An abnormal resting-state functional brain network indicates progression towards Alzheimer's disease.

Abstract:

:Brain structure and cognitive function change in the temporal lobe, hippocampus, and prefrontal cortex of patients with mild cognitive impairment and Alzheimer's disease, and brain network-connection strength, network efficiency, and nodal attributes are abnormal. However, existing research has only analyzed the differences between these patients and normal controls. In this study, we constructed brain networks using resting-state functional MRI data that was extracted from four populations (normal controls, patients with early mild cognitive impairment, patients with late mild cognitive impairment, and patients with Alzheimer's disease) using the Alzheimer's Disease Neuroimaging Initiative data set. The aim was to analyze the characteristics of resting-state functional neural networks, and to observe mild cognitive impairment at different stages before the transformation to Alzheimer's disease. Results showed that as cognitive deficits increased across the four groups, the shortest path in the resting-state functional network gradually increased, while clustering coefficients gradually decreased. This evidence indicates that dementia is associated with a decline of brain network efficiency. In addition, the changes in functional networks revealed the progressive deterioration of network function across brain regions from healthy elderly adults to those with mild cognitive impairment and Alzheimer's disease. The alterations of node attributes in brain regions may reflect the cognitive functions in brain regions, and we speculate that early impairments in memory, hearing, and language function can eventually lead to diffuse brain injury and other cognitive impairments.

journal_name

Neural Regen Res

authors

Xiang J,Guo H,Cao R,Liang H,Chen J

doi

10.3969/j.issn.1673-5374.2013.30.001

subject

Has Abstract

pub_date

2013-10-25 00:00:00

pages

2789-99

issue

30

eissn

1673-5374

issn

1876-7958

pii

NRR-8-2789

journal_volume

8

pub_type

杂志文章
  • Hydrogen sulfide intervention in focal cerebral ischemia/reperfusion injury in rats.

    abstract::The present study aimed to explore the mechanism underlying the protective effects of hydrogen sulfide against neuronal damage caused by cerebral ischemia/reperfusion. We established the middle cerebral artery occlusion model in rats via the suture method. Ten minutes after middle cerebral artery occlusion, the animal...

    journal_title:Neural regeneration research

    pub_type: 杂志文章

    doi:10.4103/1673-5374.158353

    authors: Li XJ,Li CK,Wei LY,Lu N,Wang GH,Zhao HG,Li DL

    更新日期:2015-06-01 00:00:00

  • Could autophagy dysregulation link neurotropic viruses to Alzheimer's disease?

    abstract::Neurotropic herpesviruses have been associated with the onset and progression of Alzheimer's disease, a common form of dementia that afflicts a large percentage of elderly individuals. Interestingly, among the neurotropic herpesviruses, herpes simplex virus-1, human herpesvirus-6A, and human herpesvirus-6B have been r...

    journal_title:Neural regeneration research

    pub_type: 杂志文章,评审

    doi:10.4103/1673-5374.253508

    authors: Romeo MA,Faggioni A,Cirone M

    更新日期:2019-09-01 00:00:00

  • Biodegradable magnesium wire promotes regeneration of compressed sciatic nerves.

    abstract::Magnesium (Mg) wire has been shown to be biodegradable and have anti-inflammatory properties. It can induce Schwann cells to secrete nerve growth factor and promote the regeneration of nerve axons after central nervous system injury. We hypothesized that biodegradable Mg wire may enhance compressed peripheral nerve re...

    journal_title:Neural regeneration research

    pub_type: 杂志文章

    doi:10.4103/1673-5374.197146

    authors: Li BH,Yang K,Wang X

    更新日期:2016-12-01 00:00:00

  • Tea polyphenols increase X-ray repair cross-complementing protein 1 and apurinic/apyrimidinic endonuclease/redox factor-1 expression in the hippocampus of rats during cerebral ischemia/reperfusion injury.

    abstract::Recent studies have shown that tea polyphenols can cross the blood-brain barrier, inhibit apoptosis and play a neuroprotective role against cerebral ischemia. Furthermore, tea polyphenols can decrease DNA damage caused by free radicals. We hypothesized that tea polyphenols repair DNA damage and inhibit neuronal apopto...

