Abstract:
:The Na(+)-K(+)-Cl(-) cotransporter 1 and K(+)-Cl(-) cotransporter 2 regulate the levels of intracellular chloride in hippocampal cells. Impaired chloride transport by these proteins is thought to be involved in the pathophysiological mechanisms of mesial temporal lobe epilepsy. Imbalance in the relative expression of these two proteins can lead to a collapse of Cl(-) homeostasis, resulting in a loss of gamma-aminobutyric acid-ergic inhibition and even epileptiform discharges. In this study, we investigated the expression of Na(+)-K(+)-Cl(-) cotransporter 1 and K(+)-Cl(-) cotransporter 2 in the sclerosed hippocampus of patients with mesial temporal lobe epilepsy, using western blot analysis and immunohistochemistry. Compared with the histologically normal hippocampus, the sclerosed hippocampus showed increased Na(+)-K(+)-Cl(-) cotransporter 1 expression and decreased K(+)-Cl(-) cotransporter 2 expression, especially in CA2 and the dentate gyrus. The change was more prominent for the Na(+)-K(+)-Cl(-) cotransporter 1 than for the K(+)-Cl(-) cotransporter 2. These experimental findings indicate that the balance between intracellular and extracellular chloride may be disturbed in hippocampal sclerosis, contributing to the hyperexcitability underlying epileptic seizures. Changes in Na(+)-K(+)-Cl(-) cotransporter 1 expression seems to be the main contributor. Our study may shed new light on possible therapies for patients with mesial temporal lobe epilepsy with hippocampal sclerosis.
journal_name
Neural Regen Resjournal_title
Neural regeneration researchauthors
Cai X,Yang L,Zhou J,Zhu D,Guo Q,Chen Z,Chen S,Zhou Ldoi
10.3969/j.issn.1673-5374.2013.06.010subject
Has Abstractpub_date
2013-02-25 00:00:00pages
561-8issue
6eissn
1673-5374issn
1876-7958pii
NRR-8-561journal_volume
8pub_type
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