Abstract:
:Myasthenia gravis is a rare and invalidating disease affecting the neuromuscular junction of voluntary muscles. The classical form of this autoimmune disease is characterized by the presence of antibodies against the most abundant protein in the neuromuscular junction, the nicotinic acetylcholine receptor. Other variants of the disease involve autoimmune attack of non-receptor scaffolding proteins or enzymes essential for building or maintaining the integrity of this peripheral synapse. This review summarizes the participation of the above proteins in building the neuromuscular junction and the destruction of this cholinergic synapse by autoimmune aggression in myasthenia gravis. The review also covers the application of a powerful biophysical technique, superresolution optical microscopy, to image the nicotinic receptor in live cells and follow its motional dynamics. The hypothesis is entertained that anomalous nanocluster formation by antibody crosslinking may lead to accelerated endocytic internalization and elevated turnover of the receptor, as observed in myasthenia gravis.
journal_name
Neural Regen Resjournal_title
Neural regeneration researchauthors
Barrantes FJdoi
10.4103/1673-5374.290880subject
Has Abstractpub_date
2021-02-01 00:00:00pages
242-246issue
2eissn
1673-5374issn
1876-7958pii
NeuralRegenRes_2021_16_2_242_290880journal_volume
16pub_type
杂志文章,评审abstract::Multiple-bud regeneration, i.e., multiple amplification, has been shown to exist in peripheral nerve regeneration. Multiple buds grow towards the distal nerve stump during proximal nerve fiber regeneration. Our previous studies have verified the limit and validity of multiple amplification of peripheral nerve regenera...
journal_title:Neural regeneration research
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journal_title:Neural regeneration research
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doi:10.4103/1673-5374.270297
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journal_title:Neural regeneration research
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journal_title:Neural regeneration research
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更新日期:2012-04-25 00:00:00
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journal_title:Neural regeneration research
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doi:10.4103/1673-5374.238715
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journal_title:Neural regeneration research
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doi:10.4103/1673-5374.233446
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journal_title:Neural regeneration research
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journal_title:Neural regeneration research
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doi:10.4103/1673-5374.235251
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journal_title:Neural regeneration research
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journal_title:Neural regeneration research
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journal_title:Neural regeneration research
pub_type: 杂志文章,评审
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journal_title:Neural regeneration research
pub_type: 杂志文章
doi:10.4103/1673-5374.156943
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doi:10.4103/1673-5374.191228
更新日期:2016-09-01 00:00:00
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journal_title:Neural regeneration research
pub_type: 杂志文章,评审
doi:10.4103/1673-5374.131591
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journal_title:Neural regeneration research
pub_type: 杂志文章
doi:10.4103/1673-5374.232484
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doi:10.4103/1673-5374.293132
更新日期:2021-04-01 00:00:00
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journal_title:Neural regeneration research
pub_type: 杂志文章
doi:10.4103/1673-5374.179067
更新日期:2016-03-01 00:00:00
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journal_title:Neural regeneration research
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doi:10.4103/1673-5374.217345
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journal_title:Neural regeneration research
pub_type: 杂志文章,评审
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journal_title:Neural regeneration research
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journal_title:Neural regeneration research
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journal_title:Neural regeneration research
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journal_title:Neural regeneration research
pub_type: 杂志文章
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journal_title:Neural regeneration research
pub_type: 杂志文章
doi:10.3969/j.issn.1673-5374.2012.23.002
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journal_title:Neural regeneration research
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journal_title:Neural regeneration research
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journal_title:Neural regeneration research
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journal_title:Neural regeneration research
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