What do we know about the role of lncRNAs in multiple sclerosis?

Abstract:

:Multiple sclerosis is a chronic, inflammatory and degenerative disease of the central nervous system of unknown aetiology although well-defined evidence supports an autoimmune pathogenesis. So far, the exact mechanisms leading to autoimmune diseases are still only partially understood. We know that genetic, epigenetic, molecular, and cellular factors resulting in pathogenic inflammatory responses are certainly involved. Long non-coding RNAs (lncRNAs) are non-protein coding transcripts longer than 200 nucleotides that play an important role in both innate and acquired immunity, so there is great interest in lncRNAs involved in autoimmune diseases. The research on multiple sclerosis has been enriched with many studies on the molecular role of lncRNAs in the pathogenesis of the disease and their potential application as diagnostic and prognostic biomarkers. In particular, many multiple sclerosis fields of research are based on the identification of lncRNAs as possible biomarkers able to predict the onset of the disease, its activity degree, its progression phase and the response to disease-modifying drugs. Last but not least, studies on lncRNAs can provide a new molecular target for new therapies, missing, so far, a cure for multiple sclerosis. While our knowledge on the role of lncRNA in multiple sclerosis has recently improved, further studies are required to better understand the specific role of lncRNAs in this neurological disease. In this review, we present the most recent studies on molecular characterization of lncRNAs in multiple sclerosis disorder discussing their clinical relevance as biomarkers for diagnosis and treatments.

journal_name

Neural Regen Res

authors

Nociti V,Santoro M

doi

10.4103/1673-5374.306061

subject

Has Abstract

pub_date

2021-09-01 00:00:00

pages

1715-1722

issue

9

eissn

1673-5374

issn

1876-7958

pii

NeuralRegenRes_2021_16_9_1715_306061

journal_volume

16

pub_type

杂志文章,评审
  • Differentiation of rhesus adipose stem cells into dopaminergic neurons.

    abstract::LIM homeobox transcription factor 1a (Lmx1a) has the capacity to initiate the development program of neuronal cells and promote the differentiation of embryonic stem cells into dopaminergic neurons. In this study, rhesus adipose stem cells were infected with recombinant adenovirus carrying the Lmx1a gene and co-cultur...

    journal_title:Neural regeneration research

    pub_type: 杂志文章

    doi:10.3969/j.issn.1673-5374.2012.34.001

    authors: Zhou Y,Sun M,Li H,Yan M,Xie T

    更新日期:2012-12-05 00:00:00

  • Novel nervous and multi-system regenerative therapeutic strategies for diabetes mellitus with mTOR.

    abstract::Throughout the globe, diabetes mellitus (DM) is increasing in incidence with limited therapies presently available to prevent or resolve the significant complications of this disorder. DM impacts multiple organs and affects all components of the central and peripheral nervous systems that can range from dementia to di...

    journal_title:Neural regeneration research

    pub_type: 杂志文章,评审

    doi:10.4103/1673-5374.179032

    authors: Maiese K

    更新日期:2016-03-01 00:00:00

  • Constraint-induced movement therapy promotes motor function recovery and downregulates phosphorylated extracellular regulated protein kinase expression in ischemic brain tissue of rats.

    abstract::Motor function impairment is a common outcome of stroke. Constraint-induced movement therapy (CIMT) involving intensive use of the impaired limb while restraining the unaffected limb is widely used to overcome the effects of 'learned non-use' and improve limb function after stroke. However, the underlying mechanism of...

    journal_title:Neural regeneration research

    pub_type: 杂志文章

    doi:10.4103/1673-5374.172319

    authors: Zhang B,He Q,Li YY,Li C,Bai YL,Hu YS,Zhang F

    更新日期:2015-12-01 00:00:00

  • Peripheral nerve repair: a hot spot analysis on treatment methods from 2010 to 2014.

    abstract::Therapeutic strategies for neurological deficits and for promoting nerve regeneration after peripheral nerve injuries have received much focus in clinical research. Advances in basic research in recent years have increased our understanding of the anatomy of peripheral nerves and the importance of the microenvironment...

    journal_title:Neural regeneration research

    pub_type: 杂志文章

    doi:10.4103/1673-5374.158368

    authors: Liu GY,Jin Y,Zhang Q,Li R

    更新日期:2015-06-01 00:00:00

  • Aerobic exercise combined with huwentoxin-I mitigates chronic cerebral ischemia injury.

