Moon SK,Park SU,Park JY,Hwang JW,Bae HS,Ko CN,Lee EH

更新日期：2013-06-25 00:00:00

abstract：:Polysaccharides extracted from Lycium barbarum exhibit antioxidant properties. We hypothesized that these polysaccharides resist oxidative stress-induced neuronal damage following cavernous nerve injury. In this study, rat models were intragastrically administered Lycium barbarum polysaccharides for 2 weeks at 1, 7, a...

journal_title：Neural regeneration research

authors： Zhao ZK,Yu HL,Liu B,Wang H,Luo Q,Ding XG

更新日期：2016-08-01 00:00:00

abstract：:This study aimed to summarize therapy experience of carotid endarterectomy, carotid endarterectomy combined with Fogarty catheter embolectomy, and hybrid surgery for the treatment of extracranial internal carotid artery occlusion. The study included 65 patients with extracranial internal carotid artery occlusion who u...

journal_title：Neural regeneration research

authors： Jiao L,Song G,Hua Y,Ma Y,Chen Y,Wang Y,Ling F

更新日期：2013-08-15 00:00:00

abstract：:In this study, human umbilical cord mesenchymal stem cells from full-term neonates born by vaginal delivery were cultured in medium containing 150 mg/mL of brain tissue extracts from Sprague-Dawley rats (to mimic the brain microenvironment). Immunocytochemical analysis demonstrated that the cells differentiated into n...

journal_title：Neural regeneration research

authors： Wang X,Wu H,Xue G,Hou Y

更新日期：2012-09-05 00:00:00

abstract：:A significant amount of evidence indicates that microRNAs (miRNAs) play an important role in drug addiction. The nucleus accumbens (NAc) is a critical part of the brain's reward circuit and is involved in a variety of psychiatric disorders, including depression, anxiety, and drug addiction. However, few studies have e...

journal_title：Neural regeneration research

authors： Kim J,Im HI,Moon C

更新日期：2018-01-01 00:00:00

abstract：:Cattle encephalon glycoside and ignotin (CEGI) injection is known as a multi-target neuroprotective drug that contains numerous liposoluble molecules, such as polypeptides, monosialotetrahexosyl ganglioside (GM-1), free amino acids, hypoxanthine and carnosine. CEGI has been approved by the Chinese State Food and Drug ...

journal_title：Neural regeneration research

authors： Zhong J,Li RW,Wang J,Wang Y,Ge HF,Xian JS,Feng H,Tan L

更新日期：2021-02-01 00:00:00

abstract：:In this study, we hypothesized that total flavonoid of Litsea coreana leve (TFLC) protects against focal cerebral ischemia/reperfusion injury. TFLC (25, 50, 100 mg/kg) was administered orally to a rat model of focal ischemia/reperfusion injury, while the free radical scavenging agent, edaravone, was used as a positive...

journal_title：Neural regeneration research

authors： Dong S,Tong X,Li J,Huang C,Hu C,Jiao H,Gu Y

更新日期：2013-12-05 00:00:00

abstract：:Sterile inflammatory processes are essential for the maintenance of central nervous system homeostasis, but they also contribute to various neurological disorders, including neurotrauma, stroke, and demyelinating or neurodegenerative diseases. Immune mechanisms in the central nervous system and periphery are regulated...

journal_title：Neural regeneration research

authors： Klegeris A

更新日期：2021-03-01 00:00:00

abstract：:Amniotic membranes have been widely used in ophthalmology and skin injury repair because of their anti-inflammatory properties. In this study, we measured therapeutic efficacy and determined if amniotic membranes could be used for facial nerve repair. The facial nerves of eight rats were dissected and end-to-end anast...

journal_title：Neural regeneration research

authors： Karaman M,Tuncel A,Sheidaei S,Senol MG,Karabulut MH,Deveci I,Karaman N

更新日期：2013-04-15 00:00:00

abstract：:In the present study, we examined the analgesic effect of repeated electroacupuncture at bilateral Zusanli (ST36) and Yanglingquan (GB34) once a day for 14 consecutive days in a rat model of chronic sciatic nerve constriction injury-induced neuropathic pain. In addition, concomitant changes in calcium/calmodulin-depen...

