Abstract:
:Magnesium (Mg) wire has been shown to be biodegradable and have anti-inflammatory properties. It can induce Schwann cells to secrete nerve growth factor and promote the regeneration of nerve axons after central nervous system injury. We hypothesized that biodegradable Mg wire may enhance compressed peripheral nerve regeneration. A rat acute sciatic nerve compression model was made, and AZ31 Mg wire (3 mm diameter; 8 mm length) bridged at both ends of the nerve. Our results demonstrate that sciatic functional index, nerve growth factor, p75 neurotrophin receptor, and tyrosine receptor kinase A mRNA expression are increased by Mg wire in Mg model. The numbers of cross section nerve fibers and regenerating axons were also increased. Sciatic nerve function was improved and the myelinated axon number was increased in injured sciatic nerve following Mg treatment. Immunofluorescence histopathology showed that there were increased vigorous axonal regeneration and myelin sheath coverage in injured sciatic nerve after Mg treatment. Our findings confirm that biodegradable Mg wire can promote the regeneration of acute compressed sciatic nerves.
journal_name
Neural Regen Resjournal_title
Neural regeneration researchauthors
Li BH,Yang K,Wang Xdoi
10.4103/1673-5374.197146subject
Has Abstractpub_date
2016-12-01 00:00:00pages
2012-2017issue
12eissn
1673-5374issn
1876-7958pii
NRR-11-2012journal_volume
11pub_type
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journal_title:Neural regeneration research
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pub_type: 杂志文章,评审
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journal_title:Neural regeneration research
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journal_title:Neural regeneration research
pub_type: 杂志文章,评审
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journal_title:Neural regeneration research
pub_type: 杂志文章
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journal_title:Neural regeneration research
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journal_title:Neural regeneration research
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