    abstract::Ca2+ channel blockers have been shown to protect neurons from ischemia, and aerobic exercise has significant protective effects on a variety of chronic diseases. The present study injected huwentoxin-I (HWTX-I), a spider peptide toxin that blocks Ca2+ channels, into the caudal vein of a chronic cerebral ischemia mouse...

    journal_title:Neural regeneration research

    pub_type: 杂志文章

    doi:10.4103/1673-5374.205099

    authors: Mao HF,Xie J,Chen JQ,Tang CF,Chen W,Zhou BC,Chen R,Qu HL,Wu CZ

    更新日期:2017-04-01 00:00:00

  • Tall gastrodis tuber combined with antiepileptic drugs repairs abnormal perfusion foci in focal epilepsy.

    abstract::One hundred patients with focal epilepsy were recruited for the present study and their seizures controlled with antiepileptic drugs. The patients then orally received a capsule of tall gastrodis tuber powder, a traditional Chinese drug, and underwent single photon emission computed tomography, long-term electroenceph...

    journal_title:Neural regeneration research

    pub_type: 杂志文章

    doi:10.3969/j.issn.1673-5374.2013.03.002

    authors: Wang W,Fan Z,Zhang Y,Yang Y,Liu Y,Dang X,Song W,Wu Y,Ye J

    更新日期:2013-01-25 00:00:00

  • Neuroprotective effect of ischemic preconditioning in focal cerebral infarction: relationship with upregulation of vascular endothelial growth factor.

    abstract::Neuroprotection by ischemic preconditioning has been confirmed by many studies, but the precise mechanism remains unclear. In the present study, we performed cerebral ischemic preconditioning in rats by simulating a transient ischemic attack twice (each a 20-minute occlusion of the middle cerebral artery) before induc...

    journal_title:Neural regeneration research

    pub_type: 杂志文章

    doi:10.4103/1673-5374.135313

    authors: Liu Y,Zhu S,Wang Y,Hu J,Xu L,Ding L,Liu G

    更新日期:2014-06-01 00:00:00

  • Limb-girdle muscular dystrophy subtypes: First-reported cohort from northeastern China.

    abstract::The relative frequencies of different subtypes of limb-girdle muscular dystrophies vary widely among different populations. We estimated the percentage of limb-girdle muscular dystrophy subtypes in Chinese people based on 68 patients with limb-girdle muscular dystrophy from the Myology Clinic, Neurology Department, Fi...

    journal_title:Neural regeneration research

    pub_type: 杂志文章

    doi:10.3969/j.issn.1673-5374.2013.20.010

    authors: Mahmood OA,Jiang X,Zhang Q

    更新日期:2013-07-15 00:00:00

  • Tissue engineering for the repair of peripheral nerve injury.

    abstract::Peripheral nerve injury is a common clinical problem and affects the quality of life of patients. Traditional restoration methods are not satisfactory. Researchers increasingly focus on the field of tissue engineering. The three key points in establishing a tissue engineering material are the biological scaffold mater...

    journal_title:Neural regeneration research

    pub_type: 杂志文章,评审

    doi:10.4103/1673-5374.243701

    authors: Zhang PX,Han N,Kou YH,Zhu QT,Liu XL,Quan DP,Chen JG,Jiang BG

    更新日期:2019-01-01 00:00:00

  • Apolipoprotein E mimetic peptide protects against diffuse brain injury.

    abstract::Apolipoprotein E plays a crucial role in inhibiting chronic neurodegenerative processes. However, its impact on neurological function following diffuse brain injury is still unclear. This study was designed to evaluate the therapeutic effects and mechanisms of action of apolipoprotein E mimetic peptide on diffuse brai...

    journal_title:Neural regeneration research

    pub_type: 杂志文章

    doi:10.4103/1673-5374.130060

    authors: Zhao Y,Li J,Tang Q,Gao J,Chen C,Jing L,Zhang P,Li S

    更新日期:2014-03-01 00:00:00

  • Stem cell therapy for Parkinson's disease: safety and modeling.