    journal_title:Neural regeneration research

    pub_type: 杂志文章

    doi:10.3969/j.issn.1673-5374.2012.30.005

    authors: Wang Z,Xue R,Lei X,Lv J,Wu G,Li W,Xue L,Lei X,Zhao H,Gao H,Wei X

    更新日期:2012-10-25 00:00:00

  • Electroacupuncture induces acute changes in cerebral cortical miRNA profile, improves cerebral blood flow and alleviates neurological deficits in a rat model of stroke.

    abstract::Electroacupuncture has been shown to improve cerebral blood flow in animal models of stroke. However, it is unclear whether electroacupuncture alters miRNA expression in the cortex. In this study, we examined changes in the cerebral cortical miRNA profile, cerebral blood flow and neurological function induced by elect...

    journal_title:Neural regeneration research

    pub_type: 杂志文章

    doi:10.4103/1673-5374.197135

    authors: Zheng HZ,Jiang W,Zhao XF,Du J,Liu PG,Chang LD,Li WB,Hu HT,Shi XM

    更新日期:2016-12-01 00:00:00

  • Using the endocannabinoid system as a neuroprotective strategy in perinatal hypoxic-ischemic brain injury.

    abstract::One of the most important causes of brain injury in the neonatal period is a perinatal hypoxic-ischemic event. This devastating condition can lead to long-term neurological deficits or even death. After hypoxic-ischemic brain injury, a variety of specific cellular mechanisms are set in motion, triggering cell damage a...

    journal_title:Neural regeneration research

    pub_type: 杂志文章

    doi:10.3969/j.issn.1673-5374.2013.08.008

    authors: Lara-Celador I,Goñi-de-Cerio F,Alvarez A,Hilario E

    更新日期:2013-03-15 00:00:00

  • Neuronal differentiation of adipose-derived stem cells and their transplantation for cerebral ischemia.

    abstract:OBJECTIVE:To review published data on the biological characteristics, differentiation and applications of adipose-derived stem cells in ischemic diseases. DATA RETRIEVAL:A computer-based online search of reports published from January 2005 to June 2012 related to the development of adipose-derived stem cells and their...

    journal_title:Neural regeneration research

    pub_type: 杂志文章

    doi:10.3969/j.issn.1673-5374.2012.25.011

    authors: Tian G,Zhou J,Wang J,Xu B,Li L,Zhu F,Han J,Li J,Zhang S,Luo X

    更新日期:2012-09-05 00:00:00

  • Mash1 efficiently reprograms rat astrocytes into neurons.

    abstract::To date, it remains poorly understood whether astrocytes can be easily reprogrammed into neurons. Mash1 and Brn2 have been previously shown to cooperate to reprogram fibroblasts into neurons. In this study, we examined astrocytes from 2-month-old Sprague-Dawley rats, and found that Brn2 was expressed, but Mash1 was no...

    journal_title:Neural regeneration research

    pub_type: 杂志文章

    doi:10.4103/1673-5374.125326

    authors: Ding D,Xu L,Xu H,Li X,Liang Q,Zhao Y,Wang Y

    更新日期:2014-01-01 00:00:00

  • Quantitative evaluation of extrinsic factors influencing electrical excitability in neuronal networks: Voltage Threshold Measurement Method (VTMM).

    abstract::The electrical excitability of neural networks is influenced by different environmental factors. Effective and simple methods are required to objectively and quantitatively evaluate the influence of such factors, including variations in temperature and pharmaceutical dosage. The aim of this paper was to introduce 'the...

    journal_title:Neural regeneration research

    pub_type: 杂志文章

    doi:10.4103/1673-5374.233446

    authors: An S,Zhao YF,Lü XY,Wang ZG

    更新日期:2018-06-01 00:00:00

  • Polysaccharides from Angelica sinensis alleviate neuronal cell injury caused by oxidative stress.

    abstract::Angelica sinensis has antioxidative and neuroprotective effects. In the present study, we aimed to determine the neuroprotective effect of polysaccharides isolated from Angelica sinensis. In a preliminary experiment, Angelica sinensis polysaccharides not only protected PC12 neuronal cells from H2O2-induced cytotoxicit...

    journal_title:Neural regeneration research

    pub_type: 杂志文章

    doi:10.4103/1673-5374.128218

    authors: Lei T,Li H,Fang Z,Lin J,Wang S,Xiao L,Yang F,Liu X,Zhang J,Huang Z,Liao W

    更新日期:2014-02-01 00:00:00

  • Changes in brain activation in stroke patients after mental practice and physical exercise: a functional MRI study.

