Heshouwu decoction, a Chinese herb for tonifying kidney, ameliorates hypothalamic-pituitary- testicular axis secretion in aging rats.

Abstract:

:An increasing amount of evidence demonstrates the anti-aging effect of Heshouwu in pill form. In this study, a subacute aging rat model was established by continuous intraperitoneal injection of D-galactose and treated with Heshouwu decoction (a Chinese herb for tonifying the kidney, comprising Heshouwu pill, Herba Epimedii, Radix Salviae Miltiorrhiae, and Poria). Heshouwu pill treated rats were the positive control group. Radioimmunoassay, immunohistochemical staining, and western blot assay showed hypothalamic gonadotropin-releasing hormone, hypothalamic substance P, and serum gonadotropin levels to be significantly increased in the model rats; the concentrations of hypothalamic β-endorphin, and serum levels of insulin-like growth factor 1 and testosterone were significantly decreased. 17β- and 3β-hydroxysteroid dehydrogenase expression in testicular tissue was also decreased. Intragastric administration of Heshouwu decoction at high (9.6 g/mL/100 g), medium (4.8 g/mL/100 g), and low (2.4 g/mL/100 g) doses, Heshouwu decoction pretreatment at a medium dose (4.8 g/mL/100 g), and Heshouwu pill (2.06 g/mL/100 g) significantly reversed these changes. Heshouwu decoction pretreatment and high-dose Heshouwu decoction had the greatest anti-aging effects. These experimental findings indicate that Heshouwu decoction can improve hypothalamic-pituitary-testicular axis secretion in a subacute aging rat model, and prevent and delay gonadal axis aging, with an effect superior to that of Heshouwu pill.

journal_name

Neural Regen Res

authors

Niu S,Kou S,Zhou X,Ding L

doi

10.3969/j.issn.1673-5374.2012.21.002

subject

Has Abstract

pub_date

2012-07-25 00:00:00

pages

1611-7

issue

21

eissn

1673-5374

issn

1876-7958

pii

NRR-7-1611

journal_volume

7

pub_type

杂志文章
  • The apparent diffusion coefficient does not reflect cytotoxic edema on the uninjured side after traumatic brain injury.

    abstract::After traumatic brain injury, vasogenic and cytotoxic edema appear sequentially on the involved side. Neuroimaging investigations of edema on the injured side have employed apparent diffusion coefficient measurements in diffusion tensor imaging. We investigated the changes occurring on the injured and uninjured sides ...

    journal_title:Neural regeneration research

    pub_type: 杂志文章

    doi:10.4103/1673-5374.133150

    authors: Lu H,Lei X

    更新日期:2014-05-01 00:00:00

  • DTI and pathological changes in a rabbit model of radiation injury to the spinal cord after 125I radioactive seed implantation.

    abstract::Excessive radiation exposure may lead to edema of the spinal cord and deterioration of the nervous system. Magnetic resonance imaging can be used to judge and assess the extent of edema and to evaluate pathological changes and thus may be used for the evaluation of spinal cord injuries caused by radiation therapy. Rad...

    journal_title:Neural regeneration research

    pub_type: 杂志文章

    doi:10.4103/1673-5374.228758

    authors: Cao X,Fang L,Cui CY,Gao S,Wang TW

    更新日期:2018-03-01 00:00:00

  • Neurological recovery and antioxidant effects of resveratrol in rats with spinal cord injury: a meta-analysis.

    abstract:Objective:To critically assess the neurological recovery and antioxidant effects of resveratrol in rat models of spinal cord injury. Data sources:Using "spinal cord injury", "resveratrol" and "animal experiment" as the main search terms, all studies on the treatment of spinal cord injury in rats by resveratrol were se...

    journal_title:Neural regeneration research

    pub_type: 杂志文章

    doi:10.4103/1673-5374.266064

    authors: Xu BP,Yao M,Li ZJ,Tian ZR,Ye J,Wang YJ,Cui XJ

    更新日期:2020-03-01 00:00:00

  • Treating Alzheimer's disease with Yizhijiannao granules by regulating expression of multiple proteins in temporal lobe.

    abstract::Yizhijiannao granules have been shown to improve cognitive function in Alzheimer's disease patients. The present study sought to explore the mechanisms involved in the cognitive enhancing effects of Yizhijiannao granule. Senescence-accelerated mouse prone 8 mice with learning and memory disorders were intragastrically...