    abstract::For decades, clinicians have developed medications and therapies to alleviate the symptoms of Parkinson's disease, but no treatment currently can slow or even stop the progression of this localized neurodegeneration. Fortunately, sparked by the genetic revolution, stem cell reprogramming research and the advancing cap...

    journal_title:Neural regeneration research

    pub_type: 杂志文章,评审

    doi:10.4103/1673-5374.264446

    authors: Stoddard-Bennett T,Pera RR

    更新日期:2020-01-01 00:00:00

  • Transferrin receptor 1 plays an important role in muscle development and denervation-induced muscular atrophy.

    abstract::Previous studies demonstrate an accumulation of transferrin and transferrin receptor 1 (TfR1) in regenerating peripheral nerves. However, the expression and function of transferrin and TfR1 in the denervated skeletal muscle remain poorly understood. In this study, a mouse model of denervation was produced by complete ...

    journal_title:Neural regeneration research

    pub_type: 杂志文章

    doi:10.4103/1673-5374.301024

    authors: Li Y,Cheng JX,Yang HH,Chen LP,Liu FJ,Wu Y,Fan M,Wu HT

    更新日期:2021-07-01 00:00:00

  • Comparison of walking quality variables between incomplete spinal cord injury patients and healthy subjects by using a footscan plantar pressure system.

    abstract::The main goal of spinal cord rehabilitation is to restore walking ability and improve walking quality after spinal cord injury (SCI). The spatiotemporal parameters of walking and the parameters of plantar pressure can be obtained using a plantar pressure analysis system. Previous studies have reported step asymmetry i...

    journal_title:Neural regeneration research

    pub_type: 杂志文章

    doi:10.4103/1673-5374.244798

    authors: Yuan XN,Liang WD,Zhou FH,Li HT,Zhang LX,Zhang ZQ,Li JJ

    更新日期:2019-02-01 00:00:00

  • Does diffusion tensor data reflect pathological changes in the spinal cord with chronic injury.

    abstract::Magnetic resonance diffusion tensor imaging has been shown to quantitatively measure the early pathological changes in chronic cervical spondylotic myelopathy. In this study, a novel spongy polyurethane material was implanted in the rat C3-5 epidural space to establish a rat model of chronic cervical spondylotic myelo...

    journal_title:Neural regeneration research

    pub_type: 杂志文章

    doi:10.3969/j.issn.1673-5374.2013.36.003

    authors: Lin E,Long H,Li G,Lei W

    更新日期:2013-12-25 00:00:00

  • Expression of NG2 and platelet-derived growth factor receptor alpha in the developing neonatal rat brain.

    abstract::Platelet-derived growth factor receptor alpha (PDGFRα) is a marker of oligodendrocyte precursor cells in the central nervous system. NG2 is also considered a marker of oligodendrocyte precursor cells. However, whether there are differences in the distribution and morphology of oligodendrocyte precursor cells labeled b...

    journal_title:Neural regeneration research

    pub_type: 杂志文章

    doi:10.4103/1673-5374.219045

    authors: Li P,Li HX,Jiang HY,Zhu L,Wu HY,Li JT,Lai JH

    更新日期:2017-11-01 00:00:00

  • Characteristics of mRNA dynamic expression related to spinal cord ischemia/reperfusion injury: a transcriptomics study.

    abstract::Following spinal cord ischemia/reperfusion injury, an endogenous damage system is immediately activated and participates in a cascade reaction. It is difficult to interpret dynamic changes in these pathways, but the examination of the transcriptome may provide some information. The transcriptome reflects highly dynami...

    journal_title:Neural regeneration research

    pub_type: 杂志文章

    doi:10.4103/1673-5374.179067

    authors: Qi ZP,Xia P,Hou TT,Li DY,Zheng CJ,Yang XY

    更新日期:2016-03-01 00:00:00

  • Plasticity of language pathways in patients with low-grade glioma: A diffusion tensor imaging study.

    abstract::Knowledge of the plasticity of language pathways in patients with low-grade glioma is important for neurosurgeons to achieve maximum resection while preserving neurological function. The current study sought to investigate changes in the ventral language pathways in patients with low-grade glioma located in regions li...