    abstract::Mental practice is a new rehabilitation method that refers to the mental rehearsal of motor imagery content with the goal of improving motor performance. However, the relationship between activated regions and motor recovery after mental practice training is not well understood. In this study, 15 patients who suffered...

    journal_title:Neural regeneration research

    pub_type: 杂志文章

    doi:10.4103/1673-5374.139465

    authors: Liu H,Song L,Zhang T

    更新日期:2014-08-01 00:00:00

  • Amniotic membrane covering for facial nerve repair.

    abstract::Amniotic membranes have been widely used in ophthalmology and skin injury repair because of their anti-inflammatory properties. In this study, we measured therapeutic efficacy and determined if amniotic membranes could be used for facial nerve repair. The facial nerves of eight rats were dissected and end-to-end anast...

    journal_title:Neural regeneration research

    pub_type: 杂志文章

    doi:10.3969/j.issn.1673-5374.2013.11.002

    authors: Karaman M,Tuncel A,Sheidaei S,Senol MG,Karabulut MH,Deveci I,Karaman N

    更新日期:2013-04-15 00:00:00

  • Physiological and pathological effects of amyloid-β species in neural stem cell biology.

    abstract::Although amyloid-β peptide is considered neurotoxic, it may mediate several physiological processes during embryonic development and in the adult brain. The pathological function of amyloid-β peptide has been extensively studied due to its implication in Alzheimer's disease, but its physiological function remains poor...

    journal_title:Neural regeneration research

    pub_type: 杂志文章,评审

    doi:10.4103/1673-5374.262571

    authors: Bernabeu-Zornoza A,Coronel R,Palmer C,Monteagudo M,Zambrano A,Liste I

    更新日期:2019-12-01 00:00:00

  • Brain activation and inhibition after acupuncture at Taichong and Taixi: resting-state functional magnetic resonance imaging.

    abstract::Acupuncture can induce changes in the brain. However, the majority of studies to date have focused on a single acupoint at a time. In the present study, we observed activity changes in the brains of healthy volunteers before and after acupuncture at Taichong (LR3) and Taixi (KI3) using resting-state functional magneti...

    journal_title:Neural regeneration research

    pub_type: 杂志文章

    doi:10.4103/1673-5374.152385

    authors: Zhang SQ,Wang YJ,Zhang JP,Chen JQ,Wu CX,Li ZP,Chen JR,Ouyang HL,Huang Y,Tang CZ

    更新日期:2015-02-01 00:00:00

  • Lim kinase, a bi-functional effector in injury-induced structural plasticity of synapses.

    abstract::The structural plasticity of synaptic terminals contributes to normal nervous system function but also to neural degeneration, in the form of terminal retraction, and regeneration, due to process growth. Synaptic morphological change is mediated through the actin cytoskeleton, which is enriched in axonal and dendritic...

    journal_title:Neural regeneration research

    pub_type: 杂志文章,评审

    doi:10.4103/1673-5374.187018

    authors: Wang W,Townes-Anderson E

    更新日期:2016-07-01 00:00:00

  • Acacetin protects against cerebral ischemia-reperfusion injury via the NLRP3 signaling pathway.

    abstract::Acacetin (5,7-dihydroxy-4'-methoxyflavone), a potential neuroprotective agent, has an inhibitory effect on lipopolysaccharide-induced neuroinflammatory reactions. However, whether acacetin has an effect on inflammatory corpuscle 3 (NLRP3) after cerebral ischemia-reperfusion injury has not been fully determined. This s...

    journal_title:Neural regeneration research

    pub_type: 杂志文章

    doi:10.4103/1673-5374.247465

    authors: Bu J,Shi S,Wang HQ,Niu XS,Zhao ZF,Wu WD,Zhang XL,Ma Z,Zhang YJ,Zhang H,Zhu Y

    更新日期:2019-04-01 00:00:00

  • Tissue engineering for the repair of peripheral nerve injury.

    abstract::Peripheral nerve injury is a common clinical problem and affects the quality of life of patients. Traditional restoration methods are not satisfactory. Researchers increasingly focus on the field of tissue engineering. The three key points in establishing a tissue engineering material are the biological scaffold mater...

    journal_title:Neural regeneration research

    pub_type: 杂志文章,评审

    doi:10.4103/1673-5374.243701

    authors: Zhang PX,Han N,Kou YH,Zhu QT,Liu XL,Quan DP,Chen JG,Jiang BG

    更新日期:2019-01-01 00:00:00

  • Hypoxic preconditioning stimulates angiogenesis in ischemic penumbra after acute cerebral infarction.

