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Efficacy of epothilones in central nervous system trauma treatment: what has age got to do with it?

Abstract：

:Central nervous system injury, specifically traumatic brain and spinal cord injury, can have significant long lasting effects. There are no comprehensive treatments to combat the injury and sequalae of events that occurring following a central nervous system trauma. Herein we discuss the potential for the epothilone family of microtubule stabilizing agents to improve outcomes following experimentally induced trauma. These drugs, which are able to cross the blood-brain barrier, may hold great promise for the treatment of central nervous system trauma and the current literature presents the extensive range of beneficial effects these drugs may have following trauma in animal models. Importantly, the effect of the epothilones can vary and our most recent contributions to this field indicate that the efficacy of epothilones following traumatic brain injury is dependent upon the age of the animals. Therefore, we present a case for a greater emphasis to be placed upon age when using an intervention aimed at neural regeneration and highlight the importance of tailoring the therapeutic regime in the clinic to the age of the patient to promote improved patient outcomes.

journal_name

Neural Regen Res

journal_title

Neural regeneration research

authors

Clark J,Zhu Z,Chuckowree J,Dickson T,Blizzard C

doi

10.4103/1673-5374.295312

subject

Has Abstract

pub_date

2021-04-01 00:00:00

pages

618-620

issue

4

eissn

1673-5374

issn

1876-7958

pii

NeuralRegenRes_2021_16_4_618_295312

journal_volume

16

pub_type

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