    journal_title:Neural regeneration research

    pub_type: 杂志文章

    doi:10.3969/j.issn.1673-5374.2013.07.009

    authors: Zheng G,Chen X,Xu B,Zhang J,Lv X,Li J,Li F,Hu S,Zhang T,Li Y

    更新日期:2013-03-05 00:00:00

  • Inhibition of GABAA-ρ receptors induces retina regeneration in zebrafish.

    abstract::A potential treatment for retinal diseases is to induce an endogenous Müller glia (MG)-derived regenerative response to replace damaged neurons. In contrast to mammalian MG, zebrafish MG are capable of mediating spontaneous regeneration. We seek to define the mechanisms that enable retina regeneration in zebrafish in ...

    journal_title:Neural regeneration research

    pub_type: 杂志文章

    doi:10.4103/1673-5374.286972

    authors: Kent MR,Kara N,Patton JG

    更新日期:2021-02-01 00:00:00

  • Minocycline targets multiple secondary injury mechanisms in traumatic spinal cord injury.

    abstract::Minocycline hydrochloride (MH), a semi-synthetic tetracycline derivative, is a clinically available antibiotic and anti-inflammatory drug that also exhibits potent neuroprotective activities. It has been shown to target multiple secondary injury mechanisms in spinal cord injury, via its anti-inflammatory, anti-oxidant...

    journal_title:Neural regeneration research

    pub_type: 杂志文章,评审

    doi:10.4103/1673-5374.206633

    authors: Shultz RB,Zhong Y

    更新日期:2017-05-01 00:00:00

  • Effects of repetitive transcranial magnetic stimulation on cognitive function and cholinergic activity in the rat hippocampus after vascular dementia.

    abstract::Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive treatment that can enhance the recovery of neurological function after stroke. Whether it can similarly promote the recovery of cognitive function after vascular dementia remains unknown. In this study, a rat model for vascular dementia was establis...

    journal_title:Neural regeneration research

    pub_type: 杂志文章

    doi:10.4103/1673-5374.235251

    authors: Zhang XQ,Li L,Huo JT,Cheng M,Li LH

    更新日期:2018-08-01 00:00:00

  • Optical control after transfection of channelrhodopsin-2 recombinant adenovirus in visual cortical cells.

    abstract::Channelrhodopsin-2 ectopically expressed in the retina can recover the response to blue light in genetically blind mice and rats, but is unable to restore visual function due to optic nerve or optic tract lesions. Long Evans rats at postnatal day 1 were used for primary culture of visual cortical cells, and 24 hours l...

    journal_title:Neural regeneration research

    pub_type: 杂志文章

    doi:10.3969/j.issn.1673-5374.2012.16.004

    authors: Yao J,Hou W,Wang H,Liu H,Weng C,Yin Z

    更新日期:2012-06-05 00:00:00

  • Dynamic reactive astrocytes after focal ischemia.

    abstract::Astrocytes are specialized and most numerous glial cell type in the central nervous system and play important roles in physiology. Astrocytes are also critically involved in many neural disorders including focal ischemic stroke, a leading cause of brain injury and human death. One of the prominent pathological feature...

    journal_title:Neural regeneration research

    pub_type: 杂志文章,评审

    doi:10.4103/1673-5374.147929

    authors: Ding S

    更新日期:2014-12-01 00:00:00

  • Propofol promotes spinal cord injury repair by bone marrow mesenchymal stem cell transplantation.

    abstract::Propofol is a neuroprotective anesthetic. Whether propofol can promote spinal cord injury repair by bone marrow mesenchymal stem cells remains poorly understood. We used rats to investigate spinal cord injury repair using bone marrow mesenchymal stem cell transplantation combined with propofol administration via the t...

    journal_title:Neural regeneration research

    pub_type: 杂志文章

    doi:10.4103/1673-5374.162765

    authors: Zhou YJ,Liu JM,Wei SM,Zhang YH,Qu ZH,Chen SB

    更新日期:2015-08-01 00:00:00

  • Neurological functional evaluation based on accurate motions in big animals with traumatic brain injury.

    abstract::An accurate and effective neurological evaluation is indispensable in the treatment and rehabilitation of traumatic brain injury. However, most of the existing evaluation methods in basic research and clinical practice are not objective or intuitive for assessing the neurological function of big animals, and are also ...