    abstract::Previous studies have demonstrated the protective effect of hypoxic preconditioning on acute cerebral infarction, but the mechanisms underlying this protection remain unclear. To investigate the protective mechanisms of hypoxic preconditioning in relation to its effects on angiogenesis, we induced a photochemical mode...

    journal_title:Neural regeneration research

    pub_type: 杂志文章

    doi:10.3969/j.issn.1673-5374.2013.31.002

    authors: Li S,Zhang Y,Shao G,Yang M,Niu J,Lv G,Ji X

    更新日期:2013-11-05 00:00:00

  • HLA class II alleles and risk for peripheral neuropathy in type 2 diabetes patients.

    abstract::The potential impact of human leukocyte antigen (HLA) genotype variations on development of diabetic peripheral neuropathy (DPN) is not well determined. This study aimed to identify the association of HLA class II alleles with DPN in type 2 diabetes (T2D) patients. Totally 106 T2D patients, 49 with DPN and 57 without ...

    journal_title:Neural regeneration research

    pub_type: 杂志文章

    doi:10.4103/1673-5374.194756

    authors: Marzban A,Kiani J,Hajilooi M,Rezaei H,Kahramfar Z,Solgi G

    更新日期:2016-11-01 00:00:00

  • MK-801 attenuates lesion expansion following acute brain injury in rats: a meta-analysis.

    abstract:Objective:To evaluate the efficacy and safety of MK-801 and its effect on lesion volume in rat models of acute brain injury. Data Sources:Key terms were "stroke", "brain diseases", "brain injuries", "brain hemorrhage, traumatic", "acute brain injury", "dizocilpine maleate", "dizocilpine", "MK-801", "MK801", "rat", "ra...

    journal_title:Neural regeneration research

    pub_type: 杂志文章

    doi:10.4103/1673-5374.259619

    authors: Yi NX,Zhou LY,Wang XY,Song YJ,Han HH,Zhang TS,Wang YJ,Shi Q,Xu H,Liang QQ,Zhang T

    更新日期:2019-11-01 00:00:00

  • Ginsenoside Rb1 protects dopaminergic neurons from inflammatory injury induced by intranigral lipopolysaccharide injection.

    abstract::Accumulating studies suggest that neuroinflammation characterized by microglial overactivation plays a pivotal role in the pathogenesis of Parkinson's disease. As such, inhibition of microglial overactivation might be a promising treatment strategy to delay the onset or slow the progression of Parkinson's disease. Gin...

    journal_title:Neural regeneration research

    pub_type: 杂志文章

    doi:10.4103/1673-5374.257536

    authors: Li DW,Zhou FZ,Sun XC,Li SC,Yang JB,Sun HH,Wang AH

    更新日期:2019-10-01 00:00:00

  • Peripheral nerve repair: a hot spot analysis on treatment methods from 2010 to 2014.

    abstract::Therapeutic strategies for neurological deficits and for promoting nerve regeneration after peripheral nerve injuries have received much focus in clinical research. Advances in basic research in recent years have increased our understanding of the anatomy of peripheral nerves and the importance of the microenvironment...

    journal_title:Neural regeneration research

    pub_type: 杂志文章

    doi:10.4103/1673-5374.158368

    authors: Liu GY,Jin Y,Zhang Q,Li R

    更新日期:2015-06-01 00:00:00

  • Brain cell apoptosis and enhancement of nervous excitability in pregnant rats with high plasma levels of homocysteine.

    abstract::Hyperhomocysteinemia is an important risk factor for preeclampsia-eclampsia. This study established a pregnant rat model of hyperhomocysteinemia, in which blood plasma homocysteine concentrations were twice or three times greater than that of normal pregnant rats. TUNEL revealed an increase in the number of apoptotic ...

    journal_title:Neural regeneration research

    pub_type: 杂志文章

    doi:10.3969/j.issn.1673-5374.2012.028.005

    authors: Wang J,Ge J,Yang L,Zhang H,Li X,Xue D

    更新日期:2012-10-05 00:00:00

  • Targeting β-secretase with RNAi in neural stem cells for Alzheimer's disease therapy.