journal_title：Neural regeneration research

authors： Xu Q,Liu T,Chen S,Gao Y,Wang J,Qiao L,Liu J

更新日期：2012-06-25 00:00:00

abstract：:Traumatic brain injury (TBI) is a major health problem worldwide. Following primary mechanical insults, a cascade of secondary injuries often leads to further neural tissue loss. Thus far there is no cure to rescue the damaged neural tissue. Current therapeutic strategies primarily target the secondary injuries focusi...

journal_title：Neural regeneration research

authors： Wurzelmann M,Romeika J,Sun D

更新日期：2017-01-01 00:00:00

abstract：:Suture and autologous nerve transplantation are the primary therapeutic measures for completely severed nerves. However, imbalances in the microenvironment and adhesion of surrounding tissues can affect the quality of nerve regeneration and repair. Previous studies have shown that human amniotic membrane can promote t...

journal_title：Neural regeneration research

authors： Zhang ZY,Yang J,Fan ZH,Wang DL,Wang YY,Zhang T,Yu LM,Yu CY

更新日期：2019-12-01 00:00:00

abstract：:This study investigated the effects of small interfering RNA (siRNA)-mediated silencing of chemokine receptor 4 (CXCR4) on the invasion capacity of human neuroblastoma cell line SH-SY5Y in vitro. Three siRNAs targeting CXCR4 were chemically synthesized and individually transfected into SH-SY5Y cells. Expression of CXC...

journal_title：Neural regeneration research

authors： Chen X,Zhu Y,Han L,Lu H,Hao X,Dong Q

更新日期：2014-05-15 00:00:00

abstract：:Neonatal hypoxic-ischemic encephalopathy is a serious neurological disease, often resulting in long-term neurodevelopmental disorders among surviving children. However, whether these neurodevelopmental issues can be passed to offspring remains unclear. The right common carotid artery of 7-day-old parental-generation r...

journal_title：Neural regeneration research

authors： Xue LL,Wang F,Niu RZ,Tan YX,Liu J,Jin Y,Ma Z,Zhang ZB,Jiang Y,Chen L,Xia QJ,Chen JJ,Wang TH,Xiong LL

更新日期：2020-09-01 00:00:00

abstract：:Traumatic brain injury is a major health problem worldwide. Currently, there is no effective treatment to improve neural structural repair and functional recovery of patients in the clinic. Cell transplantation is a potential strategy to repair and regenerate the injured brain. This review article summarized recent de...

journal_title：Neural regeneration research

authors： Sun D

更新日期：2016-01-01 00:00:00

abstract：:The cornea has unique features that make it a useful model for regenerative medicine studies. It is an avascular, transparent, densely innervated tissue and any pathological changes can be easily detected by slit lamp examination. Corneal sensitivity is provided by the ophthalmic branch of the trigeminal nerve that el...

journal_title：Neural regeneration research

authors： Sacchetti M,Lambiase A

更新日期：2017-08-01 00:00:00

abstract：:Apolipoprotein E plays a crucial role in inhibiting chronic neurodegenerative processes. However, its impact on neurological function following diffuse brain injury is still unclear. This study was designed to evaluate the therapeutic effects and mechanisms of action of apolipoprotein E mimetic peptide on diffuse brai...

journal_title：Neural regeneration research

authors： Zhao Y,Li J,Tang Q,Gao J,Chen C,Jing L,Zhang P,Li S

更新日期：2014-03-01 00:00:00

abstract：:[This corrects the article on p. 770 in vol. 12, PMID: 28616034.]. ...

journal_title：Neural regeneration research

authors： Lu J,Guo Y,Guo CQ,Shi XM,Du NY,Zhao RL,Du WP,Liang JR,Zhu SP,Chen H

更新日期：2017-06-01 00:00:00

abstract：:Hippocampal neurons undergo various forms of cell death after status epilepticus. Necrostatin-1 specifically inhibits necroptosis mediated by receptor interacting protein kinase 1 (RIP1) and RIP3 receptors. However, there are no reports of necroptosis in mouse models of status epilepticus. Therefore, in this study, we...

journal_title：Neural regeneration research

authors： Lin DQ,Cai XY,Wang CH,Yang B,Liang RS

更新日期：2020-05-01 00:00:00