    journal_title:Neural regeneration research

    pub_type: 杂志文章

    doi:10.4103/1673-5374.137575

    authors: Zhu H,Luo L,Hu S,Dong K,Li G,Zhang T

    更新日期:2014-07-01 00:00:00

  • Curcumin and Apigenin - novel and promising therapeutics against chronic neuroinflammation in Alzheimer's disease.

    abstract::Alzheimer's disease is a progressive neurodegenerative disorder, characterized by deposition of amyloid beta, neurofibrillary tangles, astrogliosis and microgliosis, leading to neuronal dysfunction and loss in the brain. Current treatments for Alzheimer's disease primarily focus on enhancement of cholinergic transmiss...

    journal_title:Neural regeneration research

    pub_type: 杂志文章,评审

    doi:10.4103/1673-5374.162686

    authors: Venigalla M,Gyengesi E,Münch G

    更新日期:2015-08-01 00:00:00

  • Limb-girdle muscular dystrophy subtypes: First-reported cohort from northeastern China.

    abstract::The relative frequencies of different subtypes of limb-girdle muscular dystrophies vary widely among different populations. We estimated the percentage of limb-girdle muscular dystrophy subtypes in Chinese people based on 68 patients with limb-girdle muscular dystrophy from the Myology Clinic, Neurology Department, Fi...

    journal_title:Neural regeneration research

    pub_type: 杂志文章

    doi:10.3969/j.issn.1673-5374.2013.20.010

    authors: Mahmood OA,Jiang X,Zhang Q

    更新日期:2013-07-15 00:00:00

  • Strategies for myelin regeneration: lessons learned from development.

    abstract::Myelin regeneration is indispensably important for patients suffering from several central nervous system (CNS) disorders such as multiple sclerosis (MS) and spinal cord injury (SCI), because it is not only essential for restoring neurophysiology, but also protects denuded axons for secondary degeneration. Understandi...

    journal_title:Neural regeneration research

    pub_type: 杂志文章,评审

    doi:10.4103/1673-5374.137586

    authors: Bhatt A,Fan LW,Pang Y

    更新日期:2014-07-15 00:00:00

  • Photoacoustic treatment mitigates cognitive dysfunction in a model of sleep-wake rhythm disturbance.

    abstract::Sleep-wake rhythm disturbances, which are characterized by abnormal sleep timing or duration, are associated with cognitive dysfunction. Photoacoustic treatments including light and sound stimulation have been found to be effective in modulating sleep patterns and improving cognitive behavior in abnormal sleep-wake pa...

    journal_title:Neural regeneration research

    pub_type: 杂志文章

    doi:10.4103/1673-5374.270415

    authors: Xing F,Fang X,Gong XD,Zhao X,Du Y,Ma ZL,Gu XP,Xia TJ

    更新日期:2020-06-01 00:00:00

  • Active Achilles tendon kinesitherapy accelerates Achilles tendon repair by promoting neurite regeneration.

    abstract::Active Achilles tendon kinesitherapy facilitates the functional recovery of a ruptured Achilles tendon. However, protein expression during the healing process remains a controversial issue. New Zealand rabbits, aged 14 weeks, underwent tenotomy followed immediately by Achilles tendon microsurgery to repair the Achille...

    journal_title:Neural regeneration research

    pub_type: 杂志文章

    doi:10.3969/j.issn.1673-5374.2012.35.008

    authors: Jielile J,Aibai M,Sabirhazi G,Shawutali N,Tangkejie W,Badelhan A,Nuerduola Y,Satewalede T,Buranbai D,Hunapia B,Jialihasi A,Bai J,Kizaibek M

    更新日期:2012-12-15 00:00:00

  • Effects of minocycline on apoptosis and angiogenesis-related protein expression in a rat model of intracerebral hemorrhage.

    abstract::In the present study, a rat model of non-traumatic intracerebral hemorrhage was established by type IV collagenase injection into the right globus pallidus. Bax and Bcl-2 expression in tissues surrounding hematomas was significantly increased within 14 days after injury, and it then gradually decreased. Vascular endot...

    journal_title:Neural regeneration research

    pub_type: 杂志文章

    doi:10.3969/j.issn.1673-5374.2012.08.006

    authors: Wang R,Hao D,Shi W,Pu J,Wang Z

    更新日期:2012-03-15 00:00:00

  • Tea polyphenols increase X-ray repair cross-complementing protein 1 and apurinic/apyrimidinic endonuclease/redox factor-1 expression in the hippocampus of rats during cerebral ischemia/reperfusion injury.