    abstract::There are several major pathological changes in Alzheimer's disease, including apoptosis of cholinergic neurons, overactivity or overexpression of β-site amyloid precursor protein cleaving enzyme 1 (BACE1) and inflammation. In this study, we synthesized a 19-nt oligonucleotide targeting BACE1, the key enzyme in amyloi...

    journal_title:Neural regeneration research

    pub_type: 杂志文章

    doi:10.3969/j.issn.1673-5374.2013.33.003

    authors: Liu Z,Li S,Liang Z,Zhao Y,Zhang Y,Yang Y,Wang M,Li F

    更新日期:2013-11-25 00:00:00

  • Stem cell therapy for Parkinson's disease: safety and modeling.

    abstract::For decades, clinicians have developed medications and therapies to alleviate the symptoms of Parkinson's disease, but no treatment currently can slow or even stop the progression of this localized neurodegeneration. Fortunately, sparked by the genetic revolution, stem cell reprogramming research and the advancing cap...

    journal_title:Neural regeneration research

    pub_type: 杂志文章,评审

    doi:10.4103/1673-5374.264446

    authors: Stoddard-Bennett T,Pera RR

    更新日期:2020-01-01 00:00:00

  • Puerarin accelerates neural regeneration after sciatic nerve injury.

    abstract::Puerarin is a natural isoflavone isolated from plants of the genus Pueraria and functions as a protector against cerebral ischemia. We hypothesized that puerarin can be involved in the repair of peripheral nerve injuries. To test this hypothesis, doses of 10, 5, or 2.5 mg/kg per day puerarin (8-(β-D-Glucopyranosyl-7-h...

    journal_title:Neural regeneration research

    pub_type: 杂志文章

    doi:10.4103/1673-5374.130097

    authors: Wu M,Zhao G,Yang X,Peng C,Zhao J,Liu J,Li R,Gao Z

    更新日期:2014-03-15 00:00:00

  • Current view and perspectives in amyotrophic lateral sclerosis.

    abstract::Amyotrophic lateral sclerosis (ALS), identified as a distinct clinical entity by Charcot since the end of the nineteenth century, is a devastating and fatal neurodegenerative disorder that affects motor neurons in the brain, brainstem and spinal cord. Survival of patients with ALS is associated with several factors su...

    journal_title:Neural regeneration research

    pub_type: 杂志文章,评审

    doi:10.4103/1673-5374.200794

    authors: Mathis S,Couratier P,Julian A,Corcia P,Le Masson G

    更新日期:2017-02-01 00:00:00

  • Progesterone promotes neuronal differentiation of human umbilical cord mesenchymal stem cells in culture conditions that mimic the brain microenvironment.

    abstract::In this study, human umbilical cord mesenchymal stem cells from full-term neonates born by vaginal delivery were cultured in medium containing 150 mg/mL of brain tissue extracts from Sprague-Dawley rats (to mimic the brain microenvironment). Immunocytochemical analysis demonstrated that the cells differentiated into n...

    journal_title:Neural regeneration research

    pub_type: 杂志文章

    doi:10.3969/j.issn.1673-5374.2012.25.001

    authors: Wang X,Wu H,Xue G,Hou Y

    更新日期:2012-09-05 00:00:00

  • Toxic effect of acrylamide on the development of hippocampal neurons of weaning rats.

    abstract::Although numerous studies have examined the neurotoxicity of acrylamide in adult animals, the effects on neuronal development in the embryonic and lactational periods are largely unknown. Thus, we examined the toxicity of acrylamide on neuronal development in the hippocampus of fetal rats during pregnancy. Sprague-Daw...

    journal_title:Neural regeneration research

    pub_type: 杂志文章

    doi:10.4103/1673-5374.217345

    authors: Lai SM,Gu ZT,Zhao MM,Li XX,Ma YX,Luo L,Liu J

    更新日期:2017-10-01 00:00:00

  • Optimal concentration of necrostatin-1 for protecting against hippocampal neuronal damage in mice with status epilepticus.

    abstract::Hippocampal neurons undergo various forms of cell death after status epilepticus. Necrostatin-1 specifically inhibits necroptosis mediated by receptor interacting protein kinase 1 (RIP1) and RIP3 receptors. However, there are no reports of necroptosis in mouse models of status epilepticus. Therefore, in this study, we...

    journal_title:Neural regeneration research

    pub_type: 杂志文章

    doi:10.4103/1673-5374.268903

    authors: Lin DQ,Cai XY,Wang CH,Yang B,Liang RS

    更新日期:2020-05-01 00:00:00