    journal_title:Neural regeneration research

    pub_type: 杂志文章

    doi:10.4103/1673-5374.250578

    authors: Jiang JP,Niu XG,Dai C,Ma K,Xu HY,Cheng SX,Zhang ZW,Duan F,Zhu X,Wang YT,Chen XY,Zhang S

    更新日期:2019-06-01 00:00:00

  • Does hemispheric lateralization influence therapeutic effects of transcranial direct current stimulation?

    abstract::This study investigated the effect of transcranial direct current stimulation (tDCS) polarity depending on lateralized function of task property in normal individuals performing visuomotor and simple repetitive tasks. Thirty healthy participants with no neurological disorders were recruited to participate in this stud...

    journal_title:Neural regeneration research

    pub_type: 杂志文章

    doi:10.4103/1673-5374.175057

    authors: Kwon YH,Kang KW,Lee NK,Son SM

    更新日期:2016-01-01 00:00:00

  • Diffusion kurtosis imaging of microstructural changes in brain tissue affected by acute ischemic stroke in different locations.

    abstract::The location of an acute ischemic stroke is associated with its prognosis. The widely used Gaussian model-based parameter, apparent diffusion coefficient (ADC), cannot reveal microstructural changes in different locations or the degree of infarction. This prospective observational study was reviewed and approved by th...

    journal_title:Neural regeneration research

    pub_type: 杂志文章

    doi:10.4103/1673-5374.244791

    authors: Zhu LH,Zhang ZP,Wang FN,Cheng QH,Guo G

    更新日期:2019-02-01 00:00:00

  • Graphene oxide-composited chitosan scaffold contributes to functional recovery of injured spinal cord in rats.

    abstract::The study illustrates that graphene oxide nanosheets can endow materials with continuous electrical conductivity for up to 4 weeks. Conductive nerve scaffolds can bridge a sciatic nerve injury and guide the growth of neurons; however, whether the scaffolds can be used for the repair of spinal cord nerve injuries remai...

    journal_title:Neural regeneration research

    pub_type: 杂志文章

    doi:10.4103/1673-5374.306095

    authors: Yang B,Wang PB,Mu N,Ma K,Wang S,Yang CY,Huang ZB,Lai Y,Feng H,Yin GF,Chen TN,Hu CS

    更新日期:2021-09-01 00:00:00

  • High-dose thalidomide increases the risk of peripheral neuropathy in the treatment of ankylosing spondylitis.

    abstract::Thalidomide is an effective drug for the treatment of ankylosing spondylitis but might induce peripheral neuropathy. This major adverse reaction has attracted much concern. The current study aimed to observe the incidence of thalidomide-induced peripheral neuropathy among ankylosing spondylitis patients for 1 year aft...

    journal_title:Neural regeneration research

    pub_type: 杂志文章

    doi:10.4103/1673-5374.156988

    authors: Xue HX,Fu WY,Cui HD,Yang LL,Zhang N,Zhao LJ

    更新日期:2015-05-01 00:00:00

  • Scaffoldless tissue-engineered nerve conduit promotes peripheral nerve regeneration and functional recovery after tibial nerve injury in rats.

    abstract::Damage to peripheral nerve tissue may cause loss of function in both the nerve and the targeted muscles it innervates. This study compared the repair capability of engineered nerve conduit (ENC), engineered fibroblast conduit (EFC), and autograft in a 10-mm tibial nerve gap. ENCs were fabricated utilizing primary fibr...

    journal_title:Neural regeneration research

    pub_type: 杂志文章

    doi:10.4103/1673-5374.215265

    authors: Adams AM,VanDusen KW,Kostrominova TY,Mertens JP,Larkin LM

    更新日期:2017-09-01 00:00:00

  • Electrical stimulation promotes regeneration of injured oculomotor nerves in dogs.

    abstract::Functional recovery after oculomotor nerve injury is very poor. Electrical stimulation has been shown to promote regeneration of injured nerves. We hypothesized that electrical stimulation would improve the functional recovery of injured oculomotor nerves. Oculomotor nerve injury models were created by crushing the ri...

    journal_title:Neural regeneration research

    pub_type: 杂志文章

    doi:10.4103/1673-5374.193248

    authors: Du L,Yang M,Wan L,Wang XH,Li ST

    更新日期:2016-10-01 00:00:00