    abstract::Recent studies have shown that tea polyphenols can cross the blood-brain barrier, inhibit apoptosis and play a neuroprotective role against cerebral ischemia. Furthermore, tea polyphenols can decrease DNA damage caused by free radicals. We hypothesized that tea polyphenols repair DNA damage and inhibit neuronal apopto...

    journal_title:Neural regeneration research

    pub_type: 杂志文章

    doi:10.3969/j.issn.1673-5374.2012.30.005

    authors: Wang Z,Xue R,Lei X,Lv J,Wu G,Li W,Xue L,Lei X,Zhao H,Gao H,Wei X

    更新日期:2012-10-25 00:00:00

  • Exogenous platelet-derived growth factor improves neurovascular unit recovery after spinal cord injury.

    abstract::The blood-spinal cord barrier plays a vital role in recovery after spinal cord injury. The neurovascular unit concept emphasizes the relationship between nerves and vessels in the brain, while the effect of the blood-spinal cord barrier on the neurovascular unit is rarely reported in spinal cord injury studies. Mouse ...

    journal_title:Neural regeneration research

    pub_type: 杂志文章

    doi:10.4103/1673-5374.295347

    authors: Ye LX,An NC,Huang P,Li DH,Zheng ZL,Ji H,Li H,Chen DQ,Wu YQ,Xiao J,Xu K,Li XK,Zhang HY

    更新日期:2021-04-01 00:00:00

  • Dynamic reactive astrocytes after focal ischemia.

    abstract::Astrocytes are specialized and most numerous glial cell type in the central nervous system and play important roles in physiology. Astrocytes are also critically involved in many neural disorders including focal ischemic stroke, a leading cause of brain injury and human death. One of the prominent pathological feature...

    journal_title:Neural regeneration research

    pub_type: 杂志文章,评审

    doi:10.4103/1673-5374.147929

    authors: Ding S

    更新日期:2014-12-01 00:00:00

  • Influence of Tanshinone IIa on heat shock protein 70, Bcl-2 and Bax expression in rats with spinal ischemia/reperfusion injury.

    abstract::Tanshinone IIa is an effective monomer component of Danshen, which is a traditional Chinese medicine for activating blood circulation to dissipate blood stasis. Tanshinone IIa can effectively improve brain tissue ischemia/hypoxia injury. The present study established a rat model of spinal cord ischemia/reperfusion inj...

    journal_title:Neural regeneration research

    pub_type: 杂志文章

    doi:10.3969/j.issn.1673-5374.2012.36.005

    authors: Zhang L,Gan W,An G

    更新日期:2012-12-25 00:00:00

  • The role of autophagy in Parkinson's disease.

    abstract::Although Parkinson's disease is the most common neurodegenerative movement disorder, the mechanisms of pathogenesis remain poorly understood. Recent findings have shown that deregulation of the autophagy-lysosome pathway is involved in the pathogenesis of Parkinson's disease. This review summarizes the most recent fin...

    journal_title:Neural regeneration research

    pub_type: 杂志文章,评审

    doi:10.3969/j.issn.1673-5374.2012.02.011

    authors: Zhang L,Dong Y,Xu X,Xu Z

    更新日期:2012-01-15 00:00:00

  • Effect of p62 on tau hyperphosphorylation in a rat model of Alzheimer's disease.

    abstract::Tau hyperphosphorylation is a main cause of neuronal loss in Alzheimer's disease, which can be caused by many factors, including oxidative stress. The multifunctional protein p62, which exists in neurofibrillary tangles and causes aggregation of hyperphosphorylated tau, not only serves as a receptor in selective autop...

    journal_title:Neural regeneration research

    pub_type: 杂志文章

    doi:10.3969/j.issn.1673-5374.2012.17.004

    authors: Zheng X,Wang W,Liu R,Huang H,Zhang R,Sun L

    更新日期:2012-06-15 00:00:00

  • The occurrence of diffuse axonal injury in the brain: associated with the accumulation and clearance of myelin debris.

    abstract::The accumulation of myelin debris may be a major contributor to the inflammatory response after diffuse axonal injury. In this study, we examined the accumulation and clearance of myelin debris in a rat model of diffuse axonal injury. Oil Red O staining was performed on sections from the cerebral cortex, hippocampus a...

    journal_title:Neural regeneration research

    pub_type: 杂志文章

    doi:10.4103/1673-5374.145358

    authors: Wen L,Xu J,Zhan T,Wang H,Huang X,Liu W,Yang X,Zhan R

    更新日期:2014-11-01 00:00:00

  • Efficacy of nanofibrous conduits in repair of long-segment sciatic nerve defects.

    abstract::Our previous studies have histomorphologically confirmed that nanofibrous poly(3-hydroxybutyrate-co-3-hydroxyvalerate) conduit can be used to repair 30-mm-long sciatic nerve defects. However, the repair effects on rat behaviors remain poorly understood. In this study, we used nanofibrous poly(3-hydroxybutyrate-co-3-hy...

    journal_title:Neural regeneration research

    pub_type: 杂志文章

    doi:10.3969/j.issn.1673-5374.2013.27.001

    authors: Biazar E,Keshel SH,Pouya M

    更新日期:2013-09-25 00:00:00

  • Therapeutic potential of brain-derived neurotrophic factor (BDNF) and a small molecular mimics of BDNF for traumatic brain injury.

    abstract::Traumatic brain injury (TBI) is a major health problem worldwide. Following primary mechanical insults, a cascade of secondary injuries often leads to further neural tissue loss. Thus far there is no cure to rescue the damaged neural tissue. Current therapeutic strategies primarily target the secondary injuries focusi...

    journal_title:Neural regeneration research

    pub_type: 杂志文章,评审

    doi:10.4103/1673-5374.198964

    authors: Wurzelmann M,Romeika J,Sun D

    更新日期:2017-01-01 00:00:00

  • Hydroxyethylstarch revisited for acute brain injury treatment.

    abstract::Infusion of the colloid hydroxyethylstarch has been used for volume substitution to maintain hemodynamics and microcirculation after e.g., severe blood loss. In the last decade it was revealed that hydroxyethylstarch can aggravate acute kidney injury, especially in septic patients. Because of the serious risk for crit...

    journal_title:Neural regeneration research

    pub_type: 杂志文章,评审

    doi:10.4103/1673-5374.300978

    authors: Schick MA,Burek M,Förster CY,Nagai M,Wunder C,Neuhaus W

    更新日期:2021-07-01 00:00:00

  • Regulation of neuronal bioenergetics as a therapeutic strategy in neurodegenerative diseases.

    abstract::Neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis are a heterogeneous group of debilitating disorders with multifactorial etiologies and pathogeneses that manifest distinct molecular mechanisms and clinical manifestations with abnormal ...

    journal_title:Neural regeneration research

    pub_type: 杂志文章

    doi:10.4103/1673-5374.303007

    authors: Onyango IG,Bennett JP,Stokin GB

    更新日期:2021-08-01 00:00:00

  • Overexpression of estrogen receptor beta alleviates the toxic effects of beta-amyloid protein on PC12 cells via non-hormonal ligands.

    abstract::After binding to the estrogen receptor, estrogen can alleviate the toxic effects of beta-amyloid protein, and thereby exert a therapeutic effect on Alzheimer's disease patients. Estrogen can increase the incidence of breast carcinoma and endometrial cancer in post-menopausal women, so it is not suitable for clinical t...

    journal_title:Neural regeneration research

    pub_type: 杂志文章

    doi:10.3969/j.issn.1673-5374.2012.14.008

    authors: Wang H,Si L,Li X,Deng W,Yang H,Yang Y,Fu Y

    更新日期:2012-05-15 00:00:00

  • Neuroprotective effects of the immunomodulatory drug Setarud on cerebral ischemia in male rats.

    abstract::Anti-inflammatory and anti-oxidant agents can alleviate ischemic cerebral injury. The immunomodulary drug Setarud, which is composed of herbal extracts including Rosa canina, Urtica dioica and Tanacetum vulgare, supplemented with selenium exhibits anti-inflammatory and anti-oxidant properties. Therefore, we hypothesiz...

    journal_title:Neural regeneration research

    pub_type: 杂志文章

    doi:10.3969/j.issn.1673-5374.2012.27.001

    authors: Vafaee F,Zangiabadi N,Pour FM,Dehghanian F,Asadi-Shekaari M,Afshar HK

    更新日期:2012-09-25 00:00:00

  • Adipose-derived stem cells modified by BDNF gene rescue erectile dysfunction after cavernous nerve injury.

    abstract::Cavernous nerve injury is the main cause of erectile dysfunction following radical prostatectomy. The recovery of erectile function following radical prostatectomy remains challenging. Our previous studies found that injecting adipose-derived stem cells (ADSCs) into the cavernosa could repair the damaged cavernous ner...

    journal_title:Neural regeneration research

    pub_type: 杂志文章

    doi:10.4103/1673-5374.264464

    authors: Yang M,Sun JY,Ying CC,Wang Y,Guo YL

    更新日期:2020-01-01 00:00:00

  • A paracrine role for white thermogenic adipocytes in innervation: an evidence-based hypothesis.

    abstract::White adipose tissue (WAT) stores energy and also plays an important endocrine role in producing adipokines for communication with the peripheral and central nervous system. WAT consists of the major lipogenic unilocular adipocytes and the minor populations of beige and brite multilocular adipocytes. These multilocula...

    journal_title:Neural regeneration research

    pub_type: 杂志文章,评审

    doi:10.4103/1673-5374.244777

    authors: Lee A,Ziouzenkova O

    更新日期:2019-02-01 00:00:00

  • Transplantation of vascular endothelial growth factor-modified neural stem/progenitor cells promotes the recovery of neurological function following hypoxic-ischemic brain damage.

    abstract::Neural stem/progenitor cell (NSC) transplantation has been shown to effectively improve neurological function in rats with hypoxic-ischemic brain damage. Vascular endothelial growth factor (VEGF) is a signaling protein that stimulates angiogenesis and improves neural regeneration. We hypothesized that transplantation ...

    journal_title:Neural regeneration research

    pub_type: 杂志文章

    doi:10.4103/1673-5374.191220

    authors: Yao Y,Zheng XR,Zhang SS,Wang X,Yu XH,Tan JL,Yang YJ

    更新日期:2016-09-01 00:00:00

  • Local inhibition of GABA affects precedence effect in the inferior colliculus.

    abstract::The precedence effect is a prerequisite for faithful sound localization in a complex auditory environment, and is a physiological phenomenon in which the auditory system selectively suppresses the directional information from echoes. Here we investigated how neurons in the inferior colliculus respond to the paired sou...

    journal_title:Neural regeneration research

    pub_type: 杂志文章

    doi:10.4103/1673-5374.128250

    authors: Wang Y,Wang N,Wang D,Jia J,Liu J,Xie Y,Wen X,Li X

    更新日期:2014-02-15 00:00:00

  • Current view and perspectives in amyotrophic lateral sclerosis.

    abstract::Amyotrophic lateral sclerosis (ALS), identified as a distinct clinical entity by Charcot since the end of the nineteenth century, is a devastating and fatal neurodegenerative disorder that affects motor neurons in the brain, brainstem and spinal cord. Survival of patients with ALS is associated with several factors su...

    journal_title:Neural regeneration research

    pub_type: 杂志文章,评审

    doi:10.4103/1673-5374.200794

    authors: Mathis S,Couratier P,Julian A,Corcia P,Le Masson G

    更新日期:2017-02-01 00:00:00

  • High-frequency (50 Hz) electroacupuncture ameliorates cognitive impairment in rats with amyloid beta 1-42-induced Alzheimer's disease.

    abstract::Acupuncture has been shown to ameliorate cognitive impairment of Alzheimer's disease. Acupoints and stimulation frequency influence the therapeutic effect of electroacupuncture. Rat models of Alzheimer's disease were established by injecting amyloid beta 1-42 (Aβ1-42) into the bilateral lateral ventricles. Electroacup...

    journal_title:Neural regeneration research

    pub_type: 杂志文章

    doi:10.4103/1673-5374.238620

    authors: Yu CC,Wang Y,Shen F,Kong LH,Wang YW,Zhou H,Tang L

    更新日期:2018-10-01 00:00:00

  • ISP and PAP4 peptides promote motor functional recovery after peripheral nerve injury.

    abstract::Both intracellular sigma peptide (ISP) and phosphatase and tensin homolog agonist protein (PAP4) promote nerve regeneration and motor functional recovery after spinal cord injury. However, the role of these two small peptides in peripheral nerve injury remains unclear. A rat model of brachial plexus injury was establi...

    journal_title:Neural regeneration research

    pub_type: 杂志文章

    doi:10.4103/1673-5374.294565

    authors: Lv SQ,Wu W

    更新日期:2021-08-01 